TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 475.948 | Formula: C21H22ClN5O4S
H donors: 3 H acceptors: 5 LogP: 1.03 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1c(C)ccn(c1=O)NCS(=O)(=O)c1ccc(cc1)Cl)NCc1ccnc(c1)N
InChi: 1S/C21H22ClN5O4S/c1-14-7-9-27(26-13-32(30,31)17-4-2-16(22)3-5-17)21(29)18(14)11-20(28)25-12-15-6-8-24-19(23)10-15/h2-10,26H,11-13H2,1H3,(H2,23,24)(H,25,28)
InChiKey: SJAQMPBUYFSTGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0073	0.0631	0.063
Echinococcus granulosus	neuropeptide s receptor	0.0073	0.0631	0.063
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Onchocerca volvulus		0.0014	0.0062	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0374	0.3559	0.8948
Brugia malayi	Dopamine receptor protein 2	0.0073	0.0631	0.1081
Leishmania major	hypothetical protein, conserved	0.0023	0.0148	0.8519
Loa Loa (eye worm)	hypothetical protein	0.0214	0.2008	0.5049
Onchocerca volvulus		0.0014	0.0062	0.0713
Echinococcus granulosus	neuropeptide receptor	0.0073	0.0631	0.063
Echinococcus multilocularis	lamin dm0	0.0029	0.0205	0.0204
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0014	0.0062	0.0106
Echinococcus granulosus	tumor protein p63	0.0365	0.3477	0.3477
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0417	0.3977	0.6814
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0073	0.0631	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0205	0.0351
Echinococcus granulosus	Regulator of differentiation 1	0.0013	0.0051	0.005
Schistosoma mansoni	neuropeptide receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	hypothetical protein	0.0073	0.0631	0.0854
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0073	0.0631	0.0854
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0107	0.0268
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0205	0.0513
Echinococcus multilocularis	neuroligin	0.0052	0.0427	0.0426
Schistosoma mansoni	opsin-like receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0429	0.0573
Schistosoma mansoni	cpg binding protein	0.0028	0.0194	0.0246
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0014	0.0062	0.0154
Onchocerca volvulus		0.0029	0.0205	0.3045
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0214	0.2008	0.2777
Brugia malayi	Carboxylesterase family protein	0.0052	0.0427	0.0732
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0393	0.0392
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0171	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.013
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0014	0.0062	0.0061
Brugia malayi	Carboxylesterase family protein	0.0052	0.0427	0.0732
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Echinococcus multilocularis	serotonin receptor	0.0214	0.2008	0.2008
Echinococcus multilocularis	neuropeptide receptor A26	0.0073	0.0631	0.063
Onchocerca volvulus		0.0073	0.0631	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0171	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Brugia malayi	G protein-coupled receptor	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0073	0.0631	0.063
Echinococcus granulosus	glycine receptor subunit beta	0.0014	0.0062	0.0061
Loa Loa (eye worm)	carboxylesterase	0.0052	0.0427	0.1071
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0205	0.026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0014	0.0062	0.0061
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0393	0.0392
Echinococcus multilocularis	dro:myosuppressin receptor	0.0073	0.0631	0.063
Schistosoma mansoni	polypyrimidine tract binding protein	0.0013	0.0051	0.0046
Echinococcus multilocularis	neuropeptide Y receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0073	0.0181
Schistosoma mansoni	hypothetical protein	0.0073	0.0631	0.0854
Brugia malayi	G protein-coupled receptor F59B2.13	0.0073	0.0631	0.1081
Brugia malayi	Carboxylesterase family protein	0.0308	0.2916	0.4996
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Trypanosoma cruzi	polypyrimidine tract-binding protein, putative	0.0013	0.0051	0.2523
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0429	0.0734
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0107	0.0309
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0073	0.0631	0.1081
Schistosoma mansoni	hypothetical protein	0.001	0.0023	0.0006
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0148	1
Schistosoma mansoni	lamin	0.0029	0.0205	0.026
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0.0148	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0051	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0029	0.02	0.05
Echinococcus multilocularis	neuropeptides capa receptor	0.0073	0.0631	0.063
Brugia malayi	CXXC zinc finger family protein	0.0027	0.018	0.0308
