Detailed information for compound 116974

Basic information

Technical information
  • TDR Targets ID: 116974
  • Name: N-[3-(dibenzylamino)-2-(ethoxymethyl)phenyl]m ethanesulfonamide
  • MW: 424.556 | Formula: C24H28N2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.02 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCc1c(cccc1N(Cc1ccccc1)Cc1ccccc1)NS(=O)(=O)C
  • InChi: 1S/C24H28N2O3S/c1-3-29-19-22-23(25-30(2,27)28)15-10-16-24(22)26(17-20-11-6-4-7-12-20)18-21-13-8-5-9-14-21/h4-16,25H,3,17-19H2,1-2H3
  • InChiKey: XSWQGNVIQFFQTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[bis(phenylmethyl)amino]-2-(ethoxymethyl)phenyl]methanesulfonamide
  • N-[3-(bis(phenylmethyl)amino)-2-(ethoxymethyl)phenyl]methanesulfonamide
  • N-[3-(bis(benzyl)amino)-2-(ethoxymethyl)phenyl]methanesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin L precursor 0.0017 0.002 0.0044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0552 0.0664
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0017 0.002 0.0196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0053 0.0033
Giardia lamblia Cathepsin B precursor 0.0099 0.0998 1
Onchocerca volvulus 0.0036 0.0245 0.2507
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0149 0.016
Echinococcus granulosus geminin 0.0529 0.6073 0.7565
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0054 0.0067
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0099 0.0998 0.3019
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0149 0.0319
Echinococcus granulosus neuropeptide receptor 0.0027 0.0149 0.016
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.1576
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0053 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0245 0.0528
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.0149 0.0128
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0024 0.0105 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.2539 0.3166
Echinococcus granulosus microtubule associated protein 2 0.0693 0.8021 1
Onchocerca volvulus 0.0092 0.0918 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0149 0.0185
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0053 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0245 0.2302
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0149 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Schistosoma mansoni smad1 5 8 and 0.0025 0.0123 0.0153
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0552 0.3121
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.002 0.0025
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.0149 0.0128
Echinococcus granulosus sex peptide receptor 0.0027 0.0149 0.016
Echinococcus granulosus neuropeptide s receptor 0.0027 0.0149 0.016
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0053 0.0066
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0312 0.0926
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0452 0.0433
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0306
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0105 0.1127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0053 0.0114
Plasmodium vivax unspecified product 0.0017 0.002 0.0196
Giardia lamblia DINP protein human, muc B family 0.0019 0.0054 0.0345
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Mycobacterium tuberculosis Conserved protein 0.0036 0.0245 0.0778
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0149 0.0319
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0149 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Echinococcus granulosus dna polymerase eta 0.0019 0.0054 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0053 0.0114
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0045 0.0354 0.0762
Echinococcus granulosus serotonin receptor 0.0027 0.0149 0.016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2511 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Schistosoma mansoni amine GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni neuropeptide receptor 0.0027 0.0149 0.0185
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0218 0.0198
Loa Loa (eye worm) hypothetical protein 0.0024 0.0105 0.0225
Loa Loa (eye worm) hypothetical protein 0.0038 0.0277 0.0596
Echinococcus granulosus cathepsin L 0.0031 0.0196 0.0219
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0218 0.0469
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Giardia lamblia Cathepsin B precursor 0.0099 0.0998 1
Brugia malayi hypothetical protein 0.0103 0.1039 0.2234
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0149 0.0128
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0149 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.2539 0.3166
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0053 0.0114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0284 0.3181 0.3966
Echinococcus granulosus cysteine protease 0.0031 0.0196 0.0219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0149 0.0128
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0053 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0053 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.1576
Echinococcus multilocularis cpg binding protein 0.0032 0.0198 0.0178
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0149 0.016
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0149 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0053 0.0041
Plasmodium vivax vivapain-3 0.0031 0.0196 0.1882
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.002 0.0025
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.1039 0.316
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0017 0.002 0.0196
Brugia malayi Melatonin receptor type 1A 0.0027 0.0149 0.0319
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi MH1 domain containing protein 0.0025 0.0123 0.0265
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0284 0.3181 0.6843
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0149 0.0185
