TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.485 | Formula: C22H22N2O6S
H donors: 3 H acceptors: 6 LogP: 1.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCS(=O)(=O)c1ccc2c(c1)/C(=C/c1[nH]c3c(c1CCC(=O)O)C(=O)CCC3)/C(=O)N2
InChi: 1S/C22H22N2O6S/c1-2-31(29,30)12-6-8-16-14(10-12)15(22(28)24-16)11-18-13(7-9-20(26)27)21-17(23-18)4-3-5-19(21)25/h6,8,10-11,23H,2-5,7,9H2,1H3,(H,24,28)(H,26,27)/b15-11-
InChiKey: FVSPJSBCNGWVQQ-PTNGSMBKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0091	0.0159
Schistosoma mansoni	lamin	0.0057	0.0386	0.0663
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0261	0.2075	0.3633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0136	0.0609
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0091	0.0247
Onchocerca volvulus		0.0191	0.1496	0.7566
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0211	0.1168
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0091	0.0145
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0091	0.0159
Onchocerca volvulus		0.0028	0.0153	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1496	0.4457
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0481	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0233	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0028
Schistosoma mansoni	hypothetical protein	0.0188	0.1477	0.2575
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0091	0.0159
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0163	0.0835
Trichomonas vaginalis	glutathione reductase, putative	0.0018	0.0069	0.0265
Onchocerca volvulus		0.0057	0.0386	0.1923
Trichomonas vaginalis	D-aminoacylase, putative	0.0191	0.1496	0.7555
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Schistosoma mansoni	hypothetical protein	0.0036	0.0216	0.0364
Schistosoma mansoni	ferritin light chain	0.0017	0.0061	0.0093
Trypanosoma brucei	trypanothione reductase	0.0053	0.0353	0.2141
Mycobacterium tuberculosis	Probable lipase LipD	0.0191	0.1496	0.1444
Schistosoma mansoni	tar DNA-binding protein	0.0416	0.3357	0.5871
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0136	0.0609
Trichomonas vaginalis	D-aminoacylase, putative	0.0191	0.1496	0.7555
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0009	0.0028
Loa Loa (eye worm)	transcription factor SMAD2	0.0359	0.2885	0.8594
Schistosoma mansoni	tar DNA-binding protein	0.0416	0.3357	0.5871
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0056	0.0098
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0018	0.0069	0.0186
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0091	0.0159
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0287	0.0854
Brugia malayi	beta-lactamase family protein	0.0191	0.1496	0.4443
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0444	0.2766
Echinococcus granulosus	intermediate filament protein	0.0057	0.0386	0.0676
Echinococcus multilocularis	Smad4	0.0024	0.012	0.021
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0091	0.0247
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0444	0.2667
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0071	0.0203
Echinococcus multilocularis	cpg binding protein	0.003	0.0166	0.0291
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0353	0.1992
Echinococcus multilocularis	tar DNA binding protein	0.0416	0.3357	0.5877
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0721	0.1249
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0009	0.0002
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0481	0.795
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0216	0.0643
Schistosoma mansoni	intermediate filament proteins	0.0057	0.0386	0.0663
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.012	0.091	0.0854
Schistosoma mansoni	ferritin	0.0017	0.0061	0.0093
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0042	0.0124
Brugia malayi	MH1 domain containing protein	0.0024	0.012	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0354	0.1053
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.0444	0.0385
Leishmania major	hypothetical protein, conserved	0.0191	0.1496	1
Echinococcus granulosus	lamin dm0	0.0057	0.0386	0.0676
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.051
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0018	0.0069	0.0052
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0011	0.0008	0.0014
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0167	0.0292
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0091	0.0271
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0191	0.1496	0.4457
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0029	0.0061
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0009	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0378	0.1126
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.0481	0.795
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1496	0.4457
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0163	0.0661
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0091	0.0145
Echinococcus granulosus	mothers against decapentaplegic 5	0.0024	0.012	0.021
Mycobacterium tuberculosis	Probable reductase	0.012	0.091	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1496	0.4457
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0056	0.0098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0444	0.0777
Schistosoma mansoni	ferritin	0.0017	0.0061	0.0093
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0091	0.0159
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0721	0.1262
Mycobacterium tuberculosis	Probable oxidoreductase	0.0133	0.1021	0.0966
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0287	0.0502
Echinococcus granulosus	ferritin	0.0017	0.0061	0.0107
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0163	0.2287
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0153	0.0431
Echinococcus granulosus	geminin	0.0188	0.1477	0.2586
