Detailed information for compound 1170192

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.076 | Formula: C11H5Cl6NO2S3
  • H donors: 1 H acceptors: 2 LogP: 7.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)SC(Cl)(Cl)Cl)NS(=O)(=O)c1cc(sc1Cl)Cl
  • InChi: 1S/C11H5Cl6NO2S3/c12-5-1-2-6(7(3-5)22-11(15,16)17)18-23(19,20)8-4-9(13)21-10(8)14/h1-4,18H
  • InChiKey: DOLNHLRWGHDZHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum MO15-related protein kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum cyclin-dependent kinase-related kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Theileria parva cyclin-dependent kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium knowlesi MO15-related protein kinase Get druggable targets OG5_141009 All targets in OG5_141009
Babesia bovis cyclin-dependent kinase-related kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium yoelii MO15-related protein kinase Pfmrk Get druggable targets OG5_141009 All targets in OG5_141009
Neospora caninum CAM kinase, CDPK family, putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium berghei MO15-related protein kinase Get druggable targets OG5_141009 All targets in OG5_141009
Cryptosporidium hominis cyclin-dependent kinase-related kinase Get druggable targets OG5_141009 All targets in OG5_141009
Toxoplasma gondii cell-cycle-associated protein kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium falciparum MO15-related protein kinase Get druggable targets OG5_141009 All targets in OG5_141009
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 MO15-related protein kinase 324 aa 313 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase haspin 0.001 0.009 0.0128
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1468 0.255
Schistosoma mansoni hypothetical protein 0.0036 0.0653 0.0983
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Leishmania major serine/threonine kinase-like protein, putative 0.001 0.0098 0.0635
Schistosoma mansoni smad1 5 8 and 0.0008 0.0059 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0064 0.009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0147 0.0215
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0286 0.0371
Plasmodium falciparum importin beta, putative 0.0029 0.0518 0.135
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0286 0.0138
Trichomonas vaginalis set domain proteins, putative 0.0272 0.5744 1
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0012 0.0151 0.0998
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0635 0.0949
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0286 0.1924
Loa Loa (eye worm) beta-lactamase 0.0074 0.1468 0.2204
Loa Loa (eye worm) haspin protein kinase 0.001 0.0098 0.014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0024 0.0033
Entamoeba histolytica cell division protein kinase 2, putative 0.001 0.0098 0.1433
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0151 0.029
Brugia malayi MH2 domain containing protein 0.0008 0.0059 0.0107
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.0688
Schistosoma mansoni importin beta-1 0.0029 0.0518 0.078
Echinococcus granulosus cpg binding protein 0.003 0.0533 0.0795
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0064 0.0097
Entamoeba histolytica protein kinase domain containing protein 0.001 0.0098 0.1433
Echinococcus granulosus Smad4 0.0008 0.0059 0.0081
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0351 0.091
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0286 0.5
Mycobacterium tuberculosis Conserved protein 0.0074 0.1468 0.1338
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0182 0.3809 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1468 0.3602
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0151 0.0227
Trichomonas vaginalis serine/threonine kinase, putative 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.001 0.0098 0.0162
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0182 0.3809 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0059 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0286 0.0491
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0151 0.022
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.047 0.3176
Echinococcus granulosus importin subunit beta 1 0.0029 0.0518 0.0773
Loa Loa (eye worm) hypothetical protein 0.0074 0.1468 0.2204
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0151 0.0998
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0182 0.3809 1
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0151 0.2253
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0151 0.0998
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0351 0.0521
Onchocerca volvulus 0.0035 0.0635 0.0866
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.001 0.0098 0.0635
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0398 0.2194
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Brugia malayi GSG2 0.001 0.009 0.0169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0351 0.1848
Toxoplasma gondii exonuclease III APE 0.0019 0.0286 0.074
Schistosoma mansoni protein kinase 0.001 0.0098 0.0147
Brugia malayi MH2 domain containing protein 0.0118 0.2433 0.4828
Echinococcus multilocularis cpg binding protein 0.003 0.0533 0.0795
Entamoeba histolytica hypothetical protein 0.0036 0.0653 1
Schistosoma mansoni hypothetical protein 0.0314 0.6644 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Echinococcus multilocularis snurportin 1 0.0314 0.6644 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0518 0.3508
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0635 0.0956
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0151 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.047 0.2713
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0286 0.0424
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0635 0.0949
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0059 0.0088
Schistosoma mansoni cpg binding protein 0.003 0.0533 0.0802
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1468 0.2204
Leishmania major hypothetical protein, conserved 0.0027 0.047 0.3176
Onchocerca volvulus 0.0074 0.1468 0.2356
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Entamoeba histolytica hypothetical protein 0.0036 0.0653 1
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Brugia malayi MH1 domain containing protein 0.0008 0.0059 0.0107
Trichomonas vaginalis hypothetical protein 0.0182 0.3809 0.6629
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0182 0.3809 1
Echinococcus multilocularis Smad4 0.0008 0.0059 0.0081
Mycobacterium tuberculosis Conserved protein 0.0074 0.1468 0.1338
Brugia malayi RNA, U transporter 1 0.0084 0.1685 0.3342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0635 0.0956
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.047 0.1222
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0059 0.0081
Brugia malayi beta-lactamase family protein 0.0074 0.1468 0.291
Loa Loa (eye worm) hypothetical protein 0.0074 0.1468 0.2204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0946 0.1417
Onchocerca volvulus 0.0028 0.0498 0.0621
Schistosoma mansoni serine/threonine kinase 0.001 0.0098 0.0147
