Detailed information for compound 1169963

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 218.232 | Formula: C11H12N3O2+
  • H donors: 1 H acceptors: 2 LogP: 1.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C/c1ccc[n+](c1)Cc1onc(c1)C
  • InChi: 1S/C11H11N3O2/c1-9-5-11(16-13-9)8-14-4-2-3-10(7-14)6-12-15/h2-7H,8H2,1H3/p+1/b12-6+
  • InChiKey: XEGPKNNARUTFEC-WUXMJOGZSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0169 0.0417 0.0621
Echinococcus multilocularis thyroid hormone receptor alpha 0.2146 0.6463 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.008 0.0144 0.0536
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.0417 0.0675
Brugia malayi Nuclear hormone receptor E75 0.008 0.0144 0.0536
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0098 0.02 0.0285
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0169 0.0417 0.1575
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0282 0.0764 0.0744
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.1957 0.3011
Schistosoma mansoni hypothetical protein 0.0077 0.0137 0.0187
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0022 0.0008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0644 0.1869 0.1851
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.008 0.0144 0.0216
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0144 0.0216
Echinococcus granulosus TGF beta signal transducer SmadC 0.0061 0.0087 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0098 0.02 0.2618
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0097 0.0358
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0022 0.0008
Schistosoma mansoni nuclear hormone receptor 0.008 0.0144 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.0417 0.1575
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.0417 0.1575
Trypanosoma brucei unspecified product 0.0039 0.0022 0.0282
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0644 0.1869 0.1851
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0213 0.0305
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0716 0.2089 0.2071
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0169 0.0417 0.2125
Echinococcus granulosus thioredoxin glutathione reductase 0.0283 0.0765 0.1263
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Plasmodium vivax glutathione reductase, putative 0.0282 0.0764 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0169 0.0417 0.2125
Brugia malayi nuclear hormone receptor family member nhr-6 0.008 0.0144 0.0536
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0169 0.0417 0.0675
Brugia malayi nuclear receptor NHR-88 0.008 0.0144 0.0536
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0072 0.0121 0.0446
Loa Loa (eye worm) MH2 domain-containing protein 0.0061 0.0087 0.0316
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0061 0.0087 0.0109
Trypanosoma brucei trypanothione reductase 0.0282 0.0764 1
Loa Loa (eye worm) transcription factor SMAD2 0.0891 0.2625 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0098 0.02 0.2618
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0098 0.02 0.2618
Mycobacterium leprae Conserved hypothetical protein 0.1111 0.3296 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0169 0.0417 0.0675
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0014 0.0188
Loa Loa (eye worm) nuclear receptor nhr-7B 0.008 0.0144 0.0536
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0022 0.0282
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0022 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0034 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.02 0.2618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0169 0.0417 0.1575
Brugia malayi ecdysone receptor 0.008 0.0144 0.0536
Echinococcus granulosus geminin 0.0165 0.0406 0.0657
Brugia malayi tailless protein 0.008 0.0144 0.0536
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0169 0.0417 0.0675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2618
Mycobacterium ulcerans lipoprotein LpqF 0.0064 0.0096 0.0726
Brugia malayi ecdysteroid receptor 0.0169 0.0417 0.1575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0169 0.0417 0.1575
Loa Loa (eye worm) MH1 domain-containing protein 0.0061 0.0087 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0022 0.0282
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0169 0.0417 0.1575
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0133 0.0308 0.278
Loa Loa (eye worm) hypothetical protein 0.0089 0.0173 0.0647
Schistosoma mansoni steroid hormone receptor ad4bp 0.0169 0.0417 0.0621
Echinococcus multilocularis ecdysone induced protein 78C 0.0169 0.0417 0.0621
Mycobacterium tuberculosis Probable reductase 0.0644 0.1869 0.1851
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.0417 0.1575
