Detailed information for compound 1172718

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.439 | Formula: C19H20N2O3S
  • H donors: 4 H acceptors: 3 LogP: 2.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](c1ccc(c2c1sc(=O)[nH]2)O)CN[C@@H]1CCCc2c1cccc2
  • InChi: 1S/C19H20N2O3S/c22-15-9-8-13(18-17(15)21-19(24)25-18)16(23)10-20-14-7-3-5-11-4-1-2-6-12(11)14/h1-2,4,6,8-9,14,16,20,22-23H,3,5,7,10H2,(H,21,24)/t14-,16+/m1/s1
  • InChiKey: VFSCBASJPGZOGO-ZBFHGGJFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0349 0.0592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Plasmodium vivax heat shock protein 90, putative 0.003 0.043 0.0938
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.004 0.0628 0.067
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.018 0.009
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.062 0.129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1298 0.2548
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0349 0.052
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1298 0.3681
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0672
Leishmania major heat shock protein, putative 0.003 0.043 0.0657
Loa Loa (eye worm) hypothetical protein 0.0013 0.0056 0.0014
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0017 0.015 0.0215
Brugia malayi acyl-CoA desaturase 0.0198 0.4046 0.4584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Loa Loa (eye worm) hypothetical protein 0.0174 0.3528 0.3996
Brugia malayi Cathepsin L-like precursor 0.004 0.0628 0.0658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0804 0.194
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0349 0.0467
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.2516 0.2836
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.062 0.1756
Loa Loa (eye worm) hypothetical protein 0.0031 0.0451 0.0467
Schistosoma mansoni hypothetical protein 0.004 0.0648 0.1272
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0672
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0349 0.3616
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0214 0.0087
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0346 0.0135
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0628 0.1233
Plasmodium falciparum cysteine proteinase falcipain 2a 0.004 0.0628 0.1159
Brugia malayi Bromodomain containing protein 0.0045 0.0736 0.0781
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2516 0.4937
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0762 0.1618
Mycobacterium tuberculosis Probable oxidoreductase 0.0195 0.3987 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.043 0.122
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0349 0.0337
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.018 0.0284
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0048 0.0804 0.0859
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0196 0.0161
Brugia malayi RNA binding protein 0.0127 0.2516 0.2826
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.018 0.051
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2516 0.4937
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0648 0.1211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0672
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.2865 0.3237
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.3031 0.6813
Echinococcus multilocularis phd:f box containing protein 0.0019 0.018 0.051
Echinococcus multilocularis muscleblind protein 1 0.0174 0.3528 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0349 0.0467
Trypanosoma brucei trypanothione reductase 0.0077 0.1435 0.3009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0349 0.0672
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.2865 0.8123
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.062 0.6542
Onchocerca volvulus 0.0031 0.0451 0.0306
Leishmania major cysteine peptidase A (CPA) 0.004 0.0628 0.112
Loa Loa (eye worm) hypothetical protein 0.004 0.0628 0.067
Trypanosoma cruzi fatty acid desaturase, putative 0.0017 0.015 0.0215
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0451 0.0467
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0202 0.0572
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0648 0.1838
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0762 0.1618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Onchocerca volvulus 0.004 0.0628 0.0486
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0349 0.0672
Brugia malayi Cathepsin L-like precursor 0.004 0.0628 0.0658
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0346 0.0333
Trypanosoma cruzi heat shock protein, putative 0.003 0.043 0.0857
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0175 0.3564 0.8713
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.018 0.0156
Echinococcus multilocularis endoplasmin 0.0043 0.0702 0.1989
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0491 0.0283
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.1388 0.1541
Plasmodium falciparum heat shock protein 90, putative 0.0173 0.3522 0.8643
