Detailed information for compound 1172526

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.794 | Formula: C14H20ClN5O2
  • H donors: 1 H acceptors: 4 LogP: 3.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc(nc1Cl)N(NC(=O)OC(C)(C)C)CC(C)C
  • InChi: 1S/C14H20ClN5O2/c1-9(2)8-20(19-13(21)22-14(3,4)5)12-17-7-10(6-16)11(15)18-12/h7,9H,8H2,1-5H3,(H,19,21)
  • InChiKey: RWVCFROLNWYPGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Brugia malayi hypothetical protein 0.0237 0.1652 0.1812
Mycobacterium tuberculosis Conserved protein 0.0199 0.1367 0.1862
Leishmania major oxidoreductase-like protein 0.0041 0.0204 0.1496
Leishmania major d-xylulose reductase, putative 0.0041 0.0204 0.1496
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0632 0.0693
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0599 0.5168
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0166 0.1122 0.1087
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.0114 0.0074
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0204 0.1496
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.0209 0.1568
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0271 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0166 0.1122 0.1087
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Chlamydia trachomatis acyl carrier protein 0.0067 0.0393 0.2016
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0271 0.2418
Schistosoma mansoni survival motor neuron protein 0.0048 0.0259 0.0221
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0599 0.5168
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0428 0.3055 0.6002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0056 0.0501
Schistosoma mansoni hypothetical protein 0.0067 0.0393 0.0355
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0393 0.0497
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0114 0.1012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0039 0.1003
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0164 0.0125
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0474 0.3394 0.4707
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0022 0.0068 0.0029
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.0648 0.0854
Brugia malayi hypothetical protein 0.0088 0.0554 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0039 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.0209 0.0338
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0411
Onchocerca volvulus Fatty acid synthase homolog 0.1189 0.8663 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0056 0.0017
Schistosoma mansoni hypothetical protein 0.0411 0.2928 0.29
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0207 0.1429 0.1759
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0204 0.1496
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0204 0.1822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Loa Loa (eye worm) hypothetical protein 0.0088 0.0554 0.0687
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0986 0.7166 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0169 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.1367 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0204 0.0231
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0056 0.0062
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0166 0.1122 1
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.5901 0.5885
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.0393 0.0355
Toxoplasma gondii type I fatty acid synthase 0.0101 0.0648 0.1211
Echinococcus multilocularis GPCR, family 2 0.0031 0.0133 0.0094
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0204 0.0231
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0271 0.2142
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.0393 0.0497
Mycobacterium leprae Probable polyketide synthase Pks1 0.0701 0.5064 0.6981
Schistosoma mansoni lamin 0.0026 0.0098 0.0058
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0204 0.5196
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0204 0.0231
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.4763 0.6627
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0114 0.0125
Mycobacterium ulcerans thioesterase TesA 0.055 0.3952 0.549
Schistosoma mansoni hypothetical protein 0.0367 0.2607 0.2578
Onchocerca volvulus 0.0048 0.0259 0.0299
Brugia malayi AMP-binding enzyme family protein 0.0616 0.4443 0.4875
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0133 0.0165
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0345 0.0306
Mycobacterium ulcerans oxidoreductase 0.0041 0.0204 0.0231
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0204 0.1822
Schistosoma mansoni lamin 0.0026 0.0098 0.0058
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0345 0.0607
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.0393 0.0497
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.0648 0.0854
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0056 0.0411
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0164 0.4172
Onchocerca volvulus 0.0093 0.0584 0.0675
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0204 0.0231
Loa Loa (eye worm) hypothetical protein 0.0214 0.1478 0.1832
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0204 0.0231
Echinococcus granulosus GPCR family 2 0.0031 0.0133 0.0094
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0068 0.0029
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0056 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1081 0.1046
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.066 0.4763 0.6627
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0098 0.0121
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0056 0.0033
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0701 0.5064 0.7051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0056 0.1429
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.1122 1
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.0104
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0204 0.0231
Mycobacterium ulcerans hypothetical protein 0.0067 0.0393 0.0497
Echinococcus granulosus intermediate filament protein 0.0026 0.0098 0.0058
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0164 0.1201
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0204 0.0231
Toxoplasma gondii FATC domain-containing protein 0.0029 0.0114 0.0148
Leishmania major quinone oxidoreductase, putative 0.0041 0.0204 0.1496
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.0393 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0133 0.0094
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0401 0.044
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0393 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0632 0.0783
