Detailed information for compound 1170378

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 587.606 | Formula: C24H42N7O8P
  • H donors: 3 H acceptors: 6 LogP: 0.24 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)OCCOP(=O)(OCCOC(=O)[C@H](CC(C)C)N)COCCn1cnc2c1ncnc2N)N)C
  • InChi: 1S/C24H42N7O8P/c1-16(2)11-18(25)23(32)36-7-9-38-40(34,39-10-8-37-24(33)19(26)12-17(3)4)15-35-6-5-31-14-30-20-21(27)28-13-29-22(20)31/h13-14,16-19H,5-12,15,25-26H2,1-4H3,(H2,27,28,29)/t18-,19-/m0/s1
  • InChiKey: WYTJAGWDKZSEGB-OALUTQOASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum serine repeat antigen 9 0.0273 0.0976 0.1731
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0046 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.0203 0.0324
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0913 0.3468 0.6134
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0018 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0078 0.0102
Loa Loa (eye worm) cathepsin B 0.0298 0.107 0.1867
Giardia lamblia DINP protein human, muc B family 0.004 0.0066 0.0127
Plasmodium vivax vivapain-1 0.0759 0.2867 0.5083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0078 0.0102
Brugia malayi Cathepsin L-like precursor 0.0986 0.3749 0.6635
Giardia lamblia Cathepsin B precursor 0.0298 0.107 0.6522
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0066 0.0079
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0438 0.1616 0.2866
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0759 0.2867 0.5064
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.0074 0.02 0.0318
Giardia lamblia Cathepsin L precursor 0.0273 0.0976 0.5924
Brugia malayi Papain family cysteine protease containing protein 0.1471 0.564 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0086 0.0151
Brugia malayi nuclear hormone receptor 0.0043 0.0078 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0302 0.05
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0347 0.0614
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0078 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.04 0.071
Onchocerca volvulus 0.1471 0.564 1
Giardia lamblia Cathepsin L precursor 0.0273 0.0976 0.5924
Brugia malayi cathepsin B-like cysteine proteinase 0.0352 0.128 0.2241
Loa Loa (eye worm) hypothetical protein 0.0074 0.0198 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0066 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.1154 0.2045
Brugia malayi hypothetical protein 0.0074 0.02 0.0318
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0066 0.0115
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0074 0.0094
Schistosoma mansoni cathepsin C 0.0273 0.0976 0.1699
Schistosoma mansoni cathepsin S (C01 family) 0.0273 0.0976 0.1699
Schistosoma mansoni hypothetical protein 0.0101 0.0305 0.0504
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0066 0.0044
Echinococcus granulosus GPCR family 2 0.0101 0.0305 0.0504
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0078 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.0566 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0078 0.0102
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0101 0.0305 0.0284
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0078 0.0102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0078 0.0102
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0273 0.0976 0.1699
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0296 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Echinococcus granulosus geminin 0.0335 0.1217 0.2129
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0046 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0759 0.2867 0.5083
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0046 0.0043
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0078 0.0057
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0194 0.0308
Echinococcus multilocularis cathepsin L cysteine protease 0.1471 0.564 0.563
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.1154 0.2045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Brugia malayi RNA binding protein 0.0075 0.0203 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0203 0.0324
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0078 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0198 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.04 0.0674
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0076 0.0098
Brugia malayi Latrophilin receptor protein 2 0.0101 0.0305 0.0504
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0078 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.0761 0.1316
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0066 0.0079
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Brugia malayi Pre-SET motif family protein 0.0126 0.04 0.0674
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0066 0.0116
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0078 0.0102
Onchocerca volvulus Cathepsin L homolog 0.1471 0.564 1
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0347 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0055 0.0125 0.0185
Leishmania major DNA polymerase eta, putative 0.004 0.0066 0.0116
Brugia malayi cathepsin Z-like cysteine proteinase 0.0273 0.0976 0.1699
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0076 0.0098
Entamoeba histolytica hypothetical protein 0.0273 0.0976 0.1731
Plasmodium vivax vivapain-2 0.1471 0.564 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0352 0.128 0.2241
Brugia malayi latrophilin 2 splice variant baaae 0.0218 0.0761 0.1316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0113 0.2006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.04 0.0674
Plasmodium vivax vivapain-2 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.0976 0.1699
