Detailed information for compound 1173342

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.533 | Formula: C23H34FN3O2
  • H donors: 1 H acceptors: 1 LogP: 4.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCO[C@@H]1CC[C@@](CC1)(C)N1CCC(CC1)n1c(=O)[nH]c2c1cc(C)c(c2)F
  • InChi: 1S/C23H34FN3O2/c1-4-13-29-18-5-9-23(3,10-6-18)26-11-7-17(8-12-26)27-21-14-16(2)19(24)15-20(21)25-22(27)28/h14-15,17-18H,4-13H2,1-3H3,(H,25,28)/t18-,23-
  • InChiKey: PXORDJUYHQIUMZ-RXAXNXDRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 4 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 1 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 5 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 2 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0116 0.0193
Loa Loa (eye worm) RNA binding protein 0.0256 0.2549 0.4054
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0295 0.0561
Plasmodium falciparum thioredoxin reductase 0.0016 0.0015 0.0178
Echinococcus multilocularis chromobox protein 1 0.0069 0.0581 0.0579
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi jmjC domain containing protein 0.0043 0.0304 0.0579
Brugia malayi Thioredoxin reductase 0.0045 0.0324 0.0617
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0195 0.1688
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0276 0.1023
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0276 0.0498
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0002 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.3585 0.6818
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0049 0.0046
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0121 0.0193
Trichomonas vaginalis ran, putative 0.0042 0.0295 0.0534
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0141 0.2007
Mycobacterium ulcerans lipase LipD 0.004 0.0276 0.1703
Onchocerca volvulus 0.0061 0.0495 0.1452
Loa Loa (eye worm) hypothetical protein 0.004 0.0276 0.0439
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0007 0.0005
Schistosoma mansoni chromobox protein 0.0069 0.0581 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.5252 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0034 0.0208 0.0757
Brugia malayi G protein-coupled receptor 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0098 0.0882 0.0975
Echinococcus multilocularis peregrin 0.0033 0.0195 0.0193
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0309 0.3109 0.4944
Loa Loa (eye worm) hypothetical protein 0.003 0.0171 0.0272
Loa Loa (eye worm) hypothetical protein 0.004 0.0276 0.0439
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0276 0.0439
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1375 0.445
Mycobacterium tuberculosis Probable reductase 0.0102 0.0931 0.359
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0116 0.0193
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.3072 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0276 0.0525
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3072 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0276 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.026 0.0468
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi PHD-finger family protein 0.0033 0.0195 0.0371
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0121 0.0132
Schistosoma mansoni hypothetical protein 0.061 0.6289 0.697
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0114 0.1051 0.4062
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0141 0.1862
Echinococcus granulosus importin subunit beta 1 0.0057 0.0454 0.0501
Brugia malayi CXXC zinc finger family protein 0.0061 0.0495 0.0942
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0581 0.0924
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0007 0.0005
Loa Loa (eye worm) glutathione reductase 0.0045 0.0324 0.0516
Loa Loa (eye worm) hypothetical protein 0.0033 0.0195 0.031
Schistosoma mansoni chromobox protein 0.0069 0.0581 0.0642
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0102 0.0931 0.359
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0171 0.1461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0049 0.0051
Brugia malayi Smad1 0.0026 0.0121 0.0231
Brugia malayi RE15519p 0.0014 0.0002 0.0004
Onchocerca volvulus 0.004 0.0276 0.0807
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0256 0.2549 0.4054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0882 0.1679
Brugia malayi MH1 domain containing protein 0.0026 0.0121 0.0231
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0354 0.3585 0.6818
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0304 0.0335
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0121 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0256 0.2549 0.2824
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0295 0.4223
Schistosoma mansoni cpg binding protein 0.0061 0.0495 0.0546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0403 0.1269
Brugia malayi beta-lactamase 0.004 0.0276 0.0525
Schistosoma mansoni Smad4 0.0026 0.0121 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0324 0.4651
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.033 0.0328
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0195 0.0214
Onchocerca volvulus 0.0042 0.029 0.0849
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0049 0.011
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3072 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0304 0.0945
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0454 0.0452
Schistosoma mansoni microtubule-associated protein tau 0.0711 0.7354 0.8152
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 0.4433
Mycobacterium tuberculosis Conserved protein 0.004 0.0276 0.1023
Brugia malayi TAR-binding protein 0.0256 0.2549 0.4854
Treponema pallidum bacterioferrin (TpF1) 0.0034 0.0208 0.2841
Loa Loa (eye worm) hypothetical protein 0.0039 0.026 0.0413
Echinococcus granulosus expressed protein 0.0034 0.0208 0.0228
