Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.