Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0462 | 0.1496 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.223 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0462 | 0.1496 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Schistosoma mansoni | uridine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1768 | 0.7779 | 0.7389 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Trypanosoma brucei | uridine phosphorylase | 0.0462 | 0.1496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1768 | 0.7779 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.223 | 1 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.223 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0462 | 0.1496 | 0.5 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0462 | 0.1496 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.223 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0462 | 0.1496 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0462 | 0.1496 | 0.1496 |
Toxoplasma gondii | phosphorylase family protein | 0.0462 | 0.1496 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.223 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Treponema pallidum | pfs protein (pfs) | 0.0462 | 0.1496 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0462 | 0.1496 | 0.5 |
Chlamydia trachomatis | AMP nucleosidase | 0.0462 | 0.1496 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1768 | 0.7779 | 0.7389 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.223 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.1768 | 0.7779 | 0.7389 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.41 10'-5M | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
GI50 (functional) | = 8.66 10'-6M | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
GI50 (functional) | = 8.82 10'-6M | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
LC50 (functional) | > 1.84 10'-5M | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
LC50 (functional) | > 1.9 10'-5M | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
LC50 (functional) | > 1.9 10'-5M | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
TGI (functional) | > 1.84 10'-5M | Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
TGI (functional) | > 1.9 10'-5M | Cytotoxicity against human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
TGI (functional) | > 1.9 10'-5M | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay | ChEMBL. | 20709558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.