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0269 0.0959 0.1668
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.0347 0.0326
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Brugia malayi Papain family cysteine protease containing protein 0.0759 0.2867 0.5064
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0273 0.0976 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0018 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.02 0.0355
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0499 0.0885
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0086 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0239 0.0843 0.0823
Onchocerca volvulus Cathepsin F homolog 0.1471 0.564 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0078 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.1471 0.564 1
Trypanosoma brucei unspecified product 0.004 0.0066 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0078 0.0102
Echinococcus granulosus snurportin 1 0.0302 0.1087 0.1897
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0078 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Giardia lamblia Kinase, PLK 0.0112 0.0347 0.1917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.0976 0.173
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0198 0.3492
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0336 0.1219 0.2161
Echinococcus multilocularis cathepsin L 0.0759 0.2867 0.2851
Echinococcus multilocularis muscleblind protein 0.0913 0.3468 0.3454
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Mycobacterium ulcerans hypothetical protein 0.0074 0.0198 0.3492
Brugia malayi Papain family cysteine protease containing protein 0.0759 0.2867 0.5064
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Brugia malayi Fli-1 protein 0.0221 0.0771 0.1334
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0203 0.0324
Trypanosoma cruzi cysteine peptidase, putative 0.1471 0.564 1
Leishmania major cysteine peptidase A (CPA) 0.1471 0.564 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0078 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0319 0.1154 0.2017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.0976 0.173
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0066 0.116
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0066 0.116
Brugia malayi hypothetical protein 0.0048 0.0098 0.0136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0074 0.0094
Onchocerca volvulus 0.0081 0.0227 0.0324
Loa Loa (eye worm) hypothetical protein 0.0986 0.3749 0.6635
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Schistosoma mansoni cathepsin s 0.0486 0.1802 0.3169
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1471 0.564 0.563
Loa Loa (eye worm) latrophilin receptor protein 2 0.0101 0.0305 0.0504
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.1471 0.564 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0066 0.0115
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0067 0.119
Schistosoma mansoni hypothetical protein 0.0101 0.0305 0.0504
Brugia malayi fibroinase precursor 0.0273 0.0976 0.1699
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Schistosoma mansoni hypothetical protein 0.0218 0.0761 0.1316
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0021 0.0038
Brugia malayi cathepsin L-like cysteine proteinase 0.0273 0.0976 0.1699
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0273 0.0976 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0066 0.0115
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0461 0.0783
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0078 0.0102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0078 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0078 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.0976 0.173
Giardia lamblia Cathepsin L precursor 0.0273 0.0976 0.5924
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0018 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0273 0.0976 0.1731
Loa Loa (eye worm) hypothetical protein 0.0052 0.0113 0.0164
Giardia lamblia Hypothetical protein 0.0273 0.0976 0.5924
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0067 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0078 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Schistosoma mansoni hypothetical protein 0.0335 0.1217 0.2129
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Onchocerca volvulus 0.1471 0.564 1
Onchocerca volvulus 0.0997 0.3791 0.6696
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0273 0.0976 0.1699
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0127 0.0224
Toxoplasma gondii cathepsin B 0.0298 0.107 0.1897
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0296 0.0489
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0098 0.0137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0067 0.0119
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0298 0.107 0.1897
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0273 0.0976 0.1731
Onchocerca volvulus Cathepsin L homolog 0.1471 0.564 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0273 0.0976 0.1699
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0067 0.0119
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0227 0.0366
Echinococcus granulosus expressed conserved protein 0.0093 0.0273 0.0447
Giardia lamblia Cysteine protease 0.0273 0.0976 0.5924
Loa Loa (eye worm) hypothetical protein 0.0986 0.3749 0.6635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Trypanosoma brucei polo-like protein kinase 0.0112 0.0347 0.0615
Brugia malayi Cathepsin L-like precursor 0.1471 0.564 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1471 0.564 0.563
Giardia lamblia Cysteine protease 0.0273 0.0976 0.5924
Echinococcus granulosus peregrin 0.0035 0.0046 0.0043
