Detailed information for compound 1173476

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 888.92 | Formula: C37H44N8O14S2
  • H donors: 4 H acceptors: 15 LogP: -0.21 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCN1CCN(C(=O)C1=O)C(=O)NC(C(=O)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)O)(C)C)c1ccccc1.CCOC(=O)c1cnnn1C[C@@]1(C)[C@H](C(=O)O)C2C(S1(=O)=O)CC2=O
  • InChi: 1S/C23H27N5O7S.C14H17N3O7S/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;1-3-24-13(21)7-5-15-16-17(7)6-14(2)11(12(19)20)10-8(18)4-9(10)25(14,22)23/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);5,9-11H,3-4,6H2,1-2H3,(H,19,20)/t13?,14-,15+,20-;9?,10?,11-,14-/m10/s1
  • InChiKey: LIWUXHGARJWUJE-NVXKQBOLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0105 0.2388 0.4406
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.1618 0.2985
Loa Loa (eye worm) hypothetical protein 0.0032 0.0146 0.0125
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0109 0.0109
Mycobacterium ulcerans hypothetical protein 0.0164 0.4205 1
Echinococcus multilocularis muscleblind protein 1 0.0168 0.4347 0.4347
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.1019 0.1019
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1019 0.1165
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0183 0.479 0.8837
Schistosoma mansoni tar DNA-binding protein 0.0137 0.337 0.337
Mycobacterium ulcerans hydrolase 0.0105 0.2388 0.5679
Brugia malayi jmjC domain containing protein 0.0098 0.2181 0.3551
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0377 0.2333
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0377 0.0615
Loa Loa (eye worm) hypothetical protein 0.0051 0.0733 0.1092
Schistosoma mansoni ap endonuclease 0.004 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0351 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0437 0.0499
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.1019 0.1881
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0437 0.0499
Onchocerca volvulus 0.0122 0.2921 0.4051
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0493 0.0564
Brugia malayi Matrixin family protein 0.0086 0.1807 0.2943
Mycobacterium tuberculosis Probable dehydrogenase 0.0183 0.479 0.8837
Trichomonas vaginalis set domain proteins, putative 0.0258 0.7108 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0736 0.0736
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0377 0.0431
Echinococcus multilocularis dna polymerase eta 0.0115 0.2687 0.2687
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0736 0.0736
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0183 0.479 0.8837
Onchocerca volvulus 0.0032 0.0146 0.0108
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.014 0.3463 0.3463
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0265 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0146 0.0146
Echinococcus granulosus dna polymerase eta 0.0115 0.2687 0.2687
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.8753 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.1019 0.1019
Schistosoma mansoni ap endonuclease 0.004 0.0377 0.0377
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0377 1
Loa Loa (eye worm) matrixin family protein 0.0208 0.5586 0.9086
Echinococcus multilocularis transcription factor Dp 1 0.0081 0.1643 0.1643
Brugia malayi Matrixin family protein 0.0086 0.1807 0.2943
Trypanosoma brucei trypanothione reductase 0.008 0.1618 0.1848
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0736 0.1198
Loa Loa (eye worm) matrixin family protein 0.0191 0.5053 0.8208
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.4347 0.7046
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.1019 0.1881
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Plasmodium falciparum thioredoxin reductase 0.008 0.1618 1
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0101 0.0622
Trichomonas vaginalis rotamase, putative 0.0034 0.018 0.0253
Brugia malayi Bromodomain containing protein 0.003 0.007 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1019 0.1165
Loa Loa (eye worm) glutathione reductase 0.008 0.1618 0.255
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0377 0.0431
Plasmodium vivax hypothetical protein, conserved 0.003 0.007 0.0431
Mycobacterium tuberculosis Probable oxidoreductase 0.0203 0.542 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0101 0.0142
Echinococcus multilocularis geminin 0.0351 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0073 0.1392 0.8603
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.007 0.0431
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0265 0.0265
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0183 0.479 0.7921
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0377 0.0377
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0377 0.2333
Plasmodium vivax SET domain protein, putative 0.0032 0.0146 0.0902
Echinococcus granulosus muscleblind protein 0.0168 0.4347 0.4347
Trypanosoma brucei unspecified product 0.0042 0.0437 0.0499
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.1392 0.159
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0437 0.0499
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.007 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.1618 0.1848
Schistosoma mansoni DNA polymerase eta 0.0115 0.2687 0.2687
Echinococcus granulosus tar DNA binding protein 0.0137 0.337 0.337
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.1019 0.1564
