Detailed information for compound 1170496

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.499 | Formula: C16H20N6O2S2
  • H donors: 0 H acceptors: 4 LogP: 2.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(N1CCN(CC1)c1ccccn1)SCCn1c(C)ncc1[N+](=O)[O-]
  • InChi: 1S/C16H20N6O2S2/c1-13-18-12-15(22(23)24)21(13)10-11-26-16(25)20-8-6-19(7-9-20)14-4-2-3-5-17-14/h2-5,12H,6-11H2,1H3
  • InChiKey: KENYRRNJKYASQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0141 0.0156
Brugia malayi Carboxylesterase family protein 0.0487 0.2776 0.3084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0141 0.0156
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0783 0.154
Schistosoma mansoni hypothetical protein 0.0155 0.0821 0.2927
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0141 0.0244
Entamoeba histolytica hypothetical protein 0.0148 0.0783 0.4294
Loa Loa (eye worm) fatty acid desaturase 0.017 0.091 0.1011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0977 0.1932
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0148 0.0814
Mycobacterium ulcerans hypothetical protein 0.017 0.091 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0141 0.0466
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3_2 0.017 0.091 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0141 0.0251
Echinococcus granulosus muscleblind protein 0.0479 0.2727 0.5613
Loa Loa (eye worm) hypothetical protein 0.0479 0.2727 0.303
Entamoeba histolytica hypothetical protein 0.0148 0.0783 0.4294
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0219 0.0412
Schistosoma mansoni hypothetical protein 0.0167 0.0892 0.3183
Schistosoma mansoni lamin 0.0027 0.0068 0.0202
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0168 0.0187
Schistosoma mansoni nuclear hormone receptor 0.0018 0.002 0.0028
Brugia malayi Carboxylesterase family protein 0.0082 0.0396 0.044
Brugia malayi Fatty acid desaturase family protein 0.017 0.091 0.1011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.002 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.013 0.0145
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0141 0.0466
Schistosoma mansoni nuclear receptor 0.0018 0.002 0.0028
Onchocerca volvulus 0.1717 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0783 0.1582
Brugia malayi hypothetical protein 0.0082 0.0396 0.044
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Brugia malayi PHD-finger family protein 0.0028 0.0075 0.0083
Brugia malayi Fatty acid desaturase family protein 0.017 0.091 0.1011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0023 0.0042
Onchocerca volvulus 0.0082 0.0396 0.0396
Echinococcus multilocularis neuroligin 0.0082 0.0396 0.0759
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0141 0.0244
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0082 0.0396 0.0779
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0173
Loa Loa (eye worm) carboxylesterase 0.0082 0.0396 0.044
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.017 0.091 1
Plasmodium falciparum stearoyl-CoA desaturase 0.1547 0.9001 0.5
Echinococcus multilocularis protein dispatched 1 0.005 0.0204 0.0372
Mycobacterium ulcerans carboxylesterase, LipT 0.0082 0.0396 0.3404
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0636 0.0706
Brugia malayi Zinc finger, C2H2 type family protein 0.0304 0.17 0.1889
Loa Loa (eye worm) hypothetical protein 0.0079 0.0374 0.0416
Brugia malayi nuclear hormone receptor 0.0039 0.0141 0.0156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0839 0.4843 0.9732
Trichomonas vaginalis spcc417.12 protein, putative 0.0082 0.0396 0.2171
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0141 0.0251
Onchocerca volvulus 0.0033 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Trypanosoma brucei delta-4 fatty acid desaturase 0.017 0.091 0.091
Echinococcus multilocularis BC026374 protein (S09 family) 0.0082 0.0396 0.0759
Echinococcus multilocularis acetylcholinesterase 0.0487 0.2776 0.5561
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.1547 0.9001 1
Echinococcus granulosus expressed conserved protein 0.0095 0.0473 0.0939
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0487 0.2776 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0192 0.0357
Trypanosoma cruzi ISWI complex protein 0.0017 0.0012 0.0012
Echinococcus multilocularis zinc finger protein 0.0022 0.004 0.0041
Schistosoma mansoni zinc finger protein 0.0018 0.002 0.0028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0173
Echinococcus granulosus para nitrobenzyl esterase 0.0082 0.0396 0.0779
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0516 0.0574
Schistosoma mansoni nuclear receptor 0.0018 0.002 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0148 0.0814
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0036
Onchocerca volvulus 0.0018 0.002 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0141 0.0244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0036
Onchocerca volvulus 0.017 0.091 0.091
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.017 0.091 0.091
Schistosoma mansoni hypothetical protein 0.0167 0.0892 0.3183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0141 0.0251
Brugia malayi CHE-14 protein 0.0044 0.0168 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0309 0.2292
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0107 0.0176
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.01
Schistosoma mansoni nuclear hormone receptor 0.0018 0.002 0.0028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0141 0.0156
Schistosoma mansoni BC026374 protein (S09 family) 0.0082 0.0396 0.1389
Loa Loa (eye worm) hypothetical protein 0.0487 0.2776 0.3084
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0155 0.0821 0.0912
