Detailed information for compound 1169819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 487.694 | Formula: C32H42FN3
  • H donors: 0 H acceptors: 0 LogP: 6.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(CC1)C(c1ccc(cc1)F)CN1CCN(CC1)CCCCc1cccc2c1cccc2
  • InChi: 1S/C32H42FN3/c1-34-19-16-29(17-20-34)32(28-12-14-30(33)15-13-28)25-36-23-21-35(22-24-36)18-5-4-8-27-10-6-9-26-7-2-3-11-31(26)27/h2-3,6-7,9-15,29,32H,4-5,8,16-25H2,1H3
  • InChiKey: RWOYIJLZFRIMKP-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0049 0.0832 0.057
Leishmania major hypothetical protein, conserved 0.0049 0.0832 0.0684
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0049 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0832 0.0828
Schistosoma mansoni smad 0.0008 0.0061 0.0057
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0049 0.0832 0.0776
Mycobacterium tuberculosis Probable dehydrogenase 0.0049 0.0832 0.057
Giardia lamblia Thioredoxin reductase 0.0049 0.0832 0.2215
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.3296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.34
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0832 0.0684
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0101 0.004
Loa Loa (eye worm) thioredoxin reductase 0.0535 1 1
Brugia malayi glutamate synthase 0.0049 0.0832 0.0776
Loa Loa (eye worm) Smad1 0.0008 0.0061 0.0057
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0382 0.0323
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0832 0.2076
Mycobacterium ulcerans dehydrogenase 0.0049 0.0832 0.1773
Trypanosoma cruzi NADH dehydrogenase, putative 0.0049 0.0832 0.0828
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0049 0.0832 0.1773
Treponema pallidum NADH oxidase 0.0185 0.3402 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.34
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0185 0.3402 1
Leishmania major hypothetical protein, conserved 0.0049 0.0832 0.0684
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0223 0.0219
Loa Loa (eye worm) RecQ helicase 0.0025 0.0382 0.0378
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0101 0.0097
Trichomonas vaginalis glutamate synthase, putative 0.0049 0.0832 0.2076
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0049 0.0832 0.1773
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0049 0.0832 0.0776
Toxoplasma gondii exonuclease III APE 0.002 0.0278 0.0274
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0049 0.0832 0.0776
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0049 0.0832 0.2076
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0049 0.0832 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0061 0.0057
Giardia lamblia NADH oxidase lateral transfer candidate 0.0185 0.3402 1
Trypanosoma cruzi trypanothione reductase, putative 0.0535 1 1
Echinococcus multilocularis glutamate synthase 0.0049 0.0832 0.0776
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0049 0.0832 0.0828
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0049 0.0832 0.0776
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0832 0.0828
Schistosoma mansoni DNA helicase recq1 0.001 0.0101 0.0097
Schistosoma mansoni glutamate synthase 0.0049 0.0832 0.0828
Schistosoma mansoni ap endonuclease 0.002 0.0278 0.0274
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0049 0.0832 0.1773
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0049 0.0832 0.1773
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0049 0.0832 0.057
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0185 0.3402 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0832 0.2076
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0101 0.0097
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0049 0.0832 0.0776
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0049 0.0832 0.2215
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0049 0.0832 0.0776
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0185 0.3402 0.34
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0227 0.0227
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0832 0.2076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0278 0.0274
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0049 0.0832 0.0684
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0185 0.3402 0.3213
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0049 0.0832 0.057
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0323 0.0225
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0049 0.0832 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0185 0.3402 0.3296
Trichomonas vaginalis glutathione reductase, putative 0.0185 0.3402 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0185 0.3402 0.3402
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0049 0.0832 0.0828
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0097
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0049 0.0832 0.0828
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0049 0.0832 0.057
Plasmodium falciparum thioredoxin reductase 0.0185 0.3402 0.3335
Echinococcus multilocularis muscleblind protein 0.0146 0.2669 0.2624
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0049 0.0832 0.0776
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0159 0.0155
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0049 0.0832 0.1773
Plasmodium falciparum ferrodoxin reductase-like protein 0.0049 0.0832 0.0739