Plasmodium vivax heat shock protein 86, putative 0.0046 0.0762 0.177
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Loa Loa (eye worm) hypothetical protein 0.0013 0.0056 0.0014
Echinococcus granulosus heat shock protein 0.0046 0.0762 0.2161
Brugia malayi Bromodomain containing protein 0.0089 0.1699 0.1888
Plasmodium vivax vivapain-1 0.002 0.0214 0.0395
Brugia malayi Cathepsin L-like precursor 0.004 0.0628 0.0658
Onchocerca volvulus 0.004 0.0628 0.0486
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0214 0.0181
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0214 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2865 0.5623
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Loa Loa (eye worm) hypothetical protein 0.0015 0.01 0.0065
Onchocerca volvulus Cathepsin L homolog 0.004 0.0628 0.0486
Schistosoma mansoni endoplasmin 0.0046 0.0762 0.1496
Brugia malayi heat shock protein 90 0.0046 0.0762 0.0812
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0044 0.0125
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.018 0.051
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0451 0.0454
Echinococcus multilocularis cathepsin L 0.002 0.0214 0.0606
Leishmania major trypanothione reductase 0.0077 0.1435 0.3009
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.3588 0.349
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0628 0.1311
Trichomonas vaginalis set domain proteins, putative 0.0473 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1298 0.3681
Brugia malayi jmjC domain containing protein 0.0019 0.018 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Brugia malayi hypothetical protein 0.0037 0.0563 0.0583
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.018 0.0353
Echinococcus granulosus cathepsin l cysteine peptidase 0.004 0.0628 0.1781
Echinococcus granulosus cpg binding protein 0.0037 0.0584 0.1656
Echinococcus granulosus cathepsin L 0.002 0.0214 0.0606
Schistosoma mansoni heat shock protein 0.003 0.043 0.0845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Brugia malayi intermediate filament protein 0.0031 0.0451 0.0454
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0048 0.0804 0.0872
Echinococcus granulosus heat shock protein 90 0.0039 0.062 0.1756
Trypanosoma cruzi ISWI complex protein 0.0018 0.0158 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.018 0.051
Schistosoma mansoni endoplasmin 0.0046 0.0762 0.1496
Loa Loa (eye worm) hypothetical protein 0.0082 0.1551 0.1729
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0349 0.0735
Loa Loa (eye worm) endoplasmin 0.0046 0.0762 0.0824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Plasmodium vivax vivapain-2 0.004 0.0628 0.1434
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0648 0.068
Schistosoma mansoni hypothetical protein 0.0173 0.3524 0.6916
Loa Loa (eye worm) FAT-3 protein 0.0017 0.015 0.0121
Trypanosoma cruzi fatty acid desaturase, putative 0.0017 0.015 0.0215
Brugia malayi N-terminal motif family protein 0.0176 0.3588 0.4058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0451 0.0467
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0214 0.042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0214 0.042
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0381 0.108
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.018 0.0353
Schistosoma mansoni jumonji domain containing protein 0.0019 0.018 0.0353
Loa Loa (eye worm) hypothetical protein 0.004 0.0648 0.0693
Trichomonas vaginalis heat shock protein, putative 0.0039 0.062 0.0415
Echinococcus granulosus heat shock protein 90 0.0046 0.0762 0.2161
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1076 0.2111
Loa Loa (eye worm) hypothetical protein 0.0045 0.0738 0.0796
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0495 0.0518
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0702 0.1438
Loa Loa (eye worm) hypothetical protein 0.008 0.1505 0.1676
Plasmodium falciparum cysteine proteinase falcipain 2b 0.004 0.0628 0.1159
Schistosoma mansoni phd/f-box containing protein 0.0019 0.018 0.0353
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0175 0.3564 0.8898
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.2865 0.3227
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.2516 0.2826
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0762 1
Entamoeba histolytica cysteine protease, putative 0.004 0.0628 0.7556
Onchocerca volvulus Cathepsin F homolog 0.004 0.0628 0.0486
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0349 0.0467
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0349 0.5
Echinococcus multilocularis expressed protein 0.0048 0.0804 0.2279
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0089 0.0038
Loa Loa (eye worm) heat shock protein 90 0.0046 0.0762 0.0824
Plasmodium falciparum glutathione reductase 0.0077 0.1435 0.3247
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.2865 0.8123
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0269 0.0763
