TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 371.271 | Formula: C19H19BrN2O
H donors: 0 H acceptors: 1 LogP: 4.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)C1CC(=NN1C(=O)C)c1ccc(c(c1)C)C
InChi: 1S/C19H19BrN2O/c1-12-4-5-16(10-13(12)2)18-11-19(22(21-18)14(3)23)15-6-8-17(20)9-7-15/h4-10,19H,11H2,1-3H3
InChiKey: SKPDUMIEGIXXAE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.007	0.0961	0.2803
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0203	0.0178
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0037	0.0444	0.0328
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.007	0.0961	0.2803
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.032	0.0355
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0042	0.0522	0.042
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.007	0.0961	0.2803
Echinococcus multilocularis	Smad4	0.0017	0.012	0.0184
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0019	0.0152	0.0234
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0836	0.0725
Trichomonas vaginalis	glutathione reductase, putative	0.007	0.0961	0.0919
Entamoeba histolytica	hypothetical protein	0.0039	0.0468	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Plasmodium vivax	thioredoxin reductase, putative	0.0203	0.3039	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0203	0.3039	0.4735
Toxoplasma gondii	exonuclease III APE	0.0022	0.0203	0.0178
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0019	0.0152	0.0234
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0203	0.1626
Trichomonas vaginalis	chromobox protein, putative	0.0218	0.327	0.3543
Trichomonas vaginalis	conserved hypothetical protein	0.0122	0.1771	0.184
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.007	0.0961	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Schistosoma mansoni	chromobox protein	0.0218	0.327	0.3189
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0515	0.7922	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0017	0.012	0.0184
Brugia malayi	Smad1	0.0017	0.012	0.0134
Plasmodium vivax	heterochromatin protein 1, putative	0.0036	0.0418	0.0921
Trichomonas vaginalis	chromobox protein, putative	0.0036	0.0418	0.0302
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Trichomonas vaginalis	glucosylceramidase, putative	0.0581	0.8955	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.007	0.0961	0.2803
Brugia malayi	MH1 domain containing protein	0.0009	0.0003	0.0004
Echinococcus granulosus	Chromobox protein 3	0.0036	0.0418	0.0648
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Entamoeba histolytica	hypothetical protein	0.0036	0.0418	0.8396
Trichomonas vaginalis	glucosylceramidase, putative	0.0402	0.6148	0.6812
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0203	0.0227
Onchocerca volvulus		0.0029	0.032	0.0296
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0203	0.0178
Echinococcus granulosus	glutamate synthase	0.0019	0.0152	0.0234
Loa Loa (eye worm)	MH2 domain-containing protein	0.0017	0.012	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0468	0.0727
Brugia malayi	hypothetical protein	0.0036	0.0418	0.0466
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0464	0.7113	0.8958
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0042	0.0522	0.042
Echinococcus multilocularis	dnaJ subfamily B	0.0419	0.6416	1
Onchocerca volvulus		0.0096	0.1358	0.2126
Echinococcus multilocularis	chromobox protein 1	0.0218	0.327	0.5095
Schistosoma mansoni	hypothetical protein	0.0036	0.0418	0.0301
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.007	0.0961	0.2803
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0203	0.0058
Loa Loa (eye worm)	glutathione reductase	0.0203	0.3039	0.3393
Trichomonas vaginalis	glucosylceramidase, putative	0.0581	0.8955	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Trichomonas vaginalis	Heterochromatin protein, putative	0.0036	0.0418	0.0302
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0418	0.8396
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1771	0.1977
Loa Loa (eye worm)	thioredoxin reductase	0.0203	0.3039	0.3393
Trichomonas vaginalis	mercuric reductase, putative	0.007	0.0961	0.0919
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0464	0.7113	0.8958
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0019	0.0152	0.017
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0418	0.8396
Echinococcus multilocularis	chromobox protein 1	0.0218	0.327	0.5095
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0036	0.0418	0.0648
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0203	0.0636