Brugia malayi cyclin-dependent kinase 7 homolog 0.001 0.0098 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.001 0.0098 0.0162
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0012 0.0151 0.0384
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0351 0.0521
Echinococcus granulosus serine:threonine protein kinase haspin 0.001 0.009 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Brugia malayi hypothetical protein 0.0027 0.047 0.0924
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Toxoplasma gondii ABC1 family protein 0.0074 0.1468 0.3847
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0151 0.029
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 1
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.001 0.0098 0.014
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0151 0.0387
Schistosoma mansoni ap endonuclease 0.0019 0.0286 0.0431
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1073 0.2809
Echinococcus granulosus snurportin 1 0.0314 0.6644 1
Echinococcus granulosus mitogen activated protein kinase 15 0.001 0.0098 0.014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0286 0.0371
Onchocerca volvulus 0.0074 0.1468 0.2356
Leishmania major pteridine reductase 1 0.0012 0.0151 0.0998
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1468 0.1338
Loa Loa (eye worm) hypothetical protein 0.0074 0.1468 0.2204
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Brugia malayi MH2 domain containing protein 0.0008 0.0059 0.0107
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.0521
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0064 0.009
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0182 0.3809 1
Schistosoma mansoni ran 0.0022 0.0351 0.0528
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0012 0.0151 0.0384
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1468 0.1338
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.047 0.1222
Trichomonas vaginalis ran, putative 0.0022 0.0351 0.0603
Trichomonas vaginalis protein kinase atmrk1, putative 0.001 0.0098 0.0162
Schistosoma mansoni ap endonuclease 0.0019 0.0286 0.0431
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0518 0.135
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0012 0.0151 0.0384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0946 0.1417
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0398 0.0686
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0635 0.0949
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0144 0.2991 0.7851
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Loa Loa (eye worm) hypothetical protein 0.0074 0.1468 0.2204
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.047 0.1222
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1468 0.3602
Leishmania major hypothetical protein, conserved 0.0074 0.1468 1
Onchocerca volvulus 0.0074 0.1468 0.2356
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.0749
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0286 0.056
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1468 1
Brugia malayi hypothetical protein 0.0036 0.0653 0.1289
Trichomonas vaginalis CMGC family protein kinase 0.001 0.0098 0.0162
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0006 0.0013 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Plasmodium vivax SET domain protein, putative 0.0035 0.0635 0.1657
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1468 0.255
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0286 0.1377
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.001 0.0098 0.014
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0151 0.022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0518 0.0773
Brugia malayi MH1 domain containing protein 0.0008 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.0027 0.047 0.07
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0518 0.3508
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0033
Plasmodium vivax importin-beta 2, putative 0.0029 0.0518 0.135
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.0981
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1468 0.1338
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0182 0.3809 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Loa Loa (eye worm) histone methyltransferase 0.001 0.0102 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Echinococcus multilocularis serine:threonine protein kinase haspin 0.001 0.009 0.0128
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.001 0.0098 0.0635
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0059 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0151 0.022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0946 0.1417
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0286 0.1377
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0398 0.0686
Mycobacterium ulcerans hypothetical protein 0.0074 0.1468 0.3602
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1468 0.221
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0946 0.1424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0946 0.1424
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.001 0.0098 0.0244
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0151 0.0998
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Leishmania major importin beta-1 subunit, putative 0.0024 0.0398 0.269
Schistosoma mansoni importin-beta 2 0.0006 0.0005 0.0007
Plasmodium falciparum MO15-related protein kinase 0.0144 0.2991 0.7851
Loa Loa (eye worm) oxidoreductase 0.0012 0.0151 0.022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0946 0.1417
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Schistosoma mansoni smad1 5 8 and 0.0008 0.0059 0.0088
Schistosoma mansoni hypothetical protein 0.001 0.009 0.0135
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1468 0.3847
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1468 0.1338
Mycobacterium ulcerans lipase LipD 0.0074 0.1468 0.3602
Loa Loa (eye worm) hypothetical protein 0.0035 0.0635 0.0949
Brugia malayi beta-lactamase 0.0074 0.1468 0.291
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1468 0.255
Loa Loa (eye worm) Smad1 0.0008 0.0059 0.0081
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0151 0.0387
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1468 0.291
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0351 0.2366
Schistosoma mansoni cpg binding protein 0.003 0.0533 0.0802
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0059 0.0081
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0147 0.0215
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0064 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0102 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1468 0.1338
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0286 0.0491
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0012 0.0151 0.0998
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0286 0.745
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2433 0.3657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0635 0.0956
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0064 0.009
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.001 0.009 0.0128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0653 0.0976