Echinococcus multilocularis	tumor protein p63	0.0365	0.3477	0.3477
Echinococcus granulosus	orexin receptor type 2	0.0073	0.0631	0.063
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0073	0.0631	0.063
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0171	0.1974
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0073	0.0631	0.1081
Echinococcus granulosus	fmrfamide receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Echinococcus granulosus	hypothetical protein	0.0875	0.8438	0.8438
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0014	0.0062	0.0061
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.018	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Trypanosoma brucei	Double RNA-binding domain containing protein 4	0.0013	0.0051	0.2523
Toxoplasma gondii	LsmAD domain-containing protein	0.0023	0.0148	0.2693
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Echinococcus multilocularis	Regulator of differentiation 1	0.0013	0.0051	0.005
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0073	0.0631	0.063
Loa Loa (eye worm)	ACC-1 protein	0.0014	0.0062	0.0154
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.0427	0.057
Onchocerca volvulus		0.0014	0.0062	0.0713
Schistosoma mansoni	amine GPCR	0.0073	0.0631	0.0854
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Echinococcus multilocularis	somatostatin receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Brugia malayi	G-protein coupled receptor	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Onchocerca volvulus		0.0073	0.0631	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0073	0.0631	0.0854
Brugia malayi	Cation transporter family protein	0.0014	0.0062	0.0106
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0052	0.0427	1
Brugia malayi	ORL1-like opioid receptor	0.0073	0.0631	0.1081
Echinococcus multilocularis	glycine receptor subunit beta	0.0014	0.0062	0.0061
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0511	0.4889	0.6798
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0107	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0171	0.0426
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0073	0.0631	0.063
Schistosoma mansoni	cpg binding protein	0.0027	0.018	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0014	0.0062	0.0061
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0073	0.0631	0.063
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0014	0.0062	0.0061
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.0427	0.057
Echinococcus multilocularis	conserved hypothetical protein	0.0802	0.7729	0.7729
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0073	0.0631	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0148	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Schistosoma mansoni	acetylcholinesterase	0.0052	0.0427	0.057
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0073	0.0631	0.1081
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.001	0.0023	0.0022
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0.0148	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0073	0.0631	0.063
Echinococcus granulosus	7TM GPCR rhodopsin	0.0073	0.0631	0.063
Echinococcus granulosus	neuropeptide receptor	0.0073	0.0631	0.063
Schistosoma mansoni	histamine h1 receptor	0.0073	0.0631	0.0854
Echinococcus multilocularis	neuropeptide receptor	0.0073	0.0631	0.063
Onchocerca volvulus		0.0014	0.0062	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Brugia malayi	Cation transporter family protein	0.0014	0.0062	0.0106
Echinococcus multilocularis	nAChR subunit	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	g protein coupled receptor	0.0073	0.0631	0.063
Schistosoma mansoni	microtubule-associated protein tau	0.0746	0.7184	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0417	0.3977	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	7tm_1 domain containing protein	0.0073	0.0631	0.063
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0062	0.0106
Schistosoma mansoni	amine GPCR	0.0458	0.4378	0.6085
Loa Loa (eye worm)	acetylcholinesterase 1	0.0308	0.2916	0.7331
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0014	0.0062	0.0061
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Schistosoma mansoni	biogenic amine receptor	0.0073	0.0631	0.0854
Brugia malayi	Carboxylesterase family protein	0.0052	0.0427	0.0732
Schistosoma mansoni	hypothetical protein	0.0073	0.0631	0.0854
Mycobacterium ulcerans	carboxylesterase, LipT	0.0052	0.0427	1
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1036	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0107	0.0268
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Onchocerca volvulus		0.0052	0.0427	0.6674
Schistosoma mansoni	myosin xvIII	0.0073	0.0631	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0073	0.0631	0.063