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0116 0.0193
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0256 0.2549 0.4054
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0276 0.0854
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0102 0.0931 0.359
Echinococcus multilocularis expressed protein 0.0034 0.0208 0.0206
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0195 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0141 0.024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0171 0.0187
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0276 0.0498
Brugia malayi isocitrate dehydrogenase 0.0019 0.0049 0.0092
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0121 0.0119
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0694 0.0767
Brugia malayi Heterochromatin protein 1 0.0069 0.0581 0.1106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0171 0.0169
Schistosoma mansoni importin beta-1 0.0057 0.0454 0.0501
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0276 0.0303
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0015 0.0178
Schistosoma mansoni hypothetical protein 0.0098 0.0882 0.0975
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0276 0.0498
Schistosoma mansoni tar DNA-binding protein 0.0256 0.2549 0.2824
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0276 0.0854
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0694 0.0767
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.3821 0.6077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0049 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0002 0.0003
Echinococcus granulosus tar DNA binding protein 0.0256 0.2549 0.2824
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0141 0.2007
Plasmodium falciparum thioredoxin reductase 0.0045 0.0324 0.4651
Echinococcus multilocularis cpg binding protein 0.0065 0.0531 0.0529
Mycobacterium leprae Probable lipase LipE 0.004 0.0276 0.1478
Echinococcus multilocularis plexin a4 0.002 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0404 0.0402
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0049 0.0316
Brugia malayi MH2 domain containing protein 0.0026 0.0121 0.0231
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0276 0.1703
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0404 0.0445
Echinococcus granulosus smad 0.0026 0.0121 0.0132
Brugia malayi RNA binding protein 0.0256 0.2549 0.4854
Schistosoma mansoni smad 0.0026 0.0121 0.0132
Schistosoma mansoni plexin 0.0017 0.0031 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0002 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0276 0.1023
Echinococcus multilocularis snurportin 1 0.061 0.6289 0.6288
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2292 0.4349
Brugia malayi CHD4 protein 0.0015 0.0007 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0002 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.0711 0.7354 0.7354
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0049 0.0092
Mycobacterium ulcerans bacterioferritin BfrB 0.0034 0.0208 0.1259
Schistosoma mansoni tar DNA-binding protein 0.0256 0.2549 0.2824
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0002 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0049 0.011
Echinococcus granulosus chromobox protein 1 0.0069 0.0581 0.0642
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.034 0.062
Toxoplasma gondii hypothetical protein 0.0049 0.037 0.3332
Brugia malayi Melatonin receptor type 1A 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0049 0.0064
Plasmodium falciparum importin beta, putative 0.0057 0.0454 0.6524
Mycobacterium tuberculosis Conserved protein 0.004 0.0276 0.1023
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Mycobacterium leprae conserved hypothetical protein 0.004 0.0276 0.1478
Brugia malayi Calcitonin receptor-like protein seb-1 0.0309 0.3109 0.592
Echinococcus multilocularis chromobox protein 1 0.0069 0.0581 0.0579
Loa Loa (eye worm) histone methyltransferase 0.002 0.0061 0.0097
Brugia malayi beta-lactamase family protein 0.004 0.0276 0.0525
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0022 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.0102 0.0931 0.359
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0002 0.0003
Toxoplasma gondii hypothetical protein 0.0028 0.0141 0.1186
Leishmania major trypanothione reductase 0.0045 0.0324 0.1012
Schistosoma mansoni hypothetical protein 0.0348 0.3521 0.3902
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0002 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0276 0.0498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0049 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0581 0.1081
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0295 0.2622
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0304 0.0945
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0195 0.0214
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0049 0.0051
Giardia lamblia PHD finger protein 15 0.0033 0.0195 0.6438
Brugia malayi sulfakinin receptor protein 0.0014 0.0002 0.0004
Schistosoma mansoni ferritin 0.0034 0.0208 0.0228
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0114 0.1051 0.4062
Schistosoma mansoni hypothetical protein 0.0098 0.0882 0.0975
Plasmodium vivax SET domain protein, putative 0.003 0.0171 0.2432
Mycobacterium tuberculosis Conserved protein 0.004 0.0276 0.1023
Echinococcus granulosus cpg binding protein 0.0065 0.0531 0.0587
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1358 0.2159
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0141 0.024
Echinococcus granulosus Smad4 0.0026 0.0121 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.026 0.0468
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 1
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Onchocerca volvulus Glucosylceramidase homolog 0.0336 0.3395 1
Leishmania major hypothetical protein, conserved 0.004 0.0276 0.0854
