Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.2727 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.013 | 0.7829 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0117 | 0.6983 | 0.892 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.3671 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.0556 | 0.071 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.013 | 0.7829 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.3671 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.2727 | 0.697 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0117 | 0.6983 | 0.892 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0556 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0556 | 0.1514 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0556 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.3671 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0.0556 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.2727 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0556 | 0.1514 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.3671 | 0.3671 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.3671 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.2727 | 0.7428 |
Leishmania major | trypanothione reductase | 0.0051 | 0.2727 | 0.697 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0556 | 0.1514 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.3671 | 0.4689 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.2727 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.7241 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0117 | 0.6983 | 0.892 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.2727 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0556 | 0.1514 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.2727 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.3671 | 0.3671 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0556 | 0.0437 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.3671 | 1 |
Brugia malayi | glutathione reductase | 0.0051 | 0.2727 | 0.3543 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0556 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0117 | 0.6983 | 0.892 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.2727 | 0.3483 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0556 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0117 | 0.6983 | 0.892 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0556 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.7241 | 1 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0556 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.013 | 0.7829 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0117 | 0.6983 | 0.892 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.013 | 0.7829 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.2727 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0556 | 0.0556 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0117 | 0.6983 | 0.892 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.2727 | 0.3543 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.3671 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.7241 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.2727 | 0.7428 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0556 | 0.1514 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.3671 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.