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0721	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0144	0.0429
Trypanosoma brucei	hypothetical protein, conserved	0.0191	0.1496	1
Brugia malayi	hypothetical protein	0.0019	0.0076	0.0203
Trypanosoma cruzi	hypothetical protein, conserved	0.0191	0.1496	1
Schistosoma mansoni	ferritin	0.0017	0.0061	0.0093
Schistosoma mansoni	hypothetical protein	0.0017	0.0056	0.0083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0211	0.0993
Brugia malayi	RNA binding protein	0.0416	0.3357	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0182	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0091	0.0247
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.012	0.091	0.0854
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0091	0.0247
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0069	0.0186
Trypanosoma brucei	aurora B kinase	0.0068	0.0481	0.3024
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.1975	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0018	0.0069	0.012
Echinococcus granulosus	smad	0.0024	0.012	0.021
Loa Loa (eye worm)	MH1 domain-containing protein	0.0011	0.0008	0.0024
Mycobacterium leprae	conserved hypothetical protein	0.0191	0.1496	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0042	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0157	0.0717
Mycobacterium tuberculosis	Conserved protein	0.0191	0.1496	0.1444
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0191	0.1496	0.4443
Echinococcus multilocularis	aurora kinase A	0.0068	0.0481	0.0843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Entamoeba histolytica	hypothetical protein	0.0074	0.0532	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0056	0.0142
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0182	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Trypanosoma cruzi	hypothetical protein, conserved	0.0191	0.1496	1
Brugia malayi	MH2 domain containing protein	0.0024	0.012	0.0334
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0091	0.0145
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.0481	0.0843
Loa Loa (eye worm)	MH1 domain-containing protein	0.0024	0.012	0.0358
Schistosoma mansoni	hypothetical protein	0.0188	0.1477	0.2575
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0191	0.1496	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0135	0.0403
Echinococcus multilocularis	geminin	0.0188	0.1477	0.2586
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0091	0.0159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.051
Onchocerca volvulus		0.0249	0.1975	1
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.0481	0.1413
Entamoeba histolytica	protein kinase , putative	0.0068	0.0481	0.795
Brugia malayi	Thioredoxin reductase	0.0053	0.0353	0.1029
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0354	0.1053
Echinococcus multilocularis	smad	0.0024	0.012	0.021
Brugia malayi	intermediate filament protein	0.0057	0.0386	0.1129
Plasmodium falciparum	glutathione reductase	0.0053	0.0353	0.6887
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0069	0.0186
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0011	0.0008	0.0014
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0069	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0042	0.0126
Mycobacterium tuberculosis	Probable dehydrogenase	0.012	0.091	0.0854
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0353	0.0618
Mycobacterium ulcerans	hypothetical protein	0.0191	0.1496	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Echinococcus granulosus	lamin	0.0057	0.0386	0.0676
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0091	0.0159
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0372	0.2126
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.0481	0.3024
Schistosoma mansoni	microtubule-associated protein tau	0.07	0.5712	1
Schistosoma mansoni	lamin	0.0057	0.0386	0.0663
Schistosoma mansoni	thyroid hormone receptor	0.0282	0.2248	0.3928
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0056	0.0142
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0018	0.0069	0.0052
Echinococcus multilocularis	musashi	0.0057	0.0386	0.0676
Mycobacterium ulcerans	esterase/lipase LipP	0.0191	0.1496	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0287	0.1685
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0261	0.2075	0.3633
Brugia malayi	TAR-binding protein	0.0416	0.3357	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0028	0.0049
Brugia malayi	RNA recognition motif domain containing protein	0.0416	0.3357	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0354	0.1031
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0091	0.0247
Mycobacterium ulcerans	lipase LipD	0.0191	0.1496	1
Loa Loa (eye worm)	RNA binding protein	0.0416	0.3357	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.0481	0.795
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0287	0.1685
Mycobacterium leprae	Probable lipase LipE	0.0191	0.1496	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0287	0.1685
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0721	0.2127
Brugia malayi	hypothetical protein	0.0074	0.0532	0.1563
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.012	0.091	0.5918
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0091	0.0159
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0056	0.0098
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0009	0.0003
Echinococcus granulosus	Smad4	0.0024	0.012	0.021
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0386	0.1151
Brugia malayi	MH1 domain containing protein	0.0014	0.003	0.0064
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0444	0.0764
Schistosoma mansoni	cpg binding protein	0.0028	0.0153	0.0253
Echinococcus granulosus	aurora kinase A	0.0068	0.0481	0.0843
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0532	0.0931
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0481	0.1434
