Detailed information for compound 1172232

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1072.22 | Formula: C59H65N11O9
  • H donors: 13 H acceptors: 9 LogP: 2.82 Rotable bonds: 33
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)O)Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)N
  • InChi: 1S/C59H65N11O9/c60-25-11-10-20-48(67-54(73)44(61)28-37-31-62-45-17-7-4-14-41(37)45)56(75)69-51(30-39-33-64-47-19-9-6-16-43(39)47)58(77)68-49(26-36-21-23-40(71)24-22-36)55(74)65-34-53(72)66-50(29-38-32-63-46-18-8-5-15-42(38)46)57(76)70-52(59(78)79)27-35-12-2-1-3-13-35/h1-9,12-19,21-24,31-33,44,48-52,62-64,71H,10-11,20,25-30,34,60-61H2,(H,65,74)(H,66,72)(H,67,73)(H,68,77)(H,69,75)(H,70,76)(H,78,79)/t44-,48-,49-,50-,51-,52-/m0/s1
  • InChiKey: WYZHADXHLSYSTM-PMRPOPMISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dishevelled segment polarity protein 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus granulosus segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma mansoni dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum Segment polarity protein dishevelled homolog DVL-1, putative Get druggable targets OG5_130104 All targets in OG5_130104
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum Segment polarity protein dishevelled homolog DVL-1, putative Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus multilocularis segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum ko:K02353 dishevelled, putative Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma japonicum expressed protein Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus multilocularis segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Onchocerca volvulus Segment polarity protein dishevelled homolog Get druggable targets OG5_130104 All targets in OG5_130104
Echinococcus granulosus segment polarity protein dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
Schistosoma mansoni dishevelled Get druggable targets OG5_130104 All targets in OG5_130104
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0035 0.009 0.0085
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0066 0.0306 0.03
Schistosoma mansoni hypothetical protein 0.0054 0.022 0.022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.009 0.0084
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0062 0.0156
Schistosoma mansoni zinc finger protein 0.0031 0.0064 0.0064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0062 0.0057
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.1675 0.1675
Brugia malayi ecdysteroid receptor 0.0066 0.0306 0.0301
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0176 0.0603
Plasmodium vivax thioredoxin reductase, putative 0.0089 0.0466 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0203 0.1258 0.1204
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0275 0.0275
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0071 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0306 0.0301
Echinococcus multilocularis snurportin 1 0.0342 0.2226 0.2226
Echinococcus multilocularis neuropeptide receptor A26 0.0518 0.3444 0.3444
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0066 0.0306 0.0301
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0062 0.0062
Brugia malayi TAR-binding protein 0.0062 0.0275 0.027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0062 0.0062
Trichomonas vaginalis esterase, putative 0.0072 0.035 0.1796
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0064 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0249 0.1578 0.1578
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0306 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Echinococcus multilocularis Excitatory amino acid transporter 0.1462 1 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0214 0.0214
Onchocerca volvulus 0.0034 0.0084 0.002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0062 0.0156
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0214 0.0214
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0306 0.0301
Brugia malayi nuclear receptor NHR-88 0.0066 0.0306 0.0301
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0066 0.0306 0.0306
Schistosoma mansoni hypothetical protein 0.0075 0.0369 0.0369
Brugia malayi Thioredoxin reductase 0.0089 0.0466 0.0461
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0811 0.4944
Schistosoma mansoni dishevelled 0.0116 0.0656 0.0656
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0214 0.0209
Schistosoma mansoni alpha-glucosidase 0.0146 0.0858 0.0858
Brugia malayi hypothetical protein 0.0075 0.0369 0.0364
Loa Loa (eye worm) hypothetical protein 0.004 0.0123 0.0117
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0066 0.0306 0.0306
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0066 0.0306 0.0306
Echinococcus granulosus excitatory amino acid transporter 3 0.1462 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.1022 0.1022
Mycobacterium tuberculosis Conserved protein 0.0072 0.035 0.029
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0446
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.035 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0064 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.035 0.035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0066 0.0306 0.03
Onchocerca volvulus 0.0072 0.035 0.0288
Echinococcus multilocularis thioredoxin glutathione reductase 0.009 0.047 0.047
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0275 0.0275
Loa Loa (eye worm) MBCTL1 0.0053 0.0214 0.0208
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0064 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0066 0.0306 0.0244
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0066 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0518 0.3444 0.3444
Leishmania major hypothetical protein, conserved 0.0029 0.0047 0.0087
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.3058 0.3014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0066 0.0306 0.0301
Mycobacterium tuberculosis Probable reductase 0.0203 0.1258 0.1204
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0064 0.0059
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.017 0.017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0064 0.0064
