Detailed information for compound 1168863

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.152 | Formula: C13H12BrN2+
  • H donors: 1 H acceptors: 0 LogP: 3.44 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[n+]1ccc2c(c1)[nH]c1c2cc(cc1)Br
  • InChi: 1S/C13H11BrN2/c1-2-16-6-5-10-11-7-9(14)3-4-12(11)15-13(10)8-16/h3-8H,2H2,1H3/p+1
  • InChiKey: NQQHSYVCFKRGCS-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0199 0.0199
Loa Loa (eye worm) glutathione reductase 0.0095 0.2775 0.2775
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0199 0.0199
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0199 0.0199
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0245 0.0882
Brugia malayi glutathione reductase 0.0095 0.2775 0.773
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0833 0.8974
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0833 0.0647
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.6849 0.8908
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0312 0.0312
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0697 0.6904
Loa Loa (eye worm) hypothetical protein 0.0065 0.1761 0.1761
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.09 0.2506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1126 0.1126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0245 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.09 0.3242
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1706 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0385 0.1389
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0312 0.1126
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0697 0.2512
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.2775 0.2629
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0833 0.3
Toxoplasma gondii exonuclease III APE 0.0019 0.0245 0.0882
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0838 0.0838
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0697 0.4085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0245 0.0882
Entamoeba histolytica hypothetical protein 0.0037 0.0838 0.9059
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0833 0.2319
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0199 0.0553
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.09 0.3242
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0697 0.4085
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1126 0.0946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1126 0.1126
Echinococcus multilocularis importin subunit beta 1 0.0029 0.057 0.0379
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0833 0.0647
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.09 0.0715
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.1706 0.1971
Onchocerca volvulus 0.0018 0.0199 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.09 0.09
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0199 0.0553
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0199 0.0199
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0199 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0199 0.0553
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.6849 0.8908
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1706 0.1538
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.09 0.3242
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.6849 0.8908
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0312 0.3472
Leishmania major importin beta-1 subunit, putative 0.0024 0.0385 0.1389
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0312 0.0116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.7658 1
Toxoplasma gondii thioredoxin reductase 0.0095 0.2775 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.6849 0.8908
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0697 0.2512
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.1706 0.6149
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0312 0.1126
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0312 0.087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0245 0.0882
Echinococcus granulosus dna polymerase kappa 0.0039 0.09 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0199 0.0199
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0697 0.0697
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0697 0.2512
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.1706 0.1538
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.359 0.359
Loa Loa (eye worm) hypothetical protein 0.0029 0.057 0.057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0833 0.3
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1126 0.0946
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0697 0.2512
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0199 0.0553
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.09 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0312 0.1126
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.2775 1
Schistosoma mansoni hypothetical protein 0.0037 0.0838 0.0838
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0199 0.0199
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0697 0.2512
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0199 0.0553
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0245 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1126 0.0946
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0199 0.0553
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.057 0.2053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0199 0.0199
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0312 0.1126
Entamoeba histolytica Ran family GTPase 0.0021 0.0312 0.1031
Brugia malayi RNA, U transporter 1 0.0083 0.2367 0.6592
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0199 0.0199
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0697 0.061
Trypanosoma brucei unspecified product 0.0027 0.0495 0.1783
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.1761 0.4905
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0199 0.0553
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.1706 0.4753
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0199 0.0199
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0833 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0833 0.8974
Entamoeba histolytica hypothetical protein 0.0037 0.0838 0.9059
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0199 0.0199
Echinococcus granulosus dna polymerase eta 0.0065 0.1761 0.1594
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.09 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0833 0.0647
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0199 0.0199
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0199 0.0199
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0312 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0833 0.8974
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0697 0.2512
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0697 0.0509
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0199 0.0553
Plasmodium falciparum glutathione reductase 0.0033 0.0697 0.2512
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0245 0.0882
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.09 0.09
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0697 0.2512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0199 0.0199
Plasmodium vivax glutathione reductase, putative 0.0095 0.2775 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0245 0.0245
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1126 0.1126
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0199 0.0199
Entamoeba histolytica hypothetical protein 0.0037 0.0838 0.9059
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.1706 1
Schistosoma mansoni ap endonuclease 0.0019 0.0245 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0199 0.0553
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0697 0.1941
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.09 0.09
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0245 0.0682
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0385 0.2146
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Mycobacterium tuberculosis Probable reductase 0.0216 0.6849 0.8908
