Detailed information for compound 1172526

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.794 | Formula: C14H20ClN5O2
  • H donors: 1 H acceptors: 4 LogP: 3.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc(nc1Cl)N(NC(=O)OC(C)(C)C)CC(C)C
  • InChi: 1S/C14H20ClN5O2/c1-9(2)8-20(19-13(21)22-14(3,4)5)12-17-7-10(6-16)11(15)18-12/h7,9H,8H2,1-5H3,(H,19,21)
  • InChiKey: RWVCFROLNWYPGD-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Hypothetical protein 0.0199 0.1367 0.1862
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0021 0.0056 0.1429
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.0393 0.0704
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0204 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Brugia malayi N-terminal motif family protein 0.0214 0.1478 0.1621
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0204 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0057 0.0504
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0068 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0133 0.0094
Schistosoma mansoni acyl carrier protein 0.0067 0.0393 0.0355
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0639 0.4614 0.6418
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.0393 0.0355
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0133 0.0165
Loa Loa (eye worm) hypothetical protein 0.005 0.0271 0.0336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0632 0.0783
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0204 0.0328
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0986 0.7166 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0098 0.0107
Echinococcus granulosus lamin 0.0026 0.0098 0.0058
Onchocerca volvulus 0.0048 0.0259 0.0299
Mycobacterium ulcerans oxidoreductase 0.0041 0.0204 0.0231
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0393 0.0497
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0056 0.0501
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0436 0.3116 0.4317
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.2928 0.29
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0345 0.0306
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.4763 0.6627
Brugia malayi hypothetical protein 0.0036 0.0169 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0029 0.0114 0.0074
Schistosoma mansoni intermediate filament proteins 0.0026 0.0098 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0166 0.1122 0.1087
Onchocerca volvulus 0.0026 0.0098 0.0113
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0204 0.0231
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0021 0.0056 0.0501
Loa Loa (eye worm) hypothetical protein 0.0101 0.0648 0.0803
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.0393 0.3505
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.0393 0.0432
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.0209 0.1568
Schistosoma mansoni alpha-glucosidase 0.0138 0.0917 0.0881
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0401 0.044
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0166 0.1122 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0572 0.0535
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0056 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0169 0.013
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0204 0.0231
Toxoplasma gondii type I fatty acid synthase 0.0101 0.0648 0.1211
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0204 0.1822
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0021 0.0056 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0084 0.0749
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0164 0.4172
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0204 0.0231
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0039 0.0049
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0204 0.0224
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0393 0.0271
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1081 0.1046
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0204 0.0166
Loa Loa (eye worm) hypothetical protein 0.0088 0.0554 0.0687
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0056 0.0501
Loa Loa (eye worm) acyl carrier protein 0.0303 0.2137 0.265
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.0393 0.0497
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0021 0.0056 0.0501
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0021 0.0056 0.0017
Leishmania major oxidoreductase-like protein 0.0041 0.0204 0.1496
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0531 0.3813 0.5183
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0639 0.4614 0.6418
Echinococcus granulosus intermediate filament protein 0.0026 0.0098 0.0058
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Schistosoma mansoni hypothetical protein 0.0411 0.2928 0.29
Echinococcus granulosus AMP dependent ligase 0.0067 0.0393 0.0355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0572 0.0535
Mycobacterium tuberculosis Probable thioesterase TesA 0.055 0.3952 0.549
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1081 0.1186
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0701 0.5064 0.7051
Leishmania major hypothetical protein, conserved 0.005 0.0271 0.1986
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0204 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0599 0.5168
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0039 0.0043
Leishmania major hypothetical protein, conserved 0.0042 0.0209 0.1532
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0056 0.0411
Echinococcus multilocularis microtubule associated protein 2 0.137 1 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0056 0.0062
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0166 0.1122 1
Mycobacterium leprae Polyketide synthase Pks13 0.0986 0.7166 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0401 0.0497
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0271 0.2142
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0701 0.5064 0.6981
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0267 0.1868 0.2566
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.0393 0.0497
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0345 0.0428
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.1122 0.152
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.0393 0.0497
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.0209 0.0238
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.0393 0.0454
Loa Loa (eye worm) hypothetical protein 0.0214 0.1478 0.1832
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0393 1
Brugia malayi Methyltransferase-like protein 4 0.0199 0.1367 0.1499
Mycobacterium ulcerans polyketide synthase 0.0701 0.5064 0.7051
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.1122 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0632 0.0693