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0052	0.0427	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0393	0.0392
Schistosoma mansoni	neuropeptide F-like receptor	0.0073	0.0631	0.0854
Onchocerca volvulus		0.0052	0.0427	0.6674
Loa Loa (eye worm)	G-protein coupled receptor	0.0073	0.0631	0.1584
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0073	0.0631	0.1584
Echinococcus granulosus	carboxylesterase 5A	0.0308	0.2916	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Onchocerca volvulus	Putative nachr subunit	0.0014	0.0062	0.0713
Onchocerca volvulus		0.0026	0.0171	0.2485
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0171	0.0292
Echinococcus multilocularis	g protein coupled receptor	0.0073	0.0631	0.063
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0073	0.0631	0.063
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0014	0.0062	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.013
Brugia malayi	hypothetical protein	0.0256	0.241	0.4129
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Schistosoma mansoni	amine GPCR	0.0073	0.0631	0.0854
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0171	1
Echinococcus multilocularis	acetylcholinesterase	0.0308	0.2916	0.2915
Onchocerca volvulus		0.0073	0.0631	1
Schistosoma mansoni	amine GPCR	0.0073	0.0631	0.0854
Brugia malayi	Dopamine receptor	0.0073	0.0631	0.1081
Echinococcus multilocularis	neuropeptide receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0171	0.0426
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0393	0.0987
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0073	0.0631	0.0854
Echinococcus granulosus	tm gpcr rhodopsin	0.0073	0.0631	0.063
Loa Loa (eye worm)	neuropeptide F receptor	0.0073	0.0631	0.1584
Onchocerca volvulus		0.0073	0.0631	1
Loa Loa (eye worm)	LGC-31 protein	0.0014	0.0062	0.0154
Onchocerca volvulus		0.0073	0.0631	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0308	0.2916	0.4043
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0393	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0107	0.0268
Echinococcus granulosus	g protein coupled receptor	0.0073	0.0631	0.063
Brugia malayi	Cation transporter family protein	0.0014	0.0062	0.0106
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0073	0.0631	0.0854
Onchocerca volvulus		0.0073	0.0631	1
Loa Loa (eye worm)	hypothetical protein	0.0417	0.3977	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0014	0.0062	0.0154
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0073	0.0631	0.063
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0171	0.1974
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0014	0.0062	0.0061
Schistosoma mansoni	adenoreceptor	0.0073	0.0631	0.0854
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Loa Loa (eye worm)	neuropeptide F receptor	0.0073	0.0631	0.1584
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0442	0.0591
Brugia malayi	G-protein coupled receptor	0.0073	0.0631	0.1081
Brugia malayi	Serotonin receptor	0.0608	0.5836	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0014	0.0062	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Brugia malayi	GnHR receptor homolog	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	opsin-like receptor	0.0073	0.0631	0.0854
Echinococcus granulosus	neuropeptides capa receptor	0.0073	0.0631	0.063
Onchocerca volvulus		0.0052	0.0429	0.6701
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0014	0.0062	0.0061
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0107	0.5815
Onchocerca volvulus		0.0073	0.0631	1
Schistosoma mansoni	gliotactin	0.0052	0.0427	0.057
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0073	0.0631	0.0854
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0014	0.0062	0.0061
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0073	0.0631	0.063
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0171	0.0292
Echinococcus granulosus	sex peptide receptor	0.0073	0.0631	0.063
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0014	0.0062	0.0061
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0014	0.0062	0.0106
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0107	0.5815
Echinococcus granulosus	neuroligin	0.0052	0.0427	0.0426
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0052	0.0427	0.0426
Onchocerca volvulus		0.0027	0.018	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Onchocerca volvulus		0.0073	0.0631	1
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0073	0.0631	0.063
Schistosoma mansoni	BC026374 protein (S09 family)	0.0052	0.0427	0.057
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0014	0.0062	0.0061