Toxoplasma gondii thioredoxin reductase 0.0077 0.1435 0.3812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Trypanosoma cruzi cysteine protease, putative 0.002 0.0214 0.0361
Echinococcus multilocularis heat shock protein 0.0046 0.0762 0.2161
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0648 0.1484
Brugia malayi CXXC zinc finger family protein 0.0033 0.0495 0.0504
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0648 0.068
Onchocerca volvulus 0.004 0.0628 0.0486
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0348 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.018 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.1352 0.2653
Brugia malayi Delta5 fatty acid desaturase 0.0017 0.015 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Schistosoma mansoni heat shock protein 0.0046 0.0762 0.1496
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.0017 0.015 0.0215
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0672
Loa Loa (eye worm) acyl-CoA desaturase 0.0198 0.4046 0.4592
Leishmania major hypothetical protein, conserved 0.0019 0.018 0.0071
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0762 0.1618
Schistosoma mansoni intermediate filament proteins 0.0031 0.0451 0.0885
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0349 0.099
Trypanosoma brucei fatty acid desaturase, putative 0.0215 0.4423 1
Schistosoma mansoni zinc finger protein 0.0018 0.0158 0.031
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Schistosoma mansoni protein phosphatase 2C 0.0019 0.018 0.0353
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2516 0.4937
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0136 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2516 0.4937
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Echinococcus multilocularis muscleblind protein 0.0174 0.3528 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0175 0.3564 0.8898
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0381 0.108
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0202 0.0396
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.018 0.0156
Schistosoma mansoni lamin 0.0031 0.0451 0.0885
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0349 0.3616
Echinococcus multilocularis tar DNA binding protein 0.0127 0.2516 0.7132
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0214 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Brugia malayi Thioredoxin reductase 0.0077 0.1435 0.1585
Plasmodium falciparum heat shock protein 90 0.0046 0.0762 0.1506
Schistosoma mansoni hypothetical protein 0.0024 0.0292 0.0573
Plasmodium falciparum cysteine proteinase falcipain 3 0.004 0.0628 0.1159
Echinococcus multilocularis cpg binding protein 0.0037 0.0584 0.1656
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0349 0.0592
Trypanosoma cruzi cruzipain precursor, putative 0.0151 0.3031 0.6813
Echinococcus granulosus zinc finger protein 0.0025 0.0306 0.0869
Plasmodium vivax vivapain-2 0.004 0.0628 0.1434
Echinococcus granulosus cathepsin L cysteine proteinase 0.004 0.0628 0.1781
Plasmodium vivax JmjC domain containing protein 0.0019 0.018 0.0311
Brugia malayi Cathepsin L-like precursor 0.004 0.0628 0.0658
Echinococcus granulosus lamin dm0 0.0031 0.0451 0.1279
Schistosoma mansoni tar DNA-binding protein 0.0127 0.2516 0.4937
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0349 0.0467
Leishmania major cathepsin L-like protease 0.004 0.0628 0.112
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.0762 0.1434
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0349 0.099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Schistosoma mansoni cpg binding protein 0.0037 0.0584 0.1147
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0628 0.7556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0195 0.3987 1
Echinococcus granulosus phd:f box containing protein 0.0019 0.018 0.051
Brugia malayi Muscleblind-like protein 0.0174 0.3528 0.3988
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0202 0.0396
Leishmania major fatty-acid desaturase, putative 0.0215 0.4423 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.1505 0.2953
Echinococcus multilocularis cathepsin L cysteine protease 0.004 0.0628 0.1781
Echinococcus granulosus muscleblind protein 0.0174 0.3528 1
Echinococcus granulosus lamin 0.0031 0.0451 0.1279
Echinococcus multilocularis cathepsin l cysteine peptidase 0.004 0.0628 0.1781
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0346 0.0678
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.2865 0.8123
Loa Loa (eye worm) thioredoxin reductase 0.0077 0.1435 0.1596
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.018 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Echinococcus multilocularis cysteine protease 0.004 0.0628 0.1781
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.043 0.3949
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Echinococcus multilocularis cathepsin l cysteine peptidase 0.004 0.0628 0.1781
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.0017 0.015 0.0215
Onchocerca volvulus 0.0215 0.4423 0.4338
