TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 485.531 | Formula: C30H30O4P+
H donors: 0 H acceptors: 2 LogP: 5.79 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COC1=C(OC)C(=O)C(=C(C1=O)CCC[P+](c1ccccc1)(c1ccccc1)c1ccccc1)C
InChi: 1S/C30H30O4P/c1-22-26(28(32)30(34-3)29(33-2)27(22)31)20-13-21-35(23-14-7-4-8-15-23,24-16-9-5-10-17-24)25-18-11-6-12-19-25/h4-12,14-19H,13,20-21H2,1-3H3/q+1
InChiKey: IJSMMRLMQNSMGI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	disulfide oxidoreductase	0.0073	0.0225	0.0225
Schistosoma mansoni	glutamate synthase	0.0073	0.0225	0.0225
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0073	0.0225	0.2196
Plasmodium vivax	NAD(P)H-dependent glutamate synthase, putative	0.0073	0.0225	0.0731
Wolbachia endosymbiont of Brugia malayi	NADPH-dependent glutamate synthase beta chain	0.0073	0.0225	0.2155
Schistosoma mansoni	ferritin light chain	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0796	0.308	0.3891
Echinococcus multilocularis	lamin	0.0031	0.0058	0.0083
Trypanosoma cruzi	2,4-dienoyl-coa reductase fadh1, putative	0.0073	0.0225	0.0731
Leishmania major	trypanothione reductase	0.0796	0.308	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.1815	0.7108	0.8987
Mycobacterium leprae	THIOREDOXIN TRXC (TRX) (MPT46)	0.0073	0.0225	0.0278
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0202	0.0736	0.2391
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0159	0.0515
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.018	0.0584
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0805	0.3117	0.4504
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0276	0.1026	0.3329
Loa Loa (eye worm)	MH1 domain-containing protein	0.0043	0.0108	0.035
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0067	0.0219
Onchocerca volvulus		0.0259	0.0958	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.1815	0.7108	0.8987
Trypanosoma cruzi	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0073	0.0225	0.0731
Leishmania major	cathepsin L-like protease	0.0062	0.018	0.0584
Leishmania major	cathepsin L-like protease	0.0062	0.018	0.0584
Trypanosoma brucei	NADH dehydrogenase	0.0073	0.0225	0.0156
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0073	0.0225	0.0156
Leishmania major	NADH dehydrogenase, putative	0.0073	0.0225	0.0731
Schistosoma mansoni	sulfide quinone reductase	0.0073	0.0225	0.0225
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.2017	0.7908	1
Trichomonas vaginalis	glutamate synthase, putative	0.0073	0.0225	0.2196
Schistosoma mansoni	glutamate synthase	0.0073	0.0225	0.0225
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0276	0.1026	1
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0073	0.0225	0.0156
Mycobacterium tuberculosis	Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase)	0.0073	0.0225	0.0278
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0073	0.0225	0.2196
Schistosoma mansoni	smad1 5 8 and	0.0043	0.0108	0.0108
Echinococcus granulosus	lamin dm0	0.0031	0.0058	0.0083
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0276	0.1026	1
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0225	0.2155
Echinococcus multilocularis	NADPH:adrenodoxin oxidoreductase	0.0073	0.0225	0.0325
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Echinococcus granulosus	ferritin	0.0018	0.0005	0.0008
Mycobacterium ulcerans	NADH dehydrogenase	0.0073	0.0225	0.2155
Echinococcus granulosus	glutamate synthase	0.0073	0.0225	0.0325
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0073	0.0225	0.2155
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0073	0.0225	0.2196
Entamoeba histolytica	pyridine nucleotide-disulfide oxidoreductase family protein	0.0073	0.0225	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0638	0.2457	0.7977
Echinococcus granulosus	mothers against decapentaplegic 6	0.0019	0.0013	0.0018
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0073	0.0225	0.2196
Mycobacterium tuberculosis	NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase)	0.0073	0.0225	0.0278
Brugia malayi	glutamate synthase	0.0073	0.0225	0.0731
Schistosoma mansoni	cellular tumor antigen P53	0.0259	0.0958	0.0958
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0276	0.1026	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0067	0.0219
Echinococcus multilocularis	ferritin	0.0018	0.0005	0.0008
Schistosoma mansoni	hypothetical protein	0.0073	0.0225	0.0225
Echinococcus granulosus	mothers against decapentaplegic 2	0.0019	0.0013	0.0018
Brugia malayi	Thioredoxin reductase	0.0796	0.308	1
Leishmania major	hypothetical protein, conserved	0.0073	0.0225	0.0731
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0073	0.0225	0.2196
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0276	0.1026	1