Loa Loa (eye worm) hypothetical protein 0.0098 0.0882 0.1402
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0195 0.2782
Echinococcus multilocularis geminin 0.0348 0.3521 0.352
Schistosoma mansoni smad1 5 8 and 0.0026 0.0121 0.0132
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0694 0.6076
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.026 0.076
Loa Loa (eye worm) hypothetical protein 0.0056 0.0441 0.0701
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.034 0.062
Brugia malayi glutathione reductase 0.0045 0.0324 0.0617
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0061 0.0066
Mycobacterium ulcerans hypothetical protein 0.0161 0.1548 1
Leishmania major importin beta-1 subunit, putative 0.0046 0.034 0.1063
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 1
Brugia malayi MH1 domain containing protein 0.0014 0 0.0001
Brugia malayi GnHR receptor homolog 0.0014 0.0002 0.0004
Brugia malayi AKH receptor 0.0014 0.0002 0.0004
Toxoplasma gondii thioredoxin reductase 0.0045 0.0324 0.2899
Brugia malayi Serotonin receptor 0.0014 0.0002 0.0004
Echinococcus granulosus peregrin 0.0033 0.0195 0.0214
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Plasmodium falciparum phd finger protein, putative 0.0033 0.0195 0.2782
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0404 0.1524
Brugia malayi Dopamine receptor 0.0014 0.0002 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0276 0.0854
Loa Loa (eye worm) hypothetical protein 0.0211 0.2078 0.3305
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0034 0.0208 0.0731
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi Dopamine receptor protein 2 0.0014 0.0002 0.0004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0049 0.0132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0015 0.0178
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0331 0.0364
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0512 0.5252 0.8352
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0694 0.6367
Schistosoma mansoni ferritin 0.0034 0.0208 0.0228
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0295 0.0915
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0002 0.0004
Echinococcus granulosus GPCR family 2 0.0098 0.0882 0.0975
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0002 0.0004
Brugia malayi Probable ClpP-like protease 0.008 0.0694 0.1322
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.5252 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0276 0.3951
Echinococcus granulosus plexin a4 0.002 0.0064 0.0069
Brugia malayi neuropeptide F receptor 0.0014 0.0002 0.0004
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0116 0.0193
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0002 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0038 0.0044
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0295 0.0324
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0114 0.1051 1
Echinococcus granulosus dnaJ subfamily B 0.0869 0.9021 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0049 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1998 0.3177
Schistosoma mansoni tar DNA-binding protein 0.0256 0.2549 0.2824
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1358 0.2586
Schistosoma mansoni smad1 5 8 and 0.0026 0.0121 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.5252 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0116 0.0193
Echinococcus multilocularis smad 0.0026 0.0121 0.0119
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0049 0.0665
Onchocerca volvulus Alhambra homolog 0.0033 0.0195 0.0568
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0276 0.0498
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0304 0.0945
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 1
Brugia malayi MH2 domain containing protein 0.0376 0.3821 0.7276
Schistosoma mansoni apoferritin-2 0.0034 0.0208 0.0228
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0022 0.002
Echinococcus multilocularis muscleblind protein 1 0.015 0.1431 0.1429
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0049 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0116 0.0193
Brugia malayi RNA, U transporter 1 0.0163 0.1566 0.2981
Echinococcus granulosus snurportin 1 0.061 0.6289 0.697
Plasmodium falciparum glutathione reductase 0.0016 0.0015 0.0178
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0304 0.0335
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Trichomonas vaginalis ferritin, putative 0.0034 0.0208 0.0369
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0331 0.0328
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Schistosoma mansoni ferritin 0.0034 0.0208 0.0228
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0291 0.0852
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0694 0.0692
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0102 0.0931 0.359
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0291 0.0527
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0267 0.0265
Brugia malayi putative neuropeptide receptor 0.0014 0.0002 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1358 0.1356
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0882 0.0975
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0694 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1375 0.445
Schistosoma mansoni ferritin 0.0034 0.0208 0.0228
Brugia malayi RNA recognition motif domain containing protein 0.0256 0.2549 0.4854
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.034 0.1063
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0171 0.0187
Onchocerca volvulus 0.004 0.0276 0.0807
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0022 0.0022
Trichomonas vaginalis esterase, putative 0.004 0.0276 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1358 0.1503
Echinococcus multilocularis Smad4 0.0026 0.0121 0.0119
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0195 0.0193