Loa Loa (eye worm) hypothetical protein 0.0146 0.2669 0.2666
Brugia malayi Muscleblind-like protein 0.0146 0.2669 0.2624
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0278 0.0121
Mycobacterium tuberculosis Probable oxidoreductase 0.0185 0.3402 0.3213
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0101 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.34
Plasmodium falciparum glutathione reductase 0.0535 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0185 0.3402 0.3296
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0049 0.0832 0.057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0278 0.0219
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0049 0.0832 0.0776
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0049 0.0832 0.2076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.34
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0832 0.0684
Schistosoma mansoni ap endonuclease 0.002 0.0278 0.0274
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0185 0.3402 0.3296
Plasmodium vivax ferrodoxin reductase, putative 0.0049 0.0832 0.0832
Echinococcus granulosus thioredoxin glutathione reductase 0.0535 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0185 0.3402 0.3296
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0049 0.0832 0.057
Mycobacterium tuberculosis Probable reductase 0.0049 0.0832 0.057
Loa Loa (eye worm) hypothetical protein 0.0146 0.2669 0.2666
Leishmania major hypothetical protein, conserved 0.0049 0.0832 0.0684
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0049 0.0832 0.1773
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0832 0.0828
Toxoplasma gondii thioredoxin reductase 0.0535 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0049 0.0832 0.2076
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0185 0.3402 0.3335
Schistosoma mansoni DNA helicase recq5 0.001 0.0101 0.0097
Schistosoma mansoni hypothetical protein 0.0049 0.0832 0.0828
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0185 0.3402 0.34
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0049 0.0832 0.0776
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0136 0.2473 0.2427
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0185 0.3402 0.3213
Trichomonas vaginalis glutamate synthase, putative 0.0049 0.0832 0.2076
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0832 0.0828
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0382 0.0687
Giardia lamblia Glutamate synthase 0.0049 0.0832 0.2215
Treponema pallidum thioredoxin reductase (trxB) 0.0049 0.0832 0.2437
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0049 0.0832 0.057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0101 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.34
Schistosoma mansoni Smad4 0.0008 0.0061 0.0057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0278 0.0219
Trypanosoma cruzi trypanothione reductase, putative 0.0185 0.3402 0.34
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0185 0.3402 1
Mycobacterium ulcerans monoxygenase 0.0049 0.0832 0.1773
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0278 0.0278
Entamoeba histolytica thioredoxin reductase, putative 0.0049 0.0832 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.0832 0.1773
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0281 0.0277
Schistosoma mansoni smad1 5 8 and 0.0008 0.0061 0.0057
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0049 0.0832 0.0832
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0278 0.0219
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0185 0.3402 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0185 0.3402 0.3296
Echinococcus granulosus bloom syndrome protein 0.0025 0.0382 0.0323
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0185 0.3402 0.3213
Mycobacterium ulcerans ferredoxin reductase 0.0049 0.0832 0.1773
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0185 0.3402 0.3362
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0049 0.0832 0.0739
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0049 0.0832 0.0828
Plasmodium falciparum glutathione reductase 0.0185 0.3402 0.3335
Toxoplasma gondii selenide, water dikinase 0.0049 0.0832 0.0828
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0049 0.0832 0.0828
Plasmodium vivax thioredoxin reductase, putative 0.0535 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0278 0.0179
Trypanosoma brucei trypanothione reductase 0.0535 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0049 0.0832 0.0776
Trichomonas vaginalis apoptosis inducing factor, putative 0.0049 0.0832 0.2076
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0049 0.0832 0.0684
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0049 0.0832 0.1773
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0049 0.0832 0.0828
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0049 0.0832 0.0776
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0049 0.0832 0.057
Loa Loa (eye worm) hypothetical protein 0.0128 0.2311 0.2308
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2215 0.2212
Brugia malayi MH2 domain containing protein 0.0122 0.2215 0.2167
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0185 0.3402 0.3362
Schistosoma mansoni disulfide oxidoreductase 0.0049 0.0832 0.0828
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0101 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0278 0.0274