Trypanosoma brucei ISWI complex protein 0.0017 0.0012 0.0012
Leishmania major delta-4 fatty acid desaturase 0.017 0.091 0.091
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0765 0.1545
Loa Loa (eye worm) carboxylesterase 0.0487 0.2776 0.3084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0036
Brugia malayi hypothetical protein 0.0018 0.002 0.0022
Echinococcus granulosus carboxylesterase 5A 0.0487 0.2776 0.5714
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0168 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0044 0.0168 0.0187
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0141 0.0466
Schistosoma mansoni alpha-glucosidase 0.0156 0.0829 0.2956
Trypanosoma cruzi fatty acid desaturase, putative 0.1717 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0325 0.0361
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0148 0.0814
Schistosoma mansoni lamin 0.0027 0.0068 0.0202
Toxoplasma gondii ABC1 family protein 0.0037 0.013 0.0287
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0636 0.0706
Brugia malayi nuclear receptor NHR-67 0.0018 0.002 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0181
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.017 0.091 0.091
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0141 0.0251
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0082 0.0396 0.2259
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0141 0.0244
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0765 0.1503
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Brugia malayi nuclear receptor RXR 0.0018 0.002 0.0022
Echinococcus multilocularis muscleblind protein 1 0.0479 0.2727 0.5463
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0082 0.0396 0.0759
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.0846 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.002 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0148 0.0814
Echinococcus multilocularis carboxylesterase 5A 0.0487 0.2776 0.5561
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0168
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0082 0.0396 0.2259
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0141 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0219 0.0748
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0148 0.0814
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Onchocerca volvulus 0.0037 0.013 0.013
Brugia malayi Delta5 fatty acid desaturase 0.017 0.091 0.1011
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.033
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.017 0.091 0.091
Onchocerca volvulus Huntingtin homolog 0.013 0.0677 0.0677
Onchocerca volvulus 0.0018 0.002 0.002
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0023 0.0007
Echinococcus granulosus BC026374 protein S09 family 0.0082 0.0396 0.0779
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0141 0.0156
Echinococcus granulosus geminin 0.0167 0.0892 0.1808
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0148 0.0814
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0023 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0141 0.0156
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0148 0.0814
Schistosoma mansoni alpha-glucosidase 0.0156 0.0829 0.2956
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0309 0.1075
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0226 0.0251
Echinococcus granulosus zinc finger transcription factor gli2 0.0304 0.17 0.3484
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.013 0.0223
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0147 0.0263
Brugia malayi Carboxylesterase family protein 0.0487 0.2776 0.3084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.013 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0141 0.0156
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0396 0.1389
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Echinococcus granulosus Fatty acid desaturase type 1 0.017 0.091 0.1847
Brugia malayi acyl-CoA desaturase 0.1547 0.9001 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0977 0.1932
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.033
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0309 0.1075
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0059 0.008
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0202
Leishmania major hypothetical protein, conserved 0.0017 0.0012 0.0012
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0509 0.0565
Schistosoma mansoni fatty acid desaturase 0.017 0.091 0.3251
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0141 0.0156
Schistosoma mansoni hypothetical protein 0.0042 0.0159 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0516 0.0574
Onchocerca volvulus 0.0082 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0141 0.0466
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0309 0.0584
Echinococcus multilocularis acetylcholinesterase 0.0487 0.2776 0.5561
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0033 0.0075
Trypanosoma cruzi fatty acid desaturase, putative 0.1547 0.9001 0.9001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.002 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0107 0.0344
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0147 0.0256
Trichomonas vaginalis set domain proteins, putative 0.0264 0.1461 0.8013
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Brugia malayi Nuclear hormone receptor E75 0.0018 0.002 0.0022
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.017 0.091 0.091
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.01
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0027 0.0031