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0276 0.1023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0276 0.1023
Brugia malayi MH1 domain containing protein 0.0026 0.0121 0.0231
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0121 0.0132
Brugia malayi ORL1-like opioid receptor 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0514 0.5276 0.839
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.5252 1
Schistosoma mansoni ran 0.0042 0.0295 0.0324
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0002 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0561 0.0893
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0404 0.1524
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.5252 1
Onchocerca volvulus 0.0017 0.0031 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0309 0.3109 0.592
Toxoplasma gondii ABC1 family protein 0.004 0.0276 0.2446
Plasmodium vivax importin-beta 2, putative 0.0057 0.0454 0.6524
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1548 0.6007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0007 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0882 0.1679
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0121 0.0193
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.1228 0.1359
Brugia malayi Serotonin receptor 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.015 0.1431 0.2276
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0034 0.0208 0.2841
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0121 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0304 0.0335
Schistosoma mansoni cpg binding protein 0.0065 0.0531 0.0587
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0882 0.088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0295 0.0469
Onchocerca volvulus 0.0231 0.2292 0.675
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0049 0.0077
Onchocerca volvulus 0.004 0.0276 0.0807
Brugia malayi neuropeptide F receptor 0.0014 0.0002 0.0004
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0276 0.1703
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0309 0.3109 0.4944
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0324 0.0516
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi Pre-SET motif family protein 0.003 0.0171 0.0325
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0145 0.0159
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0049 0.011
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0746 0.0825
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0116 0.0193
Schistosoma mansoni smad1 5 8 and 0.0026 0.0121 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0195 0.031
Brugia malayi G-protein coupled receptor 0.0014 0.0002 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.6289 1
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0276 0.1023
Schistosoma mansoni cpg binding protein 0.0065 0.0531 0.0587
Schistosoma mansoni tar DNA-binding protein 0.0256 0.2549 0.2824
Echinococcus multilocularis ferritin 0.0034 0.0208 0.0206
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0454 0.4114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0295 0.0915
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0102 0.0931 0.8676
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0512 0.5252 1
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0581 0.1081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0061 0.0059
Brugia malayi chromobox protein homolog 3 0.0039 0.026 0.0495
Brugia malayi MH1 domain containing protein 0.0014 0 0.0001
Mycobacterium tuberculosis Probable oxidoreductase 0.0114 0.1051 0.4062
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.029 0.0319
Echinococcus granulosus geminin 0.0348 0.3521 0.3902
Brugia malayi MH2 domain containing protein 0.0026 0.0121 0.0231
Echinococcus multilocularis GPCR, family 2 0.0098 0.0882 0.088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.2566 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0276 0.0303
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0295 0.0915
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0295 0.4223
Brugia malayi Importin beta-1 subunit 0.0057 0.0454 0.0864
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1358 0.1356
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0134 0.0147
Plasmodium falciparum glutathione reductase 0.0045 0.0324 0.4651
Echinococcus multilocularis muscleblind protein 0.015 0.1431 0.1429
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0049 0.0316
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0291 0.0527
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0276 0.1023
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0978 0.1082
Brugia malayi Pre-SET motif family protein 0.0204 0.1998 0.3804
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.3072 1
Brugia malayi plexin A 0.002 0.0064 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1358 0.1503
Loa Loa (eye worm) hypothetical protein 0.004 0.0276 0.0439
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0295 0.0293
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1082 1
Schistosoma mansoni hypothetical protein 0.0033 0.0195 0.0214
Mycobacterium ulcerans beta-lactamase 0.004 0.0276 0.1703
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0007 0.0005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0015 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0015 0.0178
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0171 0.0169
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0116 0.0193
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 0.4433
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0002 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0276 0.1023
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0002 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0049 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1375 0.445
Schistosoma mansoni hypothetical protein 0.0211 0.2078 0.2302