Brugia malayi steroid hormone receptor 0.0043 0.0078 0.0102
Giardia lamblia Cathepsin B precursor 0.0273 0.0976 0.5924
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0078 0.0102
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0198 0.3492
Schistosoma mansoni hypothetical protein 0.0101 0.0305 0.0504
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0273 0.0976 0.1731
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.04 0.0674
Schistosoma mansoni hypothetical protein 0.0269 0.0959 0.1668
Plasmodium vivax vivapain-3 0.0759 0.2867 0.5083
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0067 0.119
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0067 0.0119
Brugia malayi Pre-SET motif family protein 0.0876 0.332 0.5872
Schistosoma mansoni cathepsin F (C01 family) 0.1471 0.564 1
Plasmodium falciparum serine repeat antigen 4 0.0273 0.0976 0.1731
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.02 0.0355
Brugia malayi Calcitonin receptor-like protein seb-1 0.0319 0.1154 0.2017
Trypanosoma brucei cysteine peptidase C (CPC) 0.0298 0.107 0.1897
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0078 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0066 0.116
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0041 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0239 0.0843 0.1462
Plasmodium falciparum phd finger protein, putative 0.0035 0.0046 0.0081
Brugia malayi nuclear receptor NHR-88 0.0043 0.0078 0.0102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0352 0.128 0.2241
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0078 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0074 0.0053
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.0347 0.0579
Echinococcus multilocularis snurportin 1 0.0302 0.1087 0.1068
Echinococcus granulosus cysteine protease 0.0759 0.2867 0.5064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0078 0.0102
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0066 0.0079
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0239 0.0843 0.0823
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Brugia malayi Cathepsin L-like precursor 0.1471 0.564 1
Plasmodium falciparum serine repeat antigen 2 0.0273 0.0976 0.1731
Loa Loa (eye worm) hypothetical protein 0.0486 0.1802 0.3169
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0066 0.0115
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.1154 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1471 0.564 1
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0203 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0066 0.0116
Entamoeba histolytica cysteine protease, putative 0.0273 0.0976 0.1731
Loa Loa (eye worm) hypothetical protein 0.0074 0.0198 0.0314
Onchocerca volvulus 0.1471 0.564 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0296 0.0489
Schistosoma mansoni hypothetical protein 0.0302 0.1087 0.1897
Echinococcus multilocularis cathepsin L cysteine protease 0.1471 0.564 0.563
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.02 0.0355
Onchocerca volvulus 0.0986 0.3749 0.662
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0066 0.0116
Echinococcus granulosus dna polymerase eta 0.004 0.0066 0.0079
Schistosoma mansoni kinase 0.0057 0.0133 0.0198
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0113 0.0352 0.0588
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0239 0.0843 0.1462
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0976 0.173
Brugia malayi cathepsin L precursor 0.0273 0.0976 0.1699
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0067 0.0119
Entamoeba histolytica cysteine proteinase, putative 0.0986 0.3749 0.6648
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0066 0.116
Plasmodium vivax unspecified product 0.0759 0.2867 0.5083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0198 0.3492
Echinococcus granulosus tar DNA binding protein 0.0075 0.0203 0.0324
Brugia malayi Cathepsin L-like precursor 0.1471 0.564 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0078 0.0102
Echinococcus granulosus cathepsin L 0.0273 0.0976 0.1699
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0273 0.0976 0.1699
Loa Loa (eye worm) hypothetical protein 0.0319 0.1154 0.2017
Echinococcus multilocularis cysteine protease 0.1471 0.564 0.563
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0876 0.332 0.5872
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0078 0.0102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0273 0.0976 0.1699
Entamoeba histolytica hypothetical protein 0.0269 0.0959 0.17
Schistosoma mansoni hypothetical protein 0.0101 0.0305 0.0504
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0759 0.2867 0.5083
Echinococcus multilocularis cathepsin L 0.0273 0.0976 0.0957
Plasmodium vivax serine-repeat antigen (SERA) 0.0273 0.0976 0.1731
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0352 0.128 0.2241
Loa Loa (eye worm) hypothetical protein 0.0273 0.0976 0.1699
Giardia lamblia Cathepsin B precursor 0.0273 0.0976 0.5924
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0438 0.1616 0.2866
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0198 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Toxoplasma gondii exonuclease III APE 0.004 0.0067 0.0119
Echinococcus granulosus muscleblind protein 0.0913 0.3468 0.6134
Echinococcus granulosus cathepsin b 0.0352 0.128 0.2241
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0273 0.0976 0.5924
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Echinococcus granulosus cathepsin L cysteine proteinase 0.1471 0.564 1
Brugia malayi Ets-domain containing protein 0.0073 0.0194 0.0308
Loa Loa (eye worm) hypothetical protein 0.0059 0.0142 0.0214
Giardia lamblia Cathepsin L precursor 0.0273 0.0976 0.5924