Echinococcus granulosus dnaJ subfamily B 0.0411 0.2928 0.29
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0204 0.0166
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0209 0.0171
Schistosoma mansoni eyes absent homolog 0.0088 0.0554 0.0517
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.0393 0.0497
Schistosoma mansoni acyl carrier protein 0.0067 0.0393 0.0355
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0115 0.0143
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0531 0.3813 0.5295
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0166 0.1122 0.1391
Echinococcus multilocularis musashi 0.0026 0.0098 0.0058
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0166 0.1122 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0572 0.0535
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.0393 0.0488
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0056 0.0017
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Echinococcus granulosus serine protein kinase ATM 0.0029 0.0114 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0133 0.0094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0164 0.0203
Onchocerca volvulus 0.0041 0.0204 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0204 0.1822
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0204 0.0328
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0259 0.0285
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1652 0.1619
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0204 0.0231
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0204 0.0231
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0056 0.007
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0056 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0345 0.0428
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0133 0.0146
Brugia malayi AMP-binding enzyme family protein 0.0203 0.1397 0.1533
Schistosoma mansoni hypothetical protein 0.0048 0.0259 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0164 0.1201
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0164 0.1201
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0204 0.0231
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.1122 0.152
Brugia malayi N-terminal motif family protein 0.0214 0.1478 0.1621
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0375 0.2665 0.3685
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0056 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0121
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0164 0.1201
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1081 0.1046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0164 0.018
Mycobacterium tuberculosis Hypothetical protein 0.0199 0.1367 0.1862
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0701 0.5064 0.7051
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0204 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0164 0.1462
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0204 0.0224
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0133 0.0094
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0165
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.0648 0.0637
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.0393 0.3505
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0203 0.1397 0.1905
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0164 0.0248
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0701 0.5064 0.7051
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0164 0.1462
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0204 0.1822
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0271 0.2418
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0088
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.0393 0.0497
Toxoplasma gondii type I fatty acid synthase, putative 0.047 0.3362 0.6612
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Onchocerca volvulus 0.0041 0.0204 0.0236
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0204 0.0236
Plasmodium vivax acyl carrier protein, putative 0.0067 0.0393 0.3269
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0056 0.1429
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0531 0.3813 0.5295
Schistosoma mansoni methyltransferase-related 0.0199 0.1367 0.1332
Mycobacterium ulcerans polyketide synthase MbtC 0.0166 0.1122 0.152
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Brugia malayi intermediate filament protein 0.0026 0.0098 0.0107
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0701 0.5064 0.7051
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0056 0.0501
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0204 0.1496
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0436 0.3116 0.4317
Schistosoma mansoni intermediate filament proteins 0.0026 0.0098 0.0058
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0166 0.1122 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0164 0.0125
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0204 0.0231
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.125 0.9114 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0701 0.5064 0.7051
Plasmodium falciparum acyl carrier protein 0.0067 0.0393 0.3269
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0986 0.7166 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.055 0.3952 0.549
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0393 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.0393 0.0497
Loa Loa (eye worm) hypothetical protein 0.0101 0.0648 0.0803
Toxoplasma gondii type I fatty acid synthase, putative 0.0701 0.5064 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.066 0.4763 0.6627
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0169 0.013
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.0209 0.1865
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0056 0.0411
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0088
Loa Loa (eye worm) fatty acid synthase 0.0651 0.4698 0.5824
Echinococcus granulosus AMP dependent ligase 0.0067 0.0393 0.0355
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.0393 0.0497
Mycobacterium ulcerans oxidoreductase 0.0041 0.0204 0.0231
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0204 0.0166
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.0393 0.0497
Loa Loa (eye worm) hypothetical protein 0.0088 0.0554 0.0687
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1081 0.1186
Schistosoma mansoni hypothetical protein 0.0068 0.0401 0.0363
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0352
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0204 0.1822
Brugia malayi hypothetical protein 0.0036 0.0169 0.0185
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0393 0.0497
