TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.253 | Formula: C17H18FIN4O2
H donors: 0 H acceptors: 3 LogP: 2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)F)CN1CCN(CC1)C(=O)c1nn(cc1I)C
InChi: 1S/C17H18FIN4O2/c1-21-10-14(19)16(20-21)17(25)23-8-6-22(7-9-23)11-15(24)12-2-4-13(18)5-3-12/h2-5,10H,6-9,11H2,1H3
InChiKey: AWERQXNYLVECDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0289	0.0575
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0275	0.0541
Trypanosoma cruzi	GUP1, putative	0.0023	0.01	0.3088
Brugia malayi	TAR-binding protein	0.0265	0.3155	0.457
Trypanosoma cruzi	glycerol uptake protein, putative	0.0023	0.01	0.3088
Schistosoma mansoni	lamin	0.0028	0.0163	0.0336
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0267	0.0524
Trypanosoma brucei	glycerol uptake protein, putative	0.0023	0.01	0.3088
Echinococcus granulosus	tar DNA binding protein	0.0265	0.3155	0.7125
Schistosoma mansoni	lamin	0.0028	0.0163	0.0336
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0023	0.01	0.0141
Loa Loa (eye worm)	hhat protein	0.0023	0.01	0.0316
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0315	0.0278
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0163	0.0515
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0558	0.1768
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0023	0.01	0.0062
Echinococcus granulosus	lamin dm0	0.0028	0.0163	0.0285
Trypanosoma cruzi	glycerol uptake protein, putative	0.0023	0.01	0.3088
Toxoplasma gondii	exonuclease III APE	0.0038	0.0289	1
Onchocerca volvulus		0.005	0.0439	1
Loa Loa (eye worm)	MBOAT family protein	0.0023	0.01	0.0316
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0418	0.0381
Schistosoma mansoni	hypothetical protein	0.0364	0.4412	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0038	0.0053
Schistosoma mansoni	tar DNA-binding protein	0.0265	0.3155	0.714
Echinococcus multilocularis	survival motor neuron protein 1	0.0243	0.2884	0.2856
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0418	0.0916
Loa Loa (eye worm)	RNA binding protein	0.0265	0.3155	1
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0289	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0316
Loa Loa (eye worm)	MBOAT family protein	0.0023	0.01	0.0316
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0288	0.0251
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0418	0.0605
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0752	0.1675
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0111	0.0218
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0173	0.036
Brugia malayi	MBOAT family protein	0.0023	0.01	0.0144
Loa Loa (eye worm)	TAR-binding protein	0.0265	0.3155	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0267	0.023
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0289	1
Brugia malayi	hypothetical protein	0.0035	0.0258	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0243	0.2884	0.9141
Loa Loa (eye worm)	MBOAT family protein	0.0023	0.01	0.0316
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0603	0.0567
Entamoeba histolytica	hypothetical protein	0.0035	0.0258	0.8332
Trypanosoma cruzi	glycerol uptake protein, putative	0.0023	0.01	0.3088
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0431	0.1367
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0046	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0156	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2754	0.8729
Echinococcus multilocularis	sterol O acyltransferase 1	0.0233	0.2754	0.2726
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0023	0.01	0.0062
Loa Loa (eye worm)	hhat protein	0.0023	0.01	0.0316
Echinococcus granulosus	lamin	0.0028	0.0163	0.0285
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0023	0.01	0.0062
Schistosoma mansoni	hypothetical protein	0.005	0.0439	0.0964
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0023	0.01	0.0316
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0154	0.1752	0.2538
Echinococcus granulosus	peregrin	0.0031	0.0205	0.0381
Brugia malayi	PHD-finger family protein	0.0026	0.0142	0.0206
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0163	0.0336
Schistosoma mansoni	tar DNA-binding protein	0.0265	0.3155	0.714
Brugia malayi	jmjC domain containing protein	0.0037	0.0275	0.0398
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0289	1
Echinococcus granulosus	geminin	0.0364	0.4412	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0603	0.1291
Brugia malayi	RNA binding protein	0.0265	0.3155	0.457
Echinococcus multilocularis	zinc finger protein	0.0021	0.0071	0.0034
Loa Loa (eye worm)	hypothetical protein	0.004	0.032	0.1015
Echinococcus granulosus	potassium voltage gated channel subfamily KQT	0.0069	0.0685	0.1479
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0267	0.8841
Schistosoma mansoni	bromodomain containing protein	0.0066	0.065	0.1444
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0315	0.0632
