Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.1443 | 0.2514 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0064 | 0.1443 | 0.1499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.395 | 0.73 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.395 | 0.4352 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0334 | 0.0375 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.1443 | 0.1619 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0284 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.4262 | 0.7895 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0998 | 0.1119 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0441 | 0.0495 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.5118 | 0.5681 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0441 | 0.0495 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0256 | 0.8914 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0249 | 0.0141 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0334 | 0.613 |
Onchocerca volvulus | 0.0261 | 0.9124 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0256 | 0.8914 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0249 | 0.0236 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0545 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.5118 | 0.5742 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.395 | 0.4352 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.0545 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0441 | 0.0495 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.0545 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.004 | 0.0545 | 1 |
Onchocerca volvulus | 0.0091 | 0.2526 | 0.2667 | |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0334 | 0.613 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.004 | 0.0545 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.7892 | 0.8853 |
Brugia malayi | jmjC domain containing protein | 0.0064 | 0.1443 | 0.1619 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.5118 | 0.5681 |
Schistosoma mansoni | jumonji domain containing protein | 0.0064 | 0.1443 | 0.2514 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.9124 | 0.9094 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.395 | 0.4431 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0441 | 0.8106 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.004 | 0.0545 | 0.013 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0249 | 0.4575 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0249 | 0.0141 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0249 | 0.4575 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0441 | 0.0495 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.7892 | 0.8853 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0441 | 0.0495 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.0545 | 0.0218 |
Onchocerca volvulus | 0.0038 | 0.0441 | 0.0351 | |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0998 | 0.1665 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.004 | 0.0545 | 0.0477 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.004 | 0.0545 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0441 | 0.0111 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.004 | 0.0545 | 0.0611 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0441 | 0.036 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0334 | 0.0375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.395 | 0.73 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0334 | 0.613 |
Echinococcus granulosus | geminin | 0.0164 | 0.5365 | 0.5961 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.0545 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0441 | 0.0111 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0126 | 0.0141 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5365 | 0.5961 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0441 | 0.8106 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.004 | 0.0545 | 0.0477 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5365 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0126 | 0.0141 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0139 | 0.4358 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.004 | 0.0545 | 0.0263 |
Brugia malayi | RNA binding protein | 0.0128 | 0.395 | 0.4431 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0998 | 0.1665 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0441 | 0.0111 |
Onchocerca volvulus | 0.0033 | 0.0249 | 0.0137 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0441 | 0.0495 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0441 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0441 | 0.0495 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.004 | 0.0545 | 0.0218 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0441 | 0.0603 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.395 | 0.4431 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.395 | 0.4431 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0441 | 0.0111 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.5118 | 0.5681 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0249 | 0.0236 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.0545 | 0.08 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.0545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0126 | 0.0141 |
Onchocerca volvulus | 0.0052 | 0.0998 | 0.0969 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0202 | 0.0087 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.0334 | 0.0237 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0441 | 0.8106 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0249 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.8914 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.5118 | 0.5742 |
Onchocerca volvulus | 0.0038 | 0.0441 | 0.0351 | |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0334 | 0.613 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0064 | 0.1443 | 0.2514 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.395 | 0.73 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0064 | 0.1443 | 0.1499 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5365 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0249 | 0.0141 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.4262 | 0.7895 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0104 | 0.0117 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0139 | 0.4358 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.1443 | 0.1619 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0064 | 0.1443 | 0.1499 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0249 | 0.028 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 1 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.0334 | 0.0237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.395 | 0.73 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0064 | 0.1443 | 0.1499 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.395 | 0.4431 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0441 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0441 | 0.0495 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0139 | 0.4358 | 0.4937 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.0334 | 0.0398 |
Onchocerca volvulus | 0.0038 | 0.0441 | 0.0351 | |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0126 | 0.0141 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0126 | 0.0141 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0441 | 0.0603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.395 | 0.73 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0249 | 0.0236 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.395 | 0.4431 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0284 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0441 | 0.0495 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0249 | 0.0236 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.004 | 0.0545 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0256 | 0.8914 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.0545 | 0.0218 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0242 | 0.8374 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.004 | 0.0545 | 0.0611 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0441 | 0.8106 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0441 | 0.0495 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0441 | 0.8106 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0441 | 0.0111 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0334 | 0.613 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0441 | 0.8106 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0441 | 0.0495 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0441 | 0.0111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.