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0149 0.016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0149 0.0319
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0053 0.0114
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0149 0.0319
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0054 0.0141
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0053 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0149 0.016
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0149 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0053 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni hypothetical protein 0.0399 0.4541 0.5661
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0044
Onchocerca volvulus 0.003 0.0181 0.1794
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0036 0.0045
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0196 0.0219
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0452 0.3888
Schistosoma mansoni biogenic amine receptor 0.0027 0.0149 0.0185
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0149 0.0319
Onchocerca volvulus 0.0053 0.0452 0.4813
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0036 0.0245 0.0528
Echinococcus granulosus caspase 2 0.003 0.0181 0.0201
Brugia malayi beta-lactamase family protein 0.0036 0.0245 0.0528
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0017 0.002 0.0196
Onchocerca volvulus 0.0027 0.0149 0.1428
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0054 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0149 0.0185
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.0239 0.2645 0.5689
Echinococcus multilocularis lamin 0.0027 0.0148 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0218 0.1941
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0149 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Onchocerca volvulus 0.0038 0.0277 0.2862
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0053 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Echinococcus granulosus hypothetical protein 0.0027 0.0149 0.016
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0245 0.2302
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0053 0.0041
Schistosoma mansoni DNA polymerase eta 0.0019 0.0054 0.0067
Onchocerca volvulus 0.0053 0.0452 0.4813
Schistosoma mansoni smad1 5 8 and 0.0025 0.0123 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0149 0.0128
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0053 0.0114
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0053 0.0033
Schistosoma mansoni biogenic amine receptor 0.0027 0.0149 0.0185
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0053 0.0066
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0105 0.0316
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0149 0.0319
Schistosoma mansoni hypothetical protein 0.0021 0.0072 0.009
Echinococcus granulosus intermediate filament protein 0.0027 0.0148 0.016
Brugia malayi RE15519p 0.0027 0.0149 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi Cell death protein 3 precursor 0.003 0.0181 0.039
Schistosoma mansoni opsin-like receptor 0.0027 0.0149 0.0185
Echinococcus granulosus g protein coupled receptor 0.0027 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0149 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0053 0.0114
Loa Loa (eye worm) Smad1 0.0025 0.0123 0.0265
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0552 0.3121
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Schistosoma mansoni histamine h1 receptor 0.0027 0.0149 0.0185
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0149 0.0128
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0245 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0277 0.0596
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Echinococcus multilocularis sex peptide receptor 0.0027 0.0149 0.0128
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0149 0.0128
Loa Loa (eye worm) hypothetical protein 0.0408 0.4649 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.023 0.2539 0.5463
Loa Loa (eye worm) ctsf protein 0.0053 0.0452 0.0973
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.0452 0.4242
Onchocerca volvulus 0.0027 0.0149 0.1428
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0218 0.1941
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0148 0.0319
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0277 0.0346
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0452 0.1376
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0149 0.0319
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0054 0.0141
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0054 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0053 0.0114
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0452 0.054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi CXXC zinc finger family protein 0.0028 0.0156 0.0336
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0245 0.0528
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.8021 0.8017
Brugia malayi beta-lactamase family protein 0.0036 0.0245 0.0528
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Trichomonas vaginalis esterase, putative 0.0036 0.0245 0.2302
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0552 0.2025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Onchocerca volvulus 0.0027 0.0149 0.1428
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.0149 0.0128
Brugia malayi nuclear receptor NHR-88 0.0019 0.0053 0.0114
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3287 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0053 0.0365
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0092 0.0918 0.0899
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.2539 0.2524
Onchocerca volvulus 0.0027 0.0149 0.1428
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0149 0.0128
Trypanosoma brucei unspecified product 0.0019 0.0054 0.0141
