Detailed information for compound 1172569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 449.251 | Formula: C19H17Cl2F3N2O3
  • H donors: 2 H acceptors: 4 LogP: 3.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c(C1)c(Cl)c(c(c2Cl)O)O)CCCc1ccc(cn1)C(F)(F)F
  • InChi: 1S/C19H17Cl2F3N2O3/c20-15-12-6-7-26(9-13(12)16(21)18(29)17(15)28)14(27)3-1-2-11-5-4-10(8-25-11)19(22,23)24/h4-5,8,28-29H,1-3,6-7,9H2
  • InChiKey: ZOIDKKANKXRVIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0061 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0043 0.0033 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0042 0.1376
Schistosoma mansoni cpg binding protein 0.0068 0.0069 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0034 0.55
Brugia malayi Bromodomain containing protein 0.0165 0.0203 0.0203
Echinococcus granulosus Chromo domain 0.0035 0.0022 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0042 0.1376
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0024 0.0024
Schistosoma mansoni ap endonuclease 0.0023 0.0005 0.0004
Schistosoma mansoni chromobox protein 0.0035 0.0022 0.0023
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0005 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.015 0.0154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0061 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0305 0.0399 0.13
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0076 0.0235
Schistosoma mansoni deleted in oral cancer 1/cdk2-associated protein-like 0.2194 0.3038 0.313
Schistosoma mansoni jumonji domain containing protein 0.0086 0.0093 0.0096
Schistosoma mansoni hypothetical protein 0.0103 0.0117 0.012
Loa Loa (eye worm) hypothetical protein 0.0079 0.0083 0.0085
Echinococcus granulosus Chromobox protein 3 0.0035 0.0022 0.0058
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0061 0.0186
Mycobacterium tuberculosis Conserved protein 0.0042 0.0031 0.0785
Loa Loa (eye worm) hypothetical protein 0.0095 0.0105 0.0108
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.0124 0.0395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0184 0.0183
Mycobacterium tuberculosis Conserved protein 0.0042 0.0031 0.0785
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0005 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0031 0.0993
Schistosoma mansoni ran 0.0025 0.0008 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0065 0.0067
Trypanosoma brucei unspecified product 0.0043 0.0034 0.55
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0031 0.5094
Plasmodium vivax importin-beta 2, putative 0.0033 0.002 0.175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0005 0.069
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0022 0.0658
Loa Loa (eye worm) hypothetical protein 0.0048 0.004 0.0041
Brugia malayi chromobox protein homolog 3 0.0121 0.0142 0.0141
Brugia malayi Protein kinase domain containing protein 0.6966 0.9704 0.9703
Schistosoma mansoni cpg binding protein 0.0068 0.0069 0.007
Loa Loa (eye worm) heterochromatin protein 1 0.0215 0.0274 0.0282
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0022 0.1439
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0031 0.0993
Brugia malayi acetyltransferase, GNAT family protein 0.0324 0.0425 0.0425
Schistosoma mansoni zinc finger protein 0.0031 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Schistosoma mansoni hypothetical protein 0.0556 0.0749 0.0772
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0324 0.0425 0.1386
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0061 1
Echinococcus granulosus cpg binding protein 0.0068 0.0069 0.0212
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0035 0.0022 0.1439
Onchocerca volvulus 0.0048 0.004 0.0069
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0121 0.0142 0.0405
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0008 0.0756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0305 0.0399 0.13
Trichomonas vaginalis chromobox protein, putative 0.013 0.0154 0.5567
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.0061 0.0063
Trichomonas vaginalis Heterochromatin protein, putative 0.0035 0.0022 0.0658
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0019 0.1711
Entamoeba histolytica hypothetical protein 0.0111 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0024
Brugia malayi Bromodomain containing protein 0.0046 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0092 0.3263
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Mycobacterium ulcerans lipase LipD 0.0042 0.0031 0.5094
Schistosoma mansoni hypothetical protein 0.0556 0.0749 0.0772
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.002 0.127
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0011 0.0235
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0035 0.0022 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0042 0.1376
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.0124 0.0395
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0099 0.0111 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0031 0.0785
Schistosoma mansoni hypothetical protein 0.0033 0.0019 0.0019
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0065 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.002 0.3183
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.0061 0.0063
Schistosoma mansoni chromobox protein 0.0215 0.0274 0.0282
Leishmania major GTP-binding protein, putative 0.0025 0.0008 0.1155
Brugia malayi TAR-binding protein 0.0066 0.0065 0.0065
Echinococcus granulosus chromobox protein 1 0.0215 0.0274 0.0887
Loa Loa (eye worm) hypothetical protein 0.0063 0.0061 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0065 0.0067
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0022 0.0023
Echinococcus multilocularis importin subunit beta 1 0.0033 0.002 0.005
Loa Loa (eye worm) beta-lactamase 0.0042 0.0031 0.0032
Echinococcus granulosus chromobox protein 2 0.0035 0.0022 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0005 0.0452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0022 0.0658
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0039 0.0115
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0022 0.1736
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0129 0.0132
Echinococcus granulosus peregrin 0.0046 0.0037 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0305 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0035 0.0022 0.1439
Plasmodium falciparum importin beta, putative 0.0033 0.002 0.2084
