Detailed information for compound 1170808

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 245.663 | Formula: C9H12ClN3O3
  • H donors: 4 H acceptors: 3 LogP: 0.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON/C(=N\c1ccc(cc1)CC(=O)O)/N.Cl
  • InChi: 1S/C9H11N3O3.ClH/c10-9(12-15)11-7-3-1-6(2-4-7)5-8(13)14;/h1-4,15H,5H2,(H,13,14)(H3,10,11,12);1H
  • InChiKey: NXKHXQYIVFKIBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0057 0.0207 0.0294
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0041 0.0103 0.0146
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1105 0.7067 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0312 0.1875 0.2654
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0038 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Onchocerca volvulus Huntingtin homolog 0.0142 0.0767 0.4196
Toxoplasma gondii PCI domain-containing protein 0.0048 0.0153 0.0217
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0026 0.0009 0.0009
Mycobacterium ulcerans hypothetical protein 0.0185 0.1045 0.1343
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0251 0.1478 0.2092
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0035 0.007 0.007
Trypanosoma brucei Aph-1 protein, putative 0.0045 0.0133 0.0188
Leishmania major proteasome alpha 1 subunit, putative 0.025 0.1474 0.2086
Toxoplasma gondii proteasome subunit alpha1, putative 0.0266 0.1577 0.2232
Brugia malayi proteasome subunit beta type 2 0.0291 0.1743 0.2467
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0026 0.001 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0156 0.0221
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.1074 0.152
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0038 0.0088 0.0088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.1583 0.2117
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0245 0.1439 0.1439
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0035 0.007 0.007
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0265 0.157 0.2221
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.1431 0.2026
Loa Loa (eye worm) PCI domain-containing protein 0.0037 0.0081 0.0114
Leishmania major proteasome alpha 3 subunit, putative 0.0251 0.1478 0.2092
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0347 0.2105 0.2979
Plasmodium falciparum carbonic anhydrase 0.0035 0.0069 0.0097
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0048 0.0153 0.0153
Schistosoma mansoni alpha-glucosidase 0.0163 0.0902 0.0902
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0296 0.1774 0.2511
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0157
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0265 0.157 0.157
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0112 0.0159
Schistosoma mansoni microtubule-associated protein tau 0.1554 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0112 0.0159
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.025 0.1474 0.2086
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0291 0.1743 0.2467
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0037 0.0081 0.0114
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Brugia malayi Death domain containing protein 0.0041 0.0109 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0109 0.0154
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0045 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.016 0.0226
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0156 0.0221
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Mycobacterium ulcerans proteasome PrcB 0.1105 0.7067 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0296 0.1774 0.2511
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0068 0.0282 0.0282
Echinococcus granulosus carbonic anhydrase 0.0035 0.0069 0.0069
Echinococcus multilocularis cathepsin b 0.0068 0.0284 0.0284
Brugia malayi Proteasome subunit alpha type 7-1 0.0312 0.1875 0.2654
Trypanosoma brucei proteasome beta 6 subunit 0.0347 0.2105 0.2979
Schistosoma mansoni hypothetical protein 0.0033 0.0055 0.0055
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0037 0.0082 0.0116
Brugia malayi Trypsin family protein 0.0068 0.0282 0.0398
Brugia malayi Ubiquitin interaction motif family protein 0.0026 0.0009 0.0013
Brugia malayi Protein kinase domain containing protein 0.0041 0.0109 0.0154
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0244 0.1431 0.2026
Schistosoma mansoni hypothetical protein 0.0066 0.0267 0.0267
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0459 0.065
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0037 0.0082 0.0116
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0041 0.0103 0.0146
Echinococcus multilocularis netrin receptor unc 5 0.0041 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0038 0.0088 0.0125
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Echinococcus granulosus glycoprotein Antigen 5 0.0068 0.0282 0.0282
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0312 0.1875 0.1875
Echinococcus multilocularis gamma secretase subunit aph 1 0.0116 0.0595 0.0595
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.005 0.0165 0.0233
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0041 0.0104 0.0147
Giardia lamblia 20S proteasome alpha subunit 5 0.0265 0.157 0.2221
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0026 0.001 0.0014
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0026 0.0009 0.0009
Brugia malayi Proteasome A-type and B-type family protein 0.0919 0.5846 0.8273
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.025 0.1474 0.2086
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0112 0.0159
Onchocerca volvulus 0.0068 0.0282 0.11
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0116 0.0595 0.0841