Brugia malayi Bromodomain containing protein 0.0073 0.0354 0.0349
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0369 0.0369
Brugia malayi hypothetical protein 0.0035 0.009 0.0085
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1462 1 1
Schistosoma mansoni hypothetical protein 0.0193 0.1188 0.1188
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0066 0.0306 0.0301
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0336 0.2181 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0066 0.0306 0.0306
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0062 0.0356
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.013
Echinococcus granulosus Excitatory amino acid transporter 0.1462 1 1
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0108 0.0371
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0066 0.0306 0.0306
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0064 0.0064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0062 0.0156
Trypanosoma brucei trypanothione reductase 0.0089 0.0466 0.1963
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Loa Loa (eye worm) beta-lactamase 0.0072 0.035 0.0344
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0108 0.0446
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0064 0.0058
Mycobacterium tuberculosis Probable dehydrogenase 0.0203 0.1258 0.1204
Plasmodium falciparum glutathione reductase 0.0089 0.0466 1
Toxoplasma gondii hypothetical protein 0.0054 0.0224 0.1156
Onchocerca volvulus 0.0072 0.035 0.0288
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.035 0.1901
Plasmodium vivax importin-beta 2, putative 0.0032 0.0071 0.0559
Echinococcus granulosus neuropeptide receptor A26 0.0518 0.3444 0.3444
Brugia malayi tailless protein 0.0031 0.0064 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.0483 0.3201 0.3201
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.035 0.1796
Loa Loa (eye worm) hypothetical protein 0.0104 0.0573 0.0567
Brugia malayi DIX domain containing protein 0.0023 0.0006 0.0001
Onchocerca volvulus 0.0066 0.0306 0.0244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0084 0.0877
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0177 0.0177
Schistosoma mansoni nuclear receptor 0.0031 0.0064 0.0064
Brugia malayi Pre-SET motif family protein 0.0237 0.1494 0.1489
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0203 0.1258 0.1204
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.0466 0.2033
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0708 0.0702
Schistosoma mansoni importin beta-1 0.0032 0.0071 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.1578 1
Onchocerca volvulus 0.0072 0.035 0.0288
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.035 0.029
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0249 0.1578 0.1578
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0251 0.0251
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0648 0.4348 0.4348
Schistosoma mansoni coup transcription factor 0.0066 0.0306 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0066 0.0306 0.03
Echinococcus granulosus excitatory amino acid transporter 2 0.1462 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0199 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0177 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0066 0.0306 0.03
Brugia malayi steroid hormone receptor 0.0066 0.0306 0.0301
Schistosoma mansoni thyroid hormone receptor 0.0483 0.3201 0.3201
Loa Loa (eye worm) hypothetical protein 0.0263 0.1675 0.1669
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0062 0.007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0176 0.0685
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0108 0.0102
Schistosoma mansoni hypothetical protein 0.0342 0.2226 0.2226
Brugia malayi Importin beta-1 subunit 0.0032 0.0071 0.0065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0248 0.1018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.2181 1
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0064 0.0064
Schistosoma mansoni retinoic acid receptor RXR 0.0066 0.0306 0.0306
Echinococcus granulosus segment polarity protein dishevelled 0.0116 0.0656 0.0656
Echinococcus granulosus ecdysone induced protein 78C 0.0066 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.03 0.1932 0.1927
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0066 0.0306 0.0306
Loa Loa (eye worm) RNA binding protein 0.0062 0.0275 0.0269
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0648 0.4348 0.4348
Toxoplasma gondii thioredoxin reductase 0.0089 0.0466 0.2737
Toxoplasma gondii aldehyde dehydrogenase 0.0249 0.1578 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0177 0.0172
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0811 0.4329
Onchocerca volvulus 0.0098 0.0527 0.0466
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.035 0.1796
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0203 0.1258 0.1204
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0064 0.0059
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.035 0.0345
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 0.2226 0.2221
Loa Loa (eye worm) steroid hormone receptor 0.0066 0.0306 0.03
Echinococcus granulosus tar DNA binding protein 0.0062 0.0275 0.0275
Schistosoma mansoni RAR-like nuclear receptor 0.0066 0.0306 0.0306
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0064 0.0064
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0064 0.0059
Onchocerca volvulus 0.0104 0.0573 0.0512
Brugia malayi Pre-SET motif family protein 0.0034 0.0084 0.0079
Brugia malayi hypothetical protein 0.0031 0.0064 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Leishmania major trypanothione reductase 0.0089 0.0466 0.2033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0066 0.0306 0.0301
Onchocerca volvulus 0.0054 0.022 0.0157
Echinococcus multilocularis ecdysone induced protein 78C 0.0066 0.0306 0.0306
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0226 0.1416 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0203 0.1258 0.1204
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.035 0.1796
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0066 0.0306 0.0301
Loa Loa (eye worm) hypothetical protein 0.0072 0.035 0.0344