Loa Loa (eye worm)	MH1 domain-containing protein	0.0017	0.012	0.0132
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0042	0.0522	0.042
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0203	0.0314
Trypanosoma brucei	trypanothione reductase	0.0203	0.3039	1
Brugia malayi	Heterochromatin protein 1	0.0218	0.327	0.3652
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0203	0.0178
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0042	0.0522	0.042
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0203	0.0225
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.007	0.0961	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.007	0.0961	1
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.1213	0.1206
Brugia malayi	SET domain containing protein	0.0036	0.0428	0.0478
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0052	0.0669	0.0747
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0418	0.0921
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0203	0.0178
Trichomonas vaginalis	chromobox protein, putative	0.0131	0.1917	0.2005
Schistosoma mansoni	cpg binding protein	0.0031	0.0346	0.0229
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0019	0.0152	0.0234
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0468	0.0353
Schistosoma mansoni	hypothetical protein	0.0039	0.0468	0.0353
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0203	0.0178
Brugia malayi	M-phase phosphoprotein, mpp8	0.0036	0.0418	0.0466
Plasmodium falciparum	heterochromatin protein 1	0.0036	0.0418	0.0921
Schistosoma mansoni	chromobox protein	0.0218	0.327	0.3189
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0515	0.7922	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0418	0.0302
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0581	0.8955	1
Mycobacterium tuberculosis	Probable reductase	0.0464	0.7113	0.8958
Trichomonas vaginalis	chromobox protein, putative	0.0036	0.0418	0.0302
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0039	0.0466	0.0357
Brugia malayi	MH1 domain containing protein	0.0017	0.012	0.0134
Toxoplasma gondii	thioredoxin reductase	0.0203	0.3039	1
Brugia malayi	MH2 domain containing protein	0.0017	0.012	0.0134
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0036	0.0418	0.0302
Mycobacterium tuberculosis	Probable dehydrogenase	0.0464	0.7113	0.8958
Echinococcus multilocularis	smad	0.0017	0.012	0.0184
Echinococcus granulosus	chromobox protein 1	0.0218	0.327	0.5095
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1358	0.1515
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0019	0.0152	0.0234
Echinococcus multilocularis	chromobox protein 2	0.0036	0.0418	0.0648
Plasmodium falciparum	glutathione reductase	0.0203	0.3039	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.007	0.0961	0.2803
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0019	0.0152	0.017
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.007	0.0961	0.2803
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0428	0.0312
Echinococcus granulosus	thioredoxin glutathione reductase	0.0203	0.3039	0.4735
Schistosoma mansoni	ap endonuclease	0.0022	0.0203	0.0084
Schistosoma mansoni	sulfide quinone reductase	0.0019	0.0152	0.0032
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.007	0.0961	1
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0036	0.0418	0.0466
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0017	0.012	0.0184
Loa Loa (eye worm)	programmed cell death 8	0.0019	0.0152	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0019	0.0152	0.0234
Onchocerca volvulus	Glucosylceramidase homolog	0.0381	0.5827	1
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0036	0.0418	0.0921
Echinococcus granulosus	chromobox protein 2	0.0036	0.0418	0.0648
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.007	0.0961	1
Brugia malayi	Valyl-tRNA synthetase	0.0036	0.0418	0.0466
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0036	0.0418	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0131	0.1917	0.311
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0019	0.0152	0.0234
Loa Loa (eye worm)	nuclear factor I	0.0009	0.0003	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0203	0.0314
Loa Loa (eye worm)	transcription factor SMAD2	0.0244	0.3683	0.4112
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.007	0.0961	0.1073
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0019	0.0152	0.017
Trichomonas vaginalis	chromobox protein, putative	0.0218	0.327	0.3543
Loa Loa (eye worm)	CHromoDomain protein family member	0.0037	0.0444	0.0494
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0019	0.0152	0.0168