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0291 0.1743 0.1743
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0041 0.0103 0.0146
Giardia lamblia 20S proteasome alpha subunit 4 0.0312 0.1875 0.2654
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0069 0.0289 0.0409
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0157
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0045 0.0131 0.0185
Plasmodium falciparum proteasome subunit beta type-4 0.0242 0.1418 0.2007
Echinococcus multilocularis enteropeptidase 0.0068 0.0282 0.0282
Schistosoma mansoni netrin receptor unc5 0.0041 0.0109 0.0109
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0312 0.1875 0.1875
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0026 0.001 0.001
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.025 0.1474 0.1474
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0037 0.0081 0.0114
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0156
Echinococcus multilocularis proteasome subunit alpha type 2 0.0257 0.1518 0.1518
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0266 0.1577 0.2232
Echinococcus granulosus proteasome subunit beta type 6 0.0251 0.1482 0.1482
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0095 0.0459 0.065
Trichomonas vaginalis esterase, putative 0.0042 0.0111 0.0157
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0035 0.007 0.0099
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0112 0.0159
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.2129 0.3013
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0251 0.1482 0.2097
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0037 0.0082 0.0116
Loa Loa (eye worm) proteasome subunit beta type 3 0.0244 0.1431 0.2026
Loa Loa (eye worm) carbonic anhydrase 3 0.0095 0.0459 0.065
Loa Loa (eye worm) hypothetical protein 0.0367 0.2236 0.3165
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0157
Brugia malayi hypothetical protein 0.0068 0.0282 0.0398
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0266 0.1577 0.2232
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0041 0.0103 0.0103
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0069 0.0289 0.0409
Toxoplasma gondii proteasome subunit alpha type, putative 0.0101 0.0496 0.0701
Echinococcus granulosus enteropeptidase 0.0068 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0099
Trypanosoma cruzi 20S proteasome subunit 0.0291 0.1743 0.2467
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0242 0.1418 0.2007
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0035 0.007 0.0099
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0009 0.0013
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0311 0.0311
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0242 0.1418 0.2007
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0041 0.0103 0.0146
Loa Loa (eye worm) trypsin family protein 0.0068 0.0282 0.0398
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0038 0.0088 0.0125
Brugia malayi proteasome subunit alpha type 4 0.0231 0.1347 0.1906
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0109 0.0154
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0211 0.1217 0.1591
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0257 0.1518 0.2148
Echinococcus granulosus carbonic anhydrase 0.0035 0.0069 0.0069
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0045 0.0131 0.0185
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.025 0.1474 0.2086
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1105 0.7067 0.7067
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0041 0.0109 0.0109
Plasmodium falciparum proteasome subunit beta type-5 0.1105 0.7067 1
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0048 0.0153 0.0217
Echinococcus granulosus transmembrane protease serine 3 0.0068 0.0282 0.0282
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.005 0.0165 0.0165
Trichomonas vaginalis 26S proteasome subunit, putative 0.0037 0.0081 0.0114
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0266 0.1577 0.2232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0052 0.0073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0157
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0312 0.1875 0.2654
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0242 0.1418 0.2007
Echinococcus multilocularis carbonic anhydrase 0.0035 0.0069 0.0069
Brugia malayi proteasome subunit alpha type 3 0.0253 0.1491 0.211
Leishmania major mitochondrial DNA polymerase beta 0.035 0.2129 0.3013
Schistosoma mansoni hypothetical protein 0.0068 0.0282 0.0282
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0038 0.0088 0.0125
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0253 0.1491 0.211
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1105 0.7067 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0097
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.005 0.0165 0.0165
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.005 0.0165 0.0233
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0291 0.1743 0.1743
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0095 0.0459 0.065
Plasmodium vivax proteasome subunit beta type-4, putative 0.0242 0.1418 0.2007
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0035 0.007 0.0099
Plasmodium vivax proteasome subunit beta type-3, putative 0.0244 0.1431 0.2026
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0026 0.001 0.0014
Leishmania major proteasome beta 2 subunit, putative 0.0296 0.1774 0.2511
Echinococcus multilocularis geminin 0.0215 0.1245 0.1245
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0312 0.1875 0.2654
Echinococcus multilocularis glycoprotein Antigen 5 0.0068 0.0282 0.0282
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0347 0.2105 0.2105
