Detailed information for compound 1173104

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 812.818 | Formula: C37H41FN6O12S
  • H donors: 2 H acceptors: 8 LogP: 2.14 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNC(=O)c1c(oc2c1cc(C1CC1)c(c2)N(S(=O)(=O)C)CCOC(=O)CCC(=O)OC[C@H]1O[C@H]([C@H]2[C@@H]1OC(O2)(C)C)n1cnc(n1)C(=O)N)c1ccc(cc1)F
  • InChi: 1S/C37H41FN6O12S/c1-37(2)55-31-26(54-36(32(31)56-37)43-18-41-34(42-43)33(39)47)17-52-28(46)12-11-27(45)51-14-13-44(57(4,49)50)24-16-25-23(15-22(24)19-5-6-19)29(35(48)40-3)30(53-25)20-7-9-21(38)10-8-20/h7-10,15-16,18-19,26,31-32,36H,5-6,11-14,17H2,1-4H3,(H2,39,47)(H,40,48)/t26-,31-,32-,36-/m1/s1
  • InChiKey: KHKUSHBQGGXKHF-UETQYXGNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.009 0.036 0.0357
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Brugia malayi steroid hormone receptor 0.009 0.036 0.0627
Echinococcus granulosus jumonji domain containing protein 0.0405 0.216 0.2755
Loa Loa (eye worm) hypothetical protein 0.0047 0.0118 0.0208
Echinococcus granulosus GPCR family 2 0.0068 0.0234 0.0295
Brugia malayi beta-lactamase family protein 0.0038 0.0064 0.0108
Echinococcus multilocularis tumor protein p63 0.0371 0.1963 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.009 0.036 0.0631
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0089 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.009 0.036 0.0627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0412 0.0522
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Echinococcus granulosus zinc finger protein 0.0199 0.0985 0.1254
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0153 0.0879
Brugia malayi Pre-SET motif family protein 0.068 0.3723 0.6532
Onchocerca volvulus 0.0469 0.2524 0.4426
Schistosoma mansoni cpg binding protein 0.0098 0.0409 0.0518
Loa Loa (eye worm) PHD-finger family protein 0.0291 0.1509 0.2649
Schistosoma mansoni phd/f-box containing protein 0.0094 0.0384 0.0487
Schistosoma mansoni hypothetical protein 0.0291 0.1509 0.1924
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0053 0.0153 0.0925
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0156 0.0195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0042 0.0039
Schistosoma mansoni myst-related protein 0.0031 0.0022 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0425 0.2749
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0118 0.0148
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0954 0.5288 0.675
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0156 0.0153
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0094 0.0382 0.0484
Plasmodium vivax hypothetical protein, conserved 0.0291 0.1509 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0113
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0003 0.0005
Mycobacterium ulcerans hypothetical protein 0.0038 0.0064 0.5
Trichomonas vaginalis set domain proteins, putative 0.0773 0.4257 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0121 0.0213
Schistosoma mansoni nuclear hormone receptor 0.009 0.036 0.0456
Echinococcus granulosus retinoic acid receptor rxr beta a 0.009 0.036 0.0456
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0218
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0505 0.0502
Loa Loa (eye worm) hypothetical protein 0.038 0.2013 0.3534
Schistosoma mansoni RAR-like nuclear receptor 0.009 0.036 0.0456
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0089 0.0152
Schistosoma mansoni hypothetical protein 0.0181 0.088 0.1121
Mycobacterium ulcerans beta-lactamase 0.0038 0.0064 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0089 0.0157
Brugia malayi Bromodomain containing protein 0.0315 0.1643 0.288
Echinococcus multilocularis zinc finger protein 0.0199 0.0985 0.0982
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0095 0.0391 0.5048
Echinococcus granulosus FTZ F1 alpha 0.009 0.036 0.0456
Schistosoma mansoni jumonji domain containing protein 0.0094 0.0384 0.0487
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0089 0.0157
Echinococcus granulosus sterol regulatory element binding protein 0.0188 0.0919 0.117
Brugia malayi nuclear hormone receptor 0.009 0.036 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0268 0.1377 0.1755
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0101 0.0425 0.2711
Onchocerca volvulus Alhambra homolog 0.0291 0.1509 0.2645
Schistosoma mansoni retinoid-x-receptor (RXR) 0.009 0.036 0.0456
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0597 0.3249 0.4146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0064 0.0079
Echinococcus multilocularis protein dispatched 1 0.0214 0.107 0.1068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.009 0.036 0.0627
Loa Loa (eye worm) hypothetical protein 0.0128 0.0579 0.1016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0118 0.0208
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.0118 0.0208
Onchocerca volvulus Bile acid receptor homolog 0.009 0.036 0.0627
Echinococcus multilocularis phd:f box containing protein 0.0094 0.0384 0.0382
Trypanosoma brucei protein kinase, putative 0.0054 0.0156 0.1414