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0035 0.0022 0.0023
Schistosoma mansoni hypothetical protein 0.0356 0.0471 0.0485
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.0093 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0008 0.1155
Onchocerca volvulus 0.0035 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Loa Loa (eye worm) acetyltransferase 0.0324 0.0425 0.0438
Plasmodium falciparum phd finger protein, putative 0.0033 0.0019 0.2037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0022 0.0023
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0022 0.0057
Schistosoma mansoni hypothetical protein 0.0035 0.0022 0.0023
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0032 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0059 0.006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0005 0.069
Brugia malayi RNA binding protein 0.0066 0.0065 0.0065
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0035 0.0022 0.236
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0009 0.0009
Brugia malayi beta-lactamase family protein 0.0042 0.0031 0.0031
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0008 0.1155
Leishmania major DNA polymerase eta, putative 0.0063 0.0061 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0019 0.1242
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0005 0.069
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0022 0.0057
Echinococcus granulosus dna polymerase kappa 0.0063 0.0061 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0305 0.0399 0.0411
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0154 0.0158
Brugia malayi hypothetical protein 0.0026 0.001 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0061 0.1659
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0043 0.0043
Trichomonas vaginalis chromobox protein, putative 0.013 0.0154 0.5567
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0032
Brugia malayi SET domain containing protein 0.0037 0.0024 0.0024
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0043 0.0033 0.0033
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0061 0.21
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.004 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0042 0.1376
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0019 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.004 0.0116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.004 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0031 0.5094
Mycobacterium tuberculosis Conserved protein 0.0042 0.0031 0.0785
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0031 0.0785
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.004 0.0041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.004 0.0116
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0011 0.0235
Schistosoma mansoni ran 0.0025 0.0008 0.0007
Trypanosoma cruzi ISWI complex protein 0.0031 0.0017 0.2708
Leishmania major hypothetical protein, conserved 0.0026 0.001 0.1531
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0022 0.0658
Brugia malayi M-phase phosphoprotein, mpp8 0.0035 0.0022 0.0022
Onchocerca volvulus Diphthamide biosynthesis protein 7 homolog 0.2194 0.3038 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0061 1
Echinococcus multilocularis chromobox protein 1 0.0215 0.0274 0.0887
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0035 0.0022 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0005 0.069
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0069 0.007
Echinococcus granulosus snurportin 1 0.0356 0.0471 0.1537
Echinococcus multilocularis chromobox protein 1 0.0215 0.0274 0.0887
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0065 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Brugia malayi PHD-finger family protein 0.0062 0.006 0.006
Echinococcus multilocularis GPCR, family 2 0.0048 0.004 0.0116
Echinococcus multilocularis dna polymerase eta 0.0063 0.0061 0.0186
Loa Loa (eye worm) RNA binding protein 0.0066 0.0065 0.0067
Schistosoma mansoni bromodomain containing protein 0.002 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0027 0.0011 0.0854
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0133 0.016 0.0511
Echinococcus granulosus GPCR family 2 0.0048 0.004 0.0116
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Schistosoma mansoni bromodomain containing protein 0.0141 0.017 0.0175
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0037 0.0108
Schistosoma mansoni chromobox protein 0.0215 0.0274 0.0282
Schistosoma mansoni zinc finger protein 0.0051 0.0045 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0031 0.2801
Echinococcus multilocularis Chromo domain 0.0035 0.0022 0.0058
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0011 0.0235
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0008 0.0461
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0032
Echinococcus granulosus dnaJ subfamily B 0.087 0.1189 0.3904
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.6966 0.9704 1
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0061 0.0061
Onchocerca volvulus 0.0042 0.0031 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0305 0.0399 0.13
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0043 0.0125
Onchocerca volvulus 0.0042 0.0031 0.004
Echinococcus multilocularis dnaJ subfamily B 0.087 0.1189 0.3904
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0031 0.0785
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0008 0.0756
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0042 0.1376
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0061 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.0061 0.0186
Loa Loa (eye worm) CHromoDomain protein family member 0.0043 0.0033 0.0033
Trypanosoma brucei unspecified product 0.0063 0.0061 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0153 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Giardia lamblia PHD finger protein 15 0.0033 0.0019 0.2037
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0061 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.0061 0.4747
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0022 0.1736
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0061 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.0345 1
Schistosoma mansoni hypothetical protein 0.0048 0.004 0.0041
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.0093 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.0061 0.0063
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0031 0.0785