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.1726	0.5141
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0028
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0042	0.0073
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0056	0.0166
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0018	0.0069	0.0186
Brugia malayi	MH1 domain containing protein	0.0014	0.003	0.0064
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0009	0.0016
Schistosoma mansoni	smad1 5 8 and	0.0024	0.012	0.0196
Loa Loa (eye worm)	MH2 domain-containing protein	0.0359	0.2885	0.8594
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0287	0.1378
Onchocerca volvulus		0.0032	0.0182	0.0881
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0211	0.0993
Schistosoma mansoni	smad1 5 8 and	0.0024	0.012	0.0196
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0092	0.0349
Entamoeba histolytica	hypothetical protein	0.0074	0.0532	1
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0091	0.0271
Brugia malayi	glutathione reductase	0.0053	0.0353	0.1029
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0481	0.1434
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0024	0.012	0.021
Echinococcus granulosus	mothers against decapentaplegic 6	0.0011	0.0008	0.0014
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0481	0.1434
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0024	0.012	0.0196
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0029	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0165	0.0758
Schistosoma mansoni	cpg binding protein	0.003	0.0166	0.0277
Brugia malayi	nuclear hormone receptor	0.0021	0.0091	0.0247
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.0481	0.0843
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0287	0.1685
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0163	0.0835
Echinococcus granulosus	microtubule associated protein 2	0.07	0.5712	1
Treponema pallidum	NADH oxidase	0.0018	0.0069	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0091	0.0145
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.3261	0.5709
Schistosoma mansoni	cpg binding protein	0.003	0.0166	0.0277
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0091	0.0159
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0091	0.0421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0144	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0028
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0353	0.0618
Schistosoma mansoni	hypothetical protein	0.0261	0.2075	0.3624
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0354	0.1031
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0163	0.2287
Schistosoma mansoni	protein kinase	0.0068	0.0481	0.083
Mycobacterium tuberculosis	Conserved protein	0.0191	0.1496	0.1444
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0009	0.0002
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0353	0.1051
Entamoeba histolytica	hypothetical protein	0.0074	0.0532	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0169	0.0503
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0042	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0014	0.003	0.0088
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0042	0.0073
Loa Loa (eye worm)	intermediate filament protein	0.0057	0.0386	0.1151
Brugia malayi	Smad1	0.0024	0.012	0.0334
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0481	0.2373
Schistosoma mansoni	smad	0.0024	0.012	0.0196
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0091	0.0145
Mycobacterium tuberculosis	Conserved protein	0.0191	0.1496	0.1444
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0018	0.0069	0.0008
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0191	0.1496	0.2619
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0091	0.0159
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0091	0.0159
Brugia malayi	Pre-SET motif family protein	0.0032	0.0182	0.0518
Schistosoma mansoni	thyroid hormone receptor	0.0282	0.2248	0.3928
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0018	0.0069	0.0186
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0018	0.0069	0.5
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0444	0.2628
Loa Loa (eye worm)	hypothetical protein	0.003	0.0163	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0135	0.0403
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0091	0.0247
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0182	0.0318
Trichomonas vaginalis	mercuric reductase, putative	0.0018	0.0069	0.0265
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0211	0.0993
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0091	0.0247
Brugia malayi	MH2 domain containing protein	0.0359	0.2885	0.8591
Schistosoma mansoni	hypothetical protein	0.0013	0.0028	0.0034
Schistosoma mansoni	smad1 5 8 and	0.0024	0.012	0.0196
Toxoplasma gondii	aurora kinase	0.0068	0.0481	0.2892
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0532	0.0931
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0287	0.1378
Schistosoma mansoni	tar DNA-binding protein	0.0416	0.3357	0.5871
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.0481	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0056	0.0083
Echinococcus granulosus	beta LACTamase domain containing family member	0.0191	0.1496	0.2619
Loa Loa (eye worm)	MH2 domain-containing protein	0.0011	0.0008	0.0024
Mycobacterium ulcerans	beta-lactamase	0.0191	0.1496	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Brugia malayi	MH1 domain containing protein	0.0024	0.012	0.0334
Echinococcus multilocularis	expressed protein	0.0017	0.0061	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.0512
Brugia malayi	nuclear receptor RXR	0.0011	0.0009	0.0003
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0091	0.0145
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0091	0.0271
