TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.694 | Formula: C32H42FN3
H donors: 0 H acceptors: 0 LogP: 6.63 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCC(CC1)C(c1ccc(cc1)F)CN1CCN(CC1)CCCCc1cccc2c1cccc2
InChi: 1S/C32H42FN3/c1-34-19-16-29(17-20-34)32(28-12-14-30(33)15-13-28)25-36-23-21-35(22-24-36)18-5-4-8-27-10-6-9-26-7-2-3-11-31(26)27/h2-3,6-7,9-15,29,32H,4-5,8,16-25H2,1H3
InChiKey: RWOYIJLZFRIMKP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0049	0.0832	0.057
Leishmania major	hypothetical protein, conserved	0.0049	0.0832	0.0684
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0049	0.0832	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0832	0.0828
Schistosoma mansoni	smad	0.0008	0.0061	0.0057
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0049	0.0832	0.0776
Mycobacterium tuberculosis	Probable dehydrogenase	0.0049	0.0832	0.057
Giardia lamblia	Thioredoxin reductase	0.0049	0.0832	0.2215
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.3296
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0684
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.004
Loa Loa (eye worm)	thioredoxin reductase	0.0535	1	1
Brugia malayi	glutamate synthase	0.0049	0.0832	0.0776
Loa Loa (eye worm)	Smad1	0.0008	0.0061	0.0057
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0382	0.0323
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Mycobacterium ulcerans	dehydrogenase	0.0049	0.0832	0.1773
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0049	0.0832	0.0828
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0049	0.0832	0.1773
Treponema pallidum	NADH oxidase	0.0185	0.3402	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0185	0.3402	1
Leishmania major	hypothetical protein, conserved	0.0049	0.0832	0.0684
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0223	0.0219
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0382	0.0378
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.0097
Trichomonas vaginalis	glutamate synthase, putative	0.0049	0.0832	0.2076
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0049	0.0832	0.1773
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0049	0.0832	0.0776
Toxoplasma gondii	exonuclease III APE	0.002	0.0278	0.0274
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0049	0.0832	0.0776
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0049	0.0832	0.2076
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0049	0.0832	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0061	0.0057
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0185	0.3402	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0535	1	1
Echinococcus multilocularis	glutamate synthase	0.0049	0.0832	0.0776
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0049	0.0832	0.0828
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0049	0.0832	0.0776
Trypanosoma cruzi	hypothetical protein, conserved	0.0049	0.0832	0.0828
Schistosoma mansoni	DNA helicase recq1	0.001	0.0101	0.0097
Schistosoma mansoni	glutamate synthase	0.0049	0.0832	0.0828
Schistosoma mansoni	ap endonuclease	0.002	0.0278	0.0274
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0049	0.0832	0.1773
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0049	0.0832	0.1773
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0049	0.0832	0.057
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0185	0.3402	1
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0101	0.0097
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0049	0.0832	0.0776
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0049	0.0832	0.2215
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0049	0.0832	0.0776
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0185	0.3402	0.34
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0017	0.0227	0.0227
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0278	0.0274
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0049	0.0832	0.0684
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0185	0.3402	0.3213
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0049	0.0832	0.057
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0323	0.0225
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0049	0.0832	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3296
Trichomonas vaginalis	glutathione reductase, putative	0.0185	0.3402	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0185	0.3402	0.3402
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0049	0.0832	0.0828
Loa Loa (eye worm)	hypothetical protein	0.001	0.0101	0.0097
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0049	0.0832	0.0828
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0049	0.0832	0.057
Plasmodium falciparum	thioredoxin reductase	0.0185	0.3402	0.3335
Echinococcus multilocularis	muscleblind protein	0.0146	0.2669	0.2624
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0049	0.0832	0.0776
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0014	0.0159	0.0155
Wolbachia endosymbiont of Brugia malayi	NADPH-dependent glutamate synthase beta chain	0.0049	0.0832	0.1773
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0049	0.0832	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2669	0.2666
Brugia malayi	Muscleblind-like protein	0.0146	0.2669	0.2624
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0278	0.0121
Mycobacterium tuberculosis	Probable oxidoreductase	0.0185	0.3402	0.3213
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0101	0.004
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Plasmodium falciparum	glutathione reductase	0.0535	1	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0185	0.3402	0.3296
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0049	0.0832	0.057
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0278	0.0219
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0049	0.0832	0.0776
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0049	0.0832	0.2076
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0684
Schistosoma mansoni	ap endonuclease	0.002	0.0278	0.0274
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0185	0.3402	0.3296
Plasmodium vivax	ferrodoxin reductase, putative	0.0049	0.0832	0.0832
Echinococcus granulosus	thioredoxin glutathione reductase	0.0535	1	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0185	0.3402	0.3296
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0049	0.0832	0.057
Mycobacterium tuberculosis	Probable reductase	0.0049	0.0832	0.057
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2669	0.2666
Leishmania major	hypothetical protein, conserved	0.0049	0.0832	0.0684
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0049	0.0832	0.1773
Trypanosoma cruzi	hypothetical protein, conserved	0.0049	0.0832	0.0828
Toxoplasma gondii	thioredoxin reductase	0.0535	1	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0049	0.0832	0.2076
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0185	0.3402	0.3335
Schistosoma mansoni	DNA helicase recq5	0.001	0.0101	0.0097
Schistosoma mansoni	hypothetical protein	0.0049	0.0832	0.0828
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0185	0.3402	0.34
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0049	0.0832	0.0776
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0136	0.2473	0.2427
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0185	0.3402	0.3213
Trichomonas vaginalis	glutamate synthase, putative	0.0049	0.0832	0.2076
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0828
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0382	0.0687
Giardia lamblia	Glutamate synthase	0.0049	0.0832	0.2215
Treponema pallidum	thioredoxin reductase (trxB)	0.0049	0.0832	0.2437
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0049	0.0832	0.057
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.0097
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Schistosoma mansoni	Smad4	0.0008	0.0061	0.0057