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0008 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0099 0.0111 0.3947
Loa Loa (eye worm) hypothetical protein 0.0145 0.0175 0.018
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0035 0.0022 0.236
Mycobacterium ulcerans beta-lactamase 0.0042 0.0031 0.5094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0031 0.0785
Loa Loa (eye worm) hypothetical protein 0.0103 0.0117 0.012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0324 0.0425 0.0438
Echinococcus granulosus dna polymerase eta 0.0063 0.0061 0.0186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0065 0.02
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0005 0.0379
Brugia malayi Latrophilin receptor protein 2 0.0048 0.004 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0061 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Schistosoma mansoni hypothetical protein 0.0048 0.004 0.0041
Brugia malayi Protein cec-1. 0.0035 0.0022 0.0022
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0022 0.0022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0031 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0024
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.015 0.0154
Trichomonas vaginalis hypothetical protein 0.0035 0.0022 0.0658
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0031 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0005 0.0364
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.002 0.3183
Loa Loa (eye worm) hypothetical protein 0.0099 0.0111 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0034 0.55
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0034 0.55
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.0061 0.0186
Loa Loa (eye worm) hypothetical protein 0.0121 0.0142 0.0145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0305 0.0399 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0305 0.0399 0.13
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0043 0.0125
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0061 1
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0031 0.0785
Schistosoma mansoni hypothetical protein 0.087 0.1189 0.1225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0305 0.0399 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0033 0.1043
Onchocerca volvulus 0.0037 0.0024 0.0016
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.6966 0.9704 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0008 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0065 0.0067
Entamoeba histolytica hypothetical protein 0.0111 0.0129 1
Entamoeba histolytica hypothetical protein 0.0111 0.0129 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.001 0.1531
Brugia malayi CHD4 protein 0.0043 0.0033 0.0032
Leishmania major hypothetical protein, conserved 0.0031 0.0017 0.2708
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0042 0.0031 0.0991
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0031 0.0993
Echinococcus granulosus importin subunit beta 1 0.0033 0.002 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0031 0.0088
Echinococcus multilocularis geminin 0.0556 0.0749 0.2456
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0043 0.0033 0.0092
Leishmania major DNA polymerase kappa, putative 0.0063 0.0061 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0005 0.069
Schistosoma mansoni hypothetical protein 0.0048 0.004 0.0041
Echinococcus granulosus chromobox protein 1 0.0215 0.0274 0.0887
Trypanosoma brucei ISWI complex protein 0.0031 0.0017 0.2708
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0022 0.0658
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0005 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0022 0.1982
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0008 0.0635
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.0471 0.0485
Schistosoma mansoni hypothetical protein 0.0048 0.004 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0039 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0031 0.0032
Schistosoma mansoni cpg binding protein 0.0061 0.0059 0.006
Mycobacterium ulcerans hypothetical protein 0.0042 0.0031 0.5094
Onchocerca volvulus 0.0035 0.0022 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.004 0.0041
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0117 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0065 0.0067
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.0151 0.0184 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0142 0.5091
Plasmodium vivax heterochromatin protein 1, putative 0.0035 0.0022 0.1982
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0031 0.0993
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0061 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0184 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0011 0.173
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.001 0.0842
Giardia lamblia DINP protein human, muc B family 0.0063 0.0061 0.6547
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.001
Brugia malayi Associated with TFs and helicases family protein 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0008 0.0009
Entamoeba histolytica Ran family GTPase 0.0025 0.0008 0.0583
Brugia malayi Importin beta-1 subunit 0.0033 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0042 0.0032 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0305 0.0399 0.0411
Echinococcus multilocularis zinc finger protein 0.0051 0.0045 0.0133
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0061 1
Schistosoma mansoni hypothetical protein 0.0111 0.0129 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Schistosoma mansoni chromobox protein 0.0035 0.0022 0.0023
Schistosoma mansoni importin beta-1 0.0033 0.002 0.002
Echinococcus multilocularis chromobox protein 2 0.0035 0.0022 0.0058
Brugia malayi CXXC zinc finger family protein 0.0061 0.0059 0.0058
Loa Loa (eye worm) helicase 0.0035 0.0022 0.0023
Echinococcus granulosus zinc finger protein 0.0051 0.0045 0.0133
Onchocerca volvulus 0.0042 0.0031 0.004
Brugia malayi Heterochromatin protein 1 0.0215 0.0274 0.0273
Toxoplasma gondii ABC1 family protein 0.0042 0.0031 0.2033
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Brugia malayi MH2 domain containing protein 0.0126 0.015 0.0149
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.004 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0033 0.1043
Echinococcus multilocularis tumor protein p63 0.0328 0.0431 0.1405