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0211 0.1217 0.1723
Leishmania major proteasome beta 2 subunit, putative 0.0291 0.1743 0.2467
Schistosoma mansoni hypothetical protein 0.0215 0.1245 0.1245
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0037 0.0082 0.0116
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0048 0.0153 0.0217
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0157
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0265 0.157 0.157
Schistosoma mansoni carbonic anhydrase-related 0.0035 0.0069 0.0069
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0037 0.0082 0.0082
Loa Loa (eye worm) RNA binding protein 0.0072 0.0311 0.0439
Loa Loa (eye worm) hypothetical protein 0.0068 0.0284 0.0401
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0311 0.0311
Onchocerca volvulus 0.0068 0.0282 0.11
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.1045 0.1343
Onchocerca volvulus 0.0042 0.0111 0.0013
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0312 0.1875 0.2654
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0311 0.0311
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0296 0.1774 0.2511
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0026 0.001 0.0014
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0041 0.0103 0.0146
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0068 0.0282 0.0282
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0291 0.1743 0.2467
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0257 0.1518 0.2148
Plasmodium vivax proteasome subunit alpha type-1, putative 0.025 0.1474 0.2086
Echinococcus multilocularis carbonic anhydrase 0.0035 0.0069 0.0069
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.005 0.0165 0.0233
Giardia lamblia Proteasome subunit beta type 3 0.0244 0.1431 0.2026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0157
Giardia lamblia Proteasome subunit beta type 2 0.0291 0.1743 0.2467
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0112 0.0112
Echinococcus granulosus gamma secretase subunit aph 1 0.0116 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0097
Giardia lamblia 20S proteasome alpha subunit 6 0.025 0.1474 0.2086
Schistosoma mansoni alpha-glucosidase 0.0163 0.0902 0.0902
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0253 0.1491 0.1491
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0257 0.1518 0.2148
Giardia lamblia Proteasome subunit beta type 1 0.0347 0.2105 0.2979
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0035 0.007 0.0099
Schistosoma mansoni carbonic anhydrase-related 0.0035 0.0069 0.0069
Toxoplasma gondii heat shock protein hslv, putative 0.0211 0.1217 0.1723
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0048 0.0153 0.0153
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1105 0.7067 1
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.025 0.1474 0.2086
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0048 0.0153 0.0153
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0211 0.1217 0.1723
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0291 0.1743 0.2467
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.005 0.0165 0.0233
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0111 0.0157
Onchocerca volvulus 0.0068 0.0282 0.11
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0265 0.157 0.2221
Schistosoma mansoni carbonic anhydrase 0.0035 0.0069 0.0069
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0035 0.007 0.007
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1105 0.7067 1
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0045 0.0131 0.0185
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1743 0.2467
Toxoplasma gondii proteasome beta subunit 0.0244 0.1431 0.2026
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0037 0.0082 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0111 0.0111
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.025 0.1474 0.2086
Leishmania major proteasome alpha 1 subunit, putative 0.0266 0.1577 0.2232
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0347 0.2105 0.2979
Schistosoma mansoni hypothetical protein 0.0215 0.1245 0.1245
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0026 0.001 0.001
Echinococcus granulosus cathepsin b 0.0068 0.0284 0.0284
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0078
Echinococcus granulosus neuropeptide receptor A26 0.0514 0.3197 0.3197
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.025 0.1474 0.1474
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Toxoplasma gondii proteasome regulatory subunit 0.0037 0.0082 0.0116
Loa Loa (eye worm) hypothetical protein 0.0041 0.0109 0.0154
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0312 0.1875 0.1875
Schistosoma mansoni ankyrin 23/unc44 0.0041 0.0109 0.0109
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0251 0.1482 0.2097
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0069 0.0289 0.0409
Plasmodium vivax proteasome subunit beta type-7, putative 0.0296 0.1774 0.2511
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0099
Toxoplasma gondii peptidase, T1 family protein 0.0253 0.1491 0.211
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0038 0.0088 0.0125
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0033 0.0052 0.0073
Brugia malayi proteasome subunit alpha type 6 0.0266 0.1577 0.2232
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0041 0.0104 0.0104
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0251 0.1482 0.2097
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0443 0.2737 0.2737
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0112 0.0159
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0211 0.1217 0.1723