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0069	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0056	0.0083
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0056	0.0098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Echinococcus multilocularis	microtubule associated protein 2	0.07	0.5712	1
Plasmodium vivax	hypothetical protein, conserved	0.0191	0.1496	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0287	0.0488
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.012	0.091	0.0854
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1496	0.4457
Schistosoma mansoni	hypothetical protein	0.0017	0.0056	0.0083
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0191	0.1496	0.2609
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0069	0.0186
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0353	0.6887
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0287	0.1685
Entamoeba histolytica	protein kinase, putative	0.0068	0.0481	0.795
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0182	0.0304
Schistosoma mansoni	hypothetical protein	0.0404	0.3261	0.5703
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0091	0.0247
Onchocerca volvulus		0.0021	0.0091	0.0421
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0091	0.0247
Mycobacterium tuberculosis	Probable esterase LipL	0.0191	0.1496	0.1444
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0481	0.2373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0211	0.0993
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0018	0.0069	0.0052
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0721	0.2147
Entamoeba histolytica	protein kinase, putative	0.0068	0.0481	0.795
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0091	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0211	0.0993
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0721	0.1249
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0532	0.0918
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0163	0.0835
Echinococcus granulosus	expressed protein	0.0017	0.0061	0.0107
Echinococcus multilocularis	ferritin	0.0017	0.0061	0.0107
Loa Loa (eye worm)	Smad1	0.0024	0.012	0.0358
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0133	0.1021	0.0966
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0091	0.0145
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0481	0.2373
Schistosoma mansoni	apoferritin-2	0.0017	0.0061	0.0093
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0024	0.012	0.021
Toxoplasma gondii	ABC1 family protein	0.0191	0.1496	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0042	0.0126
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0003
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0191	0.1496	0.1444
Trichomonas vaginalis	D-aminoacylase, putative	0.0191	0.1496	0.7555
Schistosoma mansoni	ferritin	0.0017	0.0061	0.0093
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0353	0.1051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0721	0.1262
Onchocerca volvulus		0.0191	0.1496	0.7566
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0192	0.0895
Loa Loa (eye worm)	beta-lactamase	0.0191	0.1496	0.4457
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0191	0.1496	0.2609
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0091	0.0145
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0091	0.0271
Brugia malayi	hypothetical protein	0.003	0.0163	0.0462
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0182	0.0304
Trypanosoma cruzi	trypanothione reductase, putative	0.0018	0.0069	0.0186
Schistosoma mansoni	apoferritin-2	0.0017	0.0061	0.0093
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0144	0.0252
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.0512
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0416	0.3357	1
Onchocerca volvulus		0.0191	0.1496	0.7566
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.012	0.091	0.0854
Schistosoma mansoni	coup transcription factor	0.0021	0.0091	0.0145
Schistosoma mansoni	tar DNA-binding protein	0.0416	0.3357	0.5871
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0444	0.0764
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0425	0.0731
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0091	0.0159
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0287	0.0831
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0091	0.0421
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0028	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0091	0.0271
Leishmania major	trypanothione reductase	0.0053	0.0353	0.2141
Schistosoma mansoni	ferritin light chain	0.0017	0.0061	0.0093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0042	0.0126
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0024	0.012	0.021
Giardia lamblia	Aurora kinase	0.0068	0.0481	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.051
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0353	0.1992
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.3261	0.5709
Schistosoma mansoni	tar DNA-binding protein	0.0416	0.3357	0.5871
Echinococcus multilocularis	lamin dm0	0.0057	0.0386	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1496	0.4457
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0287	0.1685
Loa Loa (eye worm)	TAR-binding protein	0.0416	0.3357	1
Giardia lamblia	GTOR	0.0045	0.0287	0.5281
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0091	0.0271
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0091	0.0159
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0069	0.0106
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0211	0.1168
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0042	0.0099
Trichomonas vaginalis	penicillin-binding protein, putative	0.0191	0.1496	0.7555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0138	0.062
Loa Loa (eye worm)	nuclear factor I	0.0014	0.003	0.0088
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0444	0.2667
