TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 341.3 | Formula: C12H17N6O6+
H donors: 0 H acceptors: 5 LogP: 1.83 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: [O-]/[N+](=N\Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])/N1CC[N+](CC1)(C)C
InChi: 1S/C12H17N6O6/c1-18(2)7-5-14(6-8-18)17(23)13-24-12-4-3-10(15(19)20)9-11(12)16(21)22/h3-4,9H,5-8H2,1-2H3/q+1/b17-13-
InChiKey: XVPLIXKRBBGROX-LGMDPLHJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.0147	0.0133
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0039	0.0026
Mycobacterium ulcerans	lipase LipD	0.0297	0.035	0.0335
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.01	0.0087
Loa Loa (eye worm)	runx1	0.0054	0.0045	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0099	0.01	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0297	0.035	0.0335
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0297	0.035	0.0337
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	0.3946
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0007	0.0000099778
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0026	0.0013
Loa Loa (eye worm)	MH2 domain-containing protein	0.0033	0.0018	0.0005
Brugia malayi	TAR-binding protein	0.0125	0.0134	0.012
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0015	0.0003
Schistosoma mansoni	hypothetical protein	0.0031	0.0015	0.0002
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0015	0.0002
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.7964	1	1
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0018	0.0005
Loa Loa (eye worm)	phosphatidylinositol 3	0.0046	0.0034	0.002
Schistosoma mansoni	hypothetical protein	0.0031	0.0015	0.0002
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0003	0.0003
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0026	0.0026
Mycobacterium ulcerans	phosphoribosylamine--glycine ligase	0.0144	0.0157	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0434	0.0523	0.051
Brugia malayi	MH2 domain containing protein	0.0488	0.059	0.0578
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0072	0.0063
Onchocerca volvulus		0.0032	0.0016	0.0008
Schistosoma mansoni	inositol monophosphatase	0.004	0.0026	0.0013
Mycobacterium tuberculosis	Conserved protein	0.0297	0.035	0.0348
Wolbachia endosymbiont of Brugia malayi	phosphoribosylamine--glycine ligase	0.0144	0.0157	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.7964	1	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0061	0.0048
Mycobacterium ulcerans	esterase/lipase LipP	0.0297	0.035	0.0335
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0297	0.035	0.0337
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.001	0.0007
Loa Loa (eye worm)	MH2 domain-containing protein	0.0488	0.059	0.0578
Schistosoma mansoni	hypothetical protein	0.0125	0.0134	0.0121
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0297	0.035	0.0337
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.0134	0.012
Echinococcus multilocularis	tumor protein p63	0.2842	0.3553	0.3545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.001	0.0006
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0039	0.0036
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0297	0.035	0.0337
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0026	0.0041
Mycobacterium tuberculosis	Conserved protein	0.0297	0.035	0.0348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0022	0.0031
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0297	0.035	0.0337
Brugia malayi	MH2 domain containing protein	0.0033	0.0018	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0072	0.0059
Mycobacterium tuberculosis	Hypothetical protein	0.3789	0.4745	0.4743
Giardia lamblia	GTOR	0.0046	0.0034	0.5
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0416	0.05	0.0487
Brugia malayi	Inositol-1	0.004	0.0026	0.0013
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0061	0.0048
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.0134	0.012
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0046	0.0034	0.0012
Brugia malayi	Smad1	0.0033	0.0018	0.0005
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.7964	1	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0297	0.035	0.0724
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0046	0.0034	0.0012
Mycobacterium leprae	Probable lipase LipE	0.0297	0.035	0.0342
Leishmania major	hypothetical protein, conserved	0.0297	0.035	0.0329
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0015	0.0002
Trichomonas vaginalis	D-aminoacylase, putative	0.0297	0.035	0.0724
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0026	0.0004
Mycobacterium tuberculosis	Probable esterase LipL	0.0297	0.035	0.0348
Echinococcus multilocularis	Smad4	0.0033	0.0018	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0007	0.0000099778
Loa Loa (eye worm)	hypothetical protein	0.0297	0.035	0.0337
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.7964	1	1
Schistosoma mansoni	inositol monophosphatase	0.004	0.0026	0.0013
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0297	0.035	0.0348
Mycobacterium tuberculosis	Probable lipase LipE	0.0297	0.035	0.0348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Loa Loa (eye worm)	thymidylate synthase	0.7964	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Brugia malayi	MH2 domain containing protein	0.0033	0.0018	0.0005