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0244 0.1431 0.1431
Echinococcus granulosus neuropeptide s receptor 0.0514 0.3197 0.3197
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Brugia malayi Proteasome subunit alpha type 1 0.023 0.1343 0.19
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0112 0.0159
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0112 0.0159
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0251 0.1478 0.2092
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0265 0.157 0.2221
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0033 0.0052 0.0073
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0312 0.1875 0.2654
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Brugia malayi Trypsin family protein 0.0068 0.0282 0.0398
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0037 0.0082 0.0082
Echinococcus granulosus proteasome subunit alpha type 6 0.0266 0.1577 0.1577
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0048 0.0153 0.0153
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0242 0.1418 0.2007
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0035 0.007 0.0099
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0068 0.0282 0.0282
Leishmania major hypothetical protein, conserved 0.0042 0.0111 0.0157
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0048 0.0153 0.0217
Echinococcus granulosus adhesion regulating molecule 1 0.0443 0.2737 0.2737
Giardia lamblia 20S proteasome alpha subunit 1 0.0266 0.1577 0.2232
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0035 0.0069 0.0097
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0265 0.157 0.157
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0035 0.0069 0.0097
Loa Loa (eye worm) hypothetical protein 0.0142 0.0767 0.1086
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Echinococcus multilocularis microtubule associated protein 2 0.1554 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.025 0.1474 0.2086
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0266 0.1577 0.2232
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0242 0.1418 0.2007
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0041 0.0104 0.0147
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0311 0.0439
Echinococcus granulosus tar DNA binding protein 0.0072 0.0311 0.0311
Leishmania major proteasome beta 7 subunit, putative 0.0242 0.1418 0.2007
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0037 0.0081 0.0114
Onchocerca volvulus 0.0148 0.0803 0.4421
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0251 0.1478 0.2092
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0095 0.0459 0.0459
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0242 0.1418 0.2007
Brugia malayi hypothetical protein 0.0142 0.0767 0.1086
Brugia malayi proteasome subunit alpha type 2 0.0257 0.1518 0.2148
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0251 0.1478 0.2092
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1105 0.7067 1
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0347 0.2105 0.2979
Echinococcus multilocularis proteasome subunit beta type 6 0.0251 0.1482 0.1482
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1105 0.7067 1
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0312 0.1875 0.2654
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0111 0.0157
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0253 0.1491 0.211
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0112 0.0159
Echinococcus granulosus proteasome subunit beta type 7 0.0919 0.5846 0.5846
Trypanosoma cruzi Aph-1 protein, putative 0.0045 0.0133 0.0188
Toxoplasma gondii proteasome subunit beta type, putative 0.1105 0.7067 1
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0026 0.001 0.0014
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0296 0.1774 0.2511
Giardia lamblia 20S proteasome alpha subunit 7 0.0253 0.1491 0.211
Toxoplasma gondii hypothetical protein 0.0035 0.0069 0.0097
Echinococcus granulosus Proteasome subunit alpha beta 0.0253 0.1491 0.1491
Loa Loa (eye worm) proteasome regulatory particle 0.0045 0.0131 0.0185
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0035 0.0069 0.0097
Loa Loa (eye worm) proteasome subunit beta type 2 0.0291 0.1743 0.2467
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.016 0.0226
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0296 0.1774 0.2511
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0296 0.1774 0.2511
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0312 0.1875 0.1875
Mycobacterium ulcerans proteasome PrcA 0.0211 0.1217 0.1591
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0265 0.157 0.2221
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.005 0.0165 0.0233
Leishmania major proteasome beta 3 subunit, putative 0.0244 0.1431 0.2026
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0041 0.0103 0.0146
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0037 0.0081 0.0114
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0291 0.1743 0.1743
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0068 0.0284 0.0284
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0036 0.0074 0.0105
Echinococcus multilocularis proteasome (prosome, macropain) 0.1105 0.7067 0.7067
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0251 0.1482 0.2097
Echinococcus granulosus Ankyrin 0.0042 0.011 0.011
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0311 0.0311
Schistosoma mansoni alpha glucosidase 0.0042 0.0112 0.0112
Toxoplasma gondii proteasome subunit 0.0251 0.1482 0.2097
Toxoplasma gondii ABC1 family protein 0.0042 0.0111 0.0157
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0041 0.0103 0.0146
Loa Loa (eye worm) hypothetical protein 0.0148 0.0803 0.1136