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0408 0.4649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Echinococcus granulosus fmrfamide receptor 0.0027 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni biogenic amine receptor 0.0027 0.0149 0.0185
Onchocerca volvulus 0.0053 0.0452 0.4813
Schistosoma mansoni hypothetical protein 0.0129 0.1351 0.1684
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0196 0.1576
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.002 0.0044
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0149 0.0319
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0552 0.0688
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0452 0.4813
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0452 0.4419
Loa Loa (eye worm) hypothetical protein 0.0053 0.0452 0.0973
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0054 0.0165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0129 0.1351 0.2907
Brugia malayi Dopamine receptor 0.0027 0.0149 0.0319
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0452 0.3888
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0149 0.0185
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0196 0.0595
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.002 0.0044
Brugia malayi Cathepsin L-like precursor 0.0038 0.0277 0.0596
Brugia malayi GnHR receptor homolog 0.0027 0.0149 0.0319
Echinococcus granulosus smad 0.0025 0.0123 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0036 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0149 0.0128
Brugia malayi nuclear hormone receptor 0.0019 0.0053 0.0114
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.002 0.0196
Mycobacterium leprae Probable lipase LipE 0.0036 0.0245 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0017 0.002 0.0196
Loa Loa (eye worm) hypothetical protein 0.0279 0.3122 0.6717
Echinococcus granulosus cathepsin b 0.0284 0.3181 0.395
Onchocerca volvulus 0.0027 0.0149 0.1428
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus multilocularis cysteine protease 0.0053 0.0452 0.0433
Echinococcus multilocularis disco interacting protein 2 0.0024 0.0105 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0418 0.1272
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0054 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Toxoplasma gondii hypothetical protein 0.0047 0.0383 0.3564
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni amine GPCR 0.0027 0.0149 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1463 0.4439
Loa Loa (eye worm) hypothetical protein 0.0036 0.0245 0.0528
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0218 0.0198
Brugia malayi MH2 domain containing protein 0.0025 0.0123 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Schistosoma mansoni hypothetical protein 0.0027 0.0149 0.0185
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0149 0.0185
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.0452 0.4242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0277 0.2627
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0024 0.0105 0.0205
Echinococcus multilocularis cathepsin L 0.0031 0.0196 0.0175
Brugia malayi Cathepsin L-like precursor 0.0053 0.0452 0.0973
Loa Loa (eye worm) fibroinase 0.0053 0.0452 0.0973
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0218 0.0198
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0245 0.0778
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0044
Echinococcus granulosus cathepsin b 0.0284 0.3181 0.395
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.1039 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0245 0.0528
Mycobacterium ulcerans hypothetical protein 0.0154 0.1648 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0036 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0024 0.0105 0.0205
Schistosoma mansoni hypothetical protein 0.0027 0.0149 0.0185
Onchocerca volvulus 0.0027 0.0149 0.1428
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.1039 1
Plasmodium vivax unspecified product 0.0031 0.0196 0.1882
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0149 0.0185
Onchocerca volvulus 0.0036 0.0245 0.2507
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.0452 0.4242
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0123 0.0153
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0129 0.1351 0.1663
Onchocerca volvulus 0.0027 0.0149 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.0149 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0279 0.3122 0.6717
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0053 0.0066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0149 0.0128
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0053 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0149 0.016
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0149 0.0128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0558 0.0539
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0114 0.0142
Brugia malayi hypothetical protein 0.0111 0.1131 0.2434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1131 0.1113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0312 0.0948
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.039
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0149 0.0128
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0149 0.0319
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0245 0.0778
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0369 0.0436
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0284 0.3181 0.3966
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0053 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0149 0.0185
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0149 0.016
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.8021 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0053 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3287 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0149 0.0319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Echinococcus multilocularis somatostatin receptor 0.0027 0.0149 0.0128