Schistosoma mansoni nuclear receptor 0.0031 0.0064 0.0064
Plasmodium vivax glutathione reductase, putative 0.0089 0.0466 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0306 0.0306
Echinococcus multilocularis segment polarity protein dishevelled 0.0116 0.0656 0.0656
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0176 0.0685
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.009 0.009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0066 0.0306 0.0306
Brugia malayi nuclear receptor RXR 0.0031 0.0064 0.0059
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0071 0.0153
Loa Loa (eye worm) glutathione reductase 0.0089 0.0466 0.046
Loa Loa (eye worm) hypothetical protein 0.0072 0.035 0.0344
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0062 0.0097
Onchocerca volvulus 0.027 0.1721 0.1668
Schistosoma mansoni thyroid hormone receptor 0.0483 0.3201 0.3201
Mycobacterium ulcerans beta-lactamase 0.0072 0.035 0.1901
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0066 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.0371
Brugia malayi beta-lactamase 0.0072 0.035 0.0345
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0108 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0275 0.0275
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0116 0.0656 0.0651
Brugia malayi mbt repeat family protein 0.0046 0.017 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0084 0.0084
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0417 0.2743 0.2743
Entamoeba histolytica hypothetical protein 0.0075 0.0369 0.1898
Brugia malayi MH2 domain containing protein 0.0124 0.0708 0.0703
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0214 0.0214
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.035 0.029
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0062 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0064 0.0064
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0108 0.0446
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.035 0.1796
Echinococcus granulosus segment polarity protein dishevelled 0.0116 0.0656 0.0656
Echinococcus granulosus sodium:dicarboxylate symporter 0.1462 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Schistosoma mansoni alpha-glucosidase 0.0146 0.0858 0.0858
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0446
Echinococcus multilocularis tumor protein p63 0.0713 0.48 0.48
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0275 0.0275
Plasmodium falciparum thioredoxin reductase 0.0089 0.0466 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0071 0.011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0062 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.009 0.0085
Echinococcus multilocularis FTZ F1 alpha 0.0066 0.0306 0.0306
Echinococcus granulosus muscleblind protein 0.03 0.1932 0.1932
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.009 0.009
Echinococcus multilocularis muscleblind protein 1 0.03 0.1932 0.1932
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.1022 0.1022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.1022 0.1017
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.017 0.017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0306 0.0301
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0046 0.017 0.0164
Echinococcus granulosus tumor protein p63 0.0713 0.48 0.48
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0064 0.0058
Brugia malayi nuclear hormone receptor 0.0031 0.0064 0.0059
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0041
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0249 0.1578 0.1578
Brugia malayi hypothetical protein 0.0035 0.009 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0084
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Chlamydia trachomatis neutral amino acid transporter 0.0648 0.4348 0.4312
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0417 0.2743 0.2743
Schistosoma mansoni bromodomain containing protein 0.0062 0.0275 0.0275
Brugia malayi beta-lactamase family protein 0.0072 0.035 0.0345
Brugia malayi PHD-finger family protein 0.0024 0.0016 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.035 0.029
Onchocerca volvulus Protein ultraspiracle homolog 0.0066 0.0306 0.0244
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.035 0.1495
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0573 0.0573
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0062 0.0356
Echinococcus multilocularis excitatory amino acid transporter 3 0.1462 1 1
Schistosoma mansoni hypothetical protein 0.0417 0.2743 0.2743
Toxoplasma gondii ABC1 family protein 0.0072 0.035 0.198
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.017 0.017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0286 0.1835 0.1835
Brugia malayi beta-lactamase family protein 0.0072 0.035 0.0345
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.0952 0.4291
Echinococcus granulosus snurportin 1 0.0342 0.2226 0.2226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0446
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Schistosoma mansoni hypothetical protein 0.0193 0.1188 0.1188
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0064 0.0058
Mycobacterium tuberculosis Conserved protein 0.0072 0.035 0.029
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.035 0.035
Echinococcus multilocularis excitatory amino acid transporter 2 0.1462 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.009 0.009
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0214 0.0214
Brugia malayi nuclear hormone receptor 0.0066 0.0306 0.0301
Brugia malayi ecdysone receptor 0.0031 0.0064 0.0059
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0064 0.0064
Treponema pallidum glutamate/aspartate transporter 0.0648 0.4348 1
Echinococcus granulosus neutral amino acid transporter A 0.1462 1 1
Echinococcus multilocularis neutral amino acid transporter A 0.1462 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0203 0.1258 0.8523
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0066 0.0306 0.0306
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0369 0.0369
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0275 0.0269
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.035 0.1796
