Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.00639609 | 0.980922 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.00594309 | 0.903245 | 0.903245 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.00639609 | 0.980922 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.00639609 | 0.980922 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.00639609 | 0.980922 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.00650735 | 1 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.00639609 | 0.980922 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Schistosoma mansoni | immunophilin | 0.00650735 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.00650735 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.00650735 | 1 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.00639609 | 0.980922 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.00650735 | 1 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.00639609 | 0.980922 | 0.980922 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.00639609 | 0.980922 | 0.802819 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.00639609 | 0.980922 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.00639609 | 0.980922 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.00639609 | 0.980922 | 0.802819 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.00639609 | 0.980922 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.00639609 | 0.980922 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.00639609 | 0.980922 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.00639609 | 0.980922 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.00639609 | 0.980922 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.00650735 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of Plasmodium falciparum recombinant FabG at 20 uM by spectrophotometric analysis | ChEMBL. | 20614907 | |
Activity (binding) | Inhibition of Plasmodium falciparum recombinant FabZ at 20 uM by spectrophotometric analysis | ChEMBL. | 20614907 | |
IC50 (functional) | = 5.1 uM | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting | ChEMBL. | 20614907 |
IC50 (functional) | = 13.7 uM | Antileishmanial activity against Leishmania donovani (MHOM/ET/67/L82) amastigotes after 72 hrs | ChEMBL. | 20614907 |
IC50 (functional) | = 21.6 uM | Trypanocidal activity against trypomastigote form of Trypanosoma cruzi Tulahuen infected in rat L6 cells after 96 hrs | ChEMBL. | 20614907 |
IC50 (functional) | = 40.4 uM | Trypanocidal activity against Trypanosoma brucei rhodesiense STIB 900 after 72 hrs | ChEMBL. | 20614907 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 20614907 | |
Plasmodium falciparum | 20614907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.