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0164 0.1201
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.0209 0.1865
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1081 0.1046
Loa Loa (eye worm) fatty acid synthase 0.0651 0.4698 0.5824
Schistosoma mansoni hypothetical protein 0.0067 0.0393 0.0355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0114 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Schistosoma mansoni cpg binding protein 0.0029 0.0115 0.0076
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0204 0.0231
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0204 0.0231
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0204 0.0328
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.5901 0.5885
Echinococcus multilocularis GPCR, family 2 0.0031 0.0133 0.0094
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0375 0.2665 0.3685
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0436 0.3116 0.4183
Brugia malayi AMP-binding enzyme family protein 0.0616 0.4443 0.4875
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0133 0.0094
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0204 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0021 0.0056 0.0501
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0204 0.0224
Echinococcus granulosus dnaJ subfamily B 0.0411 0.2928 0.29
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0393 0.0497
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0204 0.0166
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0204 0.1822
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0986 0.7166 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0271 0.2418
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0056 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0133 0.0146
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0204 0.0231
Mycobacterium ulcerans short-chain dehydrogenase 0.0041 0.0204 0.0231
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.066 0.4763 0.6547
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0204 0.1822
Loa Loa (eye worm) hypothetical protein 0.1108 0.8067 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0345 0.0428
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.0209 0.1568
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0204 0.0231
Onchocerca volvulus 0.0067 0.0393 0.0454
Echinococcus granulosus geminin 0.0367 0.2607 0.2578
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.066 0.4763 0.5225
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0204 0.0231
Onchocerca volvulus 0.0041 0.0204 0.0236
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.4763 0.6627
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0021 0.0056 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0204 0.0224
Echinococcus granulosus lamin dm0 0.0026 0.0098 0.0058
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0701 0.5064 0.7051
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0616 0.4443 0.6179
Onchocerca volvulus 0.0029 0.0115 0.0133
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0204 0.0231
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0204 0.0231
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0166 0.1122 0.1231
Mycobacterium ulcerans polyketide synthase Pks13 0.0986 0.7166 1
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0161 0.109 0.1474
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0039 0.0289
Schistosoma mansoni alpha glucosidase 0.0036 0.0164 0.0125
Mycobacterium ulcerans polyketide synthase MbtC 0.0166 0.1122 0.152
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0539 0.3877 0.5385
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0133 0.0146
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0204 0.0231
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0207 0.1429 0.1759
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0203 0.1397 0.1905
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.0393 0.0271
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0204 0.1822
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0271 0.2142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.0393 0.0432
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0701 0.5064 0.7051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0088
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.0648 0.0637
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0204 0.0166
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0393 0.0497
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.0393 0.0497
Brugia malayi hypothetical protein 0.0088 0.0554 0.0608
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0164 0.0125
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0021 0.0056 0.0501
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0271 0.2418
Trypanosoma brucei acyl transferase-like protein 0.0042 0.0209 0.1865
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0259 0.0285
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0289
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0204 0.0231
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0164 0.0248
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.066 0.4763 0.6627
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.0209 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0831
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0114 0.1012
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Mycobacterium ulcerans oxidoreductase 0.0041 0.0204 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0572 0.0535
Echinococcus multilocularis serine protein kinase ATM 0.0029 0.0114 0.0074
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.0209 0.1865
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.0393 0.0488
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0021 0.0056 0.0017
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0393 0.0271
Schistosoma mansoni survival motor neuron protein 0.0048 0.0259 0.0221
Leishmania major phosphatidylinositol 3-kinase, putative 0.0021 0.0056 0.0411
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0204 0.0231
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0039 0.1003
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0204 0.1822
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0203 0.1397 0.1533
Brugia malayi hypothetical protein 0.005 0.0271 0.0298
Schistosoma mansoni microtubule-associated protein tau 0.137 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0648 0.0803
Schistosoma mansoni methyltransferase-related 0.0199 0.1367 0.1332
Plasmodium vivax acyl carrier protein, putative 0.0067 0.0393 0.3269
Mycobacterium ulcerans dehydrogenase 0.0041 0.0204 0.0231
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0204 0.0224
Onchocerca volvulus 0.0041 0.0204 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus granulosus GPCR family 2 0.0031 0.0133 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0164 0.0125