Entamoeba histolytica hypothetical protein 0.0077 0.0137 1
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0022 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.0098 0.02 1
Schistosoma mansoni retinoic acid receptor RXR 0.0169 0.0417 0.0621
Brugia malayi nuclear receptor RXR 0.008 0.0144 0.0536
Loa Loa (eye worm) steroid hormone receptor 0.0169 0.0417 0.1575
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0097 0.1276
Loa Loa (eye worm) hypothetical protein 0.0064 0.0097 0.0358
Schistosoma mansoni smad1 5 8 and 0.0061 0.0087 0.0109
Schistosoma mansoni Smad4 0.0061 0.0087 0.0109
Brugia malayi hypothetical protein 0.0089 0.0173 0.0647
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0144 0.0198
Loa Loa (eye worm) DR-78 0.008 0.0144 0.0536
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0377 0.1053 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0716 0.2089 0.2071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2618
Plasmodium vivax thioredoxin reductase, putative 0.0282 0.0764 1
Schistosoma mansoni hypothetical protein 0.1978 0.5948 0.92
Echinococcus granulosus microtubule associated protein 2 0.0673 0.1957 0.3273
Schistosoma mansoni nuclear receptor nhr-48 0.008 0.0144 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0169 0.0417 0.0621
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0061 0.0087 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2618
Mycobacterium ulcerans recombinase A 0.0105 0.0223 0.195
Brugia malayi Thioredoxin reductase 0.0282 0.0764 0.2899
Loa Loa (eye worm) hypothetical protein 0.0089 0.0173 0.0647
Schistosoma mansoni smad1 5 8 and 0.0061 0.0087 0.0109
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.1957 0.3011
Schistosoma mansoni smad1 5 8 and 0.0061 0.0087 0.0109
Schistosoma mansoni nuclear hormone receptor 0.0169 0.0417 0.0621
Brugia malayi Nuclear hormone receptor-like 1 0.0169 0.0417 0.1575
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.0417 0.0621
Entamoeba histolytica hypothetical protein 0.0077 0.0137 1
Echinococcus granulosus dna polymerase kappa 0.0039 0.0022 0.0009
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0098 0.02 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0169 0.0417 0.1575
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Onchocerca volvulus 0.0169 0.0417 0.2125
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0144 0.0216
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0169 0.0417 0.0675
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0022 0.0068
Echinococcus granulosus thyroid hormone receptor alpha 0.008 0.0144 0.0216
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0098 0.02 0.2477
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.0417 0.1575
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Brugia malayi hypothetical protein 0.0077 0.0137 0.0509
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0213 0.0332
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2477
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.0417 0.0621
Brugia malayi conserved hypotetical protein 0.008 0.0144 0.0536
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0173 0.0647
Echinococcus multilocularis thioredoxin glutathione reductase 0.0283 0.0765 0.1162
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0098 0.02 0.2477
Echinococcus granulosus nuclear receptor nhr 48 0.008 0.0144 0.0216
Echinococcus granulosus smad 0.0061 0.0087 0.0119
Brugia malayi steroid hormone receptor 0.0169 0.0417 0.1575
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.0144 0.0216
Loa Loa (eye worm) glutathione reductase 0.0282 0.0764 0.2899
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0169 0.0417 0.1575
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0022 0.0009
Echinococcus multilocularis geminin 0.0165 0.0406 0.0604
Onchocerca volvulus 0.0309 0.0845 0.5468
Brugia malayi nuclear hormone receptor family member odr-7 0.008 0.0144 0.0536
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0169 0.0417 0.0621
Echinococcus granulosus mothers against decapentaplegic 5 0.0061 0.0087 0.0119
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1978 0.5948 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0644 0.1869 0.1851
Brugia malayi hypothetical protein 0.008 0.0144 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0098 0.02 0.031
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0098 0.02 0.2618
Loa Loa (eye worm) thioredoxin reductase 0.0282 0.0764 0.2899
Entamoeba histolytica hypothetical protein 0.0077 0.0137 1
Toxoplasma gondii NADPH-glutathione reductase 0.0098 0.02 0.2477
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0098 0.02 0.2618
Echinococcus granulosus ecdysone induced protein 78C 0.0169 0.0417 0.0675
Mycobacterium tuberculosis Probable oxidoreductase 0.0716 0.2089 0.2071
