Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 16 uM | Cytotoxicity against human A375 cells after 72 hrs by MTS assay | ChEMBL. | 20719505 |
IC50 (functional) | = 29 uM | Cytotoxicity against human DaOY cells after 72 hrs by MTS assay | ChEMBL. | 20719505 |
IC50 (functional) | = 34 uM | Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTS assay | ChEMBL. | 20719505 |
IC50 (functional) | = 39 uM | Cytotoxicity against human OVCAR-3 cells after 72 hrs by MTS assay | ChEMBL. | 20719505 |
IC50 (functional) | = 41 uM | Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay | ChEMBL. | 20719505 |
IC50 (functional) | = 65 uM | Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay | ChEMBL. | 20719505 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20719505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.