Brugia malayi Steroid receptor seven-up type 2 0.0066 0.0306 0.0301
Brugia malayi hypothetical protein 0.0263 0.1675 0.167
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.017 0.017
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0446
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0075 0.0075
Brugia malayi mbt repeat family protein 0.0046 0.017 0.0165
Echinococcus multilocularis muscleblind protein 0.03 0.1932 0.1932
Leishmania major mitochondrial DNA polymerase beta 0.0336 0.2181 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Brugia malayi photoreceptor-specific nuclear receptor 0.0066 0.0306 0.0301
Echinococcus granulosus neutral amino acid transporter 0.1462 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.1675 0.1675
Brugia malayi Muscleblind-like protein 0.03 0.1932 0.1928
Treponema pallidum glutamate transporter 0.0648 0.4348 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0199 0.0199
Echinococcus multilocularis Excitatory amino acid transporter 0.1462 1 1
Brugia malayi nuclear receptor NHR-88 0.0031 0.0064 0.0059
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0062 0.0188
Entamoeba histolytica hypothetical protein 0.0075 0.0369 0.1898
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0249 0.1578 0.1525
Echinococcus multilocularis neutral amino acid transporter A 0.1462 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.035 0.035
Brugia malayi glutathione reductase 0.0089 0.0466 0.0461
Onchocerca volvulus 0.0046 0.017 0.0106
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0648 0.4348 0.4348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0066 0.0306 0.0306
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0108 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0066 0.0306 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0066 0.0306 0.03
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.017 0.0106
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0062 0.0356
Brugia malayi follicle stimulating hormone receptor 0.0507 0.3366 0.3363
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Brugia malayi RNA binding protein 0.0062 0.0275 0.027
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0062 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0177 0.0177
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.0446
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0064 0.0064
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.0446
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0306 0.0301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0177 0.0177
Brugia malayi conserved hypotetical protein 0.0031 0.0064 0.0059
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.022 0.0215
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0062 0.0097
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0108 0.0446
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0199 0.0199
Echinococcus granulosus thioredoxin glutathione reductase 0.009 0.047 0.047
Brugia malayi hypothetical protein 0.0031 0.0064 0.0059
Echinococcus multilocularis neutral amino acid transporter A 0.1462 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0064 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0306 0.0306
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0062 0.0356
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Entamoeba histolytica hypothetical protein 0.0075 0.0369 0.1898
Echinococcus multilocularis geminin 0.0193 0.1188 0.1188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0066 0.0306 0.03
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.1578 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.035 0.1901
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0071 0.011
Echinococcus multilocularis segment polarity protein dishevelled 0.0116 0.0656 0.0656
Echinococcus granulosus excitatory amino acid transporter 2 0.1462 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0177 0.0171
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.1022 0.1016
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1146 0.1146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.035 0.035
Loa Loa (eye worm) thioredoxin reductase 0.0089 0.0466 0.046
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0101
Loa Loa (eye worm) hypothetical protein 0.0053 0.0214 0.0208
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0066 0.0306 0.0244
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.182 1
Trichomonas vaginalis set domain proteins, putative 0.027 0.1721 0.9446
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0108 0.0108
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0062 0.0156
Echinococcus multilocularis excitatory amino acid transporter 2 0.1462 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.1494 0.1488
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0084 0.0084
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.017 0.017
Schistosoma mansoni aldehyde dehydrogenase 0.0249 0.1578 0.1578
Chlamydia trachomatis glutamate symporter 0.1462 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0071 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Echinococcus granulosus importin subunit beta 1 0.0032 0.0071 0.0071
Mycobacterium tuberculosis Probable oxidoreductase 0.0226 0.1416 0.1362
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0251 0.0251
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0648 0.4348 0.4348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0177 0.0177
Echinococcus granulosus FTZ F1 alpha 0.0066 0.0306 0.0306
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.035 0.029
Schistosoma mansoni survival motor neuron protein 0.0054 0.022 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0062 0.007
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1462 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.035 0.142
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0064 0.0059
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1146 0.1146
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0064 0.0059
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0064 0.0064
Plasmodium falciparum glutathione reductase 0.0031 0.0062 0.0356
Brugia malayi Bromodomain containing protein 0.0037 0.0106 0.0101
