TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.694 | Formula: C32H42FN3
H donors: 0 H acceptors: 0 LogP: 6.63 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCC(CC1)C(c1ccc(cc1)F)CN1CCN(CC1)CCCCc1cccc2c1cccc2
InChi: 1S/C32H42FN3/c1-34-19-16-29(17-20-34)32(28-12-14-30(33)15-13-28)25-36-23-21-35(22-24-36)18-5-4-8-27-10-6-9-26-7-2-3-11-31(26)27/h2-3,6-7,9-15,29,32H,4-5,8,16-25H2,1H3
InChiKey: RWOYIJLZFRIMKP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0049	0.0832	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.004
Onchocerca volvulus		0.0049	0.0832	0.5
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0049	0.0832	0.057
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0049	0.0832	0.2215
Schistosoma mansoni	smad	0.0008	0.0061	0.0057
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0049	0.0832	0.057
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0049	0.0832	0.2076
Trichomonas vaginalis	glutathione reductase, putative	0.0185	0.3402	1
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0049	0.0832	0.0828
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0061	0.0057
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Giardia lamblia	Glutamate synthase	0.0049	0.0832	0.2215
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0049	0.0832	0.1773
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0049	0.0832	0.0828
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0278	0.3341
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0049	0.0832	0.1773
Schistosoma mansoni	glutamate synthase	0.0049	0.0832	0.0828
Trypanosoma brucei	NADH dehydrogenase	0.0049	0.0832	0.0684
Brugia malayi	Muscleblind-like protein	0.0146	0.2669	0.2624
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0049	0.0832	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0278	0.0278
Echinococcus granulosus	muscleblind protein	0.0146	0.2669	0.2624
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0049	0.0832	0.0776
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0049	0.0832	0.1773
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0049	0.0832	0.0832
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3296
Loa Loa (eye worm)	hypothetical protein	0.001	0.0101	0.0097
Mycobacterium ulcerans	monoxygenase	0.0049	0.0832	0.1773
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0049	0.0832	0.1773
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0278	0.0179
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0185	0.3402	0.3296
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0223	0.0219
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Leishmania major	NADH dehydrogenase, putative	0.0049	0.0832	0.0684
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0185	0.3402	0.3335
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Loa Loa (eye worm)	Smad1	0.0008	0.0061	0.0057
Schistosoma mansoni	sulfide quinone reductase	0.0049	0.0832	0.0828
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0049	0.0832	0.2076
Trypanosoma brucei	hypothetical protein, conserved	0.0049	0.0832	0.0684
Mycobacterium ulcerans	dehydrogenase	0.0049	0.0832	0.1773
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0535	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0278	0.0219
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0832	0.1773
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3362
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0061	0.0057
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0185	0.3402	0.3362
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0185	0.3402	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0278	0.0219
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.0097
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0049	0.0832	0.0684
Trypanosoma cruzi	trypanothione reductase, putative	0.0185	0.3402	0.34
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Echinococcus granulosus	thioredoxin glutathione reductase	0.0535	1	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0061	0.0057
Plasmodium vivax	ferrodoxin reductase, putative	0.0049	0.0832	0.0832
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0049	0.0832	0.0828
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0278	0.0121
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0049	0.0832	0.0776
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0382	0.0323
Loa Loa (eye worm)	glutathione reductase	0.0535	1	1
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0049	0.0832	0.0828
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.0159	0.1908
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3296
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0185	0.3402	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0278	0.0807
Trypanosoma brucei	trypanothione reductase	0.0535	1	1
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0049	0.0832	1
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0101	0.004
Schistosoma mansoni	disulfide oxidoreductase	0.0049	0.0832	0.0828
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0323	0.0225
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0049	0.0832	0.0828
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0049	0.0832	0.0776
Trichomonas vaginalis	glutamate synthase, putative	0.0049	0.0832	0.2076
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0049	0.0832	0.0776
Schistosoma mansoni	sulfide quinone reductase	0.0049	0.0832	0.0828
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0382	0.0323
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0049	0.0832	0.0739
Trypanosoma cruzi	hypothetical protein, conserved	0.0049	0.0832	0.0828
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0382	0.0323
Trichomonas vaginalis	mercuric reductase, putative	0.0185	0.3402	1
Schistosoma mansoni	DNA helicase recq1	0.001	0.0101	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0832	0.0828
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0278	0.0368
Schistosoma mansoni	Smad4	0.0008	0.0061	0.0057
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0185	0.3402	0.34
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0185	0.3402	0.34
Trypanosoma cruzi	trypanothione reductase, putative	0.0535	1	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0185	0.3402	0.34
Plasmodium falciparum	thioredoxin reductase	0.0535	1	1
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3362
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0049	0.0832	0.0739
Schistosoma mansoni	ap endonuclease	0.002	0.0278	0.0274
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0101	0.004
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0049	0.0832	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2669	0.2666
Entamoeba histolytica	thioredoxin reductase, putative	0.0049	0.0832	1
Giardia lamblia	Thioredoxin reductase	0.0049	0.0832	0.2215
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.2669	0.2624
Loa Loa (eye worm)	programmed cell death 8	0.0049	0.0832	0.0828
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0049	0.0832	0.0776
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0828
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0049	0.0832	0.0828
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0185	0.3402	1
Treponema pallidum	NADH oxidase	0.0185	0.3402	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0382	0.0687
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.3296
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0684
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0049	0.0832	0.057
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0049	0.0832	0.0832
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0049	0.0832	0.057
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0049	0.0832	0.0776
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0049	0.0832	0.1773