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.066 0.4763 0.6627
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0204 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus multilocularis cpg binding protein 0.003 0.0127 0.0088
Onchocerca volvulus 0.0026 0.0098 0.0113
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0214 0.1478 0.1706
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.0393 0.3269
Loa Loa (eye worm) hypothetical protein 0.1108 0.8067 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0345 0.0428
Mycobacterium ulcerans polyketide synthase MbtD 0.0203 0.1397 0.1905
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0098 0.0121
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0227 0.1573 0.2152
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0056 0.0017
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.0209 0.1568
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0572 0.0535
Loa Loa (eye worm) hypothetical protein 0.0237 0.1652 0.2048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0209 0.026
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0436 0.3116 0.4183
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0204 0.0231
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0204 0.0224
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0166 0.1122 0.8213
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0393 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0572 0.0535
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0056 0.0501
Echinococcus multilocularis microtubule associated protein 2 0.137 1 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.0393 0.0497
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0056 0.0501
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0204 0.0328
Brugia malayi hypothetical protein 0.0032 0.0141 0.0154
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0057 0.0504
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0166 0.1122 0.1087
Onchocerca volvulus 0.0026 0.0098 0.0113
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.066 0.4763 0.6627
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Schistosoma mansoni alpha-glucosidase 0.0138 0.0917 0.0881
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0166 0.1122 0.1231
Mycobacterium ulcerans short-chain dehydrogenase 0.0041 0.0204 0.0231
Schistosoma mansoni microtubule-associated protein tau 0.137 1 1
Giardia lamblia GTOR 0.0021 0.0056 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0204 0.0224
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0345 0.2522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0117
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0345 0.0428
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0056 0.0501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0572 0.0535
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0209 0.0171
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0039 0.0049
Entamoeba histolytica hypothetical protein 0.0029 0.0114 0.2887
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0133 0.0094
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0204 0.0231
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0204 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.0393 0.0271
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0204 0.0231
Mycobacterium ulcerans thioesterase 0.055 0.3952 0.549
Leishmania major oxidoreductase, putative 0.0041 0.0204 0.1496
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0271 0.2418
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0639 0.4614 0.6418
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0639 0.4614 0.6418
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0393 0.0271
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1081 0.134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0831
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.0393 0.0355
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.013
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0056 0.0501
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0393 0.0497
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.0209 0.1568
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1652 0.1619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0271 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus granulosus geminin 0.0367 0.2607 0.2578
Leishmania major acyl carrier protein, putative 0.0067 0.0393 0.2879
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.0648 0.0854
Mycobacterium leprae Polyketide synthase Pks13 0.0986 0.7166 1
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.0209 0.023
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0207 0.1429 0.195
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0084 0.0749
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0501
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0531 0.3813 0.5183
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.0393 0.0497
Brugia malayi Methyltransferase-like protein 4 0.0199 0.1367 0.1499
Loa Loa (eye worm) hypothetical protein 0.005 0.0271 0.0336
Schistosoma mansoni hypothetical protein 0.0367 0.2607 0.2578
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Mycobacterium ulcerans polyketide synthase 0.0701 0.5064 0.7051
Loa Loa (eye worm) hypothetical protein 0.037 0.2625 0.3255
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.0393 0.0497
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0161 0.109 0.1474
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1081 0.1046
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0056 0.0411
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.0393 0.3505
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0345 0.0428
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.066 0.4763 0.6547
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0345 0.0306
Mycobacterium ulcerans polyketide synthase Pks13 0.0986 0.7166 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0616 0.4443 0.6179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0204 0.0231
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0204 0.1822
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.066 0.4763 0.5225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0572 0.0535
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.0114 0.0074
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0164 0.1201
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0204 0.0231
Mycobacterium ulcerans fatty acid synthase Fas 0.0207 0.1429 0.195
Loa Loa (eye worm) hypothetical protein 0.0101 0.0648 0.0803
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0204 0.1523
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.0648 0.0854
