Detailed information for compound 1174923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.505 | Formula: C25H26FN5O2
  • H donors: 1 H acceptors: 2 LogP: 3.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC1=N/C(=C\c2ccc(c(c2)OC)n2cnc(c2)C)/C(=O)N1[C@H](c1ccc(cc1)F)C
  • InChi: 1S/C25H26FN5O2/c1-5-27-25-29-21(24(32)31(25)17(3)19-7-9-20(26)10-8-19)12-18-6-11-22(23(13-18)33-4)30-14-16(2)28-15-30/h6-15,17H,5H2,1-4H3,(H,27,29)/b21-12-/t17-/m0/s1
  • InChiKey: SDPVRVXJUYISFJ-WCEBZYJUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0268 0.0657
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0189 0.0178
Brugia malayi hypothetical protein 0.0319 0.3592 0.5262
Loa Loa (eye worm) hypothetical protein 0.0121 0.1247 0.1684
Schistosoma mansoni ran 0.0022 0.0079 0.0067
Loa Loa (eye worm) hypothetical protein 0.0095 0.0945 0.1276
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0067
Trichomonas vaginalis ran, putative 0.0022 0.0079 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.024 0.0228
Mycobacterium ulcerans dehydrogenase 0.002 0.0054 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0945 0.1384
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0116
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.013 0.0269
Echinococcus multilocularis lamin 0.0029 0.0162 0.015
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0054 0.0038
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0312 0.0727
Loa Loa (eye worm) hypothetical protein 0.0319 0.3592 0.4851
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0054 0.0042
Brugia malayi hypothetical protein 0.0017 0.0012 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0189 0.0178
Entamoeba histolytica presenilin 1 peptidase, putative 0.0248 0.2755 0.7962
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0097 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0268 0.0657
Schistosoma mansoni hypothetical protein 0.0024 0.01 0.0088
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0452 0.1505
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0044 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0198 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0189 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0073
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0079 0.0131
Leishmania major importin beta-1 subunit, putative 0.0049 0.039 0.1277
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0079 0.0737
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.012 0.0223
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2652 0.766
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0452 0.8485
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0189 0.0178
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0945 0.1276
Trypanosoma brucei Nicastrin, putative 0.0044 0.034 0.1093
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0525 0.1774
Leishmania major hypothetical protein, conserved 0.0054 0.0452 0.1505
Brugia malayi hypothetical protein 0.0036 0.024 0.0352
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0189 0.0178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0189 0.0178
Onchocerca volvulus 0.0095 0.0938 0.2497
Echinococcus multilocularis GPCR, family 2 0.0095 0.0945 0.0934
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.339 0.4966
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0945 0.0934
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3449 1
Schistosoma mansoni hypothetical protein 0.0121 0.1247 0.1237
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0283 0.0882
Schistosoma mansoni hypothetical protein 0.0206 0.2258 0.2249
Brugia malayi nuclear hormone receptor 0.0032 0.0189 0.0278
Schistosoma mansoni alpha glucosidase 0.0036 0.0245 0.0233
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0189 0.0178
Schistosoma mansoni chromobox protein 0.007 0.0639 0.0628
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0245 0.059
Echinococcus multilocularis Nicastrin 0.0121 0.1247 0.1237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1491 0.148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0198 0.0268
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0079 0.0131
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.013 0.0269
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0245 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0189 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0189 0.0278
Echinococcus granulosus lamin dm0 0.0029 0.0162 0.015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0283 0.0882
Brugia malayi hypothetical protein 0.0087 0.0844 0.1236
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0283 0.0271
Echinococcus multilocularis dna polymerase eta 0.004 0.0283 0.0271
Brugia malayi AMP-binding enzyme family protein 0.0027 0.013 0.019
Onchocerca volvulus 0.0029 0.0162 0.0303
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0312 0.0786
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Trypanosoma brucei unspecified product 0.0027 0.0137 0.0345
Brugia malayi nuclear receptor NHR-88 0.0032 0.0189 0.0278
Echinococcus multilocularis cpg binding protein 0.0125 0.1301 0.1291
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.013 0.0252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0268 0.0657
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.005 0.0123
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0268 0.299 1
Brugia malayi hypothetical protein 0.0087 0.0844 0.1236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0268 0.0657
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0189 0.0178
Loa Loa (eye worm) hypothetical protein 0.0302 0.339 0.4577
Leishmania major UDP-galactopyranose mutase 0.002 0.0054 0.0038
Onchocerca volvulus 0.0029 0.0162 0.0303
Plasmodium vivax importin-beta 2, putative 0.006 0.0525 1
Loa Loa (eye worm) histone methyltransferase 0.0038 0.0262 0.0354
Schistosoma mansoni amine oxidase 0.002 0.0054 0.0042
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0079 0.0067
Brugia malayi hypothetical protein 0.0054 0.0452 0.0662
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0452 0.1505
Schistosoma mansoni chromobox protein 0.007 0.0639 0.0628
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0073
Brugia malayi CHD4 protein 0.0018 0.0029 0.0042
Schistosoma mansoni intermediate filament proteins 0.0029 0.0162 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.024 0.0228
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0107