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0762 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0381 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.004 0.0628 0.0424
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0196 0.0161
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0648 0.068
Brugia malayi Cathepsin L-like precursor 0.004 0.0628 0.0658
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0628 0.067
Echinococcus multilocularis thioredoxin glutathione reductase 0.0078 0.1458 0.4132
Toxoplasma gondii TIM10 family protein, putative 0.0048 0.0804 0.194
Onchocerca volvulus 0.004 0.0628 0.0486
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0292 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.3031 0.6813
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0702 0.0499
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0491 0.0283
Echinococcus granulosus geminin 0.0173 0.3524 0.9991
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.1248 0.3256
Brugia malayi jmjC domain containing protein 0.0071 0.1298 0.1427
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0017 0.015 0.0424
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Giardia lamblia Grp94/Hsp90 0.0043 0.0702 0.8529
Echinococcus granulosus Fatty acid desaturase type 1 0.0017 0.015 0.0424
Leishmania major stearic acid desaturase, putative 0.0215 0.4423 1
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Leishmania major cathepsin L-like protease 0.0151 0.3031 0.6743
Loa Loa (eye worm) hypothetical protein 0.0019 0.018 0.0156
Toxoplasma gondii cathepsin CPL 0.004 0.0628 0.1419
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0187 0.0301
Loa Loa (eye worm) hypothetical protein 0.0031 0.0439 0.0453
Schistosoma mansoni lamin 0.0031 0.0451 0.0885
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Schistosoma mansoni cpg binding protein 0.0037 0.0584 0.1147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.2334 0.5216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0467
Onchocerca volvulus 0.0026 0.0346 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Plasmodium vivax endoplasmin, putative 0.0046 0.0762 0.177
Onchocerca volvulus 0.0033 0.0495 0.0351
Leishmania major cathepsin L-like protease 0.004 0.0628 0.112
Echinococcus granulosus cysteine protease 0.002 0.0214 0.0606
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0702 0.1292
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0628 0.1233
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0349 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0214 0.015
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0628 0.7556
Loa Loa (eye worm) hypothetical protein 0.0174 0.3528 0.3996
Plasmodium vivax thioredoxin reductase, putative 0.0077 0.1435 0.3457
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0269 0.0763
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.01 0.0285
Echinococcus multilocularis lamin 0.0031 0.0451 0.1279
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0346
Onchocerca volvulus 0.004 0.0628 0.0486
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0349 0.0735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.0762 0.1817
Plasmodium falciparum endoplasmin, putative 0.0033 0.0491 0.0805
Leishmania major cathepsin L-like protease 0.004 0.0628 0.112
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0672
Echinococcus multilocularis zinc finger protein 0.0025 0.0306 0.0869
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.1315 0.3728
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0017 0.015 0.0424
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0214 0.0181
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.1388 0.2723
Plasmodium vivax SET domain protein, putative 0.006 0.1076 0.2556
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.0762 0.1618
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.0762 1
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0017 0.015 0.0424
Leishmania major hypothetical protein, conserved 0.0018 0.0158 0.0019
Brugia malayi jmjC domain containing protein 0.0075 0.1388 0.153
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0676 0.1917
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0138 0.2748 0.6165
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0346 0.2404
Trypanosoma brucei heat shock protein 84, putative 0.003 0.043 0.0657
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0195 0.3987 1
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0198 0.4046 1
Echinococcus multilocularis lamin dm0 0.0031 0.0451 0.1279
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0349 0.0467
Echinococcus multilocularis cathepsin L cysteine protease 0.004 0.0628 0.1781
Loa Loa (eye worm) fibroinase 0.004 0.0628 0.067
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0214 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.004 0.0628 0.0424
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0202 0.0572
