Detailed information for compound 1171490

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.796 | Formula: C20H14ClN3O3
  • H donors: 4 H acceptors: 5 LogP: 4.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Nc1nc(nc2c1cccc2)c1cc(O)c(c(c1)O)O
  • InChi: 1S/C20H14ClN3O3/c21-12-5-7-13(8-6-12)22-20-14-3-1-2-4-15(14)23-19(24-20)11-9-16(25)18(27)17(26)10-11/h1-10,25-27H,(H,22,23,24)
  • InChiKey: ZSGBXHXEPOOROG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0042 0.0108 0.0159
Trypanosoma brucei alpha tubulin, putative 0.0153 0.1713 0.2509
Plasmodium vivax tubulin gamma chain, putative 0.0309 0.3973 0.5685
Schistosoma mansoni tubulin subunit beta 0.0502 0.6778 0.6772
Brugia malayi tubulin alpha chain - mouse 0.0379 0.4984 0.7354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0821 0.0805
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0108 0.0134
Onchocerca volvulus 0.0153 0.1713 0.5
Trypanosoma brucei beta tubulin 0.0502 0.6778 1
Plasmodium vivax tubulin alpha chain, putative 0.0379 0.4984 0.7241
Trichomonas vaginalis tubulin beta chain, putative 0.0379 0.4984 0.7347
Echinococcus multilocularis tubulin alpha chain 0.0379 0.4984 0.4976
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0212 0.0196
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1713 0.2509
Echinococcus multilocularis Tubulin beta 2C chain 0.0502 0.6778 0.6772
Echinococcus granulosus Tubulin alpha 1 chain 0.0379 0.4984 0.4976
Brugia malayi MAP kinase sur-1 0.0049 0.0212 0.0313
Leishmania major beta tubulin 0.0502 0.6778 1
Schistosoma mansoni tubulin subunit delta 0.013 0.1373 0.1359
Echinococcus granulosus tubulin alpha chain 0.0379 0.4984 0.4976
Loa Loa (eye worm) hypothetical protein 0.0054 0.0277 0.0385
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0212 0.0289
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0108 0.0134
Loa Loa (eye worm) tubulin beta chain 0.013 0.1373 0.2007
Leishmania major epsilon tubulin, putative 0.0308 0.3967 0.5843
Echinococcus multilocularis tubulin subunit TubB 0.0379 0.4984 0.4976
Echinococcus granulosus tubulin alpha chain 0.0379 0.4984 0.4976
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Echinococcus multilocularis tubulin delta chain 0.013 0.1373 0.1359
Echinococcus multilocularis tubulin alpha 1C chain 0.0379 0.4984 0.4976
Loa Loa (eye worm) tubulin alpha 2 0.0249 0.3106 0.4569
Echinococcus granulosus Tubulin beta 2C chain 0.0502 0.6778 0.6772
Echinococcus multilocularis Tubulin beta 2C chain 0.0502 0.6778 0.6772
Leishmania major beta tubulin 0.0502 0.6778 1
Toxoplasma gondii alpha tubulin TUBA1 0.0379 0.4984 0.7347
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0292 0.3723 0.5482
Leishmania major beta tubulin 0.0502 0.6778 1
Schistosoma mansoni tubulin subunit beta 0.0502 0.6778 0.6772
Echinococcus multilocularis tubulin alpha 0.0283 0.3592 0.3581
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0212 0.0196
Echinococcus multilocularis geminin 0.0164 0.1875 0.1861
Echinococcus granulosus Tubulin beta 2C chain 0.0502 0.6778 0.6772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0821 0.0805
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Leishmania major beta tubulin 0.0502 0.6778 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0572 0.0556
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0572 0.0821
Echinococcus multilocularis tubulin alpha chain 0.0379 0.4984 0.4976
Echinococcus granulosus tubulin subunit beta 0.0502 0.6778 0.6772
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0502 0.6778 0.6772
Schistosoma mansoni alpha tubulin 0.0379 0.4984 0.4976
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0212 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1373 0.2007
Trichomonas vaginalis tubulin epsilon chain, putative 0.0379 0.4984 0.7347
Leishmania major beta tubulin 0.0502 0.6778 1
Trypanosoma brucei tubulin delta chain 0.0292 0.3723 0.5482
Echinococcus multilocularis tubulin subunit beta 0.0502 0.6778 0.6772
Mycobacterium ulcerans cell division protein FtsZ 0.013 0.1373 1
Echinococcus granulosus peroxisome assembly protein 26 0.0379 0.4984 0.4976