Plasmodium falciparum	type II NADH:ubiquinone oxidoreductase	0.0073	0.0225	0.0731
Mycobacterium ulcerans	glutamate synthase subunit beta	0.0073	0.0225	0.2155
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0073	0.0225	0.2196
Leishmania major	hypothetical protein, conserved	0.0073	0.0225	0.0731
Brugia malayi	MH1 domain containing protein	0.0024	0.0031	0.0101
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0073	0.0225	0.0731
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0058	0.0187
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0019	0.0013	0.0133
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0073	0.0225	0.0731
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0043	0.0108	0.0156
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.2017	0.7908	1
Brugia malayi	MH1 domain containing protein	0.0024	0.0031	0.0101
Loa Loa (eye worm)	thioredoxin reductase	0.0796	0.308	1
Brugia malayi	MH2 domain containing protein	0.0638	0.2457	0.7977
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0073	0.0225	0.2196
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0225	0.0731
Loa Loa (eye worm)	programmed cell death 8	0.0073	0.0225	0.0731
Plasmodium vivax	thioredoxin reductase, putative	0.0796	0.308	1
Leishmania major	cathepsin L-like protease	0.0062	0.018	0.0584
Brugia malayi	intermediate filament protein	0.0031	0.0058	0.0187
Loa Loa (eye worm)	Smad1	0.0043	0.0108	0.035
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0058	0.0187
Plasmodium vivax	ferrodoxin reductase, putative	0.0073	0.0225	0.0731
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0073	0.0225	0.0731
Echinococcus granulosus	thioredoxin glutathione reductase	0.0805	0.3117	0.4504
Leishmania major	2,4-dienoyl-coa reductase-like protein	0.0073	0.0225	0.0731
Echinococcus multilocularis	pyridine nucleotide disulfide oxidoreductase	0.0073	0.0225	0.0325
Mycobacterium tuberculosis	Probable thioredoxin reductase TrxB2 (TRXR) (TR)	0.0073	0.0225	0.0278
Echinococcus granulosus	smad	0.0043	0.0108	0.0156
Echinococcus multilocularis	apoptosis inducing factor 1 mitochondrial	0.0073	0.0225	0.0325
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0001	0.0004
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0276	0.1026	0.3329
Schistosoma mansoni	apoferritin-2	0.0018	0.0005	0.0005
Trypanosoma brucei	trypanothione reductase	0.0796	0.308	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.1815	0.7108	0.8987
Brugia malayi	MH2 domain containing protein	0.0043	0.0108	0.035
Toxoplasma gondii	non-proton pumping type-II NADH dehydrogenase I	0.0073	0.0225	0.0731
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Mycobacterium leprae	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0073	0.0225	0.0278
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0019	0.0013	0.0018
Mycobacterium ulcerans	ferredoxin reductase	0.0073	0.0225	0.2155
Plasmodium falciparum	ferrodoxin reductase-like protein	0.0073	0.0225	0.0731
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0043	0.0108	0.0156
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0276	0.1026	0.3329
Loa Loa (eye worm)	hypothetical protein	0.0259	0.0958	0.3111
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.1815	0.7108	0.8987
Leishmania major	hypothetical protein, conserved	0.0073	0.0225	0.0731
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0073	0.0225	0.0156
Schistosoma mansoni	apoferritin-2	0.0018	0.0005	0.0005
Plasmodium falciparum	glutathione reductase	0.0796	0.308	1
Brugia malayi	MH1 domain containing protein	0.0043	0.0108	0.035
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0276	0.1026	0.2916
Schistosoma mansoni	smad1 5 8 and	0.0043	0.0108	0.0108
Trichomonas vaginalis	ferritin, putative	0.0018	0.0005	0.0052
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0276	0.1026	0.3329
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0073	0.0225	0.2196
Entamoeba histolytica	thioredoxin reductase, putative	0.0073	0.0225	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0638	0.2457	0.7977
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0276	0.1026	0.1482
Brugia malayi	mothers against decapentaplegic homolog 3	0.0019	0.0013	0.0041
Schistosoma mansoni	Smad4	0.0019	0.0013	0.0013
Mycobacterium ulcerans	dehydrogenase	0.0073	0.0225	0.2155
Trichomonas vaginalis	mercuric reductase, putative	0.0276	0.1026	1
Treponema pallidum	NADH oxidase	0.0276	0.1026	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0073	0.0225	0.0325
Schistosoma mansoni	ferritin	0.0018	0.0005	0.0005
Onchocerca volvulus		0.0031	0.0058	0.0601
Mycobacterium ulcerans	monoxygenase	0.0073	0.0225	0.2155
Echinococcus multilocularis	Smad4	0.0043	0.0108	0.0156
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.2017	0.7908	1
Trichomonas vaginalis	glutathione reductase, putative	0.0276	0.1026	1