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0289	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0288	0.0571
Loa Loa (eye worm)	inositol-1	0.0036	0.0267	0.0848
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0023	0.01	0.0062
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0418	0.1324
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0418	0.0868
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0023	0.01	0.0141
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0289	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0267	0.8841
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0163	0.0515
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0038	0.0053
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0995	0.096
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0275	0.0591
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0289	0.0918
Brugia malayi	intermediate filament protein	0.0028	0.0163	0.0236
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0173	0.0549
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0069	0.0685	0.2171
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0023	0.01	0.0062
Schistosoma mansoni	ap endonuclease	0.0038	0.0289	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0352	0.1114
Leishmania major	glycerol uptake protein, putative	0.0023	0.01	0.3088
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0258	0.0502
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0267	0.8841
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0038	0.0053
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0289	1
Echinococcus multilocularis	lamin	0.0028	0.0163	0.0125
Echinococcus multilocularis	musashi	0.0028	0.0163	0.0125
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0267	0.8841
Schistosoma mansoni	hypothetical protein	0.0022	0.0085	0.0161
Leishmania major	glycerol uptake protein, putative	0.0023	0.01	0.3088
Echinococcus multilocularis	peregrin	0.0031	0.0205	0.0167
Loa Loa (eye worm)	voltage-gated potassium channel	0.0151	0.1719	0.5449
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0023	0.01	0.0141
Brugia malayi	MBOAT family protein	0.0023	0.01	0.0144
Leishmania major	hypothetical protein, conserved	0.0023	0.01	0.3088
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0163	0.0236
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0023	0.01	0.0193
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0275	0.087
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0258	0.0552
Brugia malayi	Inositol-1	0.0036	0.0267	0.0387
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0418	0.0916
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0023	0.01	0.0193
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0439	0.0636
Schistosoma mansoni	zinc finger protein	0.0021	0.0071	0.0129
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0023	0.01	0.0316
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0163	0.0515
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0289	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0289	1
Schistosoma mansoni	tar DNA-binding protein	0.0265	0.3155	0.714
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0023	0.01	0.0141
Onchocerca volvulus		0.0028	0.0163	0.1856
Schistosoma mansoni	tar DNA-binding protein	0.0265	0.3155	0.714
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0265	0.3155	1
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0154	0.1752	0.395
Brugia malayi	MBOAT family protein	0.0023	0.01	0.0144
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0289	1
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0267	0.0574
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0023	0.01	0.0193
Brugia malayi	MBOAT family protein	0.0023	0.01	0.0144
Echinococcus granulosus	sterol O acyltransferase 1	0.0233	0.2754	0.6208
Leishmania major	glycerol uptake protein, putative	0.0023	0.01	0.3088
Schistosoma mansoni	sterol O-acyltransferase 1	0.0233	0.2754	0.6228
Schistosoma mansoni	hypothetical protein	0.0364	0.4412	1
Schistosoma mansoni	zinc finger protein	0.0023	0.01	0.0193
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0173	0.0136
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0289	1
Schistosoma mansoni	hypothetical protein	0.0023	0.01	0.0193
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0111	0.0073
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0289	0.0252
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0023	0.01	0.0062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0418	0.0916
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0267	0.0574
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0275	0.0591
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0023	0.01	0.0062
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0023	0.01	0.0062
Echinococcus multilocularis	tar DNA binding protein	0.0265	0.3155	0.3129
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0023	0.01	0.0193