Brugia malayi Tubulin alpha-2 chain 0.0379 0.4984 0.7354
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0212 0.0289
Trichomonas vaginalis tubulin gamma chain, putative 0.013 0.1373 0.2007
Leishmania major zeta tubulin, putative 0.04 0.5301 0.7816
Toxoplasma gondii beta-tubulin, putative 0.0502 0.6778 1
Schistosoma mansoni hypothetical protein 0.0164 0.1875 0.1861
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1373 0.2007
Brugia malayi tubulin alpha-2 chain 0.0379 0.4984 0.7354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0821 0.0805
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0821 0.0805
Trypanosoma brucei epsilon tubulin 0.0308 0.3967 0.5843
Trypanosoma cruzi epsilon tubulin, putative 0.0308 0.3967 0.5843
Loa Loa (eye worm) tubulin beta chain 0.0502 0.6778 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0379 0.4984 0.4976
Echinococcus granulosus tubulin alpha chain 0.0379 0.4984 0.4976
Loa Loa (eye worm) hypothetical protein 0.0226 0.2766 0.4066
Echinococcus multilocularis tubulin alpha chain 0.0379 0.4984 0.4976
Echinococcus granulosus tubulin alpha 1C chain 0.0379 0.4984 0.4976
Echinococcus granulosus geminin 0.0164 0.1875 0.1861
Brugia malayi Inositol-1 0.0036 0.0017 0.0025
Echinococcus granulosus tubulin subunit TubB 0.0379 0.4984 0.4976
Mycobacterium leprae cell division protein FtsZ 0.013 0.1373 0.5
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0572 0.0556
Trypanosoma brucei zeta tubulin 0.04 0.5301 0.7816
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Echinococcus granulosus muscleblind protein 0.0478 0.6424 0.6418
Leishmania major hypothetical protein, conserved 0.0054 0.0277 0.0385
Echinococcus multilocularis tubulin beta 1 chain 0.0502 0.6778 0.6772
Giardia lamblia Gamma tubulin 0.0309 0.3973 0.5727
Trichomonas vaginalis tubulin epsilon chain, putative 0.0502 0.6778 1
Echinococcus granulosus Tubulin beta 2C chain 0.0502 0.6778 0.6772
Echinococcus granulosus Tubulin alpha 1 chain 0.0379 0.4984 0.4976
Leishmania major beta tubulin 0.0502 0.6778 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0502 0.6778 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1713 0.2509
Plasmodium vivax delta tubulin, putative 0.013 0.1373 0.1686
Trichomonas vaginalis tubulin beta chain, putative 0.0153 0.1713 0.2509
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0821 0.1211
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0572 0.0556
Trypanosoma brucei beta tubulin 0.0502 0.6778 1
Echinococcus granulosus beta tubulin 0.0502 0.6778 0.6772
Echinococcus granulosus Tubulin beta 2C chain 0.0502 0.6778 0.6772
Giardia lamblia Alpha-tubulin 0.0379 0.4984 0.7268
Trichomonas vaginalis tubulin beta chain, putative 0.0379 0.4984 0.7347
Trichomonas vaginalis tubulin beta chain, putative 0.0379 0.4984 0.7347
Trichomonas vaginalis tubulin alpha chain, putative 0.0283 0.3592 0.5288
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0108 0.0669
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0212 0.0289
Brugia malayi Tubulin gamma chain 0.0309 0.3973 0.5861
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0277 0.0385
Brugia malayi RNA binding protein 0.0074 0.0572 0.0843
Plasmodium vivax tubulin epsilon chain, putative 0.0308 0.3967 0.5676
Echinococcus multilocularis tubulin alpha chain 0.0379 0.4984 0.4976
Trichomonas vaginalis tubulin, putative 0.0153 0.1713 0.2509
Loa Loa (eye worm) tubulin beta-4 chain 0.0502 0.6778 1
Brugia malayi Tubulin beta chain 0.0153 0.1713 0.2528
Trypanosoma brucei alpha tubulin 0.0379 0.4984 0.7347
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0572 0.0556
Brugia malayi hypothetical protein 0.0103 0.0993 0.1465
Loa Loa (eye worm) tubulin alpha 2 0.0249 0.3106 0.4569
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0212 0.0289
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0212 0.0289
Echinococcus multilocularis beta tubulin 0.0502 0.6778 0.6772
Entamoeba histolytica tubulin alpha chain, putative 0.0379 0.4984 0.7347
Plasmodium falciparum alpha tubulin 1 0.0379 0.4984 0.7241