Plasmodium falciparum thioredoxin reductase 0.0031 0.0062 0.0356
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.182 0.4103
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0084
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.017 0.0164
Loa Loa (eye worm) DR-78 0.0031 0.0064 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0072 0.035 0.7234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0306 0.0301
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1462 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0116 0.0656 0.065
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Brugia malayi RNA, U transporter 1 0.0091 0.0481 0.0476
Loa Loa (eye worm) hypothetical protein 0.0072 0.035 0.0344
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0176 0.0685
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.035 0.0344
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0275 0.0269
Mycobacterium tuberculosis Conserved protein 0.0072 0.035 0.029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0084 0.0084
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0226 0.1416 0.1362
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0214 0.0214
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0047 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0446
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0064 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0177 0.0177
Brugia malayi nuclear receptor NHR-67 0.0031 0.0064 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0306 0.0301
Mycobacterium ulcerans hypothetical protein 0.0177 0.1077 0.6694
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0226 0.1416 0.1362
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.0952 0.4241
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0089 0.0466 0.0407
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0064 0.0064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0062 0.0156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.1077 0.1021
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0064 0.0064
Echinococcus granulosus geminin 0.0193 0.1188 0.1188
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0275 0.027
Mycobacterium ulcerans hypothetical protein 0.0072 0.035 0.1901
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0084
Loa Loa (eye worm) hypothetical protein 0.0069 0.0325 0.0319
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.035 0.029
Schistosoma mansoni alpha glucosidase 0.0038 0.0108 0.0108
Leishmania major hypothetical protein, conserved 0.0072 0.035 0.1495
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1462 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0084 0.024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.1022 0.1022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0066 0.0306 0.0301
Echinococcus granulosus Excitatory amino acid transporter 0.1462 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0066 0.0306 0.0306
Schistosoma mansoni dishevelled 0.0104 0.0571 0.0571
Mycobacterium ulcerans aldehyde dehydrogenase 0.0249 0.1578 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.182 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0336 0.2181 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1462 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0047 0.0087
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Echinococcus granulosus neutral amino acid transporter A 0.1462 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.009 0.009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0066 0.0306 0.0306
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.017 0.017
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0811 0.0754
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.0952 0.4291
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0507 0.3366 0.3362
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.182 1
Plasmodium falciparum importin beta, putative 0.0032 0.0071 0.0559
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.035 0.0344
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0708 0.0702
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0066 0.0306 0.0306
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1462 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0249 0.1578 0.7198
Loa Loa (eye worm) excitatory amino acid transporter 0.1462 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0066 0.0306 0.0306
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.035 0.1495
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0177 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Brugia malayi hypothetical protein 0.0029 0.0047 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0306 0.0306
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.009 0.0085
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0066 0.031 0.0247
Loa Loa (eye worm) hypothetical protein 0.0066 0.0306 0.03
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0108 0.0108
Echinococcus granulosus neuropeptide s receptor 0.0518 0.3444 0.3444
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0306 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0062 0.0156
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.017 0.017
Entamoeba histolytica hypothetical protein 0.0075 0.0369 0.1898
Mycobacterium ulcerans lipase LipD 0.0072 0.035 0.1901
Loa Loa (eye worm) hypothetical protein 0.03 0.1932 0.1927
Loa Loa (eye worm) hypothetical protein 0.0072 0.035 0.0344
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.035 0.029
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0199 0.0199
Trypanosoma brucei glucosidase, putative 0.0038 0.0108 0.0287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.182 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0066 0.0306 0.0301
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.0399
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.035 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0306 0.0306

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.7 uM Binding affinity at Dvl2 PDZ domain after 15 mins by fluorescence polarization assay ChEMBL. 19252499

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.