Entamoeba histolytica cysteine protease, putative 0.0273 0.0976 0.1731
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.04 0.0674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Trypanosoma cruzi cysteine proteinase, putative 0.0759 0.2867 0.5083
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0066 0.0079
Onchocerca volvulus 0.0074 0.0198 0.0272
Loa Loa (eye worm) hypothetical protein 0.0913 0.3468 0.6134
Loa Loa (eye worm) hypothetical protein 0.0042 0.0076 0.0098
Plasmodium vivax importin-beta 2, putative 0.0028 0.0021 0.0038
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0759 0.2867 0.5064
Entamoeba histolytica cysteine protease, putative 0.1471 0.564 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1471 0.564 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Giardia lamblia Cathepsin B precursor 0.0273 0.0976 0.5924
Echinococcus multilocularis protein patched 0.0042 0.0076 0.0055
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0078 0.0102
Echinococcus multilocularis expressed conserved protein 0.0093 0.0273 0.0252
Giardia lamblia Cathepsin B precursor 0.0298 0.107 0.6522
Brugia malayi Cathepsin L-like precursor 0.0486 0.1802 0.3169
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0125 0.0222
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0124 0.0219
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0438 0.1616 0.2839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0125 0.0185
Schistosoma mansoni transcription factor LCR-F1 0.0269 0.0959 0.1668
Loa Loa (eye worm) hypothetical protein 0.0101 0.0305 0.0504
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Trichomonas vaginalis set domain proteins, putative 0.0997 0.3791 0.6722
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0078 0.0057
Giardia lamblia Cathepsin L precursor 0.0273 0.0976 0.5924
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0376 0.1373 0.2434
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0101 0.0305 0.0504
Toxoplasma gondii cathepsin CPC2 0.0336 0.1219 0.2161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Onchocerca volvulus 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1471 0.564 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0352 0.128 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0486 0.1802 0.3169
Trypanosoma cruzi cruzipain precursor, putative 0.1471 0.564 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.0074 0.0198 0.0314
Loa Loa (eye worm) hypothetical protein 0.0055 0.0125 0.0185
Entamoeba histolytica cysteine proteinase, putative 0.1471 0.564 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0759 0.2867 0.5083
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0189 0.0298
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0198 0.3492
Loa Loa (eye worm) hypothetical protein 0.0486 0.1802 0.3169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0067 0.0082
Echinococcus multilocularis tar DNA binding protein 0.0075 0.0203 0.0182
Brugia malayi Cathepsin L-like precursor 0.0986 0.3749 0.6635
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Brugia malayi jmjC domain containing protein 0.0042 0.0074 0.0094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.04 0.038
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.0203 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma cruzi cysteine proteinase, putative 0.0759 0.2867 0.5083
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0066 0.0116
Schistosoma mansoni cathepsin F (C01 family) 0.0986 0.3749 0.6635
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0273 0.0976 0.1731
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0078 0.0102
Loa Loa (eye worm) RNA binding protein 0.0075 0.0203 0.0324
Loa Loa (eye worm) fibroinase 0.1471 0.564 1
Onchocerca volvulus 0.0043 0.0078 0.0059
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0194 0.0308
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0078 0.0102
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0043
Brugia malayi RNA, U transporter 1 0.008 0.0224 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0067 0.0082
Plasmodium falciparum serine repeat antigen 6 0.0273 0.0976 0.1731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 0.0976 0.173
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0273 0.0976 0.1699
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.0976 0.173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0986 0.3749 0.6647
Loa Loa (eye worm) hypothetical protein 0.0126 0.04 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.0976 0.173
Schistosoma mansoni cathepsin F (C01 family) 0.1471 0.564 1
Echinococcus granulosus cathepsin L 0.0759 0.2867 0.5064
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0227 0.0366
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0352 0.128 0.2241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0273 0.0976 0.1699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0078 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.02 0.0354
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma cruzi cysteine peptidase, putative 0.1471 0.564 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0078 0.0059
Schistosoma mansoni ets-related 0.0221 0.0771 0.1334
Schistosoma mansoni DNA polymerase eta 0.004 0.0066 0.0079
Onchocerca volvulus 0.1471 0.564 1
Entamoeba histolytica hypothetical protein 0.0269 0.0959 0.17
Entamoeba histolytica cysteine proteinase, putative 0.0759 0.2867 0.5083
Echinococcus granulosus cathepsin L cysteine protease 0.0759 0.2867 0.5064
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.1087 0.1897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0269 0.0959 0.0939
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Giardia lamblia Cathepsin L precursor 0.0273 0.0976 0.5924
