Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0401 | 0.073 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0056 | 0.0217 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0014 | 0.0025 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0075 | 0.1245 | 0.4794 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0128 | 0.2375 | 0.9148 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.112 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0763 | 0.1388 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.112 | 0.2038 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0422 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0422 | 0.0767 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.008 | 0.0145 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0075 | 0.1245 | 0.5241 |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.1245 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0421 | 0.1771 |
Brugia malayi | RNA binding protein | 0.0069 | 0.112 | 0.1776 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.2596 | 0.4723 |
Mycobacterium ulcerans | glutaminase | 0.0272 | 0.5497 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.2596 | 1 |
Schistosoma mansoni | glutaminase | 0.0272 | 0.5497 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.2596 | 0.4723 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.1245 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1245 | 0.2264 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0473 | 0.0561 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0056 | 0.0237 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0401 | 0.0425 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0422 | 0.1624 |
Loa Loa (eye worm) | beta-lactamase | 0.0075 | 0.1245 | 0.2264 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0763 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.057 | 0.1037 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.1245 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1245 | 0.2264 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.112 | 0.2038 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1245 | 0.2264 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.1245 | 0.201 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0075 | 0.1245 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0422 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0401 | 0.073 |
Loa Loa (eye worm) | glutaminase | 0.0272 | 0.5497 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0128 | 0.2375 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0422 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.2357 | 0.4288 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1245 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0475 | 0.0864 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0422 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.1291 | 0.2097 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0122 | 0.0223 |
Plasmodium vivax | hypothetical protein, conserved | 0.0075 | 0.1245 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1196 | 0.2175 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.095 | 0.366 |
Brugia malayi | beta-lactamase | 0.0075 | 0.1245 | 0.201 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.2375 | 0.432 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0075 | 0.1245 | 0.2264 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.008 | 0.0145 |
Loa Loa (eye worm) | glutaminase 2 | 0.0272 | 0.5497 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.112 | 0.2038 |
Mycobacterium leprae | Probable lipase LipE | 0.0075 | 0.1245 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0272 | 0.5497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0528 | 0.096 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0122 | 0.0515 |
Trichomonas vaginalis | glutaminase, putative | 0.0272 | 0.5497 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.112 | 0.2038 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0763 | 0.1105 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.112 | 0.4315 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0075 | 0.1245 | 0.201 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.112 | 0.1776 |
Onchocerca volvulus | 0.0075 | 0.1245 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.2357 | 0.4288 |
Brugia malayi | beta-lactamase family protein | 0.0075 | 0.1245 | 0.201 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0422 | 0.1775 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.112 | 0.2038 |
Toxoplasma gondii | ABC1 family protein | 0.0075 | 0.1245 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.112 | 0.1776 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1245 | 0.2264 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.112 | 0.2038 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0421 | 0.162 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0422 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1245 | 0.2264 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0122 | 0.0471 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.1245 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.103 | 0.1874 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0075 | 0.1245 | 0.2264 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0422 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.1245 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.112 | 0.2038 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.112 | 0.2038 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0056 | 0.0102 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.095 | 0.4001 |
Onchocerca volvulus | 0.0075 | 0.1245 | 0.5 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0075 | 0.1245 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.2357 | 0.41 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0763 | 0.1388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.