Trypanosoma brucei ISWI complex protein 0.0151 0.0711 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0438 0.2344 0.411
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0089 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.009 0.036 0.0456
Echinococcus multilocularis expressed conserved protein 0.0411 0.2192 0.219
Loa Loa (eye worm) hypothetical protein 0.0214 0.1068 0.1875
Brugia malayi PHD-finger family protein 0.012 0.0531 0.0927
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0153 0.1365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0412 0.0409
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.009 0.036 0.0627
Schistosoma mansoni steroid hormone receptor ad4bp 0.009 0.036 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.009 0.036 0.0627
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.009 0.036 0.0456
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0089 0.0111
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0008 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.009 0.036 0.0627
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0119 0.0524 0.0521
Schistosoma mansoni coup transcription factor 0.009 0.036 0.0456
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0053 0.0153 0.1364
Schistosoma mansoni phosphatidylserine receptor 0.0094 0.0384 0.0487
Onchocerca volvulus 0.1026 0.5698 1
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0919 0.2039
Echinococcus multilocularis peregrin 0.0315 0.1643 0.164
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0064 0.0335
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0214 0.1068 0.1875
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0954 0.5288 0.5287
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0089 0.0157
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0089 0.0152
Loa Loa (eye worm) hypothetical protein 0.0093 0.0376 0.066
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0156 0.1414
Loa Loa (eye worm) hypothetical protein 0.05 0.2696 0.4731
Brugia malayi beta-lactamase 0.0038 0.0064 0.0108
Brugia malayi hypothetical protein 0.0469 0.2524 0.4426
Schistosoma mansoni jumonji domain containing protein 0.0758 0.417 0.5322
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.009 0.036 0.0631
Schistosoma mansoni hypothetical protein 0.0068 0.0234 0.0295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.009 0.036 0.0627
Toxoplasma gondii PHD-finger domain-containing protein 0.0095 0.0391 0.2261
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0053 0.0153 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0377 0.1998 0.3507
Brugia malayi hypothetical protein 0.0047 0.0118 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0268 0.1377 0.1755
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0158 0.0198
Loa Loa (eye worm) CXXC zinc finger family protein 0.0098 0.0409 0.0717
Brugia malayi Nuclear hormone receptor family member nhr-19 0.009 0.036 0.0627
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Echinococcus multilocularis GPCR, family 2 0.0068 0.0234 0.0231
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0003 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.009 0.036 0.0627
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0156 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.009 0.036 0.0456
Brugia malayi MH2 domain containing protein 0.0384 0.204 0.3576
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0064 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0291 0.1509 0.1507
Echinococcus granulosus PHD finger protein rhinoceros 0.0291 0.1509 0.1924
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0212 0.1058 0.1347
Toxoplasma gondii isocitrate dehydrogenase 0.0053 0.0153 0.0611
Echinococcus multilocularis isocitrate dehydrogenase 0.0053 0.0153 0.015
Loa Loa (eye worm) hypothetical protein 0.0469 0.2524 0.4429
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0113
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0268 0.1377 0.1374
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0089 0.0111
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0153 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-41 0.009 0.036 0.0627
Loa Loa (eye worm) hypothetical protein 0.0291 0.1509 0.2649
Brugia malayi jmjC domain containing protein 0.0094 0.0384 0.067
Schistosoma mansoni hypothetical protein 0.0068 0.0234 0.0295
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0113
Echinococcus multilocularis cpg binding protein 0.0123 0.0549 0.0546
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0053 0.0153 0.1364
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0089 0.0152
Loa Loa (eye worm) hypothetical protein 0.07 0.3839 0.6738
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0094 0.0384 0.4943
Plasmodium falciparum phd finger protein, putative 0.0291 0.1509 1
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Onchocerca volvulus 0.0042 0.0089 0.0152
Loa Loa (eye worm) hypothetical protein 0.0054 0.0158 0.0277
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0234 0.0231
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0095 0.0391 0.2261