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0019	0.0013	0.0018
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0073	0.0225	0.0731
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0276	0.1026	1
Echinococcus multilocularis	smad	0.0043	0.0108	0.0156
Schistosoma mansoni	glutamate synthase	0.0073	0.0225	0.0225
Treponema pallidum	oxidoreductase	0.0073	0.0225	0.2155
Echinococcus granulosus	apoptosis inducing factor 1 mitochondrial	0.0073	0.0225	0.0325
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0073	0.0225	0.2155
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0128	0.0416
Schistosoma mansoni	Smad4	0.0019	0.0013	0.0013
Plasmodium falciparum	NAD(P)H-dependent glutamate synthase, putative	0.0073	0.0225	0.0731
Echinococcus granulosus	NADPH:adrenodoxin oxidoreductase	0.0073	0.0225	0.0325
Trypanosoma cruzi	NADH dehydrogenase, putative	0.0073	0.0225	0.0731
Loa Loa (eye worm)	MH2 domain-containing protein	0.0019	0.0013	0.0041
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0225	0.0156
Mycobacterium tuberculosis	Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase)	0.0073	0.0225	0.0278
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0276	0.1026	0.3329
Brugia malayi	MH2 domain containing protein	0.0019	0.0013	0.0041
Echinococcus granulosus	expressed protein	0.0018	0.0005	0.0008
Schistosoma mansoni	ferritin	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Possible dehydrogenase/reductase	0.0073	0.0225	0.0278
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.018	0.0584
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.018	0.0584
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Trypanosoma cruzi	trypanothione reductase, putative	0.0796	0.308	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0128	0.0416
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0058	0.0187
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0073	0.0225	1
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0073	0.0225	0.0731
Schistosoma mansoni	smad	0.0043	0.0108	0.0108
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0276	0.1026	0.2916
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0013	0.0041
Mycobacterium ulcerans	thioredoxin reductase TrxB2	0.0073	0.0225	0.2155
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0276	0.1026	0.3329
Plasmodium falciparum	thioredoxin reductase	0.0796	0.308	1
Mycobacterium tuberculosis	Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate	0.0073	0.0225	0.0278
Mycobacterium ulcerans	NADH dehydrogenase Ndh1	0.0073	0.0225	0.2155
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0276	0.1026	0.1291
Toxoplasma gondii	NADPH-glutathione reductase	0.0276	0.1026	0.3329
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0073	0.0225	0.0731
Loa Loa (eye worm)	nuclear factor I	0.0024	0.0031	0.0101
Brugia malayi	MH2 domain containing protein	0.0043	0.0108	0.035
Brugia malayi	glutathione reductase	0.0796	0.308	1
Mycobacterium tuberculosis	Probable reductase	0.1815	0.7108	0.8987
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0128	0.0415
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Echinococcus granulosus	tumor protein p63	0.1767	0.6921	1
Mycobacterium leprae	Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE)	0.0073	0.0225	0.0278
Brugia malayi	Smad1	0.0043	0.0108	0.035
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0276	0.1026	0.3329
Schistosoma mansoni	ferritin	0.0018	0.0005	0.0005
Mycobacterium ulcerans	NADPH dependent 2,4-dienoyl-CoA reductase FadH	0.0073	0.0225	0.2155
Plasmodium vivax	type II NADH:ubiquinone oxidoreductase, putative	0.0073	0.0225	0.0731
Echinococcus granulosus	lamin	0.0031	0.0058	0.0083
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0073	0.0225	0.2196
Mycobacterium leprae	PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE)	0.0073	0.0225	0.0278
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0128	0.0416
Toxoplasma gondii	NADH dehydrogenase (NDH2-II)	0.0073	0.0225	0.0731
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0073	0.0225	0.2196
Loa Loa (eye worm)	hypothetical protein	0.003	0.0055	0.018
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0276	0.1026	0.3329
Echinococcus granulosus	mothers against decapentaplegic 5	0.0043	0.0108	0.0156
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0073	0.0225	1
Echinococcus granulosus	sulfide:quinone oxidoreductase	0.0073	0.0225	0.0325
Onchocerca volvulus		0.0031	0.0058	0.0601
Trichomonas vaginalis	glutamate synthase, putative	0.0073	0.0225	0.2196
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0276	0.1026	1
Echinococcus multilocularis	lamin dm0	0.0031	0.0058	0.0083
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprA	0.0073	0.0225	0.2155