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0049 0.0832 0.0828
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0185 0.3402 0.3362
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0185 0.3402 0.3402
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0159 0.1908
Schistosoma mansoni sulfide quinone reductase 0.0049 0.0832 0.0828
Treponema pallidum oxidoreductase 0.0049 0.0832 0.2437
Leishmania major NADH dehydrogenase, putative 0.0049 0.0832 0.0684
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0061 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0382 0.0323
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0185 0.3402 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.34
Entamoeba histolytica disulphide oxidoreductase, putative 0.0049 0.0832 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0185 0.3402 1
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0049 0.0832 0.1773
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0101 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0832 0.0684
Trypanosoma cruzi NADH dehydrogenase, putative 0.0049 0.0832 0.0828
Trichomonas vaginalis mercuric reductase, putative 0.0185 0.3402 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0278 0.0807
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0049 0.0832 0.0776
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0382 0.0687
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0049 0.0832 0.0776
Schistosoma mansoni smad1 5 8 and 0.0008 0.0061 0.0057
Onchocerca volvulus 0.0049 0.0832 0.5
Leishmania major trypanothione reductase 0.0535 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0278 0.0537
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0049 0.0832 0.0832
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0049 0.0832 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0278 0.0368
Schistosoma mansoni glutamate synthase 0.0049 0.0832 0.0828
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0185 0.3402 0.3296
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0832 0.2076
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0278 0.0368
Brugia malayi Thioredoxin reductase 0.0535 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0061 0.0057
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0049 0.0832 0.1773
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0049 0.0832 0.0776
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0535 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0049 0.0832 0.0776
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0101 0.004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0185 0.3402 0.34
Echinococcus granulosus glutamate synthase 0.0049 0.0832 0.0776
Trypanosoma brucei NADH dehydrogenase 0.0049 0.0832 0.0684
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0049 0.0832 0.057
Loa Loa (eye worm) programmed cell death 8 0.0049 0.0832 0.0828
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0832 0.2076
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0049 0.0832 0.0684
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0278 0.3341
Loa Loa (eye worm) glutathione reductase 0.0535 1 1
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0004 0.0046
Schistosoma mansoni smad1 5 8 and 0.0008 0.0061 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0185 0.3402 0.3296
Plasmodium falciparum thioredoxin reductase 0.0535 1 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0049 0.0832 0.0739
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0185 0.3402 0.3335
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0185 0.3402 0.34
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0049 0.0832 0.2076
Schistosoma mansoni sulfide quinone reductase 0.0049 0.0832 0.0828
Echinococcus multilocularis thioredoxin glutathione reductase 0.0535 1 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0049 0.0832 0.1773
Mycobacterium ulcerans NADH dehydrogenase 0.0049 0.0832 0.1773
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0278 0.0274
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0136 0.2473 0.2427
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0049 0.0832 0.0828
Plasmodium vivax glutathione reductase, putative 0.0535 1 1
Echinococcus granulosus muscleblind protein 0.0146 0.2669 0.2624
Schistosoma mansoni glutamate synthase 0.0049 0.0832 0.0828
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0832 0.0828
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0832 0.2076
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2669 0.2624
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0278 0.0121
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0049 0.0832 0.0684
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0049 0.0832 0.0828
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2215 0.2212
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0049 0.0832 0.057
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0049 0.0832 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0101 0.004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0185 0.3402 1
Toxoplasma gondii NADPH-glutathione reductase 0.0185 0.3402 0.34
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0049 0.0832 0.1773

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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