Giardia lamblia Cathepsin B precursor 0.0273 0.0976 0.5924
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 0.0976 0.173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0113 0.2006
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0239 0.0843 0.1462
Loa Loa (eye worm) hypothetical protein 0.0273 0.0976 0.1699
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0074 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0198 0.0314
Brugia malayi Cathepsin L-like precursor 0.1471 0.564 1
Brugia malayi Bromodomain containing protein 0.0035 0.0046 0.0043
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0273 0.0976 0.1699
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0066 0.0079
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0227 0.0366
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Trypanosoma cruzi cysteine peptidase, putative 0.1471 0.564 1
Echinococcus multilocularis dna polymerase kappa 0.004 0.0066 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0273 0.0976 0.1699
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0078 0.0102
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0067 0.0046
Brugia malayi Ets-domain containing protein 0.0073 0.0194 0.0308
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.02 0.0355
Brugia malayi Cathepsin L-like cysteine proteinase 0.0986 0.3749 0.6635
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0078 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0298 0.107 0.1897
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0198 0.035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.04 0.038
Loa Loa (eye worm) hypothetical protein 0.0273 0.0976 0.1699
Plasmodium vivax unspecified product 0.0273 0.0976 0.1731
Echinococcus multilocularis GPCR, family 2 0.0101 0.0305 0.0284
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0319 0.1154 0.2017
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0125 0.2212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Echinococcus multilocularis peregrin 0.0035 0.0046 0.0024
Echinococcus granulosus cathepsin b 0.0352 0.128 0.2241
Plasmodium falciparum serine repeat antigen 8 0.0273 0.0976 0.1731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0078 0.0102
Plasmodium vivax serine-repeat antigen (SERA) 0.0273 0.0976 0.1731
Entamoeba histolytica hypothetical protein 0.0023 0 0.0001
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Schistosoma mansoni hypothetical protein 0.0041 0.007 0.0087
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0273 0.0976 0.1699
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0759 0.2867 0.5064
Loa Loa (eye worm) hypothetical protein 0.0099 0.0296 0.0489
Echinococcus multilocularis muscleblind protein 1 0.0913 0.3468 0.3454
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0273 0.0976 0.1731
Brugia malayi Cathepsin L-like precursor 0.1471 0.564 1
Schistosoma mansoni hypothetical protein 0.0041 0.007 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.0843 0.1462
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0273 0.0976 0.1699
Brugia malayi cathepsin L-like precursor 0.0986 0.3749 0.6635
Echinococcus granulosus dna polymerase kappa 0.004 0.0066 0.0079
Plasmodium falciparum serine repeat antigen 7 0.0273 0.0976 0.1731
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0273 0.0976 0.1731
Brugia malayi TAR-binding protein 0.0075 0.0203 0.0324
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Schistosoma mansoni ap endonuclease 0.004 0.0067 0.0082
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0066 0.0079
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0078 0.0102
Brugia malayi Papain family cysteine protease containing protein 0.0273 0.0976 0.1699
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Schistosoma mansoni cathepsin B (C01 family) 0.0273 0.0976 0.1699
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0461 0.0441
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0127 0.0224
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0074 0.0094
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Giardia lamblia Cathepsin L-like protease 0.0273 0.0976 0.5924
Loa Loa (eye worm) cysteine protease 0.1471 0.564 1
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0078 0.0102
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0273 0.0976 0.1699
Giardia lamblia Cathepsin B precursor 0.0298 0.107 0.6522
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.0347 0.0579
Trypanosoma cruzi cruzipain precursor, putative 0.0486 0.1802 0.3194
Leishmania major DNA polymerase kappa, putative 0.004 0.0066 0.0116
Echinococcus multilocularis geminin 0.0335 0.1217 0.1199
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0086 0.0152
Brugia malayi cathepsin Z-like cysteine proteinase 0.0273 0.0976 0.1699
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0067 0.0118
Trypanosoma brucei unspecified product 0.0027 0.0018 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.04 0.0674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0078 0.0057
Plasmodium falciparum serine repeat antigen 1 0.0273 0.0976 0.1731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0078 0.0102
Entamoeba histolytica cysteine protease, putative 0.0273 0.0976 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0078 0.0102
Schistosoma mansoni coup transcription factor 0.0043 0.0078 0.0102
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0046 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0499 0.0884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0046 0.0081
Brugia malayi ecdysteroid receptor 0.0043 0.0078 0.0102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.107 0.1867
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0078 0.0102
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0066 0.0079