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0149 0.0206
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0089 0.0173 0.0647
Schistosoma mansoni nuclear receptor 0.008 0.0144 0.0198
Brugia malayi MH2 domain containing protein 0.0061 0.0087 0.0316
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0098 0.02 0.0285
Loa Loa (eye worm) pax transcription factor protein 2 0.0499 0.1426 0.5424
Loa Loa (eye worm) Smad1 0.0061 0.0087 0.0316
Leishmania major trypanothione reductase 0.0282 0.0764 1
Brugia malayi orphan nuclear receptor NR2E1 0.008 0.0144 0.0536
Schistosoma mansoni nuclear receptor 0.008 0.0144 0.0198
Trypanosoma cruzi trypanothione reductase, putative 0.0282 0.0764 1
Brugia malayi nuclear hormone receptor 0.0169 0.0417 0.1575
Brugia malayi Smad1 0.0061 0.0087 0.0316
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0064 0.0096 0.0075
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Giardia lamblia NADH oxidase lateral transfer candidate 0.0098 0.02 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.008 0.0144 0.0198
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0169 0.0417 0.0621
Loa Loa (eye worm) MH2 domain-containing protein 0.0891 0.2625 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0169 0.0417 0.0621
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.008 0.0144 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0169 0.0417 0.1575
Echinococcus multilocularis smad 0.0061 0.0087 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0169 0.0417 0.1575
Brugia malayi glutathione reductase 0.0282 0.0764 0.2899
Brugia malayi MH2 domain containing protein 0.0061 0.0087 0.0316
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Onchocerca volvulus Bile acid receptor homolog 0.0169 0.0417 0.2125
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0137 0.0204
Schistosoma mansoni thyroid hormone receptor 0.2146 0.6463 1
Schistosoma mansoni zinc finger protein 0.008 0.0144 0.0198
Schistosoma mansoni Replicative DNA helicase 0.0377 0.1053 0.1607
Schistosoma mansoni hypothetical protein 0.0165 0.0406 0.0604
Plasmodium falciparum thioredoxin reductase 0.0282 0.0764 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus multilocularis mothers against decapentaplegic 5 0.0061 0.0087 0.0109
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0173 0.0244
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0169 0.0417 0.0621
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2477
Echinococcus multilocularis dna polymerase eta 0.0064 0.0097 0.0126
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0098 0.02 0.173
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0231
Loa Loa (eye worm) hypothetical protein 0.0089 0.0173 0.0647
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0169 0.0417 0.0621
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0098 0.02 0.2618
Leishmania major DNA polymerase eta, putative 0.0064 0.0097 0.1109
Toxoplasma gondii thioredoxin reductase 0.0282 0.0764 1
Brugia malayi Nuclear hormone receptor E75 0.008 0.0144 0.0536
Loa Loa (eye worm) hypothetical protein 0.0309 0.0845 0.3209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.0417 0.0675
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0169 0.0417 0.1575
Trichomonas vaginalis mercuric reductase, putative 0.0098 0.02 1
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0097 0.1276
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0644 0.1869 0.5539
Brugia malayi nuclear receptor NHR-67 0.008 0.0144 0.0536
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0098 0.02 0.2477
Brugia malayi MH2 domain containing protein 0.0891 0.2625 1
Brugia malayi Pax transcription factor protein 2 0.0499 0.1426 0.5424
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0169 0.0417 0.0621
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0098 0.02 0.173
Brugia malayi jmjC domain containing protein 0.0038 0.0016 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0144 0.0198
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0716 0.2089 0.6226
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Plasmodium falciparum glutathione reductase 0.0282 0.0764 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2618
Loa Loa (eye worm) nuclear receptor NHR-67 0.008 0.0144 0.0536
Brugia malayi nuclear hormone receptor 0.008 0.0144 0.0536
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1978 0.5948 0.92
Echinococcus multilocularis FTZ F1 alpha 0.0169 0.0417 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0169 0.0417 0.1575
Schistosoma mansoni coup transcription factor 0.0169 0.0417 0.0621
Echinococcus granulosus FTZ F1 alpha 0.0169 0.0417 0.0675
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Brugia malayi MH1 domain containing protein 0.0061 0.0087 0.0316