Echinococcus multilocularis tar DNA binding protein 0.0258 0.2871 0.2862
Echinococcus granulosus snurportin 1 0.064 0.7406 0.7403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0016
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0176 0.0164
Plasmodium vivax hypothetical protein, conserved 0.002 0.0054 0.0214
Brugia malayi Presenilin family protein 0.0248 0.2755 0.4035
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0137 0.0345
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0592 0.6827 0.9218
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0268 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0141 0.0286
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0073
Brugia malayi TAR-binding protein 0.0258 0.2871 0.4206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0189 0.0178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0198 0.0186
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0029 0.0039
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0029 0.0017
Echinococcus granulosus importin subunit beta 1 0.006 0.0525 0.0513
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0576
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0189 0.0178
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0162 0.0218
Onchocerca volvulus 0.0056 0.0477 0.1194
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0044 0.0024
Echinococcus granulosus chromobox protein 1 0.007 0.0639 0.0628
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0238
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0283 0.0415
Entamoeba histolytica hypothetical protein 0.0049 0.039 0.1017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0189 0.0256
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.2755 0.7962
Plasmodium falciparum acyl-CoA synthetase 0.002 0.005 0.0123
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0054 0.0059
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0054 0.0214
Onchocerca volvulus 0.0319 0.3592 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.002 0.0054 0.0214
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0016
Schistosoma mansoni hypothetical protein 0.0095 0.0945 0.0934
Trypanosoma brucei unspecified product 0.004 0.0283 0.0882
Loa Loa (eye worm) RNA binding protein 0.0258 0.2871 0.3877
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0283 0.0415
Onchocerca volvulus 0.0027 0.013 0.0214
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1247 0.3534
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0525 0.1774
Brugia malayi Presenilin spe-4 0.0087 0.0844 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0945 0.0934
Brugia malayi ecdysteroid receptor 0.0032 0.0189 0.0278
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0189 0.0178
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0283 0.0882
Echinococcus multilocularis lamin dm0 0.0029 0.0162 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0189 0.0256
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0189 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1491 0.148
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0283 0.0882
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0189 0.0278
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0189 0.0178
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.2755 0.7962
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0189 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0245 0.0741
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0245 0.0233
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0248 0.2755 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.059
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0945 0.1384
Schistosoma mansoni hypothetical protein 0.064 0.7406 0.7403
Brugia malayi RNA recognition motif domain containing protein 0.0258 0.2871 0.4206
Loa Loa (eye worm) hypothetical protein 0.006 0.0525 0.0709
Leishmania major DNA polymerase eta, putative 0.004 0.0283 0.0882
Chlamydia trachomatis protoporphyrinogen oxidase 0.002 0.0054 1
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0189 0.0178
Schistosoma mansoni lamin 0.0029 0.0162 0.015
Leishmania major DNA polymerase kappa, putative 0.004 0.0283 0.0882
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0333 0.0322
Entamoeba histolytica hypothetical protein 0.0044 0.034 0.0871
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.3449 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0189 0.0178
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0737
Loa Loa (eye worm) hypothetical protein 0.0056 0.0477 0.0644
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0245 0.0331
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.007 0.0644 0.2214
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0189 0.0178
Giardia lamblia DINP protein human, muc B family 0.004 0.0283 0.0703
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0253 0.2812 0.2803
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Mycobacterium ulcerans hypothetical protein 0.0027 0.013 0.0269
Echinococcus granulosus cpg binding protein 0.0125 0.1301 0.1291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0189 0.0178
Brugia malayi nuclear receptor RXR 0.0017 0.0012 0.0018
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0032
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0054 0.0038
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.2755 0.7962
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Brugia malayi AMP-binding enzyme family protein 0.0027 0.013 0.019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0268 0.0657
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.013 0.0492
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0198 0.0186
Echinococcus granulosus mixed lineage leukemia protein mll 0.0031 0.0176 0.0164
Brugia malayi Presenilin spe-4 0.0087 0.0844 0.1236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0189 0.0256
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1491 0.2013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.039 0.1017
Brugia malayi steroid hormone receptor 0.0032 0.0189 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0137 0.0345
Echinococcus multilocularis chromobox protein 1 0.007 0.0639 0.0628
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1491 0.148
Echinococcus multilocularis gamma secretase subunit aph 1 0.0592 0.6827 0.6823
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0189 0.0178