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0089 0.0111
Schistosoma mansoni bromodomain containing protein 0.0048 0.0121 0.0152
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0412 0.0522
Loa Loa (eye worm) hypothetical protein 0.0268 0.1377 0.2416
Echinococcus granulosus cpg binding protein 0.0123 0.0549 0.0697
Brugia malayi nuclear receptor RXR 0.0047 0.0118 0.0203
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0356 0.1876 0.1874
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0445 0.2382 0.3039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0234 0.0231
Schistosoma mansoni hypothetical protein 0.0068 0.0234 0.0295
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0053 0.0153 0.0191
Loa Loa (eye worm) hypothetical protein 0.0047 0.0118 0.0208
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0169 0.081 0.0808
Schistosoma mansoni zinc finger protein 0.0151 0.0711 0.0905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.009 0.036 0.0631
Echinococcus granulosus lysine specific demethylase 5A 0.0377 0.1998 0.2549
Echinococcus granulosus geminin 0.0943 0.5222 0.6665
Leishmania major hypothetical protein, conserved 0.0053 0.0153 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-25 0.009 0.036 0.0627
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0118 0.0203
Echinococcus multilocularis FTZ F1 alpha 0.009 0.036 0.0357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0234 0.0295
Onchocerca volvulus 0.0038 0.0064 0.0108
Brugia malayi isocitrate dehydrogenase 0.0053 0.0153 0.0263
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0064 0.5
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0053 0.0153 0.0757
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0089 0.0111
Echinococcus granulosus microtubule associated protein 2 0.0695 0.3812 0.4865
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0089 0.0152
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0053 0.0153 0.0191
Echinococcus multilocularis jumonji domain containing 1A 0.0094 0.0384 0.0382
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0156 0.1414
Plasmodium vivax JmjC domain containing protein 0.0094 0.0384 0.2475
Loa Loa (eye worm) hypothetical protein 0.0146 0.0682 0.1197
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.009 0.036 0.0357
Loa Loa (eye worm) hypothetical protein 0.0068 0.0234 0.0411
Entamoeba histolytica hypothetical protein 0.0115 0.0505 0.2081
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0064 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0384 0.0674
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.036 0.0357
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0118 0.0116
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0229 0.1152 0.115
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0099 0.0414 0.0412
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0005
Echinococcus granulosus Niemann Pick C1 protein 0.0438 0.2344 0.299
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.036 0.0456
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.009 0.036 0.0456
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0089 0.0152
Schistosoma mansoni jumonji/arid domain-containing protein 0.0377 0.1998 0.2549
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0053 0.0153 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0156 0.0195
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0064 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.009 0.036 0.0631
Schistosoma mansoni SET domain protein 0.003 0.0021 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0234 0.0406
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0153 0.0611
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0551 0.07
Echinococcus granulosus dnaJ subfamily B 0.1401 0.7833 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.009 0.036 0.0456
Brugia malayi Steroid receptor seven-up type 2 0.009 0.036 0.0627
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0064 0.0079
Loa Loa (eye worm) runx1 0.0059 0.0184 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.009 0.036 0.0631
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0064 0.0113
Schistosoma mansoni methyl-cpg binding protein mbd 0.0169 0.081 0.1031
Brugia malayi hypothetical protein 0.0034 0.0045 0.0074
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0095 0.0391 0.5048
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Plasmodium vivax SET domain protein, putative 0.0099 0.0414 0.2676
Echinococcus multilocularis microtubule associated protein 2 0.0695 0.3812 0.381
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Schistosoma mansoni patched 1 0.0188 0.0919 0.117
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0156 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-14 0.009 0.036 0.0627
Loa Loa (eye worm) hypothetical protein 0.023 0.116 0.2036
Brugia malayi hypothetical protein 0.0042 0.0089 0.0152
Brugia malayi hypothetical protein 0.0115 0.0505 0.0882
Brugia malayi jmjC domain containing protein 0.0094 0.0384 0.067
Schistosoma mansoni nuclear receptor 0.0042 0.0089 0.0111
