Detailed information for compound 1170451

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.496 | Formula: C17H29N3O2S
  • H donors: 0 H acceptors: 0 LogP: 0.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCN1CCOCC2(C1)OCCN(C2)Cc1cscc1)C
  • InChi: 1S/C17H29N3O2S/c1-18(2)4-5-19-6-8-21-15-17(13-19)14-20(7-9-22-17)11-16-3-10-23-12-16/h3,10,12H,4-9,11,13-15H2,1-2H3
  • InChiKey: GAOWKCAYUZYYON-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0034 0.0306 0.0445
Echinococcus multilocularis BRCA1 associated protein 0.0012 0.0027 0.0026
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0012 0.0027 0.004
Brugia malayi Histone deacetylase family protein 0.021 0.2495 0.3893
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0477 0.0742
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0646 0.0978
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0012 0.0027 0.0022
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0588 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.5862 0.5861
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Onchocerca volvulus Histone deacetylase 10 homolog 0.01 0.1127 0.4042
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0089 0.0982 0.3406
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0053 0.0114
Onchocerca volvulus 0.0037 0.0342 0.1171
Trypanosoma brucei unspecified product 0.0014 0.0053 0.0114
Brugia malayi Carboxylesterase family protein 0.0089 0.0982 0.1531
Trichomonas vaginalis histone deacetylase, putative 0.0233 0.2783 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0248 0.0354
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0667 0.0665
Loa Loa (eye worm) hypothetical protein 0.002 0.0132 0.0203
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0477 0.1665
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0021 0.0031
Echinococcus granulosus carboxylesterase 5A 0.0525 0.6409 1
Echinococcus granulosus geminin 0.0348 0.4205 0.6561
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0027 0.0022
Mycobacterium tuberculosis Conserved protein 0.0037 0.0342 0.1136
Loa Loa (eye worm) histone deacetylase 1 0.0233 0.2783 0.4341
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0588 0.2011
Loa Loa (eye worm) hypothetical protein 0.0525 0.6409 1
Echinococcus multilocularis histone deacetylase 7 0.021 0.2495 0.2494
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0012 0.0027 0.0026
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2756 0.9904
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0477 0.0476
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0012 0.0027 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0012 0.0027 0.0009
Loa Loa (eye worm) RNA binding protein 0.0063 0.0667 0.1038
Leishmania major histone deacetylase, putative 0.021 0.2495 0.8959
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0342 0.1136
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0132 0.04
Schistosoma mansoni gliotactin 0.0089 0.0982 0.1503
Giardia lamblia Histone deacetylase 0.0233 0.2783 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0132 0.0203
Leishmania major hypothetical protein, conserved 0.0037 0.0342 0.116
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0477 0.0713
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0447 0.0696
Plasmodium vivax histone deacetylase 1, putative 0.0233 0.2783 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0076 0.0116
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0132 0.04
Schistosoma mansoni hypothetical protein 0.0304 0.3662 0.5699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0306 0.0475
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.04
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0667 0.101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0342 0.0501
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0012 0.0027 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0248 0.0354
Leishmania major DNA polymerase eta, putative 0.002 0.0132 0.04
Schistosoma mansoni histone deacetylase 0.0233 0.2783 0.4323
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0012 0.0027 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0132 0.013
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0086
Trypanosoma cruzi histone deacetylase 1, putative 0.0233 0.2783 1
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0012 0.0027 0.0009
Echinococcus granulosus BC026374 protein S09 family 0.0089 0.0982 0.153
Brugia malayi Carboxylesterase family protein 0.0525 0.6409 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0447 0.0446
Trypanosoma brucei histone deacetylase 3 0.021 0.2495 0.8959
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0012 0.0027 0.0022
Leishmania major importin beta-1 subunit, putative 0.0024 0.0172 0.0544
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0342 0.116
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0027 0.0043
Mycobacterium ulcerans lipase LipD 0.0037 0.0342 0.247
Loa Loa (eye worm) hypothetical protein 0.0122 0.1396 0.2176
Plasmodium falciparum histone deacetylase, putative 0.021 0.2495 0.8959
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0053 0.0114
Toxoplasma gondii histone deacetylase HDAC3 0.0233 0.2783 1
Loa Loa (eye worm) histone deacetylase 0.021 0.2495 0.3892
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0342 0.0533
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0342 0.1136
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0504 0.0786
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0012 0.0027 0.0022
Brugia malayi Carboxylesterase family protein 0.0089 0.0982 0.1531