Brugia malayi	MBOAT family protein	0.0023	0.01	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0685	0.2171
Brugia malayi	diacylglycerol acyltransferase	0.0023	0.01	0.0144
Echinococcus granulosus	intermediate filament protein	0.0028	0.0163	0.0285
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0173	0.0549
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0173	0.3881
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0154	0.1752	0.3918
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0289	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0289	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0377	0.1195
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0173	0.3881
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0418	0.0868
Echinococcus granulosus	zinc finger protein	0.0021	0.0071	0.0076
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0289	1
Trypanosoma cruzi	GUP1, putative	0.0023	0.01	0.3088
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0038	0.0053
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0267	0.9199
Brugia malayi	PHD-finger family protein	0.0029	0.0173	0.0251
Brugia malayi	RNA recognition motif domain containing protein	0.0265	0.3155	0.457
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0023	0.01	0.0193
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0023	0.01	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0685	0.2171
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0995	0.2187
Brugia malayi	Bromodomain containing protein	0.0079	0.0805	0.1166
Schistosoma mansoni	tar DNA-binding protein	0.0265	0.3155	0.714
Echinococcus multilocularis	geminin	0.0364	0.4412	0.4391
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0289	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0418	0.0381
Brugia malayi	Bromodomain containing protein	0.004	0.0319	0.0463
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0023	0.01	0.0141
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0173	0.3881
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0173	0.0309
Schistosoma mansoni	hypothetical protein	0.0029	0.0173	0.036
Onchocerca volvulus		0.0028	0.0163	0.1856
Leishmania major	glycerol uptake protein, putative	0.0023	0.01	0.3088
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0249	0.0212
Brugia malayi	Hhat protein	0.0023	0.01	0.0144
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0267	0.9199
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0023	0.01	0.0193
Brugia malayi	jmjC domain containing protein	0.0094	0.0995	0.1441
Entamoeba histolytica	hypothetical protein	0.0035	0.0258	0.8332
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0316
Loa Loa (eye worm)	hypothetical protein	0.021	0.2466	0.7818
Leishmania major	glycerol uptake protein, putative	0.0023	0.01	0.3088
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0267	0.8841
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0289	0.0419
Schistosoma mansoni	ap endonuclease	0.0038	0.0289	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0038	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0748	0.2373
Brugia malayi	hypothetical protein	0.0243	0.2884	0.4177
Brugia malayi	Bromodomain containing protein	0.0031	0.0205	0.0296
Brugia malayi	Serotonin receptor	0.0561	0.6903	1
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0023	0.01	0.0141
Schistosoma mansoni	hypothetical protein	0.0035	0.0258	0.0552
Entamoeba histolytica	hypothetical protein	0.0035	0.0258	0.8332
Echinococcus multilocularis	lamin dm0	0.0028	0.0163	0.0125
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0258	0.0221
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0173	0.3881
Loa Loa (eye worm)	hypothetical protein	0.0023	0.01	0.0316
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0267	0.9199
Schistosoma mansoni	survival motor neuron protein	0.005	0.0439	0.0964
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0085	0.0271
Trypanosoma brucei	glycerol uptake protein, putative	0.0023	0.01	0.3088
Echinococcus granulosus	survival motor neuron protein 1	0.0243	0.2884	0.6505
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0023	0.01	0.0141
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0069	0.0685	0.0649
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0111	0.0166
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0154	0.1752	0.172
Onchocerca volvulus	Alhambra homolog	0.0029	0.0173	0.2172
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0267	0.9199
Entamoeba histolytica	hypothetical protein	0.0035	0.0258	0.8332

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4.5 nM	Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL.	20684606
Ki (binding)	= 3866 nM	Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293 cells after 1 hr by scintillation counting	ChEMBL.	20684606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1214950

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1173254