Echinococcus multilocularis lysine specific demethylase 5A 0.0353 0.1859 0.1856
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0089 0.0111
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0597 0.3249 0.3247
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0153 0.1365
Brugia malayi ecdysone receptor 0.0042 0.0089 0.0152
Schistosoma mansoni hypothetical protein 0.0068 0.0234 0.0295
Echinococcus granulosus lysine specific demethylase 6a 0.0094 0.0384 0.0487
Echinococcus granulosus expressed conserved protein 0.0411 0.2192 0.2796
Entamoeba histolytica hypothetical protein 0.0115 0.0505 0.2081
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0218
Loa Loa (eye worm) hypothetical protein 0.0188 0.0919 0.1613
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0113
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0094 0.0384 0.0487
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Onchocerca volvulus 0.0054 0.0158 0.0272
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0153 0.0879
Loa Loa (eye worm) steroid hormone receptor 0.009 0.036 0.0631
Schistosoma mansoni jumonji/arid domain-containing protein 0.0377 0.1998 0.2549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0412 0.0522
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0376 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0099 0.0414 0.0526
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.009 0.036 0.0456
Toxoplasma gondii PHD-finger domain-containing protein 0.0291 0.1509 1
Echinococcus granulosus JmjC domain containing protein 4 0.0094 0.0384 0.0487
Loa Loa (eye worm) transcription factor SMAD2 0.0384 0.204 0.358
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0089 0.0087
Brugia malayi PHD-finger family protein 0.0291 0.1509 0.2645
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0053 0.0153 0.015
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0218
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0053 0.0153 0.1364
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0505 0.0642
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0505 0.0642
Schistosoma mansoni hypothetical protein 0.0943 0.5222 0.6665
Echinococcus multilocularis JmjC domain containing protein 4 0.0094 0.0384 0.0382
Loa Loa (eye worm) hypothetical protein 0.0438 0.2344 0.4113
Loa Loa (eye worm) hypothetical protein 0.0128 0.0579 0.1016
Loa Loa (eye worm) histone methyltransferase 0.0034 0.0042 0.0074
Brugia malayi F/Y-rich N-terminus family protein 0.0148 0.069 0.1207
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0234 0.0411
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Brugia malayi conserved hypotetical protein 0.0042 0.0089 0.0152
Onchocerca volvulus 0.0038 0.0064 0.0108
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0438 0.2344 1
Schistosoma mansoni lozenge 0.0059 0.0184 0.0231
Onchocerca volvulus Protein ultraspiracle homolog 0.009 0.036 0.0627
Schistosoma mansoni protein phosphatase 2C 0.0094 0.0384 0.0487
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0412 0.0522
Onchocerca volvulus 0.0038 0.0064 0.0108
Loa Loa (eye worm) hypothetical protein 0.0094 0.0384 0.0674
Onchocerca volvulus 0.0099 0.0414 0.0723
Toxoplasma gondii PHD-finger domain-containing protein 0.0291 0.1509 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0089 0.0087
Brugia malayi hypothetical protein 0.1026 0.5698 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.036 0.0357
Schistosoma mansoni thyroid hormone receptor 0.009 0.036 0.0456
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0053 0.0153 0.015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Brugia malayi nuclear receptor RXR 0.0042 0.0089 0.0152
Schistosoma mansoni nuclear receptor 0.0042 0.0089 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.009 0.036 0.0456
Loa Loa (eye worm) hypothetical protein 0.012 0.0531 0.0932
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0089 0.0111
Leishmania major hypothetical protein, conserved 0.0094 0.0384 0.4943
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0153 0.1365
Brugia malayi Nuclear hormone receptor family member nhr-1 0.009 0.036 0.0627
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0064 0.0108
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0118 0.0148
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0234 0.0406
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0008 0.0006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0156 0.1414
Brugia malayi jmjC domain containing protein 0.0377 0.1998 0.3504
Schistosoma mansoni bromodomain containing protein 0.0632 0.3451 0.4404
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Leishmania major hypothetical protein, conserved 0.0151 0.0711 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0188 0.0919 0.1613
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0156 0.1414
Brugia malayi PHD-finger family protein 0.0252 0.1286 0.2253
Trypanosoma cruzi ISWI complex protein 0.0151 0.0711 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0384 0.204 0.358
Loa Loa (eye worm) hypothetical protein 0.0428 0.2287 0.4013