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0012 0.0027 0.0022
Trypanosoma cruzi histone deacetylase, putative 0.021 0.2495 0.8959
Plasmodium vivax histone deacetylase, putative 0.01 0.1127 0.4004
Echinococcus granulosus dna polymerase eta 0.002 0.0132 0.0203
Schistosoma mansoni cpg binding protein 0.0029 0.0234 0.0333
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.2381 0.238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0447 0.0667
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0031
Toxoplasma gondii histone deacetylase HDAC2 0.0233 0.2783 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0342 0.1136
Echinococcus multilocularis neuroligin 0.0089 0.0982 0.098
Echinococcus granulosus histone deacetylase 3 0.0233 0.2783 0.4341
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0053 0.0114
Echinococcus granulosus histone deacetylase 6 0.0222 0.2645 0.4125
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0588 0.0918
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0027 0.004
Echinococcus multilocularis cpg binding protein 0.003 0.0254 0.0253
Echinococcus granulosus tar DNA binding protein 0.0063 0.0667 0.1038
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0012 0.0027 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0342 0.116
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0021 0.002
Schistosoma mansoni histone deacetylase 4 5 0.021 0.2495 0.3873
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0588 0.0916
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0342 0.0531
Brugia malayi TAR-binding protein 0.0063 0.0667 0.104
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0027 0.0043
Brugia malayi Carboxylesterase family protein 0.0089 0.0982 0.1531
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0012 0.0027 0.0022
Echinococcus granulosus BRCA1 associated protein 0.0012 0.0027 0.004
Leishmania major hypothetical protein, conserved 0.0012 0.0027 0.0022
Schistosoma mansoni cpg binding protein 0.003 0.0254 0.0364
Brugia malayi Pre-SET motif family protein 0.0203 0.2408 0.3757
Brugia malayi histone deacetylase 11 0.01 0.1127 0.1758
Loa Loa (eye worm) hypothetical protein 0.011 0.1246 0.1943
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.056 0.0871
Onchocerca volvulus 0.0089 0.0982 0.3511
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0342 0.116
Echinococcus multilocularis acetylcholinesterase 0.0525 0.6409 0.6409
Echinococcus multilocularis histone deacetylase 6 0.021 0.2495 0.2494
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0504 0.0786
Trichomonas vaginalis histone deacetylase, putative 0.0233 0.2783 1
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.5862 0.5861
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0132 0.04
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0012 0.0027 0.0022
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0132 0.04
Loa Loa (eye worm) hypothetical protein 0.0055 0.056 0.0871
Echinococcus granulosus histone deacetylase 6 0.021 0.2495 0.3892
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.056 0.0873
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0667 0.101
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0525 0.6409 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0012 0.0027 0.0022
Trichomonas vaginalis histone deacetylase, putative 0.0233 0.2783 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Echinococcus granulosus snurportin 1 0.0311 0.3742 0.5838
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0342 0.116
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0667 0.104
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0012 0.0027 0.0026
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0076 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0588 0.2052
Plasmodium falciparum histone deacetylase 2 0.021 0.2495 0.8959
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0588 0.2052
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0588 0.2052
Loa Loa (eye worm) carboxylesterase 0.0089 0.0982 0.153
Echinococcus multilocularis carboxylesterase 5A 0.0525 0.6409 0.6409
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0132 0.0205
Brugia malayi CCR4 0.0012 0.0021 0.0033
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0031
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0027 0.0022
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.2381 0.3714
Plasmodium vivax SET domain protein, putative 0.003 0.0248 0.0819
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0667 0.101
Schistosoma mansoni ap endonuclease 0.0057 0.0588 0.0887
Toxoplasma gondii exonuclease III APE 0.0057 0.0588 0.2052
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0012 0.0027 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0588 0.2052
Brugia malayi CXXC zinc finger family protein 0.0029 0.0234 0.0365
Trichomonas vaginalis histone deacetylase, putative 0.0233 0.2783 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.04
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0982 0.1503
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0248 0.0246
Trypanosoma cruzi histone deacetylase, putative 0.021 0.2495 0.8959
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0342 0.116
Schistosoma mansoni histone deacetylase hda2 0.0222 0.2645 0.4107
Trypanosoma cruzi histone deacetylase, putative 0.021 0.2495 0.8959
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Plasmodium vivax histone deacetylase 2, putative 0.021 0.2495 0.8959
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0132 0.04
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0384
Echinococcus multilocularis para nitrobenzyl esterase 0.0089 0.0982 0.098