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0141 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0103 0.0115
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0396 0.1389
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0309 0.2513
Schistosoma mansoni acetylcholinesterase 0.0082 0.0396 0.1389
Loa Loa (eye worm) hypothetical protein 0.0758 0.4369 0.4853
Mycobacterium tuberculosis Probable conserved membrane protein 0.017 0.091 0.6635
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.013 0.0677 0.0752
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Onchocerca volvulus 0.0105 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0145
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0168 0.0307
Leishmania major hypothetical protein, conserved 0.0037 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0141 0.0156
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0977 0.1086
Brugia malayi nuclear hormone receptor 0.0018 0.002 0.0022
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.002 0.0022
Loa Loa (eye worm) carboxylesterase 0.0082 0.0396 0.044
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0141 0.0244
Echinococcus multilocularis para nitrobenzyl esterase 0.0082 0.0396 0.0759
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.002 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0103 0.0115
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0148 0.0266
Echinococcus granulosus transcription factor eb 0.0111 0.0566 0.1133
Brugia malayi Pre-SET motif family protein 0.0033 0.0107 0.0119
Mycobacterium ulcerans transmembrane alkane 1-monooxygenase AlkB 0.017 0.091 1
Echinococcus granulosus neuroligin 0.0082 0.0396 0.0779
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0082 0.0396 0.2171
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0033 0.0026
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0148 0.0814
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0518 0.1831
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0141 0.0466
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.017 0.091 0.6635
Trypanosoma brucei sphingolipid delta 4 desaturase, putative 0.017 0.091 0.091
Onchocerca volvulus 0.0039 0.0141 0.0141
Loa Loa (eye worm) fatty acid desaturase 0.017 0.091 0.1011
Echinococcus multilocularis muscleblind protein 0.0479 0.2727 0.5463
Loa Loa (eye worm) hypothetical protein 0.0052 0.0219 0.0243
Onchocerca volvulus 0.0027 0.0068 0.0068
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.1823 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0111 0.0566 0.0629
Schistosoma mansoni hypothetical protein 0.0042 0.0159 0.0531
Brugia malayi beta-lactamase family protein 0.0037 0.013 0.0145
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0309 0.0309
Leishmania major fatty-acid desaturase, putative 0.1717 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0178 0.0198
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.017 0.091 0.091
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0141 0.0466
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0145
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0047 0.0052
Echinococcus multilocularis lamin 0.0027 0.0068 0.0097
Loa Loa (eye worm) hypothetical protein 0.017 0.091 0.1011
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0148 0.0814
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.013 0.0229
Leishmania major delta-6 fatty acid desaturase 0.017 0.091 0.091
Trypanosoma brucei glucosidase, putative 0.004 0.0148 0.0148
Toxoplasma gondii sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein 0.017 0.091 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0033 0.0075
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0148 0.0814
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0141 0.0466
Echinococcus multilocularis zinc finger transcription factor gli2 0.0304 0.17 0.339
Brugia malayi steroid hormone receptor 0.0039 0.0141 0.0156
Brugia malayi beta-lactamase family protein 0.0037 0.013 0.0145
Schistosoma mansoni hypothetical protein 0.0148 0.0783 0.279
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0103 0.0115
Echinococcus granulosus acetylcholinesterase 0.0487 0.2776 0.5714
Trypanosoma cruzi ISWI complex protein 0.0017 0.0012 0.0012
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0023 0.0042
Echinococcus multilocularis transcription factor eb 0.0111 0.0566 0.1102
Entamoeba histolytica hypothetical protein 0.0148 0.0783 0.4294
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0148 0.0148
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0977 0.1086
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0141 0.0156
Loa Loa (eye worm) beta-lactamase 0.0037 0.013 0.0145
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0302 0.0586
Brugia malayi hypothetical protein 0.0758 0.4369 0.4853
Trypanosoma brucei fatty acid desaturase, putative 0.1717 1 1
Schistosoma mansoni gliotactin 0.0082 0.0396 0.1389
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0862 0.4976 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 0.1823 0.5
Brugia malayi Bromodomain containing protein 0.0083 0.0402 0.0447
Schistosoma mansoni hypothetical protein 0.007 0.0325 0.1133
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0509 0.0986
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0141 0.0156
Echinococcus multilocularis protein patched 0.0044 0.0168 0.0299
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.017 0.091 0.091
Trypanosoma brucei cytochrome b5-dependent oleate desaturase 0.017 0.091 0.091
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.0126
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0145