Onchocerca volvulus 0.003 0.0172 0.0499
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Schistosoma mansoni ferritin light chain 0.0034 0.0208 0.0228
Schistosoma mansoni apoferritin-2 0.0034 0.0208 0.0228
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0978 0.0976
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0014
Leishmania major GTP-binding protein, putative 0.0042 0.0295 0.0915
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0304 0.0484
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0495 0.0787
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1358 0.1503
Loa Loa (eye worm) hypothetical protein 0.015 0.1431 0.2276
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0454 0.1436
Brugia malayi Dopamine receptor protein 1 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0514 0.5276 0.839
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0002 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.3821 0.6077
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0454 0.1436
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Trypanosoma brucei trypanothione reductase 0.0045 0.0324 0.1012
Echinococcus granulosus microtubule associated protein 2 0.0711 0.7354 0.8152
Echinococcus granulosus muscleblind protein 0.015 0.1431 0.1585
Echinococcus multilocularis tar DNA binding protein 0.0256 0.2549 0.2548
Trichomonas vaginalis glucosylceramidase, putative 0.0512 0.5252 1
Plasmodium vivax glutathione reductase, putative 0.0045 0.0324 0.4651
Brugia malayi G-protein coupled receptor 0.0014 0.0002 0.0004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0102 0.0931 0.359
Brugia malayi larval opioid receptor 0.0014 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0454 0.0722
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0015 0.0178
Schistosoma mansoni ran 0.0042 0.0295 0.0324
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0694 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1358 0.1503
Brugia malayi latrophilin 2 splice variant baaae 0.0211 0.2078 0.3957
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1358 0.1503
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0276 0.0274
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0324 0.1012
Mycobacterium ulcerans bacterioferritin BfrA 0.0034 0.0208 0.1259
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0049 0.0665
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0404 0.2882
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0869 0.9021 1
Entamoeba histolytica hypothetical protein 0.0046 0.034 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0171 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi Plexin repeat family protein 0.0017 0.0031 0.0059
Brugia malayi jmjC domain containing protein 0.0107 0.0978 0.1862
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0324 0.1213
Mycobacterium ulcerans hypothetical protein 0.004 0.0276 0.1703
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0049 0.011
Schistosoma mansoni hypothetical protein 0.0348 0.3521 0.3902
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Brugia malayi beta-lactamase family protein 0.004 0.0276 0.0525
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0295 1
Trichomonas vaginalis importin beta-1, putative 0.0046 0.034 0.062
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Loa Loa (eye worm) nuclear factor I 0.0014 0 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0882 0.088
Brugia malayi hypothetical protein 0.0014 0.0002 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0882 0.0975
Loa Loa (eye worm) plexin A 0.002 0.0064 0.0102
Brugia malayi Muscleblind-like protein 0.015 0.1431 0.2725
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1104
Echinococcus granulosus ferritin 0.0034 0.0208 0.0228
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0882 0.1402
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0694 0.6367
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0002 0.0003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0002 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0336 0.3395 0.6454
Loa Loa (eye worm) Smad1 0.0026 0.0121 0.0193
Loa Loa (eye worm) hypothetical protein 0.004 0.0276 0.0439
Echinococcus granulosus chromobox protein 1 0.0069 0.0581 0.0642
Loa Loa (eye worm) beta-lactamase 0.004 0.0276 0.0439
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0034 0.0208 0.0757
Echinococcus granulosus jumonji domain containing protein 0.0045 0.033 0.0363
Brugia malayi Bromodomain containing protein 0.0033 0.0195 0.0371
Schistosoma mansoni ferritin light chain 0.0034 0.0208 0.0228
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0171 0.0326
Loa Loa (eye worm) hypothetical protein 0.004 0.0276 0.0439
Schistosoma mansoni hypothetical protein 0.0098 0.0882 0.0975
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0304 0.0945
Echinococcus multilocularis dnaJ subfamily B 0.0869 0.9021 0.9021
Loa Loa (eye worm) hypothetical protein 0.004 0.0276 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0171 0.0187
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0022 0.002

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 7.1 Agonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay ChEMBL. 20709550
EC50 (functional) = 7.7 Agonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay ChEMBL. 20709550
EC50 (functional) = 7.9 Agonist activity at human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 chimeric G-protein assessed as effect on calcium mobilization by FLIPR assay ChEMBL. 20709550
EC50 (functional) = 7.9 Agonist activity at human muscarinic M5 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay ChEMBL. 20709550
EC50 (functional) = 9.4 Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on calcium mobilization by FLIPR assay ChEMBL. 20709550

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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