Brugia malayi	hypothetical protein	0.0015	0.0068	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	neuropeptide receptor	0.0073	0.0631	0.0854
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0171	0.1974
Echinococcus multilocularis	geminin	0.018	0.1671	0.167
Echinococcus granulosus	dro:myosuppressin receptor	0.0073	0.0631	0.063
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0073	0.0631	0.0854
Echinococcus granulosus	serotonin receptor	0.0073	0.0631	0.063
Schistosoma mansoni	hypothetical protein	0.0052	0.0429	0.0573
Echinococcus multilocularis	g protein coupled receptor	0.0073	0.0631	0.063
Echinococcus granulosus	cpg binding protein	0.0028	0.0194	0.0193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Schistosoma mansoni	opsin-like receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0073	0.0631	0.063
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0073	0.0631	0.0854
Onchocerca volvulus		0.0052	0.0427	0.6674
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0171	1
Onchocerca volvulus		0.0073	0.0631	1
Echinococcus granulosus	microtubule associated protein 2	0.0746	0.7184	0.7183
Echinococcus multilocularis	sex peptide receptor	0.0073	0.0631	0.063
Schistosoma mansoni	hypothetical protein	0.018	0.1671	0.2307
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0073	0.0631	0.1584
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0014	0.0062	0.0061
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.241	0.2409
Brugia malayi	AKH receptor	0.0073	0.0631	0.1081
Brugia malayi	Melatonin receptor type 1A	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Schistosoma mansoni	neuropeptide F-like receptor	0.0073	0.0631	0.0854
Onchocerca volvulus		0.0029	0.0205	0.3045
Echinococcus granulosus	lamin dm0	0.0029	0.0205	0.0204
Onchocerca volvulus		0.0073	0.0631	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	intermediate filament protein	0.0029	0.0205	0.0204
Loa Loa (eye worm)	carboxylesterase	0.0308	0.2916	0.7331
Brugia malayi	Dopamine receptor protein 1	0.0073	0.0631	0.1081
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0014	0.0062	0.0061
Onchocerca volvulus		0.0073	0.0631	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0073	0.0631	0.1584
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0073	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	amine GPCR	0.0073	0.0631	0.0854
Onchocerca volvulus		0.0073	0.0631	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Brugia malayi	hypothetical protein	0.0052	0.0427	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	neuropeptide receptor A26	0.0073	0.0631	0.063
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0014	0.0062	0.0106
Echinococcus multilocularis	allatostatin A receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Brugia malayi	intermediate filament protein	0.0029	0.0205	0.0351
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0171	0.1974
Onchocerca volvulus		0.0073	0.0631	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0393	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Onchocerca volvulus		0.0073	0.0631	1
Echinococcus granulosus	BC026374 protein S09 family	0.0052	0.0427	0.0426
Trichomonas vaginalis	spcc417.12 protein, putative	0.0052	0.0427	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Echinococcus granulosus	biogenic amine 5HT receptor	0.0214	0.2008	0.2008
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Echinococcus multilocularis	para nitrobenzyl esterase	0.0052	0.0427	0.0426
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0417	0.3977	0.5524
Echinococcus multilocularis	glycine receptor subunit beta	0.0014	0.0062	0.0061
Echinococcus granulosus	neuropeptide Y receptor	0.0073	0.0631	0.063
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0062	0.0106
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0014	0.0062	0.0154
Loa Loa (eye worm)	carboxylesterase	0.0052	0.0427	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Onchocerca volvulus		0.0073	0.0631	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0073	0.0631	0.063
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Toxoplasma gondii	histone lysine methyltransferase SET1	0.005	0.0411	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0073	0.0631	0.1081
Echinococcus multilocularis	acetylcholinesterase	0.0308	0.2916	0.2915
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0014	0.0062	0.0061
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0393	0.0674
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0171	0.2222
Onchocerca volvulus		0.0052	0.0427	0.6674
Schistosoma mansoni	biogenic amine receptor	0.0073	0.0631	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0107	0.0268
Echinococcus multilocularis	g-protein coupled receptor	0.0073	0.0631	0.063
Echinococcus granulosus	tm gpcr rhodopsin	0.0073	0.0631	0.063