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0204 0.1496
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.0393 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.1367 1
Entamoeba histolytica hypothetical protein 0.0029 0.0114 0.2887
Schistosoma mansoni alpha-glucosidase 0.0138 0.0917 0.0881
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0204 0.0231
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0393 0.0497
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.0648 0.0854
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0531 0.3813 0.5295
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.1122 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.1122 0.152
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Brugia malayi hypothetical protein 0.0237 0.1652 0.1812
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0333 0.2359 0.4615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0393 0.0497
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.0104
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0166 0.1122 0.1087
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.066 0.4763 0.6627
Chlamydia trachomatis acyl carrier protein 0.0067 0.0393 0.2016
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0204 0.1822
Echinococcus multilocularis musashi 0.0026 0.0098 0.0058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1081 0.134
Echinococcus multilocularis geminin 0.0367 0.2607 0.2578
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0204 0.0231
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0164 0.018
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0204 0.1822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.0648 0.0854
Toxoplasma gondii type I fatty acid synthase, putative 0.047 0.3362 0.6612
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0166 0.1122 1
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.0393 0.0497
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0632 0.0693
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0204 0.0231
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.0393 0.0355
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0345 0.2522
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.0648 0.0854
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1652 0.1619
Mycobacterium leprae Probable polyketide synthase Pks1 0.0701 0.5064 0.6981
Loa Loa (eye worm) hypothetical protein 0.0088 0.0554 0.0687
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Schistosoma mansoni hypothetical protein 0.0048 0.0259 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0501
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0209 0.0171
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0021 0.0056 0.0411
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0164 0.0203
Mycobacterium ulcerans fatty acid synthase Fas 0.0207 0.1429 0.195
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.0393 0.0497
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0227 0.1573 0.2152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0572 0.0709
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0501
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1081 0.1046
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.066 0.4763 0.6627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Plasmodium falciparum acyl carrier protein 0.0067 0.0393 0.3269
Giardia lamblia GTOR 0.0021 0.0056 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium ulcerans Type I modular polyketide synthase 0.066 0.4763 0.6627
Mycobacterium ulcerans thioesterase 0.055 0.3952 0.549
Brugia malayi hypothetical protein 0.0032 0.0141 0.0154
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0531 0.3813 0.5295
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0209 0.0171
Loa Loa (eye worm) acyl carrier protein 0.0067 0.0393 0.0488
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0204 0.0231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0353 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0164 0.1462
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0209 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0393 0.0497
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.0209 0.023
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0204 0.0231
Leishmania major oxidoreductase, putative 0.0041 0.0204 0.1496
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0057 0.0414
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.125 0.9114 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0021 0.0056 0.1429
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1652 0.1619
Echinococcus granulosus serine protein kinase ATM 0.0029 0.0114 0.0074
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0204 0.0231
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0204 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0572 0.0535
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0204 0.5196
Echinococcus multilocularis lamin dm0 0.0026 0.0098 0.0058
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0021 0.0056 0.0501
Echinococcus granulosus cpg binding protein 0.003 0.0127 0.0088
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.0209 0.1568
Schistosoma mansoni hypothetical protein 0.0031 0.0133 0.0094
Loa Loa (eye worm) hypothetical protein 0.0099 0.0632 0.0783
Mycobacterium tuberculosis Conserved protein 0.0199 0.1367 0.1862
Echinococcus multilocularis lamin 0.0026 0.0098 0.0058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0393 0.0497
Onchocerca volvulus 0.0026 0.0098 0.0113
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0352
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0352
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Onchocerca volvulus Fatty acid synthase homolog 0.1189 0.8663 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0164 0.1201
Leishmania major d-xylulose reductase, putative 0.0041 0.0204 0.1496
Loa Loa (eye worm) hypothetical protein 0.0041 0.0204 0.0253
Leishmania major hypothetical protein, conserved 0.0199 0.1367 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.0393 0.0497
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0133 0.0094
Echinococcus multilocularis cpg binding protein 0.003 0.0127 0.0088
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0214 0.1478 0.1706
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0204 0.0166
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0204 0.1523
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0204 0.1496
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0204 0.1822
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0166 0.1122 0.2155
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0209 0.0171
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0204 0.0231