Onchocerca volvulus 0.0093 0.0376 0.0655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.009 0.036 0.0631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0214 0.1068 0.1871
Echinococcus multilocularis jumonji domain containing protein 0.0405 0.216 0.2157
Onchocerca volvulus 0.009 0.036 0.0627
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0412 0.0718
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0094 0.0384 0.4943
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0089 0.0111
Loa Loa (eye worm) hypothetical protein 0.0047 0.0118 0.0208
Schistosoma mansoni hypothetical protein 0.0181 0.088 0.1121
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0156 0.1414
Brugia malayi hypothetical protein 0.0128 0.0579 0.1012
Schistosoma mansoni hypothetical protein 0.0181 0.088 0.1121
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0042 0.005
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0229 0.1152 0.1468
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.0089 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.009 0.036 0.0357
Brugia malayi Isocitrate dehydrogenase 0.0053 0.0153 0.0263
Schistosoma mansoni thyroid hormone receptor 0.009 0.036 0.0456
Echinococcus granulosus Niemann Pick C1 protein 0.0626 0.3415 0.4357
Brugia malayi Nuclear hormone receptor family member nhr-3 0.009 0.036 0.0627
Onchocerca volvulus Huntingtin homolog 0.0128 0.0579 0.1012
Echinococcus multilocularis Niemann Pick C1 protein 0.0438 0.2344 0.2341
Brugia malayi Bromodomain containing protein 0.0379 0.2009 0.3524
Loa Loa (eye worm) jmjC domain-containing protein 0.0602 0.3278 0.5753
Trypanosoma cruzi ISWI complex protein 0.0151 0.0711 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0412 0.0409
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0291 0.1509 0.1924
Brugia malayi photoreceptor-specific nuclear receptor 0.009 0.036 0.0627
Loa Loa (eye worm) hypothetical protein 0.0047 0.0118 0.0208
Entamoeba histolytica hypothetical protein 0.0115 0.0505 0.2081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0412 0.0722
Schistosoma mansoni methyl-cpg binding protein mbd 0.0169 0.081 0.1031
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0094 0.0384 0.4943
Brugia malayi nuclear hormone receptor 0.0042 0.0089 0.0152
Echinococcus granulosus histone lysine methyltransferase setb 0.0268 0.1377 0.1755
Schistosoma mansoni cpg binding protein 0.0123 0.0549 0.0697
Echinococcus multilocularis sterol regulatory element binding protein 0.0188 0.0919 0.0916
Schistosoma mansoni microtubule-associated protein tau 0.0695 0.3812 0.4865
Brugia malayi Bromodomain containing protein 0.0748 0.4113 0.7216
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0053 0.0153 0.0878
Onchocerca volvulus 0.0042 0.0089 0.0152
Echinococcus granulosus phd:f box containing protein 0.0094 0.0384 0.0487
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0384 0.0674
Giardia lamblia PHD finger protein 15 0.0291 0.1509 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0089 0.0152
Loa Loa (eye worm) hypothetical protein 0.009 0.036 0.0631
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0376 0.0655
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.009 0.036 0.0456
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0118 0.0203
Schistosoma mansoni hypothetical protein 0.0943 0.5222 0.6665
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0156 0.0634
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0099 0.0414 0.2423
Echinococcus granulosus jumonji domain containing 1A 0.0094 0.0384 0.0487
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0682 0.1193
Schistosoma mansoni hypothetical protein 0.0181 0.088 0.1121
Brugia malayi SET domain containing protein 0.003 0.0021 0.0031
Echinococcus granulosus methyl CpG binding domain protein 2 0.0169 0.081 0.1031
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0089 0.0111
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0053 0.0153 0.1364
Echinococcus granulosus Protein patched homolog 1 0.0188 0.0919 0.117
Loa Loa (eye worm) DR-78 0.0042 0.0089 0.0157
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0089 0.0152
Brugia malayi nuclear receptor NHR-88 0.0042 0.0089 0.0152
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.009 0.036 0.0357
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0089 0.0087
Brugia malayi MAP kinase sur-1 0.0054 0.0156 0.0269
Entamoeba histolytica hypothetical protein 0.0115 0.0505 0.2081
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0156 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-49 0.009 0.036 0.0627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0412 0.0522
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0356 0.1876 0.2392
Brugia malayi hypothetical protein 0.0042 0.0089 0.0152
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.009 0.036 0.0456
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0089 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-31 0.009 0.036 0.0627
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0384 0.0674
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Loa Loa (eye worm) hypothetical protein 0.0469 0.2524 0.4429
