Detailed information for compound 1174428

Basic information

Technical information
  • TDR Targets ID: 1174428
  • Name: 1,3-dihydroxy-6-methyl-10H-acridin-9-one
  • MW: 241.242 | Formula: C14H11NO3
  • H donors: 3 H acceptors: 3 LogP: 3.18 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)[nH]c1c(c2=O)c(O)cc(c1)O
  • InChi: 1S/C14H11NO3/c1-7-2-3-9-10(4-7)15-11-5-8(16)6-12(17)13(11)14(9)18/h2-6,16-17H,1H3,(H,15,18)
  • InChiKey: PRZVHWVUXFWKSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-Dihydroxy-6-methyl-9(10)-acridinone
  • NSC662136

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.024 0.5107 1
Echinococcus granulosus importin subunit beta 1 0.0032 0.0144 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.4412 0.5826
Brugia malayi RNA, U transporter 1 0.0091 0.1545 0.2774
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0248 0.5296 0.7033
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0248 0.5296 0.7022
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0144 0.0053
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0445 1 1
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0248 0.5296 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0248 0.5296 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0248 0.5296 1
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0445 1 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0144 0.0075
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0445 1 1
Echinococcus multilocularis snurportin 1 0.034 0.7498 1
Schistosoma mansoni importin beta-1 0.0032 0.0144 0.0053
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0248 0.5296 0.7022
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0105 0.0036
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0248 0.5296 0.5296
Loa Loa (eye worm) hypothetical protein 0.0032 0.0144 0.0053
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0248 0.5296 1
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0144 0.0075
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0248 0.5296 0.7022
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0445 1 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0248 0.5296 1
Brugia malayi Importin beta-1 subunit 0.0032 0.0144 0.0075
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0445 1 1
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0445 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.7498 1
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0248 0.5296 1
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0248 0.5296 1
Echinococcus granulosus snurportin 1 0.034 0.7498 1
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0248 0.5296 0.5228
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0248 0.5296 1
Trypanosoma brucei hypothetical protein, conserved 0.0445 1 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0248 0.5296 0.5296
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0248 0.5296 0.7022
Brugia malayi Pre-SET motif family protein 0.0211 0.4412 0.8297
Trichomonas vaginalis set domain proteins, putative 0.024 0.5107 0.9642
Schistosoma mansoni hypothetical protein 0.034 0.7498 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0248 0.5296 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 50 uM Antiproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy ChEMBL. 20452101

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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