Giardia lamblia 20S proteasome alpha subunit 3 0.0251 0.1478 0.2092
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0211 0.1217 0.1723
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0211 0.1217 0.5
Brugia malayi proteasome subunit beta type 1 0.0347 0.2105 0.2979
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0052 0.0073
Brugia malayi cathepsin B-like cysteine proteinase 0.0068 0.0284 0.0401
Brugia malayi proteasome subunit beta type 3 0.0244 0.1431 0.2026
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0347 0.2105 0.2979
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0296 0.1774 0.2511
Plasmodium vivax proteasome subunit beta type-2, putative 0.0291 0.1743 0.2467
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0244 0.1431 0.2026
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0242 0.1418 0.2007
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.005 0.0165 0.0233
Plasmodium vivax proteasome subunit beta type-6, putative 0.0251 0.1482 0.2097
Echinococcus granulosus carbonic anhydrase II 0.0095 0.0459 0.0459
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0257 0.1518 0.1518
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0311 0.0439
Leishmania major proteasome alpha 7 subunit, putative 0.0253 0.1491 0.211
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0253 0.1491 0.1491
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0041 0.0104 0.0147
Echinococcus granulosus Mastin 0.0068 0.0282 0.0282
Echinococcus granulosus proteasome prosome macropain 0.1105 0.7067 0.7067
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0291 0.1743 0.2467
Toxoplasma gondii SAC3/GANP family protein 0.0035 0.007 0.0099
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0112 0.0159
Trypanosoma brucei carbonic anhydrase-like protein 0.0095 0.0459 0.065
Trypanosoma brucei glucosidase, putative 0.0042 0.0112 0.0159
Loa Loa (eye worm) hypothetical protein 0.0049 0.0156 0.0221
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0237 0.1387 0.1963
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0037 0.0082 0.0116
Echinococcus multilocularis Mastin 0.0068 0.0282 0.0282
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0038 0.0088 0.0088
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0291 0.1743 0.2467
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0311 0.0311
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0265 0.157 0.2221
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0035 0.0069 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0111 0.0157
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0111 0.0111
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0041 0.0104 0.0147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.016 0.0226
Loa Loa (eye worm) proteasome subunit beta type 1 0.0347 0.2105 0.2979
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.016 0.0226
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0026 0.0009 0.0013
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0244 0.1431 0.2026
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0312 0.1875 0.2654
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0037 0.0082 0.0116
Mycobacterium ulcerans hypothetical protein 0.0068 0.0282 0.0245
Echinococcus multilocularis Ankyrin 0.0042 0.011 0.011
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0242 0.1418 0.2007
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0108 0.0543 0.0543
Echinococcus granulosus 20S proteasome subunit alpha 6 0.025 0.1474 0.1474
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.0159
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0257 0.1518 0.2148
Giardia lamblia 26S protease regulatory subunit 6A 0.0026 0.001 0.0014
Brugia malayi Proteasome A-type and B-type family protein 0.0251 0.1482 0.2097
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0041 0.0104 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0231 0.0326
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0069 0.0289 0.0409
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0211 0.1217 0.1723
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0231 0.1348 0.1907
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0253 0.1491 0.211
Brugia malayi proteasome subunit alpha type 1 0.025 0.1474 0.2086
Echinococcus multilocularis transmembrane protease serine 3 0.0068 0.0282 0.0282
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0068 0.0282 0.0282
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0112 0.0112
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0919 0.5846 0.5846
Brugia malayi Proteasome A-type and B-type family protein 0.0242 0.1418 0.2007
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0311 0.0311
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0026 0.001 0.0014
Brugia malayi small heat shock protein 0.0367 0.2236 0.3165
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0112 0.0159
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0026 0.001 0.0014
Brugia malayi gamma-secretase subunit aph-1 0.0116 0.0595 0.0841
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0037 0.0082 0.0116
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0266 0.1577 0.2232
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0037 0.0081 0.0081
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0038 0.0088 0.0125
Onchocerca volvulus Huntingtin homolog 0.0142 0.0767 0.4196
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0111 0.0157
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0045 0.0131 0.0185
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0026 0.001 0.0014
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.005 0.0165 0.0165
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0265 0.157 0.2221