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0012 0.0016
Trichomonas vaginalis chromobox protein, putative 0.007 0.0639 0.1749
Echinococcus multilocularis chromobox protein 1 0.007 0.0639 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0189 0.0278
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0044 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0189 0.0278
Schistosoma mansoni amine oxidase 0.002 0.0054 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0245 0.059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0245 0.059
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2871 0.2862
Schistosoma mansoni alpha-glucosidase 0.0141 0.1487 0.1476
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.2493 1
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0283 0.0751
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2871 0.2862
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0189 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0277 0.0683
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0283 0.0834
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0054 0.0042
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0288 0.3231 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0189 0.0382
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0189 0.0278
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0079 0.0145
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0054 0.0059
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1247 0.3534
Echinococcus multilocularis tumor protein p63 0.0382 0.4345 0.4338
Brugia malayi Presenilin spe-4 0.0087 0.0844 0.1236
Trypanosoma brucei unspecified product 0.0027 0.0137 0.0345
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0268 0.0657
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0576
Toxoplasma gondii hypothetical protein 0.007 0.0644 0.2451
Onchocerca volvulus 0.0032 0.0189 0.0382
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0283 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0189 0.0256
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0162 0.0218
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0283 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0189 0.0278
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.013 0.0317
Trypanosoma cruzi Nicastrin, putative 0.0044 0.034 0.1093
Brugia malayi hypothetical protein 0.0087 0.0844 0.1236
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0067
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0283 0.0882
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0283 0.0271
Echinococcus multilocularis presenilin 0.0248 0.2755 0.2746
Echinococcus multilocularis 0.002 0.0054 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0189 0.0178
Loa Loa (eye worm) hypothetical protein 0.0039 0.0277 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0189 0.0278
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0283 0.0882
Schistosoma mansoni hypothetical protein 0.0859 1 1
Schistosoma mansoni cpg binding protein 0.0119 0.1221 0.121
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.0175
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0277 0.0628
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0189 0.0382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0189 0.0178
Onchocerca volvulus 0.0044 0.0333 0.0789
Brugia malayi hypothetical protein 0.0035 0.0226 0.0331
Loa Loa (eye worm) presenilin spe-4 0.0087 0.0844 0.1139
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0189 0.0278
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0268 0.0657
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0283 0.0751
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0189 0.0382
Schistosoma mansoni hypothetical protein 0.0095 0.0945 0.0934
Echinococcus granulosus Nicastrin 0.0121 0.1247 0.1237
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.3449 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.013 0.0269
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.002 0.0054 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0189 0.0256
Toxoplasma gondii hypothetical protein 0.0087 0.0844 0.3265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0189 0.0178
Echinococcus multilocularis musashi 0.0029 0.0162 0.015
Brugia malayi gamma-secretase subunit pen-2 0.0233 0.2574 0.3771
Brugia malayi hypothetical protein 0.0121 0.1247 0.1827
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.012 0.0223
Brugia malayi hypothetical protein 0.0121 0.1247 0.1827
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.339 0.4577
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0054 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0452 0.1505
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0283 0.0382
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0245 0.059
Trichomonas vaginalis importin beta-1, putative 0.0049 0.039 0.1017
Brugia malayi SWIRM domain containing protein 0.002 0.0054 0.008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.005 0.0044
Brugia malayi intermediate filament protein 0.0029 0.0162 0.0237
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0257 0.0376
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0028 0.014 0.0392
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1491 0.148
Plasmodium vivax hypothetical protein, conserved 0.002 0.0054 0.0214
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0452 0.1666
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0073
Mycobacterium ulcerans oxidoreductase 0.002 0.0054 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0847 0.985 0.985
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0452 0.8485
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0245 0.0359
Loa Loa (eye worm) hypothetical protein 0.0054 0.0452 0.061
Brugia malayi hypothetical protein 0.0017 0.0012 0.0018
Echinococcus granulosus intermediate filament protein 0.0029 0.0162 0.015
Schistosoma mansoni hypothetical protein 0.0095 0.0945 0.0934
Echinococcus granulosus presenilin 0.0248 0.2755 0.2746
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.2258 0.3308
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0245 0.059
Brugia malayi RNA, U transporter 1 0.0171 0.1836 0.2689
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0283 0.0882
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.013 0.0269
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.01 0.0088
Echinococcus multilocularis importin subunit beta 1 0.006 0.0525 0.0513
