Detailed information for compound 1173180

Basic information

Technical information
  • TDR Targets ID: 1173180
  • Name: BIM-0047432.P001
  • MW: 311.12 | Formula: C13H8Cl2N2O3
  • H donors: 1 H acceptors: 3 LogP: 3.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C13H8Cl2N2O3/c14-11-5-4-9(7-12(11)15)16-13(18)8-2-1-3-10(6-8)17(19)20/h1-7H,(H,16,18)
  • InChiKey: ZDCNKUZQMGPRIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBMicro_047362
  • MixCom6_002306
  • N-(3,4-dichlorophenyl)-3-nitrobenzamide
  • N-(3,4-dichlorophenyl)-3-nitro-benzamide
  • Oprea1_388146
  • Oprea1_745655
  • ST011192
  • ZINC00103216

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Loa Loa (eye worm) aspartyl protease 6 0.0011 0.0418 0.0489
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.035 0.0645
Schistosoma mansoni opsin-like receptor 0.001 0.035 0.0582
Brugia malayi Pepsin A precursor 0.0011 0.0418 0.0518
Brugia malayi ORL1-like opioid receptor 0.001 0.035 0.0231
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.035 0.0645
Onchocerca volvulus 0.003 0.1565 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Brugia malayi neuropeptide F receptor 0.001 0.035 0.0231
Echinococcus granulosus neuropeptide receptor 0.001 0.035 0.0645
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.035 0.0582
Schistosoma mansoni amine GPCR 0.001 0.035 0.0582
Schistosoma mansoni biogenic amine receptor 0.001 0.035 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2648 0.4397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Schistosoma mansoni hypothetical protein 0.001 0.035 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.035 0.0231
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Echinococcus granulosus neuropeptide receptor 0.001 0.035 0.0645
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0011 0.0418 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2648 1
Schistosoma mansoni amine GPCR 0.001 0.035 0.0582
Schistosoma mansoni histamine h1 receptor 0.001 0.035 0.0582
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis g protein coupled receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.035 0.0582
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Echinococcus granulosus g protein coupled receptor 0.001 0.035 0.0645
Schistosoma mansoni memapsin-2 (A01 family) 0.0011 0.0418 0.0694
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.035 0.0582
Brugia malayi RE15519p 0.001 0.035 0.0231
Echinococcus granulosus serotonin receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.035 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Echinococcus multilocularis g-protein coupled receptor 0.001 0.035 0.0645
Brugia malayi hypothetical protein 0.0011 0.0418 0.0518
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni amine GPCR 0.001 0.035 0.0582
Schistosoma mansoni myosin xvIII 0.001 0.035 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.035 0.0582
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.035 0.0582
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.035 0.0645
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.035 0.0645
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0043 0.2302 0.2183
Echinococcus granulosus cpg binding protein 0.0032 0.1669 0.6015
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Brugia malayi larval opioid receptor 0.001 0.035 0.0231
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.035 0.0645
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Echinococcus granulosus neuropeptide receptor A26 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Brugia malayi Melatonin receptor type 1A 0.001 0.035 0.0231
Brugia malayi Dopamine receptor protein 1 0.001 0.035 0.0231
Plasmodium falciparum plasmepsin IX 0.0091 0.522 1
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0043 0.2302 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Brugia malayi G-protein coupled receptor 0.001 0.035 0.0231
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.035 0.0645
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus granulosus fmrfamide receptor 0.001 0.035 0.0645
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.035 0.0645
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.035 0.0582
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1565 0.5381
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Echinococcus multilocularis fmrfamide receptor 0.001 0.035 0.0645
Schistosoma mansoni biogenic amine receptor 0.001 0.035 0.0582
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.035 0.0201
Brugia malayi aspartic protease BmAsp-1, identical 0.0011 0.0418 0.0518
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.035 0.0645
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.035 0.0645
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Schistosoma mansoni adenoreceptor 0.001 0.035 0.0582
Brugia malayi Eukaryotic aspartyl protease family protein 0.0011 0.0418 0.0518
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.035 0.0231
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.035 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2648 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.035 0.0645
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.035 0.0231
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Brugia malayi Serotonin receptor 0.001 0.035 0.0231
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.035 0.0645
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0303 0.0453
Echinococcus multilocularis serotonin receptor 0.001 0.035 0.0645
Loa Loa (eye worm) TYRA-2 protein 0.001 0.035 0.0201
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.035 0.0231
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.035 0.0231
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.035 0.0231
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Schistosoma mansoni opsin-like receptor 0.001 0.035 0.0582
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.035 0.0582
Echinococcus multilocularis neuropeptide receptor 0.001 0.035 0.0645
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.035 0.0645
Echinococcus multilocularis serotonin receptor 0.001 0.035 0.0645
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.035 0.0231
Brugia malayi G protein-coupled receptor 0.001 0.035 0.0231
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis g protein coupled receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0489
Schistosoma mansoni neuropeptide receptor 0.001 0.035 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2648 1
Brugia malayi Serotonin receptor 0.001 0.035 0.0231
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.035 0.0582
Brugia malayi G-protein coupled receptor 0.001 0.035 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0303 0.0453
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.035 0.0582
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0043 0.2302 0.2183
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.035 0.0645
Brugia malayi aspartic protease BmAsp-2, identical 0.0011 0.0418 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.035 0.0645
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus granulosus neuropeptide s receptor 0.001 0.035 0.0645
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.035 0.0201
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.035 0.0645
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0011 0.0418 0.0489
Echinococcus multilocularis orexin receptor type 2 0.001 0.035 0.0645
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Schistosoma mansoni hypothetical protein 0.001 0.035 0.0582
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Echinococcus granulosus neuropeptide Y receptor 0.001 0.035 0.0645
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.2648 1
