Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.4799 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0037 | 0.4799 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0037 | 0.4799 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.4799 | 0.3645 |
Chlamydia trachomatis | pyruvate kinase | 0.0037 | 0.4799 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.4799 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Echinococcus multilocularis | pyruvate kinase | 0.0029 | 0.2722 | 0.2722 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.4799 | 0.3645 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4799 | 0.3645 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Schistosoma mansoni | pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0057 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0037 | 0.4799 | 0.4799 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0037 | 0.4799 | 0.3645 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0057 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0037 | 0.4799 | 0.4799 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0057 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.0037 | 0.4799 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0037 | 0.4799 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0057 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0057 | 1 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0037 | 0.4799 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0026 | 0.1816 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0037 | 0.4799 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.