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1105 0.7067 1
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0069 0.0289 0.0409
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0095 0.0459 0.065
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0035 0.007 0.0099
Brugia malayi hypothetical protein 0.0148 0.0803 0.1136
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0242 0.1418 0.2007
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0291 0.1743 0.1743
Echinococcus multilocularis carbonic anhydrase 0.0035 0.0069 0.0069
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0048 0.0153 0.0217
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0265 0.157 0.2221
Brugia malayi 20S proteasome alpha5 subunit 0.0265 0.157 0.2221
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0068 0.0284 0.0401
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0242 0.1418 0.1418
Brugia malayi Trypsin family protein 0.0068 0.0282 0.0398
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0037 0.0081 0.0114
Echinococcus multilocularis carbonic anhydrase II 0.0095 0.0459 0.0459
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0055 0.0078
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0041 0.0103 0.0103
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0211 0.1217 0.1591
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0253 0.1491 0.211
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0037 0.0082 0.0116
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0311 0.0439
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0037 0.0081 0.0081
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0037 0.0082 0.0116
Echinococcus granulosus subfamily T1A non peptidase ue 0.0265 0.157 0.157
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0242 0.1418 0.2007
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0082 0.0116
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0242 0.1418 0.2007
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0347 0.2105 0.2979
Echinococcus multilocularis proteasome subunit alpha type 6 0.0266 0.1577 0.1577
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.005 0.0165 0.0233
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0035 0.0069 0.0097
Leishmania major proteasome alpha 2 subunit, putative 0.0257 0.1518 0.2148
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0347 0.2105 0.2105
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0026 0.0009 0.0009
Schistosoma mansoni proteasome regulatory subunit-related 0.0041 0.0104 0.0104
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0244 0.1431 0.2026
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0041 0.0104 0.0147
Loa Loa (eye worm) hypothetical protein 0.0068 0.0282 0.0398
Loa Loa (eye worm) RPN-3 protein 0.0048 0.0153 0.0217
Echinococcus multilocularis neuropeptide receptor A26 0.0514 0.3197 0.3197
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0251 0.1478 0.1478
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0041 0.0103 0.0103
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0068 0.0282 0.0398
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0266 0.1577 0.2232
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0251 0.1482 0.2097
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0251 0.1478 0.2092
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.007 0.0099
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0443 0.2737 0.3873
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0037 0.0082 0.0082
Echinococcus granulosus cathepsin b 0.0068 0.0284 0.0284
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0211 0.1217 0.1723
Onchocerca volvulus Notchless protein homolog 0.0253 0.1491 0.8808
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0112 0.0159
Echinococcus granulosus Proteasome subunit alpha type 7 0.0312 0.1875 0.1875
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0211 0.1217 0.1723
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0265 0.157 0.2221
Schistosoma mansoni hypothetical protein 0.0037 0.0081 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0111 0.0157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0111 0.0157
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0253 0.1491 0.211
Toxoplasma gondii proteasome subunit alpha type, putative 0.0251 0.1478 0.2092
Schistosoma mansoni carbonic anhydrase-related 0.0035 0.0069 0.0069
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2129 0.3013
Leishmania major proteasome beta 5 subunit, putative 0.1105 0.7067 1
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0244 0.1431 0.1431
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Echinococcus granulosus netrin receptor unc 5 0.0041 0.0109 0.0109
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0108 0.0543 0.0543
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0347 0.2105 0.2979
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0284 0.0284
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0035 0.007 0.0099
Schistosoma mansoni gamma-secretase subunit aph-1 0.0116 0.0595 0.0595
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0026 0.0009 0.0013
Brugia malayi PCI domain containing protein 0.0037 0.0081 0.0114
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.1074 0.1074
Entamoeba histolytica proteasome regulatory subunit, putative 0.0037 0.0081 0.0114
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0041 0.0104 0.0104
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.1074 0.1074
Echinococcus granulosus death domain containing protein 0.0041 0.0109 0.0109
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0037 0.0081 0.0114
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0035 0.007 0.0099