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0046	0.0034	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0015	0.0016
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0046	0.0034	1
Toxoplasma gondii	ABC1 family protein	0.0297	0.035	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Mycobacterium tuberculosis	Conserved protein	0.0297	0.035	0.0348
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0026	0.0014
Onchocerca volvulus		0.0416	0.05	0.0492
Brugia malayi	beta-lactamase family protein	0.0297	0.035	0.0337
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0072	0.0063
Schistosoma mansoni	microtubule-associated protein tau	0.2768	0.346	0.3451
Trichomonas vaginalis	D-aminoacylase, putative	0.0297	0.035	0.0724
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0046	0.0034	0.002
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0015	0.0002
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0046	0.0034	0.0022
Echinococcus granulosus	Smad4	0.0033	0.0018	0.0006
Echinococcus multilocularis	thymidylate synthase	0.7964	1	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0015	0.0002
Trichomonas vaginalis	penicillin-binding protein, putative	0.0297	0.035	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0297	0.035	0.0337
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0072	0.0059
Onchocerca volvulus		0.0235	0.0272	0.0264
Echinococcus multilocularis	Protein lozenge	0.0054	0.0045	0.0031
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0135	0.0147	0.0133
Onchocerca volvulus		0.0297	0.035	0.0343
Trypanosoma brucei	hypothetical protein, conserved	0.0297	0.035	0.035
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0046	0.0034	1
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.0134	0.012
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0072	0.0063
Brugia malayi	hypothetical protein	0.0434	0.0523	0.051
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.0134	0.012
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0034	0.0019	0.001
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1899	0.2367	0.2365
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.0134	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0022	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0297	0.035	0.0337
Brugia malayi	beta-lactamase	0.0297	0.035	0.0337
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.7964	1	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.3789	0.4745	0.4733
Mycobacterium leprae	PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT	0.0144	0.0157	0.0148
Trichomonas vaginalis	D-aminoacylase, putative	0.0297	0.035	0.0724
Brugia malayi	Pre-SET motif family protein	0.0206	0.0236	0.0223
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0026	0.001
Trypanosoma cruzi	hypothetical protein, conserved	0.0297	0.035	0.0329
Brugia malayi	MH1 domain containing protein	0.0033	0.0018	0.0005
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0015	0.0002
Schistosoma mansoni	hypothetical protein	0.0068	0.0061	0.0048
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0046	0.0034	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0007	0.0000099778
Mycobacterium ulcerans	beta-lactamase	0.0297	0.035	0.0335
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0018	0.0005
Echinococcus multilocularis	smad	0.0033	0.0018	0.0005
Brugia malayi	Probable ClpP-like protease	0.0076	0.0072	0.0059
Echinococcus granulosus	tumor protein p63	0.2842	0.3553	0.3546
Echinococcus granulosus	tar DNA binding protein	0.0125	0.0134	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0013	0.0013
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.0134	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0025	0.0038
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.7964	1	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0039	0.0036
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0015	0.0003
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0072	0.0063
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.0134	0.012
Brugia malayi	MH1 domain containing protein	0.0033	0.0018	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0297	0.035	0.0337
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	0.0063
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.7964	1	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0033	0.0018	0.0005
Brugia malayi	RNA binding protein	0.0125	0.0134	0.012
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.0147	0.0133
Onchocerca volvulus		0.0297	0.035	0.0343
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.7964	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0022	0.0031
Echinococcus multilocularis	microtubule associated protein 2	0.2768	0.346	0.3451
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.0236	0.0223
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0046	0.0034	0.0012
Loa Loa (eye worm)	RNA binding protein	0.0125	0.0134	0.012
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0015	0.0002
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0033	0.0018	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0034	0.0056
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0039	0.003