Onchocerca volvulus		0.0073	0.0631	1
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Brugia malayi	RE15519p	0.0073	0.0631	0.1081
Echinococcus granulosus	neuropeptide Y receptor	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0171	0.1974
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0073	0.0631	0.063
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0014	0.0062	0.0061
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Onchocerca volvulus		0.0014	0.0062	0.0713
Echinococcus multilocularis	cpg binding protein	0.0028	0.0194	0.0193
Schistosoma mansoni	hypothetical protein	0.0073	0.0631	0.0854
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0052	0.0427	0.057
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0171	0.1974
Echinococcus multilocularis	fmrfamide receptor	0.0073	0.0631	0.063
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0073	0.0631	0.1081
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0052	0.0427	0.057
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0062	0.0106
Echinococcus granulosus	nAChR subunit	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0014	0.0062	0.0061
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0205	0.0513
Echinococcus granulosus	biogenic amine 5HT receptor	0.0511	0.4889	0.4889
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Echinococcus granulosus	geminin	0.018	0.1671	0.167
Echinococcus multilocularis	g protein coupled receptor	0.0073	0.0631	0.063
Schistosoma mansoni	growth hormone secretagogue receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	hypothetical protein	0.018	0.1671	0.2307
Brugia malayi	neuropeptide F receptor	0.0073	0.0631	0.1081
Schistosoma mansoni	cpg binding protein	0.0028	0.0194	0.0246
Echinococcus multilocularis	neuropeptide Y receptor	0.0073	0.0631	0.063
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0171	0.1974
Loa Loa (eye worm)	melatonin receptor type 1A	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0014	0.0062	0.0106
Echinococcus multilocularis	fmrfamide receptor	0.0073	0.0631	0.063
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Brugia malayi	Serotonin receptor	0.0073	0.0631	0.1081
Echinococcus multilocularis	lamin	0.0029	0.0205	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2916	0.7331
Onchocerca volvulus		0.0052	0.0427	0.6674
Loa Loa (eye worm)	TYRA-2 protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0393	0.0523
Echinococcus granulosus	g-protein coupled receptor	0.0073	0.0631	0.063
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0205	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0214	0.2008	0.5049
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.241	0.2409
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	G protein coupled receptor 139	0.0073	0.0631	0.063
Echinococcus granulosus	G protein coupled receptor 139	0.0073	0.0631	0.063
Schistosoma mansoni	biogenic amine receptor	0.0073	0.0631	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0014	0.0062	0.0106
Onchocerca volvulus		0.0053	0.0442	0.6911
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0052	0.0427	0.5
Brugia malayi	putative neuropeptide receptor	0.0073	0.0631	0.1081
Echinococcus granulosus	g protein coupled receptor	0.0073	0.0631	0.063
Brugia malayi	follicle stimulating hormone receptor	0.0073	0.0631	0.1081
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0052	0.0427	0.0426
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0052	0.0427	1
Brugia malayi	hypothetical protein	0.0023	0.0148	0.0254
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Brugia malayi	Carboxylesterase family protein	0.0308	0.2916	0.4996
Brugia malayi	hypothetical protein	0.0073	0.0631	0.1081
Onchocerca volvulus		0.0014	0.0062	0.0713
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0148	1
Echinococcus granulosus	acetylcholinesterase	0.0308	0.2916	0.2915
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0073	0.0631	0.0854
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0171	0.0292
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0014	0.0062	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0062	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0056	0.047	0.063
Onchocerca volvulus		0.0073	0.0631	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0058	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0148	0.037
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0107	0.5
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0014	0.0062	0.0106
Echinococcus multilocularis	carboxylesterase 5A	0.0308	0.2916	0.2915
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0631	0.1584
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0052	0.0427	0.0426