Loa Loa (eye worm) histone deacetylase 3 0.0233 0.2783 0.4341
Loa Loa (eye worm) hypothetical protein 0.0233 0.2783 0.4341
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0012 0.0027 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0342 0.116
Loa Loa (eye worm) hypothetical protein 0.01 0.1127 0.1757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0447 0.0667
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0086
Echinococcus multilocularis histone deacetylase 6 0.0222 0.2645 0.2644
Loa Loa (eye worm) hypothetical protein 0.0029 0.024 0.0372
Echinococcus multilocularis histone deacetylase 6 0.021 0.2495 0.2494
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Echinococcus multilocularis BC026374 protein (S09 family) 0.0089 0.0982 0.098
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0012 0.0027 0.0026
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.024 0.0792
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0588 1
Trypanosoma brucei histone deacetylase 2 0.01 0.1127 0.4004
Onchocerca volvulus 0.0037 0.0342 0.1171
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0021 0.002
Schistosoma mansoni ap endonuclease 0.0057 0.0588 0.0887
Trypanosoma cruzi histone deacetylase 1, putative 0.0233 0.2783 1
Onchocerca volvulus 0.0089 0.0982 0.3511
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0588 0.5371
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0012 0.0027 0.004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0588 0.2052
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.284 1
Brugia malayi beta-lactamase family protein 0.0037 0.0342 0.0533
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0012 0.0027 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0172 0.0544
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0342 0.0531
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0447 0.0698
Schistosoma mansoni hypothetical protein 0.0348 0.4205 0.655
Mycobacterium leprae Probable lipase LipE 0.0037 0.0342 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0132 0.0173
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0342 0.1136
Brugia malayi Carboxylesterase family protein 0.0525 0.6409 1
Brugia malayi mbt repeat family protein 0.0048 0.0477 0.0744
Onchocerca volvulus 0.0089 0.0982 0.3511
Echinococcus granulosus dna polymerase kappa 0.002 0.0132 0.0203
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0342 0.5
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0027 0.0022
Trypanosoma brucei unspecified product 0.0014 0.0053 0.0114
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0342 0.0501
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0031
Echinococcus multilocularis importin subunit beta 1 0.0029 0.024 0.0239
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0588 0.2052
Loa Loa (eye worm) histone deacetylase 11 0.01 0.1127 0.1757
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0172 0.0544
Loa Loa (eye worm) carboxylesterase 0.0089 0.0982 0.153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0248 0.0819
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0012 0.0027 0.0043
Echinococcus multilocularis dna polymerase eta 0.002 0.0132 0.013
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0248 0.0384
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0477 0.0713
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0342 0.116
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0234 0.0363
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0012 0.0027 0.0022
Leishmania major hypothetical protein, conserved 0.0012 0.0027 0.0022
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0021 0.0031
Schistosoma mansoni hypothetical protein 0.0348 0.4205 0.655
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.056 0.0871
Toxoplasma gondii histone deacetylase HDAC5 0.01 0.1127 0.4004
Schistosoma mansoni BC026374 protein (S09 family) 0.0089 0.0982 0.1503
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0012 0.0027 0.004
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0089 0.0982 0.3477
Trichomonas vaginalis histone deacetylase, putative 0.0233 0.2783 1
Plasmodium falciparum importin beta, putative 0.0029 0.024 0.0792
Echinococcus granulosus histone deacetylase 0.021 0.2495 0.3892
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0132 0.0391
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0342 0.116
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.5862 0.9146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0076 0.0116
Schistosoma mansoni histone deacetylase 4 5 0.021 0.2495 0.3873
Schistosoma mansoni brca1-associated protein (brap2) 0.0012 0.0027 0.0009
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0027 0.004
Brugia malayi histone deacetylase 3 (HD3) 0.0233 0.2783 0.4342
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0089 0.0982 0.098
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0742
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0588 0.2052
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0477 0.0476
Toxoplasma gondii histone deacetylase HDAC1 0.021 0.2495 0.8959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0447 0.0667
Echinococcus multilocularis acetylcholinesterase 0.0525 0.6409 0.6409
Plasmodium falciparum histone deacetylase 1 0.0233 0.2783 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0.0027 0.0022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0.0027 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Echinococcus multilocularis GPCR, family 2 0.0016 0.0076 0.0075
Schistosoma mansoni brca1-associated protein (brap2) 0.0012 0.0027 0.0009