Leishmania major	protein kinase, putative	0.0068	0.0481	0.3024
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0069	0.018
Brugia malayi	beta-lactamase	0.0191	0.1496	0.4443
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.0512
Echinococcus granulosus	tar DNA binding protein	0.0416	0.3357	0.5877
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0057	0.0386	0.1151
Loa Loa (eye worm)	MH2 domain-containing protein	0.0024	0.012	0.0358
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0721	0.1262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0091	0.0271
Mycobacterium tuberculosis	Probable lipase LipE	0.0191	0.1496	0.1444
Trichomonas vaginalis	ferritin, putative	0.0017	0.0061	0.0226
Echinococcus multilocularis	lamin	0.0057	0.0386	0.0676
Echinococcus granulosus	cpg binding protein	0.003	0.0166	0.0291
Brugia malayi	MH2 domain containing protein	0.0024	0.012	0.0334
Mycobacterium tuberculosis	Probable hydrolase	0.0191	0.1496	0.1444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0287	0.0502
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0282	0.2248	0.3936
Echinococcus granulosus	GPCR family 2	0.0017	0.0056	0.0098
Entamoeba histolytica	hypothetical protein	0.0074	0.0532	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0182	0.0318
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0091	0.0247
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0091	0.0159
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0091	0.0145
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0444	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0018	0.0069	0.0186
Leishmania major	hypothetical protein, conserved	0.003	0.0163	0.0835
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0091	0.0247
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0133	0.1021	0.0966
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0211	0.1168
Trichomonas vaginalis	penicillin-binding protein, putative	0.0191	0.1496	0.7555
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0163	0.0661
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0091	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0008	0.0024
Brugia malayi	Intermediate filament tail domain containing protein	0.0057	0.0386	0.1129
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0153	0.0455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0138	0.062
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0091	0.0247
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0353	0.1992
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0353	0.2141
Brugia malayi	Pre-SET motif family protein	0.0219	0.1726	0.5129
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0192	0.0865
Brugia malayi	ecdysteroid receptor	0.0021	0.0091	0.0247
Onchocerca volvulus		0.0057	0.0386	0.1923
Brugia malayi	beta-lactamase family protein	0.0191	0.1496	0.4443
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.0353	0.0294
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0138	0.062
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0091	0.0247
Echinococcus granulosus	mothers against decapentaplegic 2	0.0011	0.0008	0.0014
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0191	0.1496	0.1444
Plasmodium vivax	SET domain protein, putative	0.0032	0.0182	0.0791
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.0481	0.1413
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0056	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0091	0.0247
Schistosoma mansoni	hypothetical protein	0.0074	0.0532	0.0918
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0069	0.0186
Brugia malayi	serine/threonine kinase 12	0.0068	0.0481	0.1413
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0091	0.0421
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0182	0.0791
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0091	0.0145
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0091	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1496	0.4457
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0091	0.0159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0091	0.0271
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0191	0.1496	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0133	0.1021	0.669
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0721	0.1262
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0182	0.0304
Schistosoma mansoni	Smad4	0.0024	0.012	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0117	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0091	0.0271
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0091	0.0247
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0009	0.0016
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0091	0.0159
Brugia malayi	steroid hormone receptor	0.0021	0.0091	0.0247
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0069	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0182	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0287	0.1378
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.0481	0.2892
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0444	0.2667
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.0481	0.795
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0169	0.048
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0481	0.2373
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0018	0.0069	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0042	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0028
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0216	0.062
Trichomonas vaginalis	esterase, putative	0.0191	0.1496	0.7555

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.057 uM	Inhibition of recombinant aurora A	ChEMBL.	20681538
Inhibition (binding)	= 7 %	Inhibition of recombinant aurora B at 1 uM	ChEMBL.	20681538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1214928

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1172508