Brugia malayi MH2 domain containing protein 0.037 0.42 0.9035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0053 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0149 0.1428
Schistosoma mansoni hypothetical protein 0.0027 0.0149 0.0185
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0149 0.0128
Brugia malayi ORL1-like opioid receptor 0.0027 0.0149 0.0319
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0149 0.0319
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0053 0.0041
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Entamoeba histolytica hypothetical protein 0.0111 0.1131 1
Loa Loa (eye worm) cathepsin B 0.0099 0.0998 0.2147
Leishmania major hypothetical protein, conserved 0.0036 0.0245 0.0724
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0149 0.0128
Brugia malayi steroid hormone receptor 0.0019 0.0053 0.0114
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0245 0.2302
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0087 0.0132
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0149 0.0128
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0017 0.002 0.0196
Onchocerca volvulus 0.0027 0.0149 0.1428
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0149 0.0185
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0024 0.0105 0.0205
Schistosoma mansoni cpg binding protein 0.0032 0.0198 0.0247
Brugia malayi AKH receptor 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0041 0.0312 0.0672
Onchocerca volvulus 0.0027 0.0149 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0024 0.0105 0.0205
Echinococcus multilocularis dna polymerase eta 0.0019 0.0054 0.0034
Schistosoma mansoni hypothetical protein 0.0111 0.1131 0.1411
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0245 0.2302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0105 0.0316
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0099 0.0998 0.3036
Echinococcus granulosus lamin dm0 0.0027 0.0148 0.016
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0284 0.3181 0.9678
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0123 0.0128
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0149 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.1039 0.3143
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.002 0.0196
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0181 0.0161
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0245 0.2302
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0245 0.0778
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0452 0.0973
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.002 0.0062
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0092 0.0918 0.1144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1463 0.4452
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0196 0.0595
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0123 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.2539 0.3148
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.42 0.9035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0149 0.0128
Brugia malayi beta-lactamase 0.0036 0.0245 0.0528
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0054 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Toxoplasma gondii cathepsin B 0.0099 0.0998 0.9601
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0129 0.1351 0.1334
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0245 0.0225
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0218 0.0469
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.0244
Echinococcus granulosus cathepsin l1 0.0038 0.0277 0.0321
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0218 0.0663
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0284 0.3181 0.3966
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0024 0.0105 0.0316
Schistosoma mansoni hypothetical protein 0.0027 0.0149 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Onchocerca volvulus 0.0027 0.0149 0.1428
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.42 0.9035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0054 0.0141
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0196 0.1576
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1131 0.1411
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0181 0.0201
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.002 0.0196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0245 0.0306
Schistosoma mansoni Smad4 0.0025 0.0123 0.0153
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0218 0.0198
Schistosoma mansoni hypothetical protein 0.0129 0.1351 0.1684
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Brugia malayi hypothetical protein 0.0066 0.0608 0.1309
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0218 0.0247
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0245 0.0724
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.1039 1
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0149 0.0128
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0452 0.4813
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0277 0.0843
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0149 0.016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0105 0.0316
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0312 0.0948
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Leishmania major hypothetical protein, conserved 0.0103 0.1039 0.3143
Onchocerca volvulus Deterin homolog 0.0092 0.0918 1
Brugia malayi Dopamine receptor protein 1 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0092 0.0918 0.1974
Brugia malayi G protein-coupled receptor 0.0027 0.0149 0.0319
Echinococcus multilocularis caspase 2 0.003 0.0181 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0053 0.0114
Leishmania major cysteine peptidase A (CPA) 0.0053 0.0452 0.1355
