TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.317 | Formula: C20H19Cl2N7O
H donors: 2 H acceptors: 4 LogP: 3.5 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NCc1c(C)nc2n(c1c1ccc(cc1Cl)Cl)cc(n2)C(=O)Nc1cc(nn1C)C
InChi: 1S/C20H19Cl2N7O/c1-10-6-17(28(3)27-10)26-19(30)16-9-29-18(13-5-4-12(21)7-15(13)22)14(8-23)11(2)24-20(29)25-16/h4-7,9H,8,23H2,1-3H3,(H,26,30)
InChiKey: BVKYXWNXHBSXKO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 9	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 8	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus multilocularis	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania mexicana	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma japonicum	ko:K08656 dipeptidyl-peptidase 9, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129743	All targets in OG5_129743
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania braziliensis	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus granulosus	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma brucei gambiense	dipeptidyl-peptidase 8-like serine protease	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania infantum	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129743	All targets in OG5_129743
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania donovani	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0143	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0248	0.6826	0.6815
Loa Loa (eye worm)	prolyl oligopeptidase	0.035	1	1
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0345	0.9861	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.004	0.0304	0.0269
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.0304	0.0304
Schistosoma mansoni	hypothetical protein	0.0178	0.4626	0.4607
Brugia malayi	beta-lactamase family protein	0.0035	0.0143	0.0107
Entamoeba histolytica	hypothetical protein	0.0075	0.1399	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.0304	0.0269
Schistosoma mansoni	hypothetical protein	0.0178	0.4626	0.4607
Onchocerca volvulus		0.0249	0.6843	0.6832
Brugia malayi	nuclear receptor NHR-88	0.004	0.0304	0.0269
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.005	0.0611	0.0579
Entamoeba histolytica	hypothetical protein	0.0075	0.1399	1
Echinococcus granulosus	transcription factor btf3	0.0071	0.1266	0.1266
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.0304	0.0269
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0042	0.0042
Schistosoma mansoni	tar DNA-binding protein	0.0185	0.4851	0.4832
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.0304	0.0304
Schistosoma mansoni	hypothetical protein	0.0032	0.0042	0.0006
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.005	0.0611	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Brugia malayi	beta-lactamase	0.0035	0.0143	0.0107
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.2176	0.2148
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0042	0.0011
Giardia lamblia	Alanyl dipeptidyl peptidase	0.005	0.0611	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0042	0.0006
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.0304	0.0269
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.004	0.0304	0.0304
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.0304	0.0304
Echinococcus granulosus	tar DNA binding protein	0.0185	0.4851	0.4851
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0304	0.0269
Echinococcus granulosus	geminin	0.0178	0.4626	0.4626
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.0304	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0143	0.0107
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.005	0.0611	0.0699
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.2662	0.2636
Brugia malayi	beta-lactamase family protein	0.0035	0.0143	0.0107
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.005	0.0611	1
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.005	0.0611	0.0579
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.018	0.4692	0.4692
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0143	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1266	0.1677
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.005	0.0611	0.0699
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.005	0.0611	0.0577
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0143	0.0107
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0143	0.0168
Loa Loa (eye worm)	hypothetical protein	0.005	0.0611	0.0577
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.0304	0.0304
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.0304	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0042	0.0006
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.0304	0.0269
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.1399	0.1399
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0143	0.0168
Schistosoma mansoni	tar DNA-binding protein	0.0185	0.4851	0.4832
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0143	0.0143
Schistosoma mansoni	hypothetical protein	0.0032	0.0042	0.0006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.0304	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0143	0.0107
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0143	0.0168
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0611	0.4672
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0211	0.5656	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.005	0.0611	0.0577
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0345	0.9861	0.9861
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0143	0.0168
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.0304	0.0269
Plasmodium falciparum	basic transcription factor 3b, putative	0.0071	0.1266	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.018	0.4692	0.4673
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0143	0.0107
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.1399	0.1368
