Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.3609 | 0.2598 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.3609 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.3609 | 0.3609 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0035 | 0.3609 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.7275 | 0.5736 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.3609 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.7275 | 0.6844 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.3609 | 0.3609 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.3609 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.3609 | 0.2598 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.3609 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0035 | 0.3609 | 0.5 |
Leishmania major | pyruvate kinase | 0.0035 | 0.3609 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.3609 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3769 | 0.3769 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3769 | 0.2784 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0035 | 0.3609 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.3609 | 0.3609 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.3769 | 0.025 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.3609 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.7275 | 0.5736 |
Leishmania major | pyruvate kinase | 0.0035 | 0.3609 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.3609 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0035 | 0.3609 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.3609 | 0.2598 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.3609 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.3609 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0025 | 0.1365 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.3609 | 0.3609 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.7275 | 0.6844 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.3609 | 0.2598 |
Mycobacterium ulcerans | pyruvate kinase | 0.0035 | 0.3609 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0035 | 0.3609 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.3609 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0028 | 0.2047 | 0.2047 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0035 | 0.3609 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 21 mm | Antimicrobial activity against Escherichia coli ATCC 25922 at 100 ug/ml after 24 hrs by paper disk diffusion method | ChEMBL. | 20675130 |
MIC (functional) | = 16.5 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by agar streak dilution method | ChEMBL. | 20675130 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.