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.1306 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Echinococcus granulosus survival motor neuron protein 1 0.0758 0.4369 0.9016
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0141 0.0156
Echinococcus granulosus lamin 0.0027 0.0068 0.01
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 0.1823 1
Schistosoma mansoni hypothetical protein 0.0042 0.0159 0.0531
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.0075
Trypanosoma brucei delta-6 fatty acid desaturase, putative 0.017 0.091 0.091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.013 0.0145
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0302 0.057
Onchocerca volvulus 0.0264 0.1461 0.1461
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0516 0.0574
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0141 0.0466
Schistosoma mansoni patched 1 0.0044 0.0168 0.0565
Leishmania major fatty acid desaturase, putative 0.017 0.091 0.091
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0141 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.013 0.0714
Brugia malayi Carboxylesterase family protein 0.0082 0.0396 0.044
Loa Loa (eye worm) acetylcholinesterase 1 0.0487 0.2776 0.3084
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0033 0.0027
Loa Loa (eye worm) hypothetical protein 0.0479 0.2727 0.303
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Loa Loa (eye worm) hypothetical protein 0.0082 0.0396 0.044
Brugia malayi Carboxylesterase family protein 0.0082 0.0396 0.044
Brugia malayi Nuclear hormone receptor E75 0.0018 0.002 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0148 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0148 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0141 0.0251
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0148 0.0513
Brugia malayi tailless protein 0.0018 0.002 0.0022
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0141 0.0156
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0148 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0192 0.0651
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0141 0.0156
Echinococcus multilocularis expressed conserved protein 0.0095 0.0473 0.0913
Mycobacterium tuberculosis Carboxylesterase LipT 0.0082 0.0396 0.2259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0192 0.0357
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.013 0.0714
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.013 0.0714
Brugia malayi Muscleblind-like protein 0.0479 0.2727 0.303
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0783 0.279
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0141 0.0466
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0141 0.0156
Echinococcus multilocularis geminin 0.0167 0.0892 0.1759
Echinococcus multilocularis GPCR, family 2 0.0033 0.0103 0.0168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0192 0.0651
Schistosoma mansoni survival motor neuron protein 0.0155 0.0821 0.2927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0141 0.0244
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0141 0.0251
Brugia malayi conserved hypotetical protein 0.0018 0.002 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.013 0.0428
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.017 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0047 0.0191 0.0212
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0141 0.0141
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0141 0.0251
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.017 0.091 0.1797
Schistosoma mansoni coup transcription factor 0.0039 0.0141 0.0466
Mycobacterium ulcerans hypothetical protein 0.017 0.091 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0309 0.2292
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0977 0.1985
Loa Loa (eye worm) hypothetical protein 0.013 0.0677 0.0752
Plasmodium vivax hypothetical protein, conserved 0.0037 0.013 0.0026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0033 0.0036
Onchocerca volvulus Huntingtin homolog 0.013 0.0677 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0168 0.0922
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.002 0.0022
Onchocerca volvulus 0.0082 0.0396 0.0396
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.0846 0.6084
Loa Loa (eye worm) hypothetical protein 0.0103 0.0516 0.0574
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0141 0.0251
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.013 0.0714
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0192 0.0347
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0115
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0309 0.06
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0141 0.0156
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0097
Schistosoma mansoni alpha glucosidase 0.004 0.0148 0.0493
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0148 0.0165
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0509 0.1014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0141 0.0466
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0192 0.0347
Brugia malayi intermediate filament protein 0.0027 0.0068 0.0075
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.013 0.013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0192 0.0213
Echinococcus granulosus GPCR family 2 0.0033 0.0103 0.0173
Loa Loa (eye worm) hypothetical protein 0.0487 0.2776 0.3084
Brugia malayi ecdysteroid receptor 0.0039 0.0141 0.0156
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0168
Echinococcus multilocularis musashi 0.0027 0.0068 0.0097
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Treponema pallidum fructose-bisphosphate aldolase 0.0325 0.1823 0.5