Mycobacterium tuberculosis Probable reductase 0.0183 0.479 0.8837
Toxoplasma gondii hypothetical protein 0.005 0.0692 0.4278
Trichomonas vaginalis rotamase, putative 0.0034 0.0205 0.0288
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.014 0.3463 0.5639
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1058 0.1627
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.3463 0.3956
Echinococcus granulosus expressed protein 0.0034 0.0205 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0736 0.0736
Brugia malayi PHD-finger family protein 0.003 0.007 0.0114
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.2181 0.2181
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.2687 0.4375
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.8753 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0377 0.0898
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.018 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0137 0.337 0.337
Onchocerca volvulus Matrilysin homolog 0.0191 0.5053 0.708
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.8753 1
Echinococcus multilocularis tar DNA binding protein 0.0137 0.337 0.337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0736 0.0736
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.014 0.3463 0.3956
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1019 0.1165
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.018 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Brugia malayi Matrixin family protein 0.0208 0.5586 0.9096
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0377 0.0431
Echinococcus granulosus thioredoxin glutathione reductase 0.0081 0.1651 0.1651
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0101 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Loa Loa (eye worm) hypothetical protein 0.0086 0.1807 0.2861
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0493 0.0564
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.018 0.1112
Loa Loa (eye worm) hypothetical protein 0.0115 0.2687 0.431
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0433 0.0433
Trypanosoma brucei unspecified product 0.0042 0.0437 0.0499
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.337 0.5436
Giardia lamblia PHD finger protein 15 0.003 0.007 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0736 0.0736
Echinococcus multilocularis muscleblind protein 0.0168 0.4347 0.4347
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0146 0.0146
Brugia malayi Matrixin family protein 0.0086 0.1807 0.2943
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Loa Loa (eye worm) hypothetical protein 0.0156 0.3951 0.6393
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.007 0.007
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0265 0.0322
Schistosoma mansoni hypothetical protein 0.003 0.007 0.007
Leishmania major trypanothione reductase 0.008 0.1618 0.1848
Loa Loa (eye worm) hypothetical protein 0.0086 0.1807 0.2861
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.1019 0.166
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.3691 0.4216
Loa Loa (eye worm) RNA binding protein 0.0137 0.337 0.5436
Echinococcus multilocularis thioredoxin glutathione reductase 0.0081 0.1651 0.1651
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.2181 0.2181
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0101 0.0622
Onchocerca volvulus 0.0086 0.1807 0.2468
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0205 0.0288
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0313 0.8832 0.8832
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.014 0.3463 0.3463
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.1019 0.1434
Loa Loa (eye worm) hypothetical protein 0.0168 0.4347 0.7046
Schistosoma mansoni flap endonuclease-1 0.0028 0.0009 0.0009
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0205 0.0334
Echinococcus multilocularis expressed protein 0.0034 0.0205 0.0205
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0203 0.542 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0313 0.8832 0.8832
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.3691 0.4216
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0377 0.0431
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.6141 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0736 0.0736
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.1019 0.2733
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.337 0.5488
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0203 0.542 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0493 0.0564
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.3691 0.4216
Schistosoma mansoni hypothetical protein 0.0122 0.2921 0.2921
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0736 0.1097
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0101 0.0115
Plasmodium vivax thioredoxin reductase, putative 0.008 0.1618 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.337 0.337
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0101 0.0115
Plasmodium vivax glutathione reductase, putative 0.008 0.1618 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0183 0.479 0.8837
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0377 0.0823
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.018 0.0206
Brugia malayi RNA binding protein 0.0137 0.337 0.5488
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0086 0.1807 0.1807
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.007 0.0431