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0073	0.0225	1
Plasmodium falciparum	glutathione reductase	0.0276	0.1026	0.3329
Echinococcus multilocularis	musashi	0.0031	0.0058	0.0083
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0225	0.0731
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0073	0.0225	0.0156
Plasmodium falciparum	thioredoxin reductase	0.0276	0.1026	0.3329
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0058	0.0058
Echinococcus multilocularis	expressed protein	0.0018	0.0005	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0225	0.0731
Trypanosoma cruzi	pyridine nucleotide-disulphide oxidoreductase, putative	0.0073	0.0225	0.0731
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0043	0.0108	0.0156
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0276	0.1026	1
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0276	0.1026	0.3329
Plasmodium vivax	glutathione reductase, putative	0.0796	0.308	1
Echinococcus granulosus	intermediate filament protein	0.0031	0.0058	0.0083
Echinococcus granulosus	pyridine nucleotide disulfide oxidoreductase	0.0073	0.0225	0.0325
Schistosoma mansoni	Smad4	0.0043	0.0108	0.0108
Mycobacterium tuberculosis	Probable oxidoreductase	0.2017	0.7908	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0276	0.1026	0.1026
Echinococcus multilocularis	sulfide:quinone oxidoreductase	0.0073	0.0225	0.0325
Echinococcus granulosus	Smad4	0.0043	0.0108	0.0156
Entamoeba histolytica	disulphide oxidoreductase, putative	0.0073	0.0225	1
Loa Loa (eye worm)	glutathione reductase	0.0796	0.308	1
Mycobacterium ulcerans	NADPH:adrenodoxin oxidoreductase FprB	0.0073	0.0225	0.2155
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0128	0.0416
Echinococcus multilocularis	tumor protein p63	0.1767	0.6921	1
Toxoplasma gondii	selenide, water dikinase	0.0073	0.0225	0.0731
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0276	0.1026	0.2916
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Toxoplasma gondii	thioredoxin reductase	0.0796	0.308	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0058	0.0187
Schistosoma mansoni	ferritin light chain	0.0018	0.0005	0.0005
Loa Loa (eye worm)	MH1 domain-containing protein	0.0019	0.0013	0.0041
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0073	0.0225	0.0731
Schistosoma mansoni	lamin	0.0031	0.0058	0.0058
Schistosoma mansoni	smad1 5 8 and	0.0043	0.0108	0.0108
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0073	0.0225	0.0731
Wolbachia endosymbiont of Brugia malayi	thioredoxin reductase	0.0073	0.0225	0.2155
Onchocerca volvulus		0.0073	0.0225	0.235
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.1815	0.7108	0.8987
Brugia malayi	MH1 domain containing protein	0.0043	0.0108	0.035
Leishmania major	2,4-dienoyl-coa reductase fadh1, putative	0.0073	0.0225	0.0731
Trypanosoma cruzi	2,4-dienoyl-coa reductase-like protein, putative	0.0073	0.0225	0.0731
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.018	0.0584
Schistosoma mansoni	hypothetical protein	0.0033	0.0067	0.0067
Trypanosoma cruzi	trypanothione reductase, putative	0.0276	0.1026	0.3329
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0276	0.1026	0.1482
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0073	0.0225	0.0325
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0202	0.0736	0.2391
Schistosoma mansoni	lamin	0.0031	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0101
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0001	0.0004
Schistosoma mansoni	ferritin	0.0018	0.0005	0.0005
Mycobacterium tuberculosis	Probable dehydrogenase	0.1815	0.7108	0.8987
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0276	0.1026	0.3329
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0073	0.0225	0.0325
Mycobacterium ulcerans	NADH dehydrogenase Ndh	0.0073	0.0225	0.2155
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0276	0.1026	0.3329
Schistosoma mansoni	sulfide quinone reductase	0.0073	0.0225	0.0225
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0276	0.1026	0.2916
Loa Loa (eye worm)	MH2 domain-containing protein	0.0043	0.0108	0.035
Echinococcus multilocularis	glutamate synthase	0.0073	0.0225	0.0325
Entamoeba histolytica	glutamate synthase beta subunit, putative	0.0073	0.0225	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0043	0.0108	0.0108
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0073	0.0225	0.0325
Toxoplasma gondii	pyridine nucleotide-disulfide oxidoreductase domain-containing protein	0.0073	0.0225	0.0731
Schistosoma mansoni	smad	0.0019	0.0013	0.0013
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0073	0.0225	0.2196
Treponema pallidum	thioredoxin reductase (trxB)	0.0073	0.0225	0.2155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1229091

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1172977