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0073	0.0631	0.063
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0014	0.0062	0.0061
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.001	0.0023	0.0022
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0062	0.0106
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0014	0.0062	0.0061
Brugia malayi	neuropeptide F receptor	0.0073	0.0631	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.1071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0062	0.0106
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0014	0.0062	0.0061
Echinococcus multilocularis	neuropeptides capa receptor	0.0073	0.0631	0.063
Schistosoma mansoni	nAChR subunit	0.0014	0.0062	0.0061
Echinococcus granulosus	para nitrobenzyl esterase	0.0052	0.0427	0.0426
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0511	0.4889	0.4889
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0073	0.0631	0.063
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0062	0.0106
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0148	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0014	0.0062	0.0061
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Echinococcus multilocularis	musashi	0.0029	0.0205	0.0204
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0073	0.0631	0.0854
Schistosoma mansoni	lamin	0.0029	0.0205	0.026
Schistosoma mansoni	neuropeptide receptor	0.0073	0.0631	0.0854
Echinococcus granulosus	lamin	0.0029	0.0205	0.0204
Schistosoma mansoni	polypyrimidine tract binding protein	0.0013	0.0051	0.0046
Brugia malayi	hypothetical protein	0.0013	0.0051	0.0088
Echinococcus granulosus	somatostatin receptor	0.0073	0.0631	0.063
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0014	0.0062	0.0061
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0171	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Brugia malayi	sulfakinin receptor protein	0.0073	0.0631	0.1081
Echinococcus granulosus	neuropeptide FF receptor 2	0.0073	0.0631	0.063
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0073	0.0631	0.0854
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0171	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0393	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2916	0.7331
Loa Loa (eye worm)	ACC-1 protein	0.0014	0.0062	0.0154
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0171	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0014	0.0062	0.0154
Echinococcus granulosus	allatostatin A receptor	0.0073	0.0631	0.063
Echinococcus granulosus	glycine receptor subunit beta	0.0014	0.0062	0.0061
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0014	0.0062	0.0154
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0058	0.0057
Schistosoma mansoni	neuropeptide receptor	0.0073	0.0631	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Brugia malayi	excitatory GABA receptor EXP-1A	0.0014	0.0062	0.0106
Brugia malayi	Carboxylesterase family protein	0.0052	0.0427	0.0732
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0014	0.0062	0.0061
Loa Loa (eye worm)	G-protein coupled receptor	0.0073	0.0631	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0256	0.241	0.6058
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0073	0.0631	0.063
Schistosoma mansoni	neuropeptide f receptor 76f	0.0073	0.0631	0.0854
Echinococcus multilocularis	serotonin receptor	0.0214	0.2008	0.2008
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0171	0.1974
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0058	0.0057
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0062	0.0106
Brugia malayi	larval opioid receptor	0.0073	0.0631	0.1081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0171	0.2222
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0073	0.0631	0.0854
Echinococcus granulosus	neuropeptides capa receptor	0.0073	0.0631	0.063
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0014	0.0062	0.0061
Echinococcus multilocularis	orexin receptor type 2	0.0073	0.0631	0.063
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0051	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0442	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0062	0.0154
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0073	0.0631	0.0854
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0171	0.5
Echinococcus granulosus	acetylcholinesterase	0.0308	0.2916	0.2915
Echinococcus multilocularis	microtubule associated protein 2	0.0746	0.7184	0.7183
Loa Loa (eye worm)	hypothetical protein	0.001	0.0018	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0171	0.0426
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0014	0.0062	0.0061

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1196959

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1169368