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0086
Echinococcus granulosus importin subunit beta 1 0.0029 0.024 0.0372
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0021 0.0031
Plasmodium vivax importin-beta 2, putative 0.0029 0.024 0.0792
Trichomonas vaginalis histone deacetylase, putative 0.0233 0.2783 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Loa Loa (eye worm) histone deacetylase 7A 0.021 0.2495 0.3892
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0982 0.1503
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0031
Loa Loa (eye worm) acetylcholinesterase 1 0.0525 0.6409 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0504 0.0784
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.024 0.0792
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0982 0.1503
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.3742 0.5838
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0012 0.0027 0.004
Schistosoma mansoni histone deacetylase hda2 0.01 0.1127 0.1731
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0477 0.0713
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0226 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.0531
Mycobacterium tuberculosis Conserved protein 0.0037 0.0342 0.1136
Brugia malayi RNA binding protein 0.0063 0.0667 0.104
Onchocerca volvulus 0.0037 0.0342 0.1171
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0021 0.0031
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0031
Loa Loa (eye worm) beta-lactamase 0.0037 0.0342 0.0531
Trypanosoma brucei unspecified product 0.002 0.0132 0.04
Echinococcus multilocularis snurportin 1 0.0311 0.3742 0.3741
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0021 0.002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Brugia malayi Pre-SET motif family protein 0.003 0.0248 0.0386
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.056 0.0558
Echinococcus granulosus neuroligin 0.0089 0.0982 0.153
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0027 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0588 0.2052
Entamoeba histolytica hypothetical protein 0.0024 0.0172 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0248 0.0354
Brugia malayi mbt repeat family protein 0.0048 0.0477 0.0744
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0132 0.0203
Echinococcus granulosus acetylcholinesterase 0.0525 0.6409 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2408 0.3756
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Brugia malayi RNA, U transporter 1 0.0083 0.0907 0.1416
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0667 0.1038
Entamoeba histolytica histone deacetylase, putative 0.0233 0.2783 1
Loa Loa (eye worm) carboxylesterase 0.0525 0.6409 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0342 0.247
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0021 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0306 0.0477
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0342 0.034
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.0531
Brugia malayi Histone deacetylase family protein 0.021 0.2495 0.3893
Echinococcus multilocularis histone deacetylase 8 0.01 0.1127 0.1126
Echinococcus granulosus GPCR family 2 0.0016 0.0076 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0076 0.0119
Brugia malayi beta-lactamase 0.0037 0.0342 0.0533
Trypanosoma brucei histone deacetylase 4 0.021 0.2495 0.8959
Brugia malayi histone deacetylase 1 (HD1) 0.0233 0.2783 0.4342
Trypanosoma brucei histone deacetylase 1 0.0233 0.2783 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0588 0.0916
Trichomonas vaginalis BRCA1-associated protein, putative 0.0012 0.0027 0.0022
Leishmania major histone deacetylase, putative 0.0233 0.2783 1
Echinococcus granulosus para nitrobenzyl esterase 0.0089 0.0982 0.153
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0.0027 0.0022
Echinococcus multilocularis synaptojanin 1 0.0012 0.0021 0.002
Echinococcus multilocularis histone deacetylase 0.021 0.2495 0.2494
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0248 0.0354
Schistosoma mansoni cpg binding protein 0.003 0.0254 0.0364
Giardia lamblia Hypothetical protein 0.0012 0.0027 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0076 0.0075
Trypanosoma brucei histone deacetylase, putative 0.021 0.2495 0.8959
Onchocerca volvulus 0.0089 0.0982 0.3511
Brugia malayi BRCA1-associated protein 2 containing protein 0.0012 0.0027 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0342 0.1136
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0089 0.0982 0.153
Schistosoma mansoni histone deacetylase 1 2 3 0.01 0.1127 0.1731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0447 0.0446
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0132 0.04
Onchocerca volvulus 0.0089 0.0982 0.3511
Trypanosoma cruzi histone deacetylase, putative 0.01 0.1127 0.4004
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0021 0.0031
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0477 0.0742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0233 0.2783 1
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0086
Loa Loa (eye worm) MBCTL1 0.0055 0.056 0.0871
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.056 0.0558
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0588 0.0587
Mycobacterium ulcerans beta-lactamase 0.0037 0.0342 0.247
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0342 0.247
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0132 0.0391
Toxoplasma gondii ABC1 family protein 0.0037 0.0342 0.116
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0132 0.04
