Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3694 | 0.3694 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.2501 | 0.2501 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.2501 | 0.2501 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3694 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0603 | 0.0603 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0286 | 0.0286 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3694 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0231 | 0.0231 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3694 | 0.3694 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0286 | 0.0286 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.1273 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3694 | 0.3694 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3694 | 0.3694 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0286 | 0.0286 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2788 | 0.7546 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.1273 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0286 | 0.0286 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2812 | 0.2812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3694 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2812 | 0.7612 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1273 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.2812 | 0.2812 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3694 | 0.3694 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2812 | 0.7612 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0231 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1273 | 0.1273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3694 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0152 | 1 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0231 | 0.0231 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1273 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2812 | 0.2812 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0286 | 0.0775 |
Brugia malayi | hypothetical protein | 0.0027 | 0.1273 | 0.1273 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.2812 | 0.2812 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.1273 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2296 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3694 | 0.3694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3694 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0286 | 0.0775 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1273 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2812 | 0.2812 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.1273 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.2501 | 0.2501 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3694 | 0.3694 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.2501 | 0.2501 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1273 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3694 | 0.3694 |
Echinococcus granulosus | muscleblind protein | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.209 | 0.209 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2812 | 0.2812 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2788 | 0.7546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2812 | 0.7612 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 338 nM | Antagonist activity at human kappa opioid receptor expressed in HEK cells assessed as inhibition of dynorphin A-induced [35S]GTPgammaS binding | ChEMBL. | 20719509 |
IC50 (functional) | = 3077 nM | Antagonist activity at human mu opioid receptor expressed in HEK cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding | ChEMBL. | 20719509 |
IC50 (functional) | > 30000 nM | Antagonist activity at human delta opioid receptor expressed in HEK cells assessed as inhibition of SNC-80-induced [35S]GTPgammaS binding | ChEMBL. | 20719509 |
IC50 (binding) | = 1.1 uM | Inhibition of human ERG by electrophysiology assay | ChEMBL. | 20719509 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.