Toxoplasma gondii	NADPH-glutathione reductase	0.0185	0.3402	0.34
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.2215	0.2212
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0049	0.0832	0.057
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0049	0.0832	0.0776
Plasmodium vivax	thioredoxin reductase, putative	0.0535	1	1
Leishmania major	hypothetical protein, conserved	0.0049	0.0832	0.0684
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0049	0.0832	0.0684
Brugia malayi	MH2 domain containing protein	0.0122	0.2215	0.2167
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0049	0.0832	0.0739
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2311	0.2308
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0185	0.3402	0.3335
Mycobacterium ulcerans	NADH dehydrogenase	0.0049	0.0832	0.1773
Treponema pallidum	oxidoreductase	0.0049	0.0832	0.2437
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0049	0.0832	0.0776
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0061	0.0057
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0185	0.3402	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0136	0.2473	0.2427
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0049	0.0832	0.0776
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0061	0.0057
Mycobacterium tuberculosis	Probable dehydrogenase	0.0049	0.0832	0.057
Loa Loa (eye worm)	thioredoxin reductase	0.0535	1	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0159	0.0155
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0185	0.3402	0.3213
Plasmodium vivax	glutathione reductase, putative	0.0535	1	1
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0049	0.0832	0.0684
Leishmania major	hypothetical protein, conserved	0.0049	0.0832	0.0684
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0185	0.3402	1
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0049	0.0832	0.0776
Leishmania major	trypanothione reductase	0.0535	1	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0185	0.3402	0.3402
Toxoplasma gondii	exonuclease III APE	0.002	0.0278	0.0274
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0049	0.0832	0.057
Brugia malayi	glutamate synthase	0.0049	0.0832	0.0776
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0382	0.0687
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0227	0.0227
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0049	0.0832	0.2076
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0049	0.0832	0.0684
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0049	0.0832	0.1773
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0049	0.0832	0.0776
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0101	0.004
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0049	0.0832	0.2076
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0049	0.0832	0.0828
Wolbachia endosymbiont of Brugia malayi	NADPH-dependent glutamate synthase beta chain	0.0049	0.0832	0.1773
Schistosoma mansoni	hypothetical protein	0.0049	0.0832	0.0828
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0049	0.0832	0.2076
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0049	0.0832	0.0776
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0049	0.0832	0.057
Echinococcus multilocularis	muscleblind protein	0.0146	0.2669	0.2624
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0049	0.0832	0.0776
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0049	0.0832	0.1773
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0185	0.3402	0.3402
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0049	0.0832	0.0828
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0185	0.3402	0.3296
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0101	0.0097
Echinococcus granulosus	glutamate synthase	0.0049	0.0832	0.0776
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0049	0.0832	0.1773
Echinococcus multilocularis	glutamate synthase	0.0049	0.0832	0.0776
Trypanosoma cruzi	hypothetical protein, conserved	0.0049	0.0832	0.0828
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0185	0.3402	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0049	0.0832	0.057
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0278	0.0121
Plasmodium falciparum	glutathione reductase	0.0185	0.3402	0.3335
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0185	0.3402	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Brugia malayi	Thioredoxin reductase	0.0535	1	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0278	0.0537
Schistosoma mansoni	DNA helicase recq5	0.001	0.0101	0.0097
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0535	1	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0185	0.3402	0.3296
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0049	0.0832	0.057
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0185	0.3402	0.3213
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0278	0.0274
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0049	0.0832	0.0776
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0049	0.0832	0.0828
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0382	0.0378
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0278	0.0368
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0049	0.0832	0.0828
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0185	0.3402	0.3213
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0136	0.2473	0.2427
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0049	0.0832	0.0828
Toxoplasma gondii	selenide, water dikinase	0.0049	0.0832	0.0828
Mycobacterium ulcerans	ferredoxin reductase	0.0049	0.0832	0.1773
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.3296
Mycobacterium tuberculosis	Probable reductase	0.0049	0.0832	0.057
Schistosoma mansoni	glutamate synthase	0.0049	0.0832	0.0828
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0278	0.0219
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0185	0.3402	0.3296
Entamoeba histolytica	recQ family DNA helicase	0.0005	0.0004	0.0046
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0049	0.0832	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0049	0.0832	0.0776
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0049	0.0832	0.057
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0061	0.0057
Leishmania major	hypothetical protein, conserved	0.0049	0.0832	0.0684
Plasmodium falciparum	thioredoxin reductase	0.0185	0.3402	0.3335
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0101	0.004
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0278	0.0274
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0278	0.0274
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0049	0.0832	0.1773
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.34
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0049	0.0832	0.1773
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0185	0.3402	1
Trichomonas vaginalis	glutamate synthase, putative	0.0049	0.0832	0.2076
Treponema pallidum	thioredoxin reductase (trxB)	0.0049	0.0832	0.2437
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0828
Schistosoma mansoni	ap endonuclease	0.002	0.0278	0.0274
Plasmodium falciparum	glutathione reductase	0.0535	1	1
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0684
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.2215	0.2212
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0281	0.0277
Mycobacterium tuberculosis	Probable oxidoreductase	0.0185	0.3402	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2669	0.2666
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0049	0.0832	1
Toxoplasma gondii	thioredoxin reductase	0.0535	1	1
Schistosoma mansoni	glutamate synthase	0.0049	0.0832	0.0828

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1196208

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1169819