Leishmania major delta-12 fatty acid desaturase 0.017 0.091 0.091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0141 0.0156
Echinococcus granulosus tm gpcr rhodopsin 0.0839 0.4843 1
Onchocerca volvulus 0.0082 0.0396 0.0396
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0059 0.0171
Brugia malayi hypothetical protein 0.013 0.0677 0.0752
Loa Loa (eye worm) DR-78 0.0018 0.002 0.0022
Echinococcus granulosus acetylcholinesterase 0.0487 0.2776 0.5714
Brugia malayi nuclear receptor NHR-88 0.0018 0.002 0.0022
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0141 0.0156
Onchocerca volvulus 0.0155 0.0821 0.0821
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.017 0.091 0.1797
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0309 0.1521
Leishmania major delta-5 fatty acid desaturase 0.017 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Onchocerca volvulus 0.1717 1 1
Brugia malayi Pre-SET motif family protein 0.0232 0.1273 0.1414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0219 0.0748
Schistosoma mansoni zinc finger protein 0.0022 0.004 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0033 0.0036
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.002 0.0022
Onchocerca volvulus 0.0037 0.013 0.013
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.01 0.0166
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0141 0.0466
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0145
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.017 0.091 0.6635
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0168 0.0299
Echinococcus multilocularis survival motor neuron protein 1 0.0758 0.4369 0.8774
Trichomonas vaginalis esterase, putative 0.0037 0.013 0.0714
Onchocerca volvulus 0.0027 0.0068 0.0068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Brugia malayi beta-lactamase 0.0037 0.013 0.0145
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.017 0.091 0.1847
Schistosoma mansoni neuroligin 3 (S09 family) 0.0082 0.0396 0.1389
Brugia malayi ecdysone receptor 0.0018 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0325 0.0361
Loa Loa (eye worm) hypothetical protein 0.0111 0.0563 0.0625
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0141 0.0244
Brugia malayi nuclear receptor RXR 0.0021 0.0033 0.0036
Loa Loa (eye worm) FAT-3 protein 0.017 0.091 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.013 0.013
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.0846 0.9169
Schistosoma mansoni hypothetical protein 0.0042 0.0159 0.0531
Brugia malayi hypothetical protein 0.0021 0.0033 0.0036
Brugia malayi MH2 domain containing protein 0.0123 0.0636 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0141 0.0156
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.017 0.091 0.091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0219 0.0401
Brugia malayi hypothetical protein 0.0148 0.0783 0.087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0309 0.2292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0107 0.0344
Trypanosoma cruzi fatty acid desaturase, putative 0.017 0.091 0.091
Loa Loa (eye worm) zinc finger protein 0.0304 0.17 0.1889
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.1273 0.1414
Brugia malayi hypothetical protein 0.0021 0.0033 0.0036
Brugia malayi Carboxylesterase family protein 0.0082 0.0396 0.044
Brugia malayi hypothetical protein 0.0018 0.002 0.0022
Entamoeba histolytica hypothetical protein 0.0148 0.0783 0.4294
Echinococcus granulosus zinc finger protein 0.0022 0.004 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0141 0.0244
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.017 0.091 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0033 0.0036
Loa Loa (eye worm) acyl-CoA desaturase 0.1547 0.9001 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.0075
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0148 0.0259
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0148 0.0165
Brugia malayi Bromodomain containing protein 0.0043 0.0162 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0192 0.0651
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.033
Echinococcus multilocularis Fatty acid desaturase, type 1 0.017 0.091 0.1797
Mycobacterium ulcerans electron transfer protein FdxB 0.017 0.091 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0192 0.0213
Leishmania major fatty acid desaturase, putative 0.017 0.091 0.091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 0.1823 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.013 0.0714
Onchocerca volvulus 0.0037 0.013 0.013
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0111 0.0563 0.0625
Onchocerca volvulus 0.0082 0.0396 0.0396
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0141 0.0141
Brugia malayi nuclear receptor NHR-88 0.0039 0.0141 0.0156
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0396 0.1389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0036
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0059 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0141 0.0156
Schistosoma mansoni bromodomain containing protein 0.007 0.0326 0.1135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0141 0.0251
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0022
Trypanosoma cruzi fatty acid desaturase, putative 0.017 0.091 0.091
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0156
Trypanosoma cruzi fatty acid desaturase, putative 0.1547 0.9001 0.9001
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0509 0.279
Loa Loa (eye worm) hypothetical protein 0.0102 0.0509 0.0565
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0141 0.0156

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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