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.1019 0.1019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0493 0.0564
Echinococcus multilocularis peregrin 0.003 0.007 0.007
Brugia malayi Muscleblind-like protein 0.0168 0.4347 0.7079
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0377 0.0531
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0377 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0736 0.0736
Brugia malayi hypothetical protein 0.0156 0.3951 0.6434
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0377 0.0696
Brugia malayi Pre-SET motif family protein 0.0032 0.0146 0.0238
Toxoplasma gondii thioredoxin reductase 0.008 0.1618 1
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.1019 0.2424
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.3463 0.3956
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0146 0.0902
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.4205 0.7757
Echinococcus granulosus flap endonuclease 1 0.0031 0.0101 0.0101
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.1019 0.1434
Brugia malayi Thioredoxin reductase 0.008 0.1618 0.2635
Brugia malayi Flap endonuclease-1 0.0031 0.0101 0.0164
Trypanosoma cruzi DNA polymerase eta, putative 0.0115 0.2687 0.3069
Onchocerca volvulus Matrilysin homolog 0.0086 0.1807 0.2468
Leishmania major DNA polymerase eta, putative 0.0073 0.1392 0.159
Leishmania major DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0377 0.3703
Plasmodium falciparum flap endonuclease 1 0.0031 0.0101 0.0622
Brugia malayi TAR-binding protein 0.0137 0.337 0.5488
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0205 0.0223
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.1019 0.2424
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0101 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0183 0.479 0.8837
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0101 0.0101
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.018 0.0206
Echinococcus granulosus dna polymerase kappa 0.0061 0.1019 0.1019
Echinococcus granulosus peregrin 0.003 0.007 0.007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0146 0.0146
Brugia malayi Pre-SET motif family protein 0.0226 0.6141 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0265 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Plasmodium falciparum glutathione reductase 0.008 0.1618 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0191 0.5053 0.708
Trypanosoma brucei unspecified product 0.0061 0.1019 0.1165
Leishmania major DNA polymerase eta, putative 0.0115 0.2687 0.3069
Onchocerca volvulus 0.0156 0.3951 0.5514
Loa Loa (eye worm) hypothetical protein 0.0086 0.1807 0.2861
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.018 0.0206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0351 1 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.337 0.337
Toxoplasma gondii exonuclease III APE 0.004 0.0377 0.2333
Echinococcus multilocularis dna polymerase kappa 0.0061 0.1019 0.1019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0265 0.0265
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.3463 0.3956
Loa Loa (eye worm) TAR-binding protein 0.0137 0.337 0.5436
Loa Loa (eye worm) hypothetical protein 0.0105 0.2388 0.3818
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0203 0.542 1
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0101 0.0987
Brugia malayi glutathione reductase 0.008 0.1618 0.2635
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0146 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Schistosoma mansoni rotamase 0.0034 0.0205 0.0205
Loa Loa (eye worm) thioredoxin reductase 0.008 0.1618 0.255
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1019 0.1165
Loa Loa (eye worm) matrix metalloproteinase 0.0086 0.1807 0.2861
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.007 0.007
Schistosoma mansoni jumonji domain containing protein 0.0078 0.1556 0.1556
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0105 0.2388 0.3888
Giardia lamblia DINP protein human, muc B family 0.0061 0.1019 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.337 0.337
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0433 0.0433
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.014 0.3463 0.5589
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0146 0.0146
Plasmodium falciparum phd finger protein, putative 0.003 0.007 0.0431
Brugia malayi Hemopexin family protein 0.0122 0.2921 0.4756
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.014 0.3463 0.3463
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0146 0.0146
Echinococcus granulosus transcription factor Dp 1 0.0081 0.1643 0.1643
Trypanosoma brucei DNA polymerase eta, putative 0.0115 0.2687 0.3069
Onchocerca volvulus 0.0258 0.7108 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.014 0.3463 1
Brugia malayi jmjC domain containing protein 0.0036 0.0265 0.0432
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.1019 0.1019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0789 0.0901
Brugia malayi Matrixin family protein 0.0086 0.1807 0.2943
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.8753 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.1019 0.1165
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0377 0.0531
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0377 0.0507

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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