Echinococcus granulosus cathepsin l1 0.0986 0.3749 0.6635
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.0499 0.0885
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0203 0.0324
Schistosoma mansoni hypothetical protein 0.0335 0.1217 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Schistosoma mansoni hypothetical protein 0.0041 0.007 0.0087
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1471 0.564 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0336 0.1219 0.747
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Giardia lamblia Encystation-specific protease 0.0336 0.1219 0.747
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.02 0.0355
Plasmodium vivax unspecified product 0.0486 0.1802 0.3195
Giardia lamblia Cathepsin L-like protease 0.0273 0.0976 0.5924
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0239 0.0843 0.1462
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0438 0.1616 0.2866
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0198 0.3492
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0198 0.035
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0067 1
Schistosoma mansoni gabp alpha 0.0073 0.0194 0.0308
Echinococcus multilocularis dna polymerase eta 0.004 0.0066 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0347 0.0614
Trypanosoma cruzi cysteine peptidase, putative 0.0486 0.1802 0.3194
Giardia lamblia Cysteine protease 0.0273 0.0976 0.5924
Entamoeba histolytica cysteine proteinase, putative 0.0759 0.2867 0.5083
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0113 0.2006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0438 0.1616 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0273 0.0976 0.1731
Loa Loa (eye worm) TAR-binding protein 0.0075 0.0203 0.0324
Loa Loa (eye worm) hypothetical protein 0.0055 0.0125 0.0185
Schistosoma mansoni jumonji domain containing protein 0.009 0.0261 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0113 0.2006
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0066 0.0115
Loa Loa (eye worm) hypothetical protein 0.0986 0.3749 0.6635
Brugia malayi hypothetical protein 0.0269 0.0959 0.1668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Toxoplasma gondii cathepsin CPL 0.1471 0.564 1
Trypanosoma cruzi cysteine protease, putative 0.0759 0.2867 0.5083
Trypanosoma cruzi major cysteine proteinase, putative 0.0273 0.0976 0.173
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0382 0.0642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.0347 0.0538
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0078 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0066 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0086 0.0151
Schistosoma mansoni patched 1 0.0042 0.0076 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0078 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0066 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0066 0.0116
Giardia lamblia Cathepsin B precursor 0.0273 0.0976 0.5924
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0041 0.0034
Leishmania major hypothetical protein, conserved 0.0074 0.02 0.0355
Echinococcus granulosus cathepsin l1 0.1471 0.564 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.0347 0.0615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.0843 0.1462
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0078 0.0102
Leishmania major importin beta-1 subunit, putative 0.0023 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1471 0.564 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0076 0.0134
Plasmodium vivax SET domain protein, putative 0.0126 0.04 0.071
Mycobacterium ulcerans hypothetical protein 0.0168 0.0566 1
Entamoeba histolytica cysteine protease, putative 0.0273 0.0976 0.1731
Brugia malayi PHD-finger family protein 0.0035 0.0046 0.0043
Brugia malayi cathepsin F-like cysteine proteinase 0.0486 0.1802 0.3169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0078 0.0102
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Plasmodium falciparum importin beta, putative 0.0028 0.0021 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.1471 0.564 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0227 0.0206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0101 0.0305 0.0504
Loa Loa (eye worm) hypothetical protein 0.0055 0.0125 0.0185
Trypanosoma brucei unspecified product 0.0027 0.0018 0.0031
Trypanosoma cruzi major cysteine proteinase, putative 0.0273 0.0976 0.173
Entamoeba histolytica hypothetical protein 0.0269 0.0959 0.17
Loa Loa (eye worm) hypothetical protein 0.0062 0.0153 0.0235
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.0347 0.0579
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0078 0.0059
Echinococcus multilocularis protein dispatched 1 0.0048 0.01 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.02 0.0354
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0078 0.0102
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0125 0.2212
Loa Loa (eye worm) ctsf protein 0.1471 0.564 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0078 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0078 0.0059
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0078 0.0102
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0486 0.1802 0.3169
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0347 0.0614
Loa Loa (eye worm) hypothetical protein 0.0352 0.128 0.2241
Schistosoma mansoni hypothetical protein 0.0041 0.007 0.0087
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0067 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0046 0.0043
Schistosoma mansoni ap endonuclease 0.004 0.0067 0.0082
Trypanosoma cruzi cysteine peptidase, putative 0.0759 0.2867 0.5083
Brugia malayi Papain family cysteine protease containing protein 0.0273 0.0976 0.1699