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0676 0.1917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0702 0.0499
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0349 0.0138
Schistosoma mansoni cathepsin s 0.0013 0.0056 0.011
Schistosoma mansoni heat shock protein 0.0046 0.0762 0.1496
Mycobacterium tuberculosis Probable reductase 0.0175 0.3564 0.8898
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0702 1
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0349 0.0672
Plasmodium vivax vivapain-3 0.002 0.0214 0.0395
Trypanosoma cruzi fatty acid desaturase, putative 0.0198 0.4046 0.9138
Loa Loa (eye worm) hypothetical protein 0.0176 0.3588 0.4066
Leishmania major cathepsin L-like protease 0.004 0.0628 0.112
Schistosoma mansoni hypothetical protein 0.0018 0.0158 0.031
Brugia malayi Endoplasmin precursor 0.0046 0.0762 0.0812
Trypanosoma cruzi ISWI complex protein 0.0018 0.0158 0.0233
Loa Loa (eye worm) fatty acid desaturase 0.0017 0.015 0.0121
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.018 0.0284
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0467
Loa Loa (eye worm) hypothetical protein 0.0019 0.018 0.0156
Brugia malayi Pre-SET motif family protein 0.0416 0.8761 1
Trypanosoma brucei ISWI complex protein 0.0018 0.0158 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.1505 0.2953
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.1435 0.3159
Loa Loa (eye worm) glutathione reductase 0.0077 0.1435 0.1596
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0762 0.1434
Onchocerca volvulus Cathepsin L homolog 0.004 0.0628 0.0486
Echinococcus multilocularis cysteine protease 0.004 0.0628 0.1781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0804 0.1614
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0349 0.0467
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Brugia malayi jmjC domain containing protein 0.0019 0.018 0.0142
Brugia malayi glutathione reductase 0.0077 0.1435 0.1585
Treponema pallidum heat shock protein 90 0.0043 0.0702 1
Plasmodium vivax glutathione reductase, putative 0.0077 0.1435 0.3457
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1298 0.3681
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.8761 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0346 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1076 0.2111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.2865 0.8123
Toxoplasma gondii heat shock protein 75, putative 0.003 0.043 0.0833
Brugia malayi jmjC domain containing protein 0.0019 0.018 0.0142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.1013 0.2871
Trypanosoma cruzi fatty acid desaturase, putative 0.0198 0.4046 0.9138
Trypanosoma cruzi fatty acid desaturase, putative 0.0215 0.4423 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0346 0.0333
Onchocerca volvulus 0.004 0.0628 0.0486
Brugia malayi Hsp90 protein 0.003 0.043 0.043
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.1505 0.4265
Loa Loa (eye worm) hypothetical protein 0.0019 0.018 0.0156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.1388 0.2723
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.043 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.062 0.129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0214 0.015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0077 0.1435 0.335
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1076 0.305
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0214 0.0361
Leishmania major cathepsin L-like protease 0.0151 0.3031 0.6743
Toxoplasma gondii Hsp90 domain-containing protein 0.0173 0.3522 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1076 0.2747
Brugia malayi TAR-binding protein 0.0127 0.2516 0.2826
Echinococcus multilocularis musashi 0.0031 0.0451 0.1279
Leishmania major cathepsin L-like protease 0.0151 0.3031 0.6743
Onchocerca volvulus 0.0031 0.0451 0.0306
Schistosoma mansoni fatty acid desaturase 0.0017 0.015 0.0294
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0017 0.015 0.0424
Mycobacterium tuberculosis Probable dehydrogenase 0.0175 0.3564 0.8898
Brugia malayi jmjC domain containing protein 0.0019 0.018 0.0142
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0648 0.1479
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0349 0.3616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0346 0.0135
Loa Loa (eye worm) hypothetical protein 0.0047 0.0797 0.0864
Echinococcus granulosus endoplasmin 0.0043 0.0702 0.1989
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0628 0.0658
Plasmodium falciparum thioredoxin reductase 0.0027 0.0349 0.0438
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.043 0.122
Brugia malayi Fatty acid desaturase family protein 0.0017 0.015 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Brugia malayi Cathepsin L-like precursor 0.004 0.0628 0.0658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0214 0.0361
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0217 0.0199
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0349 0.0438
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.018 0.009