Schistosoma mansoni tubulin subunit beta 0.0502 0.6778 0.6772
Trypanosoma cruzi tubulin delta chain 0.0292 0.3723 0.5482
Entamoeba histolytica tubulin family protein 0.0502 0.6778 1
Leishmania major beta tubulin 0.0502 0.6778 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0212 0.0196
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0212 0.0196
Giardia lamblia Epsilon tubulin 0.0155 0.1748 0.234
Echinococcus granulosus tubulin beta 1 chain 0.0502 0.6778 0.6772
Echinococcus multilocularis microtubule associated protein 2 0.0724 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0379 0.4984 0.4976
Echinococcus granulosus tubulin alpha 0.0283 0.3592 0.3581
Echinococcus multilocularis Tubulin beta 2C chain 0.0502 0.6778 0.6772
Toxoplasma gondii beta-1 tubulin, putative 0.0502 0.6778 1
Trypanosoma brucei beta tubulin 0.0283 0.3592 0.5288
Echinococcus multilocularis Tubulin alpha 1 chain 0.0379 0.4984 0.4976
Trichomonas vaginalis tubulin gamma chain, putative 0.0308 0.3967 0.5843
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.013 0.1373 1
Leishmania major beta tubulin 0.0502 0.6778 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0212 0.0289
Echinococcus multilocularis muscleblind protein 1 0.0478 0.6424 0.6418
Schistosoma mansoni tubulin subunit alpha 0.0379 0.4984 0.4976
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Echinococcus multilocularis tubulin alpha chain 0.0379 0.4984 0.4976
Trypanosoma cruzi beta tubulin, putative 0.0502 0.6778 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0212 0.0196
Plasmodium falciparum tubulin epsilon chain, putative 0.0308 0.3967 0.5676
Loa Loa (eye worm) tubulin beta-2A chain 0.0502 0.6778 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0226 0.2766 0.4066
Schistosoma mansoni tubulin subunit beta 0.013 0.1373 0.1359
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0572 0.0556
Echinococcus multilocularis tubulin epsilon chain 0.0308 0.3967 0.3957
Entamoeba histolytica tubulin alpha-1 chain 0.0379 0.4984 0.7347
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0108 0.0134
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0277 0.0385
Echinococcus multilocularis Tubulin alpha 1 chain 0.0379 0.4984 0.4976
Trichomonas vaginalis tubulin epsilon chain, putative 0.013 0.1373 0.2007
Trypanosoma brucei protein kinase, putative 0.0049 0.0212 0.0289
Brugia malayi Cell division protein ftsZ 0.013 0.1373 0.2026
Schistosoma mansoni tubulin subunit alpha 0.0379 0.4984 0.4976
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0283 0.3592 0.5288
Schistosoma mansoni microtubule-associated protein tau 0.0724 1 1
Brugia malayi Tubulin beta chain 0.013 0.1373 0.2026
Leishmania major beta tubulin 0.0502 0.6778 1
Leishmania major cytochrome p450-like protein 0.0042 0.0108 0.0134
Mycobacterium tuberculosis Cell division protein FtsZ 0.013 0.1373 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0212 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0821 0.0805
Trichomonas vaginalis tubulin alpha chain, putative 0.0153 0.1713 0.2509
Schistosoma mansoni tubulin subunit gamma 0.0309 0.3973 0.3962
Loa Loa (eye worm) beta-tubulin 0.0502 0.6778 1
Plasmodium falciparum tubulin gamma chain 0.0309 0.3973 0.5685
Loa Loa (eye worm) hypothetical protein 0.0103 0.0993 0.1443
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0379 0.4984 0.7347
Echinococcus granulosus tubulin gamma 1 chain 0.0309 0.3973 0.3962
Entamoeba histolytica tubulin family protein 0.0502 0.6778 1
Echinococcus granulosus tubulin alpha chain 0.0379 0.4984 0.4976
Brugia malayi Tubulin alpha chain 0.013 0.1373 0.2026
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0212 0.0289
Loa Loa (eye worm) tubulin alpha-2 chain 0.0379 0.4984 0.7347
Plasmodium falciparum alpha tubulin 2 0.0379 0.4984 0.7241
Echinococcus multilocularis beta tubulin 0.0502 0.6778 0.6772
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0212 0.0289
Toxoplasma gondii beta tubulin 0.0502 0.6778 1
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Trichomonas vaginalis tubulin, putative 0.0502 0.6778 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0502 0.6778 0.6772