Schistosoma mansoni cpg binding protein 0.0032 0.0198 0.0247
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0129 0.1351 0.1334
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1648 0.6488
Loa Loa (eye worm) hypothetical protein 0.0036 0.0245 0.0528
Loa Loa (eye worm) hypothetical protein 0.0103 0.1039 0.2234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0053 0.0114
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0369 0.035
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0149 0.0128
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0053 0.0033
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0149 0.0319
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0149 0.016
Echinococcus granulosus lamin 0.0027 0.0148 0.016
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0452 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0053 0.0114
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0044
Echinococcus granulosus Smad4 0.0025 0.0123 0.0128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0053 0.0114
Echinococcus granulosus g protein coupled receptor 0.0027 0.0149 0.016
Echinococcus multilocularis zinc finger protein 0.0021 0.0078 0.0058
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0105 0.1127
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0196 0.0421
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0072 0.0155
Brugia malayi neuropeptide F receptor 0.0027 0.0149 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0129 0.1351 0.2907
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0054 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Schistosoma mansoni hypothetical protein 0.0279 0.3122 0.3893
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0149 0.0128
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0092 0.0918 0.1974
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.0025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0149 0.0185
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0029 0.0011
Schistosoma mansoni bromodomain containing protein 0.0066 0.0601 0.0749
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus cpg binding protein 0.0032 0.0198 0.0222
Onchocerca volvulus 0.0027 0.0149 0.1428
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0255 0.0293
Brugia malayi hypothetical protein 0.003 0.0181 0.039
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0552 0.0688
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0452 0.0564
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0552 0.5217
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0148 0.0319
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0149 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.2539 0.3148
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0218 0.0663
Brugia malayi Cathepsin L-like precursor 0.0053 0.0452 0.0973
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0149 0.016
Schistosoma mansoni hypothetical protein 0.0092 0.0918 0.1144
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0149 0.0128
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0053 0.0114
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0149 0.016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3287 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0114 0.0093
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0196 0.0572
Echinococcus multilocularis cathepsin b 0.0284 0.3181 0.3167
Brugia malayi Bromodomain containing protein 0.0078 0.0741 0.1595
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0452 0.4419
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0452 0.1376
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0053 0.0365
Echinococcus granulosus dnaJ subfamily B 0.0399 0.4541 0.565
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0053 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0284 0.3181 0.3966
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0149 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0054 0.0165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1131 0.1389
Schistosoma mansoni intermediate filament proteins 0.0027 0.0148 0.0185
Onchocerca volvulus 0.0028 0.0156 0.1511
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0245 0.0778
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0196 0.172
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi larval opioid receptor 0.0027 0.0149 0.0319
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0036 0.002
Schistosoma mansoni amine GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni inhibitor of apoptosis protein 0.0092 0.0918 0.1144
Loa Loa (eye worm) beta-lactamase 0.0036 0.0245 0.0528
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0218 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.1576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0053 0.0114
Schistosoma mansoni hypothetical protein 0.0129 0.1351 0.1684
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0149 0.016
Onchocerca volvulus 0.0053 0.0452 0.4813
Mycobacterium ulcerans hypothetical protein 0.0036 0.0245 0.12
Entamoeba histolytica hypothetical protein 0.0111 0.1131 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0129 0.1351 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0196 0.1791
Schistosoma mansoni hypothetical protein 0.0129 0.1351 0.1684
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0452 0.0433
Schistosoma mansoni neuropeptide receptor 0.0027 0.0149 0.0185
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0054 0.0042
Brugia malayi putative neuropeptide receptor 0.0027 0.0149 0.0319
Schistosoma mansoni hypothetical protein 0.0046 0.0369 0.046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0053 0.0114
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0452 0.0973
Brugia malayi Smad1 0.0025 0.0123 0.0265
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0053 0.0066
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0114