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0143	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0611	0.0699
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.0304	0.0269
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0304	0.0269
Onchocerca volvulus		0.0035	0.0143	0.0107
Onchocerca volvulus		0.015	0.3732	0.371
Toxoplasma gondii	NAC domain-containing protein	0.0071	0.1266	0.2189
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0248	0.6826	0.6815
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0042	0.0006
Loa Loa (eye worm)	ICD-1 protein	0.0071	0.1266	0.1234
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0143	0.0168
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.005	0.0611	0.0577
Trypanosoma cruzi	oligopeptidase b	0.005	0.0611	0.0579
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.005	0.0611	0.0579
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0143	0.0107
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.004	0.0304	0.0269
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0042	0.0011
Brugia malayi	prolyl oligopeptidase family protein	0.005	0.0611	0.0577
Trypanosoma cruzi	prolyl endopeptidase	0.005	0.0611	0.0579
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1266	0.1677
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0611	0.0579
Schistosoma mansoni	hypothetical protein	0.0075	0.1399	0.1368
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0304	0.0269
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.2176	0.2148
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0143	0.0865
Leishmania major	basic transcription factor 3a, putative	0.0071	0.1266	0.1246
Brugia malayi	hypothetical protein	0.0161	0.41	0.4078
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.005	0.0611	0.0579
Entamoeba histolytica	transcription factor BTF3, putative	0.0071	0.1266	0.8309
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0143	0.0107
Echinococcus granulosus	GPCR family 2	0.0032	0.0042	0.0042
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0345	0.9861	1
Brugia malayi	hypothetical protein	0.015	0.3732	0.371
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.0304	0.0269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.0304	0.0269
Toxoplasma gondii	hypothetical protein	0.005	0.0611	0.1023
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0345	0.9861	1
Onchocerca volvulus		0.0035	0.0143	0.0107
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.0304	0.0269
Echinococcus granulosus	acylamino acid releasing enzyme	0.005	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0143	0.0107
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0042	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0184	0.4816	0.4797
Schistosoma mansoni	tar DNA-binding protein	0.0185	0.4851	0.4832
Loa Loa (eye worm)	prolyl oligopeptidase	0.005	0.0611	0.0577
Trypanosoma brucei	transcription factor BTF3, putative	0.0071	0.1266	0.1246
Entamoeba histolytica	hypothetical protein	0.0075	0.1399	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.1188	0.1157
Schistosoma mansoni	hypothetical protein	0.0068	0.1188	0.1157
Echinococcus multilocularis	prolyl endopeptidase	0.005	0.0611	0.0577
Onchocerca volvulus	Bile acid receptor homolog	0.004	0.0304	0.0269
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.005	0.0611	0.0577
Loa Loa (eye worm)	RNA binding protein	0.0185	0.4851	0.4832
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0304	0.0304
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.0304	0.0269
Brugia malayi	ecdysteroid receptor	0.004	0.0304	0.0269
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0304	0.0269
Trypanosoma brucei	prolyl endopeptidase	0.005	0.0611	0.0579
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.0304	0.0269
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.035	1	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.004	0.0304	0.0269
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.0304	0.0269
Schistosoma mansoni	transcription factor btf3	0.0071	0.1266	0.1234
Brugia malayi	Steroid receptor seven-up type 2	0.004	0.0304	0.0269
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0143	0.0107
Brugia malayi	nuclear hormone receptor	0.004	0.0304	0.0269
Schistosoma mansoni	tar DNA-binding protein	0.0185	0.4851	0.4832
Echinococcus multilocularis	tar DNA binding protein	0.0185	0.4851	0.4832
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0345	0.9861	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.0304	0.0269
Brugia malayi	beta-NAC-like protein	0.0071	0.1266	0.1234
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.0304	0.0304
Schistosoma mansoni	coup transcription factor	0.004	0.0304	0.0269
Brugia malayi	prolyl oligopeptidase family protein	0.0345	0.9861	0.986
Trypanosoma brucei	RNA helicase, putative	0.0107	0.2402	0.2403
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0143	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0143	0.0107
Plasmodium vivax	basic transcription factor 3b, putative	0.0071	0.1266	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0345	0.9861	0.986
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.0304	0.0269
Echinococcus multilocularis	thyroid hormone receptor alpha	0.004	0.0304	0.0269
Trypanosoma brucei	oligopeptidase b	0.005	0.0611	0.0579
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.005	0.0611	0.0579
Toxoplasma gondii	prolyl endopeptidase	0.005	0.0611	0.1023
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0304	0.0269
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.004	0.0304	0.0269
Brugia malayi	RNA recognition motif domain containing protein	0.0185	0.4851	0.4832
Giardia lamblia	Alanyl dipeptidyl peptidase	0.005	0.0611	0.5
Echinococcus multilocularis	acylamino acid releasing enzyme	0.005	0.0611	0.0577
Brugia malayi	Pre-SET motif family protein	0.0219	0.5898	0.5883
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0304	0.0269
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0042	0.0006