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0098 0.02 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2618
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0137 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.0417 0.1575
Brugia malayi hypothetical protein 0.008 0.0144 0.0536
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0377 0.1053 0.2988
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0133 0.0308 0.0287
Brugia malayi hypothetical protein 0.0309 0.0845 0.3209
Brugia malayi MH1 domain containing protein 0.0061 0.0087 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0169 0.0417 0.1575
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Echinococcus granulosus Smad4 0.0061 0.0087 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.0169 0.0417 0.0621
Loa Loa (eye worm) hypothetical protein 0.0169 0.0417 0.1575
Loa Loa (eye worm) twinkle helicase 0.0108 0.023 0.0863
Schistosoma mansoni smad 0.0061 0.0087 0.0109
Schistosoma mansoni hypothetical protein 0.0165 0.0406 0.0604
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0105 0.0223 0.0265
Treponema pallidum replicative DNA helicase (dnaB) 0.0377 0.1053 1
Leishmania major DNA polymerase kappa, putative 0.0039 0.0022 0.0096
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.0144 0.0198
Loa Loa (eye worm) hypothetical protein 0.0089 0.0173 0.0647
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0098 0.02 0.173
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0089 0.0173 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0022 0.0282
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0169 0.0417 0.0675
Treponema pallidum recombinase A 0.0105 0.0223 0.0265
Schistosoma mansoni thyroid hormone receptor 0.2146 0.6463 1
Brugia malayi nuclear receptor RXR 0.0089 0.0173 0.0647
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0173 0.0647
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0089 0.0173 0.0244
Brugia malayi Steroid receptor seven-up type 2 0.0169 0.0417 0.1575
Echinococcus multilocularis Smad4 0.0061 0.0087 0.0109
Schistosoma mansoni nuclear hormone receptor 0.008 0.0144 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus granulosus dna polymerase eta 0.0064 0.0097 0.0137
Onchocerca volvulus 0.0499 0.1426 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.008 0.0144 0.0198
Loa Loa (eye worm) hypothetical protein 0.0089 0.0173 0.0647
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0169 0.0417 0.1575
Brugia malayi hypothetical protein 0.0089 0.0173 0.0647
Chlamydia trachomatis replicative DNA helicase 0.0377 0.1053 1
Schistosoma mansoni DNA polymerase eta 0.0064 0.0097 0.0126
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0169 0.0417 0.0621
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0022 0.0008
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0089 0.0173 0.0265
Brugia malayi jmjC domain containing protein 0.0102 0.0213 0.0798
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0169 0.0417 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.0417 0.1575
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0377 0.1053 1
Chlamydia trachomatis recombinase RecA 0.0105 0.0223 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0169 0.0417 0.1575
Brugia malayi nuclear receptor NHR-88 0.0169 0.0417 0.1575
Loa Loa (eye worm) nuclear hormone receptor 0.008 0.0144 0.0536
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0644 0.1869 0.1851
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0022 0.0068
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.008 0.0144 0.0198
Entamoeba histolytica hypothetical protein 0.0077 0.0137 1
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0034 0.0027
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0105 0.0223 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Echinococcus multilocularis nuclear receptor nhr 48 0.008 0.0144 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0169 0.0417 0.1575
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0016 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0098 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0022 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0098 0.02 0.2618
Trypanosoma brucei beta lactamase 0.0064 0.0096 0.1263
Brugia malayi photoreceptor-specific nuclear receptor 0.0169 0.0417 0.1575
Loa Loa (eye worm) hypothetical protein 0.008 0.0144 0.0536
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3032 0.917 0.9168
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0137 0.0187
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0072 0.0121 0.0446
Mycobacterium tuberculosis Probable dehydrogenase 0.0644 0.1869 0.1851

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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