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0105 0.0225
Onchocerca volvulus 0.0053 0.0452 0.4813
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0149 0.016
Onchocerca volvulus 0.0036 0.0245 0.2507
Entamoeba histolytica cysteine protease, putative 0.0053 0.0452 0.3888
Brugia malayi Cathepsin L-like precursor 0.0053 0.0452 0.0973
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0149 0.0128
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0452 0.1376
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0054 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.0244
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0181 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Onchocerca volvulus 0.0027 0.0149 0.1428
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0087 0.0132
Brugia malayi intermediate filament protein 0.0027 0.0148 0.0319
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0053 0.0066
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0149 0.016
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0053 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0218 0.064
Brugia malayi cathepsin B-like cysteine proteinase 0.0284 0.3181 0.6843
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0245 0.12
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus orexin receptor type 2 0.0027 0.0149 0.016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0149 0.0185
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0312 0.0948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0149 0.0128
Echinococcus granulosus dna polymerase kappa 0.0019 0.0054 0.0042
Brugia malayi cathepsin L-like precursor 0.0038 0.0277 0.0596
Mycobacterium ulcerans beta-lactamase 0.0036 0.0245 0.12
Echinococcus granulosus cathepsin l1 0.0053 0.0452 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0196 0.0572
Mycobacterium ulcerans lipase LipD 0.0036 0.0245 0.12
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0036 0.0078
Echinococcus multilocularis musashi 0.0027 0.0148 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0054 0.0141
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.002 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0123 0.0265
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0149 0.016
Schistosoma mansoni opsin-like receptor 0.0027 0.0149 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0053 0.0066
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0149 0.016
Schistosoma mansoni smad1 5 8 and 0.0025 0.0123 0.0153
Brugia malayi Disco-interacting protein 2 homolog 0.0024 0.0105 0.0225
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0452 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Brugia malayi Cathepsin L-like precursor 0.0053 0.0452 0.0973
Schistosoma mansoni myosin xvIII 0.0027 0.0149 0.0185
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0129 0.1351 0.1663
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0149 0.0185
Loa Loa (eye worm) cysteine protease 0.0053 0.0452 0.0973
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0408 0.4649 1
Onchocerca volvulus 0.0053 0.0452 0.4813
Schistosoma mansoni lamin 0.0027 0.0148 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0105 0.0316
Echinococcus multilocularis cathepsin b 0.0284 0.3181 0.3167
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0053 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0245 0.0747
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.002 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.023 0.2539 0.5463
Leishmania major DNA polymerase eta, putative 0.0019 0.0054 0.0141
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.002 0.0044
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0149 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0245 0.0778
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.002 0.0044
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0552 0.0532
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0054 0.0165
Onchocerca volvulus 0.0027 0.0148 0.1425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0053 0.0033
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0452 0.4813
Echinococcus multilocularis Smad4 0.0025 0.0123 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Echinococcus granulosus allatostatin A receptor 0.0027 0.0149 0.016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0245 0.0528
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0029 0.0009
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.2907
Schistosoma mansoni adenoreceptor 0.0027 0.0149 0.0185
Echinococcus granulosus g protein coupled receptor 0.0027 0.0149 0.016
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0105 0.1127
Brugia malayi Cathepsin L-like precursor 0.0053 0.0452 0.0973
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Echinococcus multilocularis lamin dm0 0.0027 0.0148 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.002 0.0025
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0017 0.002 0.0196
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0149 0.0128
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0149 0.0319
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0218 0.0272
Brugia malayi Serotonin receptor 0.0027 0.0149 0.0319
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0149 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0245 0.0306
Schistosoma mansoni neuropeptide receptor 0.0027 0.0149 0.0185
Brugia malayi fibroinase precursor 0.0017 0.002 0.0044
Plasmodium vivax vivapain-2 0.0053 0.0452 0.4355
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0452 0.0433
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0218 0.064
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0196 0.0595
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.4541 0.453
Onchocerca volvulus 0.0053 0.0452 0.4813
Trypanosoma cruzi ISWI complex protein 0.0015 0.0008 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0245 0.0747