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0143	0.0102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.0304	0.0269
Brugia malayi	prolyl oligopeptidase family protein	0.005	0.0611	0.0577
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0304	0.0269
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0042	0.0006
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0042	0.0006
Brugia malayi	prolyl oligopeptidase family protein	0.005	0.0611	0.0577
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0143	0.0168
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.035	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0042	0.0006
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0042	0.0042
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.6005	1
Toxoplasma gondii	ABC1 family protein	0.0035	0.0143	0.0189
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0042	0.0006
Echinococcus granulosus	FTZ F1 alpha	0.004	0.0304	0.0304
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0185	0.4851	0.4832
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.0304	0.0269
Mycobacterium tuberculosis	Probable peptidase	0.005	0.0611	0.0953
Loa Loa (eye worm)	TAR-binding protein	0.0185	0.4851	0.4832
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0304	0.0269
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0042	0.0006
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.005	0.0611	0.1023
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.0304	0.0269
Onchocerca volvulus		0.004	0.0304	0.0269
Entamoeba histolytica	hypothetical protein	0.0071	0.1266	0.8309
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.1266	0.1677
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0304	0.0269
Brugia malayi	TAR-binding protein	0.0185	0.4851	0.4832
Schistosoma mansoni	hypothetical protein	0.0107	0.2402	0.2374
Leishmania major	hypothetical protein, conserved	0.0035	0.0143	0.0102
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0143	0.0168
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.015	0.3732	0.371
Plasmodium falciparum	peptidase, putative	0.005	0.0611	0.4646
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0042	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1188	0.1157
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.0304	0.0269
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0143	0.0102
Entamoeba histolytica	hypothetical protein	0.0075	0.1399	1
Echinococcus multilocularis	transcription factor btf3	0.0071	0.1266	0.1234
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0345	0.9861	0.986
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.0304	0.0269
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.1399	0.1368
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.5898	0.5883
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0345	0.9861	1
Onchocerca volvulus		0.0035	0.0143	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0304	0.0269
Brugia malayi	MH2 domain containing protein	0.0115	0.2662	0.2636
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.0304	0.0269
Schistosoma mansoni	hypothetical protein	0.0032	0.0042	0.0006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.0304	0.0269
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.0304	0.0269
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0304	0.0269
Echinococcus granulosus	prolyl endopeptidase	0.005	0.0611	0.0611
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.6843	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0143	0.0168
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.0304	0.0269
Leishmania major	oligopeptidase b	0.005	0.0611	0.0579
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0304	0.0269
Trypanosoma cruzi	transcription factor btf3, putative	0.0071	0.1266	0.1246
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0042	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.0304	0.0269
Brugia malayi	steroid hormone receptor	0.004	0.0304	0.0269
Brugia malayi	hypothetical protein	0.0075	0.1399	0.1368
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0304	0.0269
Schistosoma mansoni	hypothetical protein	0.0032	0.0042	0.0006
Echinococcus multilocularis	geminin	0.0178	0.4626	0.4607
Schistosoma mansoni	tar DNA-binding protein	0.0185	0.4851	0.4832
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0143	0.0107
Trypanosoma brucei	prolyl oligopeptidase, putative	0.005	0.0611	0.0579
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.005	0.0611	0.0579
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0611	0.0579
Loa Loa (eye worm)	hypothetical protein	0.004	0.0304	0.0269
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.0304	0.0269
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0042	0.0006
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0042	0.0006
Trypanosoma cruzi	oligopeptidase b	0.005	0.0611	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0161	0.41	0.4078
Trypanosoma cruzi	transcription factor btf3, putative	0.0071	0.1266	0.1246
Loa Loa (eye worm)	hypothetical protein	0.005	0.0611	0.0577
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0042	0.0006
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.005	0.0611	0.0953
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0143	0.0107
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.035	1	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.005	0.0611	0.0577
Brugia malayi	RNA binding protein	0.0185	0.4851	0.4832
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.2662	0.2636
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0042	0.0006

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.7 nM	Inhibition of human DPP8	ChEMBL.	20684603
Ki (binding)	= 0.9 nM	Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA cleavage	ChEMBL.	20684603
Ki (binding)	= 0.9 nM	Inhibition of human DPP9	ChEMBL.	20684603

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1215089

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1174857