Echinococcus granulosus	microtubule associated protein 2	0.2768	0.346	0.3452
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0033	0.0018	0.0006
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0026	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.001	0.0007
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0022	0.0022
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.0134	0.0121
Echinococcus granulosus	GPCR family 2	0.0031	0.0015	0.0003
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0026	0.0041
Loa Loa (eye worm)	beta-lactamase	0.0297	0.035	0.0337
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0046	0.0034	0.0034
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0015	0.0002
Schistosoma mansoni	smad1 5 8 and	0.0033	0.0018	0.0005
Schistosoma mansoni	smad	0.0033	0.0018	0.0005
Mycobacterium leprae	PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE)	0.0032	0.0016	0.0007
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.0134	0.012
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.7964	1	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0033	0.0018	0.0005
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0033	0.0018	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Trichomonas vaginalis	esterase, putative	0.0297	0.035	0.0724
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0046	0.0034	0.0034
Loa Loa (eye worm)	transcription factor SMAD2	0.0488	0.059	0.0578
Onchocerca volvulus		0.0434	0.0523	0.0515
Schistosoma mansoni	cellular tumor antigen P53	0.0416	0.05	0.0487
Trypanosoma cruzi	hypothetical protein, conserved	0.0297	0.035	0.0329
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.01	0.0087
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.0134	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0297	0.035	0.0337
Mycobacterium tuberculosis	Probable lipase LipD	0.0297	0.035	0.0348
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0026	0.0726
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0072	0.006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Echinococcus granulosus	thymidylate synthase	0.7964	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0015	0.0002
Mycobacterium tuberculosis	Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase)	0.0032	0.0016	0.0014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0019	0.0025
Schistosoma mansoni	Smad4	0.0033	0.0018	0.0005
Mycobacterium tuberculosis	Probable hydrolase	0.0297	0.035	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.3789	0.4745	1
Brugia malayi	hypothetical protein	0.3789	0.4745	0.4738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0022	0.0031
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0026	0.0004
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0297	0.035	0.0348
Onchocerca volvulus		0.0297	0.035	0.0343
Schistosoma mansoni	lozenge	0.0054	0.0045	0.0031
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0034	0.0056
Echinococcus granulosus	mothers against decapentaplegic 5	0.0033	0.0018	0.0006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.001	0.0006
Mycobacterium ulcerans	hypothetical protein	0.0297	0.035	0.0335
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.01	0.0087
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0297	0.035	0.0348
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	0.0056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0034	0.0056
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.0021	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0007	0.0000099778
Brugia malayi	beta-lactamase family protein	0.0297	0.035	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0297	0.035	0.0337
Loa Loa (eye worm)	inositol-1	0.004	0.0026	0.0013
Mycobacterium leprae	conserved hypothetical protein	0.0297	0.035	0.0342
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0039	0.0027
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.0134	0.012
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0046	0.0034	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0434	0.0523	0.051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0022	0.0031
Echinococcus granulosus	smad	0.0033	0.0018	0.0006
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0013	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.001	0.0007
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0021	0.0019
Onchocerca volvulus		0.7964	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0013	0.0001
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0026	0.0041
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0072	0.0059
Loa Loa (eye worm)	Smad1	0.0033	0.0018	0.0005
Onchocerca volvulus		0.003	0.0013	0.0005
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.0272	0.0558
Plasmodium vivax	hypothetical protein, conserved	0.0297	0.035	0.0342
Plasmodium vivax	SET domain protein, putative	0.003	0.0013	0.0004
Mycobacterium ulcerans	thymidylate synthase	0.7964	1	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	0.0056
Echinococcus granulosus	beta LACTamase domain containing family member	0.0297	0.035	0.0339
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0072	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0015	0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1196979

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1174653