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.002 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0099 0.0998 0.1244
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0024 0.0105 0.0205
Entamoeba histolytica hypothetical protein 0.0111 0.1131 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Brugia malayi PHD-finger family protein 0.0027 0.0142 0.0305
Schistosoma mansoni cathepsin C 0.0017 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0044
Echinococcus granulosus inhibitor of apoptosis protein 0.0092 0.0918 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0099 0.0998 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0024 0.0105 0.0205
Echinococcus multilocularis serotonin receptor 0.0027 0.0149 0.0128
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0114 0.0116
Echinococcus granulosus neuropeptide receptor 0.0027 0.0149 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Brugia malayi hypothetical protein 0.0239 0.2645 0.5689
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0149 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0481 0.4519
Schistosoma mansoni opsin-like receptor 0.0027 0.0149 0.0185
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0552 0.1658
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0149 0.0128
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0123 0.0265
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0148 0.0319
Onchocerca volvulus 0.0027 0.0149 0.1428
Brugia malayi MH2 domain containing protein 0.0025 0.0123 0.0265
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0053 0.0114
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0255 0.0235
Schistosoma mansoni amine GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni zinc finger protein 0.0015 0.0008 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0149 0.016
Echinococcus multilocularis cysteine protease 0.0053 0.0452 0.0433
Schistosoma mansoni coup transcription factor 0.0019 0.0053 0.0066
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0452 0.054
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0123 0.0103
Brugia malayi Bromodomain containing protein 0.0039 0.0283 0.0609
Brugia malayi G-protein coupled receptor 0.0027 0.0149 0.0319
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0149 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Mycobacterium tuberculosis Conserved protein 0.0036 0.0245 0.0778
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.0149 0.016
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0218 0.2099
Schistosoma mansoni smad 0.0025 0.0123 0.0153
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0149 0.0319
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0558 0.0672
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.002 0.0196
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0149 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0053 0.0114
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1463 0.4439
Schistosoma mansoni amine GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0181 0.1794
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0054 0.0165
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0053 0.0033
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0245 0.0778
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0054 0.0303
Onchocerca volvulus 0.0027 0.0149 0.1428
Echinococcus granulosus zinc finger protein 0.0021 0.0078 0.0072
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0053 0.0041
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0149 0.0319
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Brugia malayi Cathepsin L-like cysteine proteinase 0.0038 0.0277 0.0596
Schistosoma mansoni cpg binding protein 0.0028 0.0156 0.0194
Brugia malayi neuropeptide F receptor 0.0027 0.0149 0.0319
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0105 0.1127
Echinococcus multilocularis serotonin receptor 0.0027 0.0149 0.0128
Schistosoma mansoni zinc finger protein 0.0021 0.0078 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0196 0.1791
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0029 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0452 0.1376
Brugia malayi MH1 domain containing protein 0.0025 0.0123 0.0265
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0053 0.0041
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0245 0.0778
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0053 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0053 0.0041
Toxoplasma gondii ABC1 family protein 0.0036 0.0245 0.221
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0245 0.0281
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0245 0.2363
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0053 0.0114
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0149 0.0319
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0149 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.2539 0.2524
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0196 0.0595
Toxoplasma gondii cathepsin CPL 0.0053 0.0452 0.4242
Loa Loa (eye worm) hypothetical protein 0.0027 0.0148 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0149 0.0128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0452 0.0973
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0149 0.016
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0452 0.1376
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0053 0.0041
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0017 0.002 0.0196
Schistosoma mansoni hypothetical protein 0.0529 0.6073 0.7571
Plasmodium vivax vivapain-1 0.0031 0.0196 0.1882
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0054 0.0345
Giardia lamblia Cathepsin B precursor 0.0099 0.0998 1
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0196 0.0421
Brugia malayi Cathepsin L-like precursor 0.0053 0.0452 0.0973
