Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0394 | 0.0394 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0092 | 0.0231 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Brugia malayi | hypothetical protein | 0.012 | 0.5152 | 0.5152 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.2757 | 0.3563 |
Loa Loa (eye worm) | fli-1 protein | 0.0217 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0394 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.215 | 0.215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1422 | 0.1422 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.5152 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.5152 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.5404 | 0.5404 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0444 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0444 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.5404 | 0.5404 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0394 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0394 | 0.1468 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0394 | 0.1665 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1422 | 0.1422 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0444 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1422 | 0.1422 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0394 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.5404 | 0.5404 |
Echinococcus multilocularis | geminin | 0.0172 | 0.7738 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7738 | 0.7738 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.5404 | 0.5404 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0929 | 0.0929 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0394 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.215 | 0.2778 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5152 | 0.5152 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5152 | 0.5152 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1422 | 0.1838 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1729 | 0.1729 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1422 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0394 | 0.0394 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.215 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.5404 | 0.6983 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2241 | 0.2241 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0444 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.5404 | 0.6983 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.2757 | 0.3563 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.215 | 0.215 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0444 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0092 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1422 | 0.1838 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.5404 | 0.5404 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0929 | 0.0929 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.215 | 0.2778 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.2757 | 0.2757 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0444 | 0.0444 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0394 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.2757 | 0.2757 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0394 | 0.1468 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1422 | 0.1422 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7738 | 0.7738 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0394 | 0.0394 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.2757 | 0.2757 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0444 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0394 | 0.0394 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0394 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0394 | 0.1468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.2757 | 0.2757 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0394 | 0.1665 |
Brugia malayi | RNA binding protein | 0.0125 | 0.5404 | 0.5404 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0929 | 0.0929 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0444 | 0.0444 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1729 | 0.1729 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1422 | 0.1422 |
Schistosoma mansoni | ets-related | 0.0217 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.7738 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0444 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0394 | 0.0394 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1422 | 0.1838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.