Schistosoma mansoni tubulin subunit alpha 0.013 0.1373 0.1359
Trichomonas vaginalis tubulin, putative 0.0156 0.1754 0.2569
Schistosoma mansoni alpha tubulin 0.0379 0.4984 0.4976
Loa Loa (eye worm) hypothetical protein 0.0478 0.6424 0.9477
Brugia malayi TAR-binding protein 0.0074 0.0572 0.0843
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0572 0.0556
Loa Loa (eye worm) hypothetical protein 0.0478 0.6424 0.9477
Brugia malayi Cytochrome P450 family protein 0.0085 0.073 0.1078
Brugia malayi Muscleblind-like protein 0.0478 0.6424 0.9479
Leishmania major beta tubulin 0.0502 0.6778 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0502 0.6778 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0212 0.0289
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Echinococcus multilocularis tubulin alpha 3 chain 0.0379 0.4984 0.4976
Trypanosoma cruzi epsilon tubulin, putative 0.0308 0.3967 0.5843
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0277 0.0385
Trypanosoma cruzi alpha tubulin, putative 0.0379 0.4984 0.7347
Trypanosoma brucei tubulin gamma chain 0.0309 0.3973 0.5851
Loa Loa (eye worm) tubulin gamma chain 0.0309 0.3973 0.5851
Schistosoma mansoni tubulin subunit alpha 0.0379 0.4984 0.4976
Loa Loa (eye worm) alpha-tubulin 0.0379 0.4984 0.7347
Echinococcus multilocularis tubulin gamma 1 chain 0.0309 0.3973 0.3962
Leishmania major beta tubulin 0.0502 0.6778 1
Echinococcus multilocularis hypothetical protein 0.0379 0.4984 0.4976
Giardia lamblia Beta tubulin 0.0502 0.6778 1
Entamoeba histolytica tubulin gamma chain 0.0309 0.3973 0.5851
Trichomonas vaginalis tubulin beta chain, putative 0.0379 0.4984 0.7347
Trichomonas vaginalis tubulin, putative 0.0153 0.1713 0.2509
Schistosoma mansoni tubulin subunit beta 0.0502 0.6778 0.6772
Leishmania major beta tubulin 0.0502 0.6778 1
Trypanosoma brucei epsilon tubulin 0.0308 0.3967 0.5843
Brugia malayi alpha-tubulin 0.0379 0.4984 0.7354
Echinococcus granulosus tubulin beta 4A class IVa 0.0502 0.6778 0.6772
Giardia lamblia Beta tubulin 0.0502 0.6778 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0108 0.0134
Leishmania major beta tubulin 0.0502 0.6778 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0108 0.0134
Schistosoma mansoni tubulin subunit epsilon 0.0308 0.3967 0.3957
Trypanosoma brucei alpha tubulin 0.0379 0.4984 0.7347
Echinococcus granulosus tubulin epsilon chain 0.0308 0.3967 0.3957
Brugia malayi beta-tubulin, identical 0.0502 0.6778 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0153 0.1713 0.2509
Trichomonas vaginalis tubulin gamma chain, putative 0.0502 0.6778 1
Leishmania major delta tubulin, putative 0.0292 0.3723 0.5482
Echinococcus granulosus Tubulin beta 2C chain 0.0502 0.6778 0.6772
Echinococcus granulosus Tubulin alpha 1 chain 0.0379 0.4984 0.4976
Giardia lamblia Alpha-tubulin 0.0379 0.4984 0.7268
Echinococcus granulosus tubulin alpha 1C chain 0.0379 0.4984 0.4976
Brugia malayi Cytochrome P450 family protein 0.0042 0.0108 0.0159
Brugia malayi hypothetical protein 0.0054 0.0277 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0821 0.0805
Trichomonas vaginalis tubulin beta chain, putative 0.0379 0.4984 0.7347
Loa Loa (eye worm) tubulin alpha chain 0.0379 0.4984 0.7347
Trichomonas vaginalis tubulin gamma chain, putative 0.0309 0.3973 0.5851
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Echinococcus multilocularis muscleblind protein 0.0478 0.6424 0.6418
Echinococcus multilocularis tubulin alpha 1C chain 0.0379 0.4984 0.4976
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0572 0.0843
Schistosoma mansoni eyes absent homolog 0.0103 0.0993 0.0978
Leishmania major beta tubulin 0.0502 0.6778 1
Loa Loa (eye worm) alpha-tubulin 0.0379 0.4984 0.7347
Trypanosoma brucei alpha tubulin 0.0379 0.4984 0.7347
Giardia lamblia Beta tubulin 0.0502 0.6778 1
Echinococcus granulosus tubulin delta chain 0.013 0.1373 0.1359
Trichomonas vaginalis tubulin beta chain, putative 0.0379 0.4984 0.7347
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0212 0.0289
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0155 0.1748 0.2561