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Brugia malayi PCI domain containing protein 0.0041 0.0104 0.0147
Plasmodium vivax proteasome subunit beta type-5, putative 0.1105 0.7067 1
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0037 0.0082 0.0116
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0042 0.011 0.011
Echinococcus granulosus carbonic anhydrase 0.0035 0.0069 0.0069
Brugia malayi 26S protease regulatory subunit 6A 0.0026 0.001 0.0014
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0041 0.0103 0.0146
Echinococcus multilocularis adhesion regulating molecule 1 0.0443 0.2737 0.2737
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0347 0.2105 0.2105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0111 0.0111
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0026 0.0005 0.0007
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0922 0.1305
Loa Loa (eye worm) PAS-3 protein 0.0231 0.1347 0.1906
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.0159
Trypanosoma brucei proteasome alpha 7 subunit 0.0253 0.1491 0.211
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0026 0.001 0.0014
Echinococcus multilocularis cathepsin b 0.0068 0.0284 0.0284
Toxoplasma gondii proteasome 26S regulatory subunit 0.0026 0.0005 0.0007
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0251 0.1478 0.2092
Toxoplasma gondii PCI domain-containing protein 0.0045 0.0131 0.0185
Brugia malayi beta-lactamase 0.0042 0.0111 0.0157
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0251 0.1482 0.2097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0097
Brugia malayi beta-lactamase family protein 0.0042 0.0111 0.0157
Giardia lamblia 20S proteasome alpha subunit 2 0.0257 0.1518 0.2148
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0281 0.1678 1
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0026 0.001 0.0014
Onchocerca volvulus 0.0042 0.0111 0.0013
Brugia malayi TAR-binding protein 0.0072 0.0311 0.0439
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.005 0.0165 0.0165
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0111 0.0157
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0231 0.1348 0.1908
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0156 0.0221
Onchocerca volvulus 0.0068 0.0282 0.11
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0257 0.1518 0.2148
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2129 0.3013
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0242 0.1418 0.2007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0405 0.2489 0.2489
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0069 0.0289 0.0409
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.0159
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0112 0.0159
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0041 0.0109 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0111 0.0157
Plasmodium vivax proteasome subunit beta type-1, putative 0.0347 0.2105 0.2979
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Entamoeba histolytica proteasome regulatory subunit, putative 0.0041 0.0104 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0111 0.0157
Echinococcus multilocularis proteasome subunit beta type 7 0.0919 0.5846 0.5846
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0253 0.1491 0.211
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0037 0.0082 0.0116
Loa Loa (eye worm) beta-lactamase 0.0042 0.0111 0.0157
Schistosoma mansoni hypothetical protein 0.0041 0.0109 0.0109
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0242 0.1418 0.1418
Onchocerca volvulus 0.0068 0.0282 0.11
Echinococcus granulosus proteasome subunit alpha type 2 0.0257 0.1518 0.1518
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0035 0.0069 0.0097
Brugia malayi Proteasome/cyclosome repeat family protein 0.0033 0.0052 0.0073
Schistosoma mansoni multiubiquitin binding protein S5a 0.0026 0.0009 0.0009
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0037 0.0082 0.0082
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0251 0.1478 0.2092
Brugia malayi Trypsin-like protease protein 5 0.0068 0.0282 0.0398
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0037 0.0082 0.0116
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0347 0.2105 0.2979
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0037 0.0082 0.0082
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0253 0.1491 0.211
Loa Loa (eye worm) PCI domain-containing protein 0.0041 0.0104 0.0147
Loa Loa (eye worm) proteasome Regulatory Particle 0.0041 0.0103 0.0146
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0026 0.001 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0211 0.1217 0.1217
Brugia malayi 26S proteasome regulatory complex subunit p97 0.005 0.0165 0.0233
Leishmania major proteasome alpha 7 subunit, putative 0.0312 0.1875 0.2654
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1105 0.7067 1
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0026 0.001 0.001
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0242 0.1418 0.1418
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0111 0.0111
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0095 0.0459 0.065
Onchocerca volvulus 0.0042 0.0111 0.0013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0251 0.1482 0.2097
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0045 0.0131 0.0185
Brugia malayi Uncoordinated protein 44 0.0041 0.0109 0.0154
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0111 0.0157
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0026 0.0005 0.0007
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0312 0.1875 0.2654
Loa Loa (eye worm) hypothetical protein 0.0142 0.0767 0.1086
Leishmania major hypothetical protein, conserved 0.0231 0.1348 0.1907