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0351 0.091
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0012 0.0151 0.0384
Mycobacterium ulcerans beta-lactamase 0.0074 0.1468 0.3602
Brugia malayi Cell division protein kinase 2 0.001 0.0098 0.0185
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0024 0.0033
Mycobacterium tuberculosis Conserved protein 0.0074 0.1468 0.1338
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trypanosoma brucei protein kinase, putative 0.001 0.0098 0.0635
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Schistosoma mansoni smad1 5 8 and 0.0008 0.0059 0.0088
Entamoeba histolytica hypothetical protein 0.0024 0.0398 0.6074
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.6644 1
Echinococcus granulosus serine:threonine protein kinase haspin 0.001 0.009 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Echinococcus multilocularis serine:threonine protein kinase haspin 0.001 0.009 0.0128
Brugia malayi Importin beta-1 subunit 0.0029 0.0518 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Schistosoma mansoni smad 0.0008 0.0059 0.0088
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0135 0.2787 0.7313
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0151 0.0227
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.047 0.2713
Echinococcus multilocularis smad 0.0008 0.0059 0.0081
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0151 0.0384
Echinococcus multilocularis cyclin dependent kinase 9 0.001 0.0098 0.014
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Entamoeba histolytica Ran family GTPase 0.0022 0.0351 0.5342
Schistosoma mansoni hypothetical protein 0.0012 0.0147 0.0222
Echinococcus multilocularis serine:threonine protein kinase NLK 0.001 0.0098 0.014
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0653 0.0983
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0286 0.074
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1468 0.2204
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0098 0.0147
Brugia malayi hypothetical protein 0.001 0.009 0.0169
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1468 0.2204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0635 0.0956
Brugia malayi hypothetical protein 0.0018 0.0262 0.0512
Echinococcus granulosus cyclin dependent kinase 9 0.001 0.0098 0.014
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0151 0.0387
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0635 0.1657
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0946 0.1417
Leishmania major GTP-binding protein, putative 0.0022 0.0351 0.2366
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1468 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0099 0.0188
Trichomonas vaginalis esterase, putative 0.0074 0.1468 0.255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0653 0.0976
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.047 0.1222
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Plasmodium falciparum enoyl-acyl carrier reductase 0.0182 0.3809 1
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Schistosoma mansoni hypothetical protein 0.001 0.009 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0351 0.1848
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1468 0.1338
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0518 0.0773
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2433 0.3657
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0286 0.0424
Loa Loa (eye worm) hypothetical protein 0.0074 0.1468 0.2204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1212 0.1824
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0151 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1468 0.3602
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0059 0.0081
Schistosoma mansoni ran 0.0022 0.0351 0.0528
Brugia malayi Pre-SET motif family protein 0.0239 0.5034 1
Schistosoma mansoni Smad4 0.0008 0.0059 0.0088
Trypanosoma brucei pteridine reductase 1 0.0012 0.0151 0.0998
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0946 0.1424
Echinococcus multilocularis hypothetical protein 0.001 0.009 0.0128
Echinococcus granulosus Cell division cycle 2 protein kinase 0.001 0.0098 0.014
Brugia malayi beta-lactamase family protein 0.0074 0.1468 0.291
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Loa Loa (eye worm) haspin protein kinase 0.001 0.009 0.0128
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1468 1
Brugia malayi Protein kinase domain containing protein 0.001 0.0098 0.0185
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0286 0.1924
Brugia malayi Pre-SET motif family protein 0.0035 0.0635 0.1253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1468 0.221
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0182 0.3809 0.3714
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1468 0.1338
Echinococcus granulosus serine:threonine protein kinase NLK 0.001 0.0098 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0024 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0286 0.4346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0946 0.1871
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0286 0.0424
Brugia malayi Smad1 0.0008 0.0059 0.0107
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0102 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0595 0.0888
Loa Loa (eye worm) hypothetical protein 0.0074 0.1468 0.2204
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.001 0.0098 0.014
Entamoeba histolytica hypothetical protein 0.0036 0.0653 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.5034 0.7575
Trichomonas vaginalis CMGC family protein kinase 0.001 0.0098 0.0162
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0059 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1468 0.255
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0024 0.0033
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0286 0.074
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Entamoeba histolytica hypothetical protein 0.001 0.009 0.131
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Trichomonas vaginalis helicase, putative 0.0006 0.0024 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.001 0.0098 0.0162
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0351 0.091
Loa Loa (eye worm) haspin protein kinase 0.001 0.009 0.0128
Onchocerca volvulus 0.0272 0.5744 1
Leishmania major oxidoreductase-like protein 0.0012 0.0151 0.0998
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.0743
Echinococcus granulosus smad 0.0008 0.0059 0.0081
Mycobacterium leprae Probable lipase LipE 0.0074 0.1468 0.3602
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1468 0.255
Trichomonas vaginalis AGC family protein kinase 0.001 0.0098 0.0162
Entamoeba histolytica hypothetical protein 0.0036 0.0653 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0398 0.0686

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 19.7 uM Inhibition of His6x-tagged Plasmodium falciparum Pfmrk expressed in Escherichia coli by microtiter plate scintillation counting ChEMBL. 20627564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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