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0053 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0053 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0105 0.0316
Echinococcus granulosus somatostatin receptor 0.0027 0.0149 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.2539 0.3166
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0092 0.0918 0.1974
Echinococcus multilocularis smad 0.0025 0.0123 0.0103
Trypanosoma cruzi ISWI complex protein 0.0015 0.0008 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0196 0.0244
Echinococcus granulosus GPCR family 2 0.0129 0.1351 0.1663
Brugia malayi sulfakinin receptor protein 0.0239 0.2645 0.5689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0277 0.2627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.039
Brugia malayi G-protein coupled receptor 0.0027 0.0149 0.0319
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0218 0.1941
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0123 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0196 0.1576
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Plasmodium vivax vivapain-2 0.0053 0.0452 0.4355
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0245 0.12
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.002 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0053 0.0066
Leishmania major DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0054 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0092 0.0918 0.1122
Brugia malayi Serotonin receptor 0.0027 0.0149 0.0319
Brugia malayi hypothetical protein 0.0027 0.0149 0.0319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0053 0.0066
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3287 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0452 0.4419
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0054 0.0034
Schistosoma mansoni lamin 0.0027 0.0148 0.0185
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0149 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0054 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0149 0.0185
Schistosoma mansoni hypothetical protein 0.003 0.0181 0.0226
Echinococcus multilocularis geminin 0.0529 0.6073 0.6065
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0149 0.0185
Onchocerca volvulus 0.0027 0.0149 0.1428
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0017 0.002 0.0196
Leishmania major cathepsin L-like protease 0.0053 0.0452 0.1355
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0149 0.016
Trypanosoma brucei cysteine peptidase C (CPC) 0.0099 0.0998 0.3019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0452 0.1355
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0024 0.0105 0.013
Schistosoma mansoni hypothetical protein 0.0529 0.6073 0.7571
Brugia malayi ecdysteroid receptor 0.0019 0.0053 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0552 0.3121
Onchocerca volvulus 0.0019 0.0053 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0053 0.0114
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0218 0.0667
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0452 0.4419
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0054 0.0165
Loa Loa (eye worm) hypothetical protein 0.0038 0.0277 0.0596
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0149 0.0319
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0527 0.0657
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0149 0.0128
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0277 0.0596
Onchocerca volvulus 0.0027 0.0149 0.1428
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.1039 1
Onchocerca volvulus 0.0027 0.0149 0.1428
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0196 0.0595
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0149 0.016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0149 0.0128
Entamoeba histolytica cysteine protease, putative 0.0031 0.0196 0.1576
Echinococcus granulosus disco interacting protein 2 0.0024 0.0105 0.0105
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0105 0.0316
Entamoeba histolytica hypothetical protein 0.0111 0.1131 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0156 0.0336
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0277 0.2312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0116
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0149 0.1428
Loa Loa (eye worm) hypothetical protein 0.0092 0.0918 0.1974
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.1039 0.316
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0218 0.064
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0149 0.0128
Schistosoma mansoni neuropeptide receptor 0.0027 0.0149 0.0185
Echinococcus multilocularis inhibitor of apoptosis protein 0.0092 0.0918 0.0899
Loa Loa (eye worm) hypothetical protein 0.0072 0.0671 0.1444
Mycobacterium tuberculosis Conserved protein 0.0036 0.0245 0.0778
Brugia malayi isocitrate dehydrogenase 0.0033 0.0218 0.0469
Echinococcus multilocularis GPCR, family 2 0.0129 0.1351 0.1334
Brugia malayi Calcitonin receptor-like protein seb-1 0.0408 0.4649 1
Brugia malayi Dopamine receptor protein 2 0.0027 0.0149 0.0319
Onchocerca volvulus 0.0027 0.0148 0.1425
Loa Loa (eye worm) hypothetical protein 0.0036 0.0245 0.0528

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) nM Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase ChEMBL. 15081010
IC50 (functional) 0 nM Functional activity towards human glucocorticoid receptor in genetically engineered cell line containing glucocorticoid response element and reporter gene encoding a secreted form of alkaline phosphatase ChEMBL. 15081010
IC50 (binding) = 290 nM Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand ChEMBL. 15081010
IC50 (binding) = 290 nM Binding affinity against human Glucocorticoid receptor (GR) using [3H]-dexamethasone as radioligand ChEMBL. 15081010

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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