Trypanosoma cruzi Aph-1 protein, putative 0.0045 0.0133 0.0188
Schistosoma mansoni hypothetical protein 0.0108 0.0543 0.0543
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0251 0.1482 0.2097
Brugia malayi beta-lactamase family protein 0.0042 0.0111 0.0157
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0045 0.0131 0.0131
Echinococcus granulosus proteasome subunit beta t family 0.0244 0.1431 0.1431
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.0922 0.1305
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0265 0.1568 0.2219
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0041 0.0104 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0111 0.0157
Entamoeba histolytica proteasome regulatory subunit, putative 0.0041 0.0103 0.0146
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1105 0.7067 1
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0251 0.1478 0.1478
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0009 0.0013
Schistosoma mansoni hypothetical protein 0.0035 0.0069 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0284 0.0284
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.0159
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.005 0.0165 0.0233
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0037 0.0082 0.0116
Schistosoma mansoni 26S proteasome subunit S9 0.0045 0.0131 0.0131
Onchocerca volvulus 0.0068 0.0282 0.11
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0041 0.0103 0.0146
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0237 0.1387 0.1963
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0035 0.007 0.0099
Brugia malayi Proteasome A-type and B-type family protein 0.1105 0.7067 1
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0026 0.001 0.0014
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0265 0.157 0.2221
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0045 0.0131 0.0185
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0266 0.1577 0.2232
Giardia lamblia Hypothetical protein 0.0045 0.0131 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.0159
Schistosoma mansoni cercarial elastase (S01 family) 0.0068 0.0282 0.0282
Leishmania major carbonic anhydrase-like protein 0.0095 0.0459 0.065
Toxoplasma gondii PCI domain-containing protein 0.0037 0.0081 0.0114
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0095 0.0459 0.0459
Loa Loa (eye worm) proteasome subunit alpha type 1 0.025 0.1474 0.2086
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0257 0.1518 0.2148
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0244 0.1431 0.2026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0284 0.0284
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.005 0.0165 0.0165
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0244 0.1431 0.1431
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0037 0.0082 0.0116
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0035 0.007 0.0099
Echinococcus multilocularis neuropeptide s receptor 0.0514 0.3197 0.3197
Leishmania major proteasome beta-1 subunit, putative 0.0251 0.1482 0.2097
Echinococcus granulosus geminin 0.0215 0.1245 0.1245
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0257 0.1518 0.2148
Brugia malayi RNA binding protein 0.0072 0.0311 0.0439
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0266 0.1577 0.2232
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0291 0.1743 0.2467
Entamoeba histolytica proteasome regulatory subunit, putative 0.0048 0.0153 0.0217
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0922 0.1305
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0037 0.0082 0.0116
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0045 0.0131 0.0185
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.1074 0.152
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0082 0.0116
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0265 0.157 0.2221
Toxoplasma gondii hypothetical protein 0.0033 0.0052 0.0073
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0265 0.157 0.2221
Loa Loa (eye worm) hypothetical protein 0.0443 0.2737 0.3873
Onchocerca volvulus 0.0109 0.0553 0.2828
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0068 0.0282 0.0282
Trypanosoma brucei proteasome beta 7 subunit 0.0242 0.1418 0.2007
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0266 0.1577 0.1577
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0443 0.2737 0.3873
Schistosoma mansoni hypothetical protein 0.0265 0.1568 0.1568
Echinococcus granulosus nuclear factor of activated T cells 5 0.0405 0.2489 0.2489
Schistosoma mansoni hypothetical protein 0.0068 0.0282 0.0282
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.1074 0.1074
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0296 0.1774 0.2511
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0069 0.0289 0.0409
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0048 0.0153 0.0217
Entamoeba histolytica proteasome regulatory subunit, putative 0.0045 0.0131 0.0185
Loa Loa (eye worm) hypothetical protein 0.0265 0.1568 0.2219
Brugia malayi Trypsin family protein 0.0068 0.0282 0.0398
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0251 0.1478 0.1478
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0312 0.1875 0.2654
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0251 0.1478 0.2092
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0251 0.1482 0.1482
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0253 0.1491 0.211

Activities

Activity type Activity value Assay description Source Reference
NOHA (functional) < 0.2 % Nitric oxide (NO) formation during oxidation of NADPH and O2, catalyzed by NOS II detected spectrophotometrically using hemoglobin assay. ChEMBL. 11831907

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.