Echinococcus granulosus histone deacetylase 7 0.021 0.2495 0.3892
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0342 0.1136
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0.0027 0.0022
Echinococcus multilocularis histone deacetylase 1 0.0233 0.2783 0.2782
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0447 0.0696
Brugia malayi Carboxylesterase family protein 0.0089 0.0982 0.1531
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0132 0.0173
Brugia malayi Importin beta-1 subunit 0.0029 0.024 0.0374
Echinococcus multilocularis dna polymerase kappa 0.002 0.0132 0.013
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0342 0.116
Toxoplasma gondii histone deacetylase HDAC4 0.01 0.1127 0.4004
Giardia lamblia DINP protein human, muc B family 0.002 0.0132 0.04
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0027 0.0022
Schistosoma mansoni hypothetical protein 0.0311 0.3742 0.5825
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.056 0.0843
Mycobacterium tuberculosis Conserved protein 0.0037 0.0342 0.1136
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.024 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0667 0.101
Plasmodium vivax histone deacetylase, putative 0.021 0.2495 0.8959
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0012 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0076 0.0116
Leishmania major histone deacetylase, putative 0.0233 0.2783 1
Echinococcus granulosus histone deacetylase 8 0.01 0.1127 0.1757
Onchocerca volvulus 0.003 0.0248 0.0827
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0588 0.2052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0248 0.0246
Echinococcus granulosus neuropeptide s receptor 0.0481 0.5862 0.9146
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0012 0.0027 0.0022
Echinococcus granulosus histone deacetylase 1 0.0233 0.2783 0.4341
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0021 0.0033
Mycobacterium ulcerans carboxylesterase, LipT 0.0089 0.0982 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0089 0.0982 0.3406
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0342 0.247
Echinococcus multilocularis histone deacetylase 3 0.0233 0.2783 0.2782
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0132 0.04
Onchocerca volvulus 0.0029 0.0234 0.0777
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0447 0.0696
Trichomonas vaginalis brca1-associated protein, putative 0.0012 0.0027 0.0022
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0012 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.005 0.0504 0.0784
Loa Loa (eye worm) hypothetical protein 0.0525 0.6409 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0667 0.1038
Brugia malayi Histone deacetylase 1 0.0233 0.2783 0.4342
Echinococcus multilocularis geminin 0.0348 0.4205 0.4204
Echinococcus granulosus acetylcholinesterase 0.0525 0.6409 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0477 0.0742
Onchocerca volvulus 0.0048 0.0477 0.1665
Onchocerca volvulus 0.0231 0.2756 1
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0012 0.0027 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.0531
Echinococcus granulosus synaptojanin 1 0.0012 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Mycobacterium tuberculosis Carboxylesterase LipT 0.0089 0.0982 0.3406
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0566 0.1971
Brugia malayi hypothetical protein 0.0089 0.0982 0.1531
Schistosoma mansoni neuroligin 3 (S09 family) 0.0089 0.0982 0.1503
Leishmania major DNA polymerase kappa, putative 0.002 0.0132 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.0531
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0021 0.002
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0076 0.0119
Schistosoma mansoni importin beta-1 0.0029 0.024 0.0342
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.04
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0132 0.0205
Trichomonas vaginalis esterase, putative 0.0037 0.0342 0.116
Trypanosoma cruzi histone deacetylase, putative 0.01 0.1127 0.4004
Echinococcus granulosus cpg binding protein 0.003 0.0254 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Leishmania major histone deacetylase, putative 0.021 0.2495 0.8959
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0172 0.0544
Echinococcus granulosus histone deacetylase 6 0.021 0.2495 0.3892
Schistosoma mansoni DNA polymerase eta 0.002 0.0132 0.0173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.0531
Schistosoma mansoni histone deacetylase 0.0233 0.2783 0.4323
Trichomonas vaginalis spcc417.12 protein, putative 0.0089 0.0982 0.3477
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0172 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0132 0.04
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0012 0.0027 0.0022
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0012 0.0027 0.0022
Schistosoma mansoni acetylcholinesterase 0.0089 0.0982 0.1503
Brugia malayi beta-lactamase family protein 0.0037 0.0342 0.0533
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0233 0.2783 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0982 0.153
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0132 0.04
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0342 0.1136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0132 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.0531
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0588 0.2052
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0233 0.2783 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0667 0.101

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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