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0204 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0271 0.0462
Onchocerca volvulus 0.1148 0.8361 0.9652
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0204 0.0166
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.0114 0.1012
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.0393 0.0432
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0353 0.0315
Leishmania major hypothetical protein, conserved 0.005 0.0271 0.1986
Mycobacterium ulcerans dehydrogenase 0.0041 0.0204 0.0231
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0169 0.013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0345 0.0306
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0204 0.0231
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0539 0.3877 0.5385
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0164 0.4172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Giardia lamblia Methyltransferase like 2 0.0199 0.1367 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0632 0.0693
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.0393 0.0497
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.0783
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0267 0.1868 0.2566
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0204 0.0231
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0204 0.0231
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.0209 0.1865
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0204 0.0253
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0166 0.1122 1
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.0393 0.0704
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0333 0.2359 0.4615
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0204 0.0231
Treponema pallidum acyl carrier protein 0.0067 0.0393 1
Onchocerca volvulus 0.0616 0.4443 0.5129
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0204 0.0231
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0572 0.0627
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0701 0.5064 0.6981
Echinococcus multilocularis lamin dm0 0.0026 0.0098 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Schistosoma mansoni alpha-glucosidase 0.0138 0.0917 0.0881
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0393 1
Onchocerca volvulus 0.0067 0.0393 0.0454
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0204 0.1822
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.0393 0.0432
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0572 0.0709
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0393 0.0497
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.066 0.4763 0.6547
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.2928 0.29
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.1122 0.152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0572 0.0535
Onchocerca volvulus 0.0029 0.0115 0.0133
Schistosoma mansoni cpg binding protein 0.0029 0.0115 0.0076
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0204 0.0166
Trypanosoma brucei acyl transferase-like protein 0.0042 0.0209 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0098 0.0107
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0204 0.0231
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.0393 0.0454
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0204 0.5196
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0501
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0056 0.0017
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.055 0.3952 0.5384
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0209 0.0171
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.4763 0.6627
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0204 0.0231
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0393 0.0355
Mycobacterium ulcerans polyketide synthase Pks9 0.0436 0.3116 0.4317
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0616 0.4443 0.5508
Echinococcus granulosus lamin 0.0026 0.0098 0.0058
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.4763 0.6627
Brugia malayi CXXC zinc finger family protein 0.0029 0.0115 0.0126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0393 0.0497
Loa Loa (eye worm) acyl carrier protein 0.0067 0.0393 0.0488
Trypanosoma brucei glucosidase, putative 0.0036 0.0164 0.1462
Echinococcus granulosus lamin dm0 0.0026 0.0098 0.0058
Schistosoma mansoni alpha glucosidase 0.0036 0.0164 0.0125
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0209 0.0171
Leishmania major hypothetical protein, conserved 0.0042 0.0209 0.1532
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0039 0.0289
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.0393 0.0355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0572 0.0535
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.1122 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0039 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0393 0.0497
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0166 0.1122 1
Leishmania major hypothetical protein, conserved 0.0199 0.1367 1
Echinococcus multilocularis geminin 0.0367 0.2607 0.2578
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Echinococcus granulosus NADH dehydrogenase 0.0067 0.0393 0.0355
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0289
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0204 0.5196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0056 0.0062
Loa Loa (eye worm) hypothetical protein 0.0068 0.0401 0.0497
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0209 0.0171
Brugia malayi hypothetical protein 0.005 0.0271 0.0298
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0701 0.5064 0.6981
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0068 0.0029
Echinococcus multilocularis lamin 0.0026 0.0098 0.0058
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.0209 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0056 0.0501
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0345 0.0306
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0204 0.1822
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0133 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Loa Loa (eye worm) acyl carrier protein 0.0303 0.2137 0.265
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0057 0.0414
Echinococcus granulosus cpg binding protein 0.003 0.0127 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0305 0.0529
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0166 0.1122 0.2155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0352
Mycobacterium ulcerans polyketide synthase 0.066 0.4763 0.6627

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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