Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.292 | 0.0969 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.838 | 0.7934 |
Brugia malayi | RNA binding protein | 0.0064 | 0.838 | 0.7934 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0071 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.292 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.216 | 0.216 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.292 | 0.0969 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.216 | 0.7399 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.838 | 0.7934 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.838 | 0.838 |
Schistosoma mansoni | chromobox protein | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.838 | 0.838 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.838 | 0.838 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Cytotoxicity against human NCI-H460 cells after 72 hrs by SRB assay | ChEMBL. | 20702096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.