Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Onchocerca volvulus | 0.0031 | 0.0679 | 0.5019 | |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1263 | 0.1766 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0252 | 0.6903 | 0.6893 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.1312 | 0.1834 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0222 | 0.55 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0404 | 1 |
Schistosoma mansoni | smad | 0.0008 | 0.0042 | 0.0042 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0679 | 0.0679 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.8901 | 0.8901 |
Brugia malayi | MH2 domain containing protein | 0.0261 | 0.7154 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0261 | 0.7154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.6903 | 0.9649 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0404 | 0.0373 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0729 | 0.0699 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0318 | 0.0287 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0318 | 0.0287 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0404 | 0.0373 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.3817 | 0.3797 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0404 | 0.2366 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0404 | 0.2366 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0095 | 0.0132 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0008 | 0.0042 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1312 | 0.1834 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3475 | 0.3475 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0318 | 0.0318 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0042 | 0.0058 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.3475 | 0.4857 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0404 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0404 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.3817 | 0.3797 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1707 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.3817 | 0.3817 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0318 | 0.0445 |
Loa Loa (eye worm) | nuclear factor I | 0.001 | 0.0095 | 0.0132 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.1312 | 0.1284 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0404 | 0.0404 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0252 | 0.6903 | 0.6893 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0095 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0362 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.013 | 0.3475 | 0.4857 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0404 | 0.0564 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3475 | 0.3475 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.1312 | 0.1284 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.1312 | 0.1834 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0318 | 0.0287 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0222 | 0.55 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.3817 | 0.5335 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0209 | 0.5706 | 0.5692 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.3817 | 0.3797 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0318 | 0.0318 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.1707 | 0.168 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.145 | 0.8494 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.006 | 0.1519 | 0.1492 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0261 | 0.7154 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.0404 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1519 | 0.2123 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.1707 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | MBCTL1 | 0.006 | 0.1519 | 0.2123 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0729 | 0.0729 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0318 | 0.0287 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1707 | 1 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0042 | 0.0042 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0222 | 0.55 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0042 | 0.0058 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0404 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0085 | 0.0053 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0209 | 0.5706 | 0.5692 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.1312 | 0.1312 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0085 | 0.0118 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.3475 | 0.4857 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1707 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3475 | 0.3475 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0679 | 0.095 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0404 | 0.0373 |
Onchocerca volvulus | 0.0053 | 0.1312 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.3817 | 0.3797 |
Onchocerca volvulus | 0.0051 | 0.1263 | 0.9614 | |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.006 | 0.1519 | 0.1492 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 0.2366 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1263 | 0.1263 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0404 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.006 | 0.1519 | 0.1519 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.006 | 0.1519 | 0.1492 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0318 | 0.0445 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0318 | 0.0318 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0042 | 0.0058 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3475 | 0.3475 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0404 | 0.0564 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0318 | 0.0445 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0404 | 0.0373 |
Echinococcus granulosus | smad | 0.0018 | 0.0318 | 0.0287 |
Echinococcus granulosus | mothers against decapentaplegic 2 | 0.0008 | 0.0042 | 0.0009 |
Brugia malayi | hypothetical protein | 0.0252 | 0.6903 | 0.9649 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.0404 | 0.0564 |
Echinococcus multilocularis | mothers against decapentaplegic 2 | 0.0008 | 0.0042 | 0.0009 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.1312 | 0.1284 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1707 | 0.1707 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0095 | 0.0132 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0404 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0404 | 0.0373 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0404 | 0.0373 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.0404 | 0.2366 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0404 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0404 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0085 | 0.0053 |
Brugia malayi | Smad1 | 0.0018 | 0.0318 | 0.0445 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0404 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0318 | 0.0445 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0729 | 0.0699 |
Echinococcus multilocularis | geminin | 0.0362 | 1 | 1 |
Echinococcus multilocularis | smad | 0.0018 | 0.0318 | 0.0287 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.1645 | 0.1645 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1707 | 0.1707 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0222 | 0.55 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.1312 | 0.1834 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.3817 | 0.3817 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1263 | 0.1263 |
Echinococcus granulosus | mothers against decapentaplegic 6 | 0.0008 | 0.0042 | 0.0009 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.3817 | 0.3817 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.1707 | 0.168 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.1707 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0679 | 0.095 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.3475 | 0.4857 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0729 | 0.0729 |
Schistosoma mansoni | smad | 0.0018 | 0.0318 | 0.0318 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0362 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.1707 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.1312 | 0.1312 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0318 | 0.0445 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0404 | 0.2366 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.1312 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0042 | 0.0058 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0318 | 0.0287 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0222 | 0.55 |
Brugia malayi | RNA binding protein | 0.013 | 0.3475 | 0.4857 |
Echinococcus multilocularis | mothers against decapentaplegic 6 | 0.0008 | 0.0042 | 0.0009 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.006 | 0.1519 | 0.1492 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.3475 | 0.3454 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0318 | 0.0445 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.3475 | 0.3454 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0318 | 0.0445 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.3817 | 0.5335 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0404 | 0.0404 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0318 | 0.0287 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0081 | 0.0114 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0318 | 0.0318 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0404 | 0.0564 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0318 | 0.0318 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.1312 | 0.1284 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.1312 | 0.1312 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.006 | 0.1519 | 0.2123 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3475 | 0.3475 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.3475 | 0.4857 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0404 | 0.0404 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0404 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.