Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma japonicum | ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma mansoni | retinoic acid receptor RXR | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0277 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0119 | 0.3344 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0161 | 0.4873 | 0.4873 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.4873 | 0.4873 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0161 | 0.4873 | 0.4873 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0161 | 0.4873 | 0.4873 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.405 | 0.405 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1581 | 0.1581 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0128 | 0.3678 | 0.3678 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0277 | 0.0277 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0176 | 0.0362 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0176 | 0.0176 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.3344 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.3344 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0176 | 0.0176 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0119 | 0.3344 | 0.3344 |
Schistosoma mansoni | hypothetical protein | 0.03 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0119 | 0.3344 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0277 | 0.0277 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0277 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0277 | 0.5 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1581 | 0.1581 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.2791 | 0.5727 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0176 | 0.0176 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0161 | 0.4873 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0277 | 0.0829 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0277 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0277 | 0.0277 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0176 | 0.0362 |
Echinococcus multilocularis | snurportin 1 | 0.03 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0176 | 0.0176 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0277 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0176 | 0.0176 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0119 | 0.3344 | 0.3344 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0128 | 0.3678 | 0.3678 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.2791 | 0.2791 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0119 | 0.3344 | 0.3344 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.405 | 0.405 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.03 | 1 | 1 |
Onchocerca volvulus | 0.0093 | 0.2383 | 0.5 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0277 | 0.0569 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0277 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0277 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0176 | 0.0176 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0176 | 0.0176 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1906 | 0.3911 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0119 | 0.3344 | 0.3344 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0277 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0176 | 0.0176 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0277 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0277 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.2791 | 0.5727 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0176 | 0.0176 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.3344 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0277 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2791 | 0.2791 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0176 | 0.0176 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0277 | 0.0277 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0277 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1581 | 0.3244 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0277 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0123 | 0.35 | 0.35 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0119 | 0.3344 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0277 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1 uM | Agonist activity at human RXRalpha expressed in human COS7 cells by luciferase reporter gene assay | ChEMBL. | 20667726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.