Trichomonas vaginalis	hypothetical protein	0.0036	0.0418	0.0302
Trypanosoma cruzi	trypanothione reductase, putative	0.007	0.0961	0.2803
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.007	0.0961	0.1496
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0122	0.1771	0.2854
Loa Loa (eye worm)	heterochromatin protein 1	0.0218	0.327	0.3651
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0019	0.0152	0.0234
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.007	0.0961	0.1496
Schistosoma mansoni	hypothetical protein	0.0019	0.0152	0.0032
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.007	0.0961	0.2803
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0203	0.0178
Trichomonas vaginalis	glucosylceramidase, putative	0.0581	0.8955	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0203	0.0058
Brugia malayi	glutathione reductase	0.0203	0.3039	0.3394
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0003	0.0002
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0042	0.0522	0.042
Schistosoma mansoni	disulfide oxidoreductase	0.0019	0.0152	0.0032
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Brugia malayi	MH2 domain containing protein	0.0017	0.012	0.0134
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Schistosoma mansoni	cpg binding protein	0.0031	0.0346	0.0229
Trypanosoma cruzi	trypanothione reductase, putative	0.0203	0.3039	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0042	0.0522	0.042
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0019	0.0152	0.0234
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0203	0.0636
Brugia malayi	Thioredoxin reductase	0.0203	0.3039	0.3394
Echinococcus multilocularis	Chromo domain	0.0036	0.0418	0.0648
Schistosoma mansoni	glutamate synthase	0.0019	0.0152	0.0032
Treponema pallidum	NADH oxidase	0.007	0.0961	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0515	0.7922	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.007	0.0961	0.0852
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0036	0.0418	0.0301
Schistosoma mansoni	cpg binding protein	0.0029	0.032	0.0202
Plasmodium falciparum	thioredoxin reductase	0.0203	0.3039	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0581	0.8955	1
Schistosoma mansoni	hypothetical protein	0.0419	0.6416	0.6373
Leishmania major	trypanothione reductase	0.0203	0.3039	1
Echinococcus granulosus	Smad4	0.0017	0.012	0.0184
Onchocerca volvulus		0.0036	0.0418	0.0468
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0036	0.0418	0.0648
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0203	0.3039	0.3716
Echinococcus granulosus	cpg binding protein	0.0031	0.0346	0.0537
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0037	0.0444	0.0689
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Entamoeba histolytica	hypothetical protein	0.0036	0.0418	0.8396
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0464	0.7113	0.8958
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0019	0.0152	0.0234
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Echinococcus granulosus	smad	0.0017	0.012	0.0184
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Echinococcus multilocularis	cpg binding protein	0.0031	0.0346	0.0537
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0418	0.0302
Echinococcus granulosus	dnaJ subfamily B	0.0419	0.6416	1
Brugia malayi	Associated with TFs and helicases family protein	0.0036	0.0418	0.0466
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0468	0.0727
Toxoplasma gondii	NADPH-glutathione reductase	0.007	0.0961	0.2803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0042	0.0522	0.042
Brugia malayi	MH1 domain containing protein	0.0009	0.0003	0.0004
Brugia malayi	CXXC zinc finger family protein	0.0029	0.032	0.0357
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0019	0.0152	0.0234
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0019	0.0152	0.0234
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0037	0.0444	0.0689
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0039	0.0474	0.0366
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0036	0.0418	0.8396
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.007	0.0961	0.2803
Schistosoma mansoni	glutamate synthase	0.0019	0.0152	0.0032
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0464	0.7113	0.8958
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0581	0.8955	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0052	0.0669	0.0747
Trichomonas vaginalis	chromobox protein, putative	0.0036	0.0418	0.0302
Schistosoma mansoni	glutamate synthase	0.0019	0.0152	0.0032
Echinococcus multilocularis	glutamate synthase	0.0019	0.0152	0.0234