Schistosoma mansoni tubulin subunit beta 0.0502 0.6778 0.6772
Brugia malayi Tubulin alpha chain 0.0379 0.4984 0.7354
Echinococcus granulosus tubulin alpha chain 0.0379 0.4984 0.4976
Trypanosoma cruzi zeta tubulin, putative 0.04 0.5301 0.7816
Trichomonas vaginalis tubulin beta-1 chain, putative 0.013 0.1373 0.2007
Trypanosoma cruzi tubulin delta chain 0.0292 0.3723 0.5482
Trypanosoma cruzi zeta tubulin, putative 0.04 0.5301 0.7816
Loa Loa (eye worm) tubulin alpha 2 0.0096 0.0887 0.1287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0821 0.0805
Echinococcus granulosus tubulin alpha 3 chain 0.0379 0.4984 0.4976
Leishmania major beta tubulin 0.0502 0.6778 1
Plasmodium vivax tubulin beta chain, putative 0.0502 0.6778 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0502 0.6778 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0226 0.2766 0.4066
Trichomonas vaginalis tubulin epsilon chain, putative 0.0379 0.4984 0.7347
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0212 0.0289
Treponema pallidum cell division protein FtsZ 0.013 0.1373 0.5
Loa Loa (eye worm) BEN-1 protein 0.0502 0.6778 1
Leishmania major alpha tubulin 0.0379 0.4984 0.7347
Loa Loa (eye worm) RNA binding protein 0.0074 0.0572 0.0821
Trichomonas vaginalis tubulin beta chain, putative 0.0502 0.6778 1
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0108 0.0134
Loa Loa (eye worm) hypothetical protein 0.0103 0.0993 0.1443
Loa Loa (eye worm) tubulin alpha chain 0.0379 0.4984 0.7347
Loa Loa (eye worm) BEN-1 protein 0.0502 0.6778 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0572 0.0821
Schistosoma mansoni hypothetical protein 0.0164 0.1875 0.1861
Plasmodium falciparum tubulin beta chain 0.0502 0.6778 1
Echinococcus granulosus alpha tubulin 0.0379 0.4984 0.4976
Trypanosoma brucei beta tubulin 0.0502 0.6778 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0821 0.1189
Loa Loa (eye worm) hypothetical protein 0.0249 0.3106 0.4569
Trypanosoma brucei zeta tubulin, putative 0.04 0.5301 0.7816
Plasmodium falciparum tubulin delta chain, putative 0.013 0.1373 0.1686
Toxoplasma gondii alpha-tubulin I, putative 0.0379 0.4984 0.7347
Echinococcus multilocularis Tubulin beta 2C chain 0.0502 0.6778 0.6772
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0249 0.3106 0.4569
Leishmania major gamma-tubulin 0.0309 0.3973 0.5851
Brugia malayi Tubulin beta-1 chain 0.0502 0.6778 1
Leishmania major beta tubulin 0.0502 0.6778 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0085 0.073 0.1055
Echinococcus granulosus beta tubulin 0.0502 0.6778 0.6772
Leishmania major beta tubulin 0.0502 0.6778 1
Schistosoma mansoni tubulin subunit beta 0.0502 0.6778 0.6772
Trypanosoma brucei epsilon tubulin 0.0283 0.3592 0.5288
Brugia malayi Tubulin alpha-2 chain 0.0379 0.4984 0.7354
Trypanosoma brucei beta tubulin 0.0502 0.6778 1
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0277 0.0385
Echinococcus multilocularis Tubulin alpha 1 chain 0.0379 0.4984 0.4976
Echinococcus multilocularis tubulin alpha 3 chain 0.0379 0.4984 0.4976
Giardia lamblia Delta tubulin 0.013 0.1373 0.1769
Plasmodium vivax tubulin alpha chain, putative 0.0379 0.4984 0.7241
Leishmania major beta tubulin 0.0502 0.6778 1
Trypanosoma cruzi tubulin gamma chain 0.0309 0.3973 0.5851
Trypanosoma brucei alpha tubulin 0.0379 0.4984 0.7347
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0249 0.3106 0.4569
Loa Loa (eye worm) hypothetical protein 0.0379 0.4984 0.7347
Echinococcus granulosus tar DNA binding protein 0.0074 0.0572 0.0556
Schistosoma mansoni alpha tubulin 0.0379 0.4984 0.4976

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 550 nM Antiproliferative activity against ConA-stimulated human PBMC after 72 hrs by BrdU incorporation assay ChEMBL. 20674367
IC50 (functional) = 4250 nM Antiproliferative activity against human Jurkat cells after 72 hrs by BrdU incorporation assay ChEMBL. 20674367

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20674367

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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