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0278	0.0219
Trypanosoma cruzi	trypanothione reductase, putative	0.0185	0.3402	0.34
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0185	0.3402	1
Mycobacterium ulcerans	monoxygenase	0.0049	0.0832	0.1773
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0278	0.0278
Entamoeba histolytica	thioredoxin reductase, putative	0.0049	0.0832	1
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0832	0.1773
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0281	0.0277
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0061	0.0057
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0049	0.0832	0.0832
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0278	0.0219
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0185	0.3402	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0185	0.3402	0.3296
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0382	0.0323
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0185	0.3402	0.3213
Mycobacterium ulcerans	ferredoxin reductase	0.0049	0.0832	0.1773
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0185	0.3402	0.3362
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0049	0.0832	0.0739
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0049	0.0832	0.0828
Plasmodium falciparum	glutathione reductase	0.0185	0.3402	0.3335
Toxoplasma gondii	selenide, water dikinase	0.0049	0.0832	0.0828
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0049	0.0832	0.0828
Plasmodium vivax	thioredoxin reductase, putative	0.0535	1	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0278	0.0179
Trypanosoma brucei	trypanothione reductase	0.0535	1	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0049	0.0832	0.0776
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0049	0.0832	0.2076
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0049	0.0832	0.0684
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0049	0.0832	0.1773
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0049	0.0832	0.0828
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0049	0.0832	0.0776
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0049	0.0832	0.057
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2311	0.2308
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.2215	0.2212
Brugia malayi	MH2 domain containing protein	0.0122	0.2215	0.2167
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3362
Schistosoma mansoni	disulfide oxidoreductase	0.0049	0.0832	0.0828
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0101	0.004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0278	0.0274
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0049	0.0832	0.0828
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3362
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0185	0.3402	0.3402
Entamoeba histolytica	recQ family helicase, putative	0.0014	0.0159	0.1908
Schistosoma mansoni	sulfide quinone reductase	0.0049	0.0832	0.0828
Treponema pallidum	oxidoreductase	0.0049	0.0832	0.2437
Leishmania major	NADH dehydrogenase, putative	0.0049	0.0832	0.0684
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0061	0.0057
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0382	0.0323
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0185	0.3402	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.34
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0049	0.0832	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0185	0.3402	1
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0049	0.0832	0.1773
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0101	0.004
Trypanosoma brucei	hypothetical protein, conserved	0.0049	0.0832	0.0684
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0049	0.0832	0.0828
Trichomonas vaginalis	mercuric reductase, putative	0.0185	0.3402	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0278	0.0807
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0049	0.0832	0.0776
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0382	0.0687
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0049	0.0832	0.0776
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0061	0.0057
Onchocerca volvulus		0.0049	0.0832	0.5
Leishmania major	trypanothione reductase	0.0535	1	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0278	0.0537
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0049	0.0832	0.0832
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0049	0.0832	1
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0278	0.0368
Schistosoma mansoni	glutamate synthase	0.0049	0.0832	0.0828
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0185	0.3402	0.3296
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0278	0.0368
Brugia malayi	Thioredoxin reductase	0.0535	1	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0061	0.0057
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0049	0.0832	0.1773
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0049	0.0832	0.0776
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0535	1	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0049	0.0832	0.0776
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0101	0.004
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0185	0.3402	0.34
Echinococcus granulosus	glutamate synthase	0.0049	0.0832	0.0776
Trypanosoma brucei	NADH dehydrogenase	0.0049	0.0832	0.0684
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0049	0.0832	0.057
Loa Loa (eye worm)	programmed cell death 8	0.0049	0.0832	0.0828
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0049	0.0832	0.0684
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0278	0.3341
Loa Loa (eye worm)	glutathione reductase	0.0535	1	1
Entamoeba histolytica	recQ family DNA helicase	0.0005	0.0004	0.0046
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0061	0.0057
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.3296
Plasmodium falciparum	thioredoxin reductase	0.0535	1	1
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0049	0.0832	0.0739
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0185	0.3402	0.3335
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0185	0.3402	0.34
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0049	0.0832	0.2076
Schistosoma mansoni	sulfide quinone reductase	0.0049	0.0832	0.0828
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0535	1	1
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0049	0.0832	0.1773
Mycobacterium ulcerans	NADH dehydrogenase	0.0049	0.0832	0.1773
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0278	0.0274
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0136	0.2473	0.2427
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0049	0.0832	0.0828
Plasmodium vivax	glutathione reductase, putative	0.0535	1	1
Echinococcus granulosus	muscleblind protein	0.0146	0.2669	0.2624
Schistosoma mansoni	glutamate synthase	0.0049	0.0832	0.0828
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0049	0.0832	0.0828
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0049	0.0832	0.2076
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.2669	0.2624
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0278	0.0121
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0049	0.0832	0.0684
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0049	0.0832	0.0828
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.2215	0.2212
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0049	0.0832	0.057
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0049	0.0832	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0101	0.004
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0185	0.3402	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0185	0.3402	0.34
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0049	0.0832	0.1773

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1196208

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1169819