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Schistosoma mansoni	chromobox protein	0.0036	0.0418	0.0301
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0019	0.0152	0.0234
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0036	0.0418	0.0921
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0017	0.012	0.0184
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0203	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Brugia malayi	MH2 domain containing protein	0.0244	0.3683	0.4113
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0732	0.2008
Loa Loa (eye worm)	helicase	0.0036	0.0418	0.0464
Brugia malayi	glutamate synthase	0.0019	0.0152	0.017
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.007	0.0961	0.2803
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.1213	0.1206
Trichomonas vaginalis	conserved hypothetical protein	0.0122	0.1771	0.184
Brugia malayi	hypothetical protein	0.0039	0.0468	0.0523
Brugia malayi	MH1 domain containing protein	0.0017	0.012	0.0134
Plasmodium falciparum	thioredoxin reductase	0.007	0.0961	0.2803
Schistosoma mansoni	sulfide quinone reductase	0.0019	0.0152	0.0032
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0203	0.0636
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.007	0.0961	0.1042
Loa Loa (eye worm)	MH2 domain-containing protein	0.0244	0.3683	0.4112
Entamoeba histolytica	hypothetical protein	0.0039	0.0468	1
Echinococcus granulosus	chromobox protein 1	0.0218	0.327	0.5095
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0042	0.0522	0.042
Entamoeba histolytica	hypothetical protein	0.0039	0.0468	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Giardia lamblia	NADH oxidase lateral transfer candidate	0.007	0.0961	1
Loa Loa (eye worm)	Smad1	0.0017	0.012	0.0132
Plasmodium falciparum	glutathione reductase	0.007	0.0961	0.2803
Trichomonas vaginalis	chromobox protein, putative	0.0131	0.1917	0.2005
Echinococcus granulosus	mothers against decapentaplegic 5	0.0017	0.012	0.0184
Entamoeba histolytica	hypothetical protein	0.0039	0.0468	1
Brugia malayi	Protein cec-1.	0.0036	0.0418	0.0466
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0036	0.0418	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0036	0.0418	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0418	0.0464
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0474	0.0366
Trichomonas vaginalis	glucosylceramidase, putative	0.0581	0.8955	1
Onchocerca volvulus		0.0036	0.0418	0.0468
Entamoeba histolytica	hypothetical protein	0.0036	0.0418	0.8396
Brugia malayi	chromobox protein homolog 3	0.0122	0.1771	0.1978
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Mycobacterium tuberculosis	Probable oxidoreductase	0.0515	0.7922	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0381	0.5827	0.6447
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.007	0.0961	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0418	0.0921
Onchocerca volvulus		0.0036	0.0428	0.0486
Echinococcus multilocularis	Chromobox protein 3	0.0036	0.0418	0.0648
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0203	0.0636
Trichomonas vaginalis	glucosylceramidase, putative	0.0402	0.6148	0.6812
Schistosoma mansoni	chromobox protein	0.0036	0.0418	0.0301
Plasmodium vivax	glutathione reductase, putative	0.0203	0.3039	1
Brugia malayi	CHD4 protein	0.0037	0.0444	0.0496
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0036	0.0418	0.0921
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.007	0.0961	0.2803
Trichomonas vaginalis	glucosylceramidase, putative	0.0581	0.8955	1
Schistosoma mansoni	ap endonuclease	0.0022	0.0203	0.0084
Echinococcus granulosus	Chromo domain	0.0036	0.0418	0.0648
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0464	0.7113	0.8958
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.007	0.0961	0.2803
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.007	0.0961	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.007	0.0961	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0152	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0418	0.0302
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0036	0.0418	0.0921

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 20.61 uM	Inhibition of histidine-tagged recombinant EGFR autophosphorylation expressed in Sf9 cells by solid-phase ELISA	ChEMBL.	20627597
MIC (functional)	= 25 ug ml-1	Antimicrobial activity against Escherichia coli ATCC 35218 by MTT assay	ChEMBL.	20594840

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1173023

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1168469