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0428 0.3055 0.6002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0095 0.0599 0.5168
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0271 0.0462
Giardia lamblia Methyltransferase like 2 0.0199 0.1367 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0393 1
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.0393 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Schistosoma mansoni hypothetical protein 0.0367 0.2607 0.2578
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0572 0.0535
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0021 0.0056 0.0501
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0021 0.0056 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0572 0.0627
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0345 0.0428
Mycobacterium ulcerans hypothetical protein 0.0067 0.0393 0.0497
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0164 0.4172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0204 0.5196
Schistosoma mansoni lamin 0.0026 0.0098 0.0058
Treponema pallidum acyl carrier protein 0.0067 0.0393 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0164 0.1201
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0204 0.0231
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0204 0.0231
Mycobacterium ulcerans polyketide synthase MbtD 0.0203 0.1397 0.1905
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0164 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0166 0.1122 0.8213
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0204 0.0231
Mycobacterium ulcerans polyketide synthase Pks9 0.0436 0.3116 0.4317
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.013
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0345 0.0428
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0166 0.1122 1
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.0393 0.3269
Schistosoma mansoni eyes absent homolog 0.0088 0.0554 0.0517
Leishmania major quinone oxidoreductase, putative 0.0041 0.0204 0.1496
Toxoplasma gondii type I fatty acid synthase, putative 0.0701 0.5064 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0701 0.5064 0.6981
Loa Loa (eye worm) hypothetical protein 0.0042 0.0209 0.026
Toxoplasma gondii FATC domain-containing protein 0.0029 0.0114 0.0148
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0029 0.0114 0.1012
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0098 0.0121
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0068 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0204 0.1822
Loa Loa (eye worm) hypothetical protein 0.037 0.2625 0.3255
Schistosoma mansoni hypothetical protein 0.0068 0.0401 0.0363
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.055 0.3952 0.5384
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0098 0.0121
Echinococcus granulosus NADH dehydrogenase 0.0067 0.0393 0.0355
Loa Loa (eye worm) phosphatidylinositol 3 0.0021 0.0056 0.007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0133 0.0094
Schistosoma mansoni cpg binding protein 0.003 0.0127 0.0088
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.0393 0.0497
Mycobacterium ulcerans thioesterase TesA 0.055 0.3952 0.549
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0204 0.1496
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.0393 0.0497
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0166 0.1122 0.1391
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0345 0.0306
Schistosoma mansoni hypothetical protein 0.0367 0.2607 0.2578
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0169 0.013
Onchocerca volvulus 0.0093 0.0584 0.0675
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0166 0.1122 0.1087
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0701 0.5064 0.7051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Onchocerca volvulus 0.0616 0.4443 0.5129
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0393 0.0355
Brugia malayi intermediate filament protein 0.0026 0.0098 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0271 0.2142
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0164 0.1462
Mycobacterium ulcerans polyketide synthase 0.066 0.4763 0.6627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0572 0.0535
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0701 0.5064 0.7051
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0271 0.2418
Schistosoma mansoni lamin 0.0026 0.0098 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0039 0.0352
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0305 0.0529
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0345 0.0306
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.0393 0.3505
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0207 0.1429 0.195
Schistosoma mansoni hypothetical protein 0.0022 0.0068 0.0029
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.0393 0.0355
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0345 0.0306
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0164 0.1201
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.4288
Toxoplasma gondii target of rapamycin (TOR), putative 0.0021 0.0056 0.0033
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0166 0.1122 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.066 0.4763 0.6547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0572 0.0535
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0474 0.3394 0.4707
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0209 0.0171
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0204 0.5196
Leishmania major acyl carrier protein, putative 0.0067 0.0393 0.2879
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0164 0.1201
Loa Loa (eye worm) hypothetical protein 0.0237 0.1652 0.2048
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0616 0.4443 0.5508
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0021 0.0056 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0115 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0056 0.0411
Trypanosoma brucei glucosidase, putative 0.0036 0.0164 0.1462
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.0648 0.0854
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0169 0.013
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0204 0.1496
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.0393 0.0497
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0165
Brugia malayi CXXC zinc finger family protein 0.0029 0.0115 0.0126
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.066 0.4763 0.6627
Onchocerca volvulus 0.1148 0.8361 0.9652
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0345 0.0607
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0289
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0021 0.0056 0.0411

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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