Schistosoma mansoni hypothetical protein 0.0204 0.1013 0.129
Brugia malayi Pre-SET motif family protein 0.0099 0.0414 0.0723
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.036 0.0456
Brugia malayi hypothetical protein 0.0053 0.0153 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0089 0.0087
Brugia malayi ecdysteroid receptor 0.009 0.036 0.0627
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0094 0.0384 0.2214
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0089 0.0111
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0156 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0099 0.0414 0.0526
Mycobacterium ulcerans lipase LipD 0.0038 0.0064 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.009 0.036 0.0456
Mycobacterium leprae Probable lipase LipE 0.0038 0.0064 0.5
Loa Loa (eye worm) hypothetical protein 0.0403 0.2147 0.3768
Echinococcus multilocularis Protein lozenge 0.0059 0.0184 0.0181
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.123 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.009 0.036 0.0357
Echinococcus multilocularis ecdysone induced protein 78C 0.009 0.036 0.0357
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0156 0.1414
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0156 0.1414
Echinococcus multilocularis lysine specific demethylase 6a 0.0094 0.0384 0.0382
Onchocerca volvulus 0.0098 0.0409 0.0713
Loa Loa (eye worm) bromodomain containing protein 0.0175 0.0845 0.1483
Schistosoma mansoni hypothetical protein 0.0095 0.0391 0.0496
Loa Loa (eye worm) hypothetical protein 0.1026 0.5698 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0008 0.0005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0053 0.0153 0.0268
Echinococcus multilocularis protein patched 0.0188 0.0919 0.0916
Schistosoma mansoni zinc finger protein 0.0042 0.0089 0.0111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0234 0.0295
Echinococcus granulosus tumor protein p63 0.0371 0.1963 0.2503
Onchocerca volvulus Huntingtin homolog 0.0128 0.0579 0.1012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0113
Echinococcus granulosus peregrin 0.0315 0.1643 0.2094
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0053 0.0153 0.1364
Loa Loa (eye worm) beta-lactamase 0.0038 0.0064 0.0113
Echinococcus granulosus fetal alzheimer antigen falz 0.0229 0.1152 0.1468
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.009 0.036 0.0456
Loa Loa (eye worm) hypothetical protein 0.0053 0.0153 0.0268
Onchocerca volvulus 0.0773 0.4257 0.7469
Brugia malayi jmjC domain containing protein 0.0954 0.5288 0.9281
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0157
Schistosoma mansoni hypothetical protein 0.0151 0.0711 0.0905
Echinococcus multilocularis dnaJ subfamily B 0.1401 0.7833 0.7832
Toxoplasma gondii histone lysine methyltransferase SET1 0.0213 0.1064 0.6921
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0094 0.0384 0.2214
Schistosoma mansoni hypothetical protein 0.0146 0.0682 0.0868
Brugia malayi nuclear receptor NHR-67 0.0042 0.0089 0.0152
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0113
Brugia malayi CXXC zinc finger family protein 0.0098 0.0409 0.0713
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0089 0.0087
Loa Loa (eye worm) PHD-finger family protein 0.0204 0.1013 0.1777
Schistosoma mansoni zinc finger protein 0.0199 0.0985 0.1254
Plasmodium falciparum JmjC domain-containing protein, putative 0.0094 0.0384 0.2436
Schistosoma mansoni cpg binding protein 0.0123 0.0549 0.0697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.009 0.036 0.0631
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0119 0.0524 0.0666
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0376 0.0373
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0008 0.0006
Brugia malayi AF-10 protein 0.0095 0.0391 0.0682
Onchocerca volvulus 0.003 0.0021 0.0031
Brugia malayi nuclear receptor NHR-88 0.009 0.036 0.0627
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.068 0.3723 0.6534
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0214 0.1068 0.1871
Schistosoma mansoni myst-related protein 0.0031 0.0022 0.0025
Brugia malayi CHE-14 protein 0.0188 0.0919 0.1609
Brugia malayi beta-lactamase family protein 0.0038 0.0064 0.0108
Schistosoma mansoni hypothetical protein 0.1401 0.7833 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0064 0.0079
Toxoplasma gondii isocitrate dehydrogenase 0.0053 0.0153 0.0611
Echinococcus multilocularis Niemann Pick C1 protein 0.0626 0.3415 0.3413
Echinococcus multilocularis geminin 0.0943 0.5222 0.522
Brugia malayi jmjC domain containing protein 0.0094 0.0384 0.067
Brugia malayi tailless protein 0.0042 0.0089 0.0152
Brugia malayi hypothetical protein 0.0047 0.0118 0.0203
Loa Loa (eye worm) hypothetical protein 0.0094 0.0384 0.0674
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0376 0.0476
Brugia malayi jmjC domain containing protein 0.0094 0.0384 0.067
Schistosoma mansoni hypothetical protein 0.0115 0.0505 0.0642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0118 0.0148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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