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0349 0.0438
Onchocerca volvulus 0.0215 0.4423 0.4338
Echinococcus granulosus tar DNA binding protein 0.0127 0.2516 0.7132
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0214 0.0606
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0044 0.0125
Echinococcus multilocularis heat shock protein 90 0.0039 0.062 0.1756
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.018 0.051
Brugia malayi Pre-SET motif family protein 0.006 0.1076 0.1172
Brugia malayi hypothetical protein 0.0037 0.0563 0.0583
Echinococcus multilocularis geminin 0.0173 0.3524 0.9991
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.018 0.051
Brugia malayi Cathepsin L-like precursor 0.0026 0.0346 0.0333
Echinococcus multilocularis heat shock protein 90 0.0046 0.0762 0.2161
Brugia malayi PHD-finger family protein 0.0031 0.0441 0.0442
Schistosoma mansoni zinc finger protein 0.0025 0.0306 0.0601
Schistosoma mansoni cpg binding protein 0.0033 0.0495 0.0972
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0349 0.0672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2865 0.5623
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0804 0.1874
Schistosoma mansoni hypothetical protein 0.0173 0.3524 0.6916
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Plasmodium falciparum stearoyl-CoA desaturase 0.0198 0.4046 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0702 1
Toxoplasma gondii heat shock protein HSP90 0.0046 0.0762 0.1817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2865 0.5623
Leishmania major cathepsin L-like protease 0.004 0.0628 0.112
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0349 0.0685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.0121
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0048 0.0804 0.1578
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0136 0.0092
Loa Loa (eye worm) TAR-binding protein 0.0127 0.2516 0.2836
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0195 0.3987 1
Plasmodium falciparum thioredoxin reductase 0.0077 0.1435 0.3247
Brugia malayi Fatty acid desaturase family protein 0.0017 0.015 0.0108
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.1315 0.3728
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Onchocerca volvulus 0.004 0.0628 0.0486
Trypanosoma brucei heat shock protein, putative 0.0046 0.0762 0.1434
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0348 0.0137
Brugia malayi cathepsin L-like precursor 0.0026 0.0346 0.0333
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0762 0.1618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.3031 0.6743
Loa Loa (eye worm) fatty acid desaturase 0.0017 0.015 0.0121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0886 0.0966
Plasmodium vivax heat shock protein, putative 0.0173 0.3522 0.8686
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.0762 0.1434
Onchocerca volvulus 0.006 0.1076 0.094
Loa Loa (eye worm) RNA binding protein 0.0127 0.2516 0.2836
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0175 0.3564 0.8898
Loa Loa (eye worm) ctsf protein 0.004 0.0628 0.067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.01 0.0285
Echinococcus granulosus cathepsin l1 0.004 0.0628 0.1781
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0175 0.3564 0.8898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Loa Loa (eye worm) heat shock protein 75 0.003 0.043 0.0443
Echinococcus granulosus cathepsin l1 0.0026 0.0346 0.098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0051
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.1505 0.4265
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0017 0.015 0.0215
Echinococcus granulosus expressed protein 0.0048 0.0804 0.2279
Echinococcus granulosus intermediate filament protein 0.0031 0.0451 0.1279
Plasmodium falciparum glutathione reductase 0.0027 0.0349 0.0438
Schistosoma mansoni bromodomain containing protein 0.0075 0.1405 0.2757
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0056 0.0014
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.018 0.051
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.1388 0.3934
Loa Loa (eye worm) hypothetical protein 0.0013 0.0056 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0078 0.1458 0.4132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0628 0.0424
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0628 0.0424
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0762 0.0561
Plasmodium vivax unspecified product 0.002 0.0214 0.0395
Leishmania major heat shock protein 83-1 0.0046 0.0762 0.1434
Loa Loa (eye worm) cysteine protease 0.004 0.0628 0.067
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.3031 0.6813

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 9.4 nM Displacement of [3H]CGP12177 from human beta2 adrenoceptor ChEMBL. 20655218
Ki (binding) = 112 nM Displacement of [3H]CGP12177 from human beta-1 adrenoceptor ChEMBL. 20655218

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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