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0113 0.0352 0.0331
Giardia lamblia Cysteine protease 0.0273 0.0976 0.5924
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0298 0.107 0.1897
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0076 0.0055
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0296 0.0525
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0198 0.035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0198 0.3492
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.0347 0.0615
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0336 0.1219 0.2161
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0067 0.0118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0067 0.0118
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0125 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0078 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0078 0.0102
Entamoeba histolytica cysteine proteinase, putative 0.0759 0.2867 0.5083
Leishmania major cathepsin L-like protease 0.1471 0.564 1
Schistosoma mansoni hypothetical protein 0.0033 0.0041 0.0034
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0066 0.0116
Entamoeba histolytica cysteine protease, putative 0.0273 0.0976 0.1731
Loa Loa (eye worm) hypothetical protein 0.0043 0.0078 0.0102
Brugia malayi jmjC domain containing protein 0.0113 0.0352 0.0588
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0125 0.0222
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0198 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0986 0.3749 0.6647
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0198 0.035
Entamoeba histolytica cysteine proteinase 2 0.0759 0.2867 0.5083
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0198 0.035
Echinococcus multilocularis cathepsin b 0.0352 0.128 0.1262
Loa Loa (eye worm) hypothetical protein 0.0273 0.0976 0.1699
Toxoplasma gondii hypothetical protein 0.0051 0.0112 0.0198
Onchocerca volvulus 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0273 0.0976 0.173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0043
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0021 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0078 0.0057
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0098 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0198 0.3492
Onchocerca volvulus Cathepsin L homolog 0.0273 0.0976 0.1663
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0078 0.0102
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0438 0.1616 0.2866
Plasmodium falciparum serine repeat antigen 3 0.0273 0.0976 0.1731
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0198 0.3492
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0273 0.0976 0.1699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.0843 0.1462
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0078 0.0102
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0067 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0759 0.2867 0.5083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0759 0.2867 0.5083
Onchocerca volvulus 0.0273 0.0976 0.1663
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1471 0.564 1
Entamoeba histolytica hypothetical protein 0.0269 0.0959 0.17
Loa Loa (eye worm) fli-1 protein 0.0221 0.0771 0.1334
Entamoeba histolytica cysteine protease, putative 0.0273 0.0976 0.1731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0759 0.2867 0.5083
Brugia malayi Cathepsin L-like precursor 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0986 0.3749 0.6647
Onchocerca volvulus 0.0126 0.04 0.0634
Toxoplasma gondii preprocathepsin c precursor, putative 0.0438 0.1616 0.2866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1471 0.564 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0759 0.2867 0.5083
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0198 0.0314
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0021 0.0038
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0198 0.3492
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0486 0.1802 0.3169
Toxoplasma gondii cathepsin CPC1 0.0438 0.1616 0.2866
Echinococcus multilocularis cathepsin b 0.0352 0.128 0.1262
Entamoeba histolytica cysteine proteinase, putative 0.0759 0.2867 0.5083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0273 0.0976 0.173
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.1154 0.2046
Loa Loa (eye worm) hypothetical protein 0.0273 0.0976 0.1699
Brugia malayi CHE-14 protein 0.0042 0.0076 0.0098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0101 0.0305 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0273 0.0976 0.173
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0336 0.1219 0.747
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0076 0.0098
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0067 0.0138
Echinococcus multilocularis cysteine protease 0.1471 0.564 0.563
Loa Loa (eye worm) hypothetical protein 0.0081 0.0227 0.0366
Brugia malayi Papain family cysteine protease containing protein 0.0273 0.0976 0.1699
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0101 0.0305 0.0284
Plasmodium falciparum serine repeat antigen 5 0.0273 0.0976 0.1731
Entamoeba histolytica cysteine protease, putative 0.0759 0.2867 0.5083
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0198 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0067 0.0082
Giardia lamblia Hypothetical protein 0.0273 0.0976 0.5924
Schistosoma mansoni tar DNA-binding protein 0.0075 0.0203 0.0324
Brugia malayi Muscleblind-like protein 0.0913 0.3468 0.6134
Onchocerca volvulus 0.1471 0.564 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0273 0.0976 0.173

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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