Brugia malayi Dopamine receptor 0.001 0.035 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0489
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Plasmodium vivax aspartyl protease, putative 0.0091 0.522 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Echinococcus multilocularis neuropeptide receptor 0.001 0.035 0.0645
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.035 0.0645
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0043 0.2302 0.2183
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.035 0.0645
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.035 0.0645
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.035 0.0645
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.7436 0.7396
Brugia malayi Dopamine receptor protein 2 0.001 0.035 0.0231
Schistosoma mansoni neuropeptide receptor 0.001 0.035 0.0582
Echinococcus granulosus allatostatin A receptor 0.001 0.035 0.0645
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0011 0.0418 0.092
Echinococcus multilocularis somatostatin receptor 0.001 0.035 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Echinococcus granulosus orexin receptor type 2 0.001 0.035 0.0645
Brugia malayi AKH receptor 0.001 0.035 0.0231
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0489
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.035 0.0645
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.035 0.0645
Schistosoma mansoni cpg binding protein 0.0032 0.1669 0.2772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Brugia malayi hypothetical protein 0.0011 0.0418 0.0518
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.035 0.0645
Schistosoma mansoni neuropeptide receptor 0.001 0.035 0.0582
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.017 1 1
Echinococcus multilocularis allatostatin A receptor 0.001 0.035 0.0645
Giardia lamblia NADPH oxidoreductase, putative 0.017 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus granulosus G protein coupled receptor 139 0.001 0.035 0.0645
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.035 0.0582
Schistosoma mansoni cathepsin D (A01 family) 0.0104 0.6021 1
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni amine GPCR 0.001 0.035 0.0582
Plasmodium vivax aspartyl protease, putative 0.0091 0.522 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0011 0.0418 0.092
Echinococcus granulosus g protein coupled receptor 0.001 0.035 0.0645
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.035 0.0582
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Echinococcus granulosus neuropeptides capa receptor 0.001 0.035 0.0645
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.035 0.0645
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis g protein coupled receptor 0.001 0.035 0.0645
Echinococcus granulosus hypothetical protein 0.001 0.035 0.0645
Echinococcus granulosus neuropeptides capa receptor 0.001 0.035 0.0645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2648 0.4397
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.035 0.0645
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.035 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Echinococcus granulosus g-protein coupled receptor 0.001 0.035 0.0645
Echinococcus granulosus g protein coupled receptor 0.001 0.035 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.3613 0.6001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.035 0.0582
Schistosoma mansoni biogenic amine receptor 0.001 0.035 0.0582
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.035 0.0645
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0043 0.2302 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2648 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.035 0.0645
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0011 0.0418 0.027
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni hypothetical protein 0.001 0.035 0.0582
Schistosoma mansoni hypothetical protein 0.001 0.035 0.0582
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.035 0.0201
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.035 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis fmrfamide receptor 0.001 0.035 0.0645
Entamoeba histolytica hypothetical protein 0.0043 0.2302 0.5
Schistosoma mansoni cathepsin D (A01 family) 0.0104 0.6021 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.035 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.3199 0.5792
Brugia malayi sulfakinin receptor protein 0.001 0.035 0.0231
Schistosoma mansoni amine GPCR 0.001 0.035 0.0582
Echinococcus granulosus sex peptide receptor 0.001 0.035 0.0645
Brugia malayi CXXC zinc finger family protein 0.003 0.1565 0.5396
Echinococcus multilocularis sex peptide receptor 0.001 0.035 0.0645
Brugia malayi GnHR receptor homolog 0.001 0.035 0.0231
Brugia malayi hypothetical protein 0.001 0.035 0.0231
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.035 0.0582
Onchocerca volvulus 0.0011 0.0418 0.0556
Plasmodium falciparum plasmepsin X 0.0091 0.522 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.035 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.035 0.0582
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.035 0.0645
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Schistosoma mansoni cpg binding protein 0.003 0.1565 0.2599
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.035 0.0582
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.017 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2648 0.4397
Schistosoma mansoni opsin-like receptor 0.001 0.035 0.0582
Toxoplasma gondii aspartyl protease ASP3 0.0091 0.522 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.035 0.0645
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Echinococcus granulosus neuropeptide Y receptor 0.001 0.035 0.0645
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.2648 1
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.2302 0.2183
Schistosoma mansoni neuropeptide receptor 0.001 0.035 0.0582
Brugia malayi follicle stimulating hormone receptor 0.001 0.035 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.035 0.0645
Echinococcus granulosus somatostatin receptor 0.001 0.035 0.0645
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0192 0.0319
Trichomonas vaginalis modulator of drug activity B, putative 0.0043 0.2302 0.2183
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.035 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.017 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.035 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.035 0.0645
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.035 0.0231
Giardia lamblia NADPH oxidoreductase, putative 0.017 1 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.035 0.0582
Onchocerca volvulus 0.0011 0.0418 0.0556
Echinococcus multilocularis neuropeptide s receptor 0.001 0.035 0.0645
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.035 0.0582
Brugia malayi neuropeptide F receptor 0.001 0.035 0.0231
Brugia malayi putative neuropeptide receptor 0.001 0.035 0.0231
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.035 0.0645
Loa Loa (eye worm) hypothetical protein 0.001 0.035 0.0201
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.035 0.0645
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0011 0.0418 0.0694
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.017 1 1
Echinococcus multilocularis cpg binding protein 0.0032 0.1669 0.6015
Schistosoma mansoni cpg binding protein 0.0032 0.1669 0.2772

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 22 % Antiparasitic activity against Trichomonas vaginalis T1 at 100 uM after 24 hrs by hemocytometric analysis ChEMBL. 20667728

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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