Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.037 | 0.037 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.037 | 0.0038 |
Echinococcus granulosus | dna polymerase eta | 0.007 | 0.3758 | 0.3543 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.3941 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.1518 | 0.1454 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.1906 | 0.1627 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.037 | 0.0038 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.037 | 0.0046 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.3941 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.1518 | 0.7965 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1518 | 0.7904 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1913 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3758 | 0.3758 |
Brugia malayi | hypothetical protein | 0.0143 | 0.8682 | 0.8682 |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Brugia malayi | hypothetical protein | 0.0042 | 0.1913 | 0.1913 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.1913 | 0.1939 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.037 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.1035 | 0.2625 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.1906 | 0.4835 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.3941 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.1906 | 0.4835 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.037 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.037 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8682 | 0.8682 |
Leishmania major | DNA polymerase eta, putative | 0.0041 | 0.1822 | 0.4624 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2999 | 0.2999 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.007 | 0.3758 | 0.3758 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.1035 | 0.2625 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.037 | 0.0038 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1518 | 0.3851 |
Onchocerca volvulus | Cathepsin F homolog | 0.0019 | 0.037 | 0.0426 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2999 | 0.2999 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.1518 | 0.7965 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.1906 | 0.1906 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.037 | 0.0038 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.1906 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.1518 | 0.7965 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.1906 | 0.1627 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1518 | 0.7965 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.037 | 0.0038 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1913 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.1035 | 0.2625 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1518 | 0.7965 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.1906 | 0.4835 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.037 | 0.0939 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.1906 | 0.193 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.007 | 0.3758 | 0.9535 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.1035 | 0.2625 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.7233 | 0.7233 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.037 | 0.0038 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.037 | 0.0426 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.1906 | 0.1627 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.1518 | 0.1518 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.037 | 0.037 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.037 | 0.0046 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1913 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.1906 | 0.1906 |
Echinococcus multilocularis | dna polymerase eta | 0.007 | 0.3758 | 0.3543 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.037 | 0.0038 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.037 | 0.0939 |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 0.8682 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.037 | 0.037 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.1906 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2999 | 0.2999 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.1906 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1913 | 0.1939 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1913 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.1906 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.8482 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.037 | 0.1934 |
Leishmania major | DNA polymerase eta, putative | 0.007 | 0.3758 | 0.9535 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0019 | 0.037 | 0.0939 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.037 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.1518 | 0.1226 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.037 | 0.0939 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.037 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0066 | 0.3521 | 0.8934 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1518 | 0.7965 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0333 | 0.0333 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.7233 | 0.7233 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0333 | 0.0333 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.037 | 0.0939 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.1913 | 0.1635 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.037 | 0.037 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1765 | 0.1757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.3941 | 1 |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.1518 | 0.3851 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.037 | 0.0038 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.037 | 0.037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.037 | 0.037 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.1518 | 0.3851 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0163 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.1906 | 0.1627 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.1906 | 0.193 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.1518 | 0.1226 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0163 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0041 | 0.1822 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0333 | 0.0333 |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.037 | 0.037 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1765 | 0.1765 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1518 | 0.7934 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1518 | 0.7965 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0073 | 0.3941 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.037 | 0.037 |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.1906 | 0.4835 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Leishmania major | cysteine peptidase A (CPA) | 0.0019 | 0.037 | 0.0939 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Giardia lamblia | DINP protein human, muc B family | 0.0042 | 0.1906 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Schistosoma mansoni | DNA polymerase eta | 0.007 | 0.3758 | 0.4203 |
Onchocerca volvulus | 0.0094 | 0.5404 | 0.6224 | |
Onchocerca volvulus | Huntingtin homolog | 0.0143 | 0.8682 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1518 | 0.7934 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2999 | 0.2999 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0029 | 0.1035 | 0.2625 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.1906 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.7233 | 0.7233 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.037 | 0.037 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.1518 | 0.7965 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8682 | 0.8682 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0333 | 0.0333 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1765 | 0.1765 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.037 | 0.1934 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.037 | 0.5 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.037 | 0.037 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.1913 | 0.1635 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.007 | 0.3758 | 0.9535 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.037 | 0.037 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.1906 | 0.4835 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1518 | 0.3851 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.1518 | 0.1518 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Onchocerca volvulus | 0.0019 | 0.037 | 0.0426 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Leishmania major | cathepsin L-like protease | 0.0073 | 0.3941 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.1906 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.3941 | 1 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.037 | 0.0939 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.8482 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.037 | 0.1934 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.037 | 0.0426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.037 | 0.1942 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0057 | 0.2905 | 0.737 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.1906 | 0.4835 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.1518 | 0.7965 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.1906 | 0.996 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0041 | 0.1822 | 0.4624 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0073 | 0.3941 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.