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1126 0.1126
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.2775 0.2629
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.7658 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0245 0.0882
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1444 0.1444
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0697 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Brugia malayi ecdysteroid receptor 0.0018 0.0199 0.0553
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0385 0.2146
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0838 0.0653
Brugia malayi MH2 domain containing protein 0.0119 0.359 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0697 0.4085
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0245 0.1435
Brugia malayi Importin beta-1 subunit 0.0029 0.057 0.1587
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.09 0.3242
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.057 0.2053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Leishmania major DNA polymerase kappa, putative 0.0039 0.09 0.3242
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0697 0.2512
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0199 0.0553
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.09 0.3242
Plasmodium vivax importin-beta 2, putative 0.0029 0.057 0.2053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0697 0.2512
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0199 0.0553
Leishmania major DNA polymerase eta, putative 0.0065 0.1761 0.6345
Leishmania major DNA polymerase eta, putative 0.0038 0.0861 0.3103
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.1761 0.6345
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0199 0.5
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0697 0.2512
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0833 0.0647
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.09 0.3242
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0312 0.1126
Brugia malayi nuclear receptor NHR-88 0.0018 0.0199 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0199 0.0553
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.09 0.0883
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0861 0.3103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0199 0.0199
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.1706 0.1706
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.09 0.0715
Schistosoma mansoni ap endonuclease 0.0019 0.0245 0.0245
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.7658 1
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0199 0.0199
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.09 0.5273
Loa Loa (eye worm) hypothetical protein 0.0037 0.0833 0.0833
Plasmodium falciparum glutathione reductase 0.0095 0.2775 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1126 0.0946
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Schistosoma mansoni DNA polymerase eta 0.0065 0.1761 0.1761
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0833 0.3
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.1761 0.6345
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0245 0.0882
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0838 0.0653
Schistosoma mansoni coup transcription factor 0.0018 0.0199 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0697 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Trypanosoma brucei unspecified product 0.0039 0.09 0.3242
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Echinococcus multilocularis dna polymerase kappa 0.0039 0.09 0.0715
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.2775 0.3413
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0697 0.6904
Entamoeba histolytica hypothetical protein 0.0037 0.0838 0.9059
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0405 0.1127
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0495 0.1783
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0697 0.2512
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0495 0.1783
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.09 0.0883
Trypanosoma brucei unspecified product 0.0027 0.0495 0.1783
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.09 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.057 0.2053
Echinococcus multilocularis snurportin 1 0.031 1 1
Treponema pallidum NADH oxidase 0.0033 0.0697 1
Plasmodium falciparum importin beta, putative 0.0029 0.057 0.2053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0199 0.0199
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0697 0.2512
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.2775 0.2775
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0697 0.2512
Leishmania major GTP-binding protein, putative 0.0021 0.0312 0.1126
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.09 0.3242
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.2775 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.6849 0.8908
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.359 0.359
Entamoeba histolytica hypothetical protein 0.0024 0.0385 0.2146
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.09 0.3242
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.7658 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0199 0.5
Schistosoma mansoni ran 0.0021 0.0312 0.0312
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0697 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1126 0.3136
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0312 0.1126
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0861 0.3103
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0833 0.8974
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.09 0.5273
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0697 0.2512
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0697 0.2512
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0199 0.0553
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0833 0.3
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0833 0.0833
Plasmodium falciparum thioredoxin reductase 0.0095 0.2775 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0697 0.7747
Schistosoma mansoni ran 0.0021 0.0312 0.0312
Leishmania major trypanothione reductase 0.0095 0.2775 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0199 0.0199
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0245 0.2722
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0833 0.0833
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0405 0.1127
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0697 0.0509
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0697 0.2512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0199 0.0553
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0199 0.0553
Brugia malayi nuclear hormone receptor 0.0018 0.0199 0.0553
Schistosoma mansoni hypothetical protein 0.031 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0833 0.9253
Trichomonas vaginalis ran, putative 0.0021 0.0312 0.1031
Brugia malayi Thioredoxin reductase 0.0095 0.2775 0.773
Brugia malayi steroid hormone receptor 0.0018 0.0199 0.0553
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0199 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0199 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0495 0.1783
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0385 0.2146
Trypanosoma brucei trypanothione reductase 0.0095 0.2775 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0199 0.0199
Brugia malayi hypothetical protein 0.0037 0.0838 0.2335
Echinococcus multilocularis dna polymerase eta 0.0065 0.1761 0.1594
Schistosoma mansoni importin beta-1 0.0029 0.057 0.057
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0833 0.0647
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0199 0.0553
Echinococcus granulosus importin subunit beta 1 0.0029 0.057 0.0379
Plasmodium falciparum thioredoxin reductase 0.0033 0.0697 0.2512
Giardia lamblia DINP protein human, muc B family 0.0039 0.09 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.09 0.3242

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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