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.002 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0099 0.0111 0.7259
Leishmania major hypothetical protein, conserved 0.0042 0.0031 0.5094
Mycobacterium leprae Probable lipase LipE 0.0042 0.0031 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0061 0.21
Brugia malayi jmjC domain containing protein 0.0047 0.0039 0.0039
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0099 0.0111 0.3947
Echinococcus granulosus histone acetyltransferase KAT2B 0.031 0.0406 0.1323
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0008 0.0007
Brugia malayi beta-lactamase 0.0042 0.0031 0.0031
Echinococcus multilocularis cpg binding protein 0.0068 0.0069 0.0212
Loa Loa (eye worm) hypothetical protein 0.0048 0.004 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0061 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.2194 0.3038 0.313
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0031 0.5094
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0129 0.0409
Onchocerca volvulus 0.0061 0.0059 0.013
Toxoplasma gondii exonuclease III APE 0.0023 0.0005 0.0275
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.001 0.1002
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0022 0.1982
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0031 0.0785
Echinococcus granulosus histone acetyltransferase KAT2B 0.0099 0.0111 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Trichomonas vaginalis chromobox protein, putative 0.0215 0.0274 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.001 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0092 0.3263
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0031 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0042 0.1376
Trichomonas vaginalis ran, putative 0.0025 0.0008 0.0105
Brugia malayi PHD-finger family protein 0.0033 0.0019 0.0019
Onchocerca volvulus 0.0095 0.0105 0.0285
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0039 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.001 0.1531
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0129 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.001 0.1002
Trypanosoma cruzi ISWI complex protein 0.0031 0.0017 0.2708
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0031 0.0032
Entamoeba histolytica hypothetical protein 0.0035 0.0022 0.1736
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.001 0.0611
Brugia malayi hypothetical protein 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0032
Entamoeba histolytica hypothetical protein 0.0035 0.0022 0.1736
Schistosoma mansoni hypothetical protein 0.0031 0.0017 0.0017
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0019 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0031 0.0031
Leishmania major importin beta-1 subunit, putative 0.0027 0.0011 0.173
Echinococcus multilocularis snurportin 1 0.0356 0.0471 0.1537
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0026 0.0009 0.137
Brugia malayi hypothetical protein 0.0111 0.0129 0.0128
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0022 0.1736
Entamoeba histolytica hypothetical protein 0.0111 0.0129 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0142 0.5091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0022 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0022 0.0658
Brugia malayi beta-lactamase family protein 0.0042 0.0031 0.0031
Schistosoma mansoni DNA polymerase eta 0.0063 0.0061 0.0063
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0899 0.1229 0.4038
Echinococcus multilocularis Chromobox protein 3 0.0035 0.0022 0.0058
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0005 0.0452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Echinococcus granulosus tar DNA binding protein 0.0066 0.0065 0.02
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0133 0.016 0.0511
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0086 0.0094 0.0093
Brugia malayi jmjC domain containing protein 0.0108 0.0124 0.0124
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0099 0.0111 0.7259
Plasmodium falciparum heterochromatin protein 1 0.0035 0.0022 0.236
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0024 0.0063
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0031 0.5094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0042 0.1376
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0076 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0065 0.0067
Echinococcus multilocularis peregrin 0.0046 0.0037 0.0107
Echinococcus granulosus geminin 0.0556 0.0749 0.2456
Trichomonas vaginalis chromobox protein, putative 0.0215 0.0274 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0008 0.1155
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0024 0.0063
Brugia malayi RNA, U transporter 1 0.0095 0.0106 0.0105
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.0093 0.7231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0184 0.0189
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0061 0.0061
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0019 0.1242
Echinococcus multilocularis Cyclin dependent kinase 2 associated protein 0.2194 0.3038 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0022 0.0658
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0061 0.1659
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0031 0.0993
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0042 0.1376
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0065 0.0067
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0035 0.0022 0.0058
Schistosoma mansoni ap endonuclease 0.0023 0.0005 0.0004
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0061 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0035 0.0022 0.1736
Loa Loa (eye worm) hypothetical protein 0.0091 0.0101 0.0103
Trypanosoma brucei unspecified product 0.0043 0.0034 0.55
Onchocerca volvulus Heterochromatin protein 1 homolog 0.013 0.0154 0.0448
Brugia malayi Valyl-tRNA synthetase 0.0035 0.0022 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0031 0.5094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0023
Echinococcus granulosus tumor protein p63 0.0328 0.0431 0.1405
Echinococcus granulosus Cyclin dependent kinase 2 associated protein 0.2194 0.3038 1
Trichomonas vaginalis esterase, putative 0.0042 0.0031 0.0993
Loa Loa (eye worm) bromodomain containing protein 0.0044 0.0035 0.0035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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