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1491 0.148
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.013 0.0269
Echinococcus granulosus tumor protein p63 0.0382 0.4345 0.4338
Trypanosoma cruzi Nicastrin, putative 0.0044 0.034 0.1093
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.2546 0.9231
Echinococcus multilocularis snurportin 1 0.064 0.7406 0.7403
Echinococcus granulosus nicalin 0.0044 0.034 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0258 0.2871 0.3877
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Brugia malayi Importin beta-1 subunit 0.006 0.0525 0.0769
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0073
Brugia malayi hypothetical protein 0.002 0.0054 0.008
Schistosoma mansoni importin beta-1 0.006 0.0525 0.0513
Trypanosoma brucei Aph-1 protein, putative 0.0231 0.2546 0.9231
Schistosoma mansoni gamma-secretase subunit aph-1 0.0592 0.6827 0.6823
Entamoeba histolytica Ran family GTPase 0.0022 0.0079 0.0104
Brugia malayi Heterochromatin protein 1 0.007 0.0639 0.0937
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.1757 0.1747
Echinococcus granulosus dna polymerase eta 0.004 0.0283 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0189 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1491 0.148
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0054 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.013 0.0317
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0283 0.0882
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0245 0.0741
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.2755 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.002 0.0054 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0154 0.0142
Brugia malayi Pre-SET motif family protein 0.0211 0.2311 0.3386
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0044 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0189 0.0278
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0189 0.0178
Schistosoma mansoni hypothetical protein 0.0095 0.0945 0.0934
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.013 0.0492
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Echinococcus multilocularis dna polymerase kappa 0.004 0.0283 0.0271
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1589 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0198 0.029
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0576
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.1757 0.2373
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1491 0.2184
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0176 0.0164
Echinococcus granulosus tar DNA binding protein 0.0258 0.2871 0.2862
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0248 0.2755 0.2746
Schistosoma mansoni lamin 0.0029 0.0162 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.039 0.1017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0016
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.2546 0.9231
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.1757 0.2574
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0189 0.0278
Echinococcus granulosus chromobox protein 1 0.007 0.0639 0.0628
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0283 0.0703
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0245 0.059
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2871 0.2862
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.1221 0.1649
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0079 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0198 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.3449 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0283 0.0382
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.013 0.0269
Schistosoma mansoni alpha-glucosidase 0.0141 0.1487 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.024 0.0228
Onchocerca volvulus 0.0031 0.0177 0.0345
Plasmodium vivax protoporphyrinogen oxidase, putative 0.002 0.0054 0.0214
Schistosoma mansoni hypothetical protein 0.0368 0.4173 0.4166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1491 0.148
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0079 0.0131
Brugia malayi Presenilin-like protein At2g29900 0.0087 0.0844 0.1236
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0283 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2871 0.2862
Leishmania major hypothetical protein, conserved 0.007 0.0644 0.2214
Plasmodium falciparum importin beta, putative 0.006 0.0525 1
Schistosoma mansoni hypothetical protein 0.0036 0.024 0.0228
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0245 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.064 0.7406 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0198 0.0186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0189 0.0178
Plasmodium vivax SET domain protein, putative 0.0032 0.0198 0.3207
Mycobacterium ulcerans monoamine oxidase 0.002 0.0054 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.339 0.4966
Onchocerca volvulus 0.0119 0.1221 0.3298
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0189 0.0256
Echinococcus granulosus lamin 0.0029 0.0162 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0189 0.0256
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.005 0.0019
Plasmodium falciparum protoporphyrinogen oxidase 0.002 0.0054 0.0214
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0283 0.0703
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.039 0.1277
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0288 0.3231 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0176 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0277 0.0683
Schistosoma mansoni ran 0.0022 0.0079 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0248 0.2755 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0044 0.0032
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0312 0.0786
Brugia malayi CXXC zinc finger family protein 0.0119 0.1221 0.1789
Trichomonas vaginalis chromobox protein, putative 0.007 0.0639 0.1749
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0189 0.0178
Toxoplasma gondii histone lysine-specific demethylase 0.002 0.0054 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0189 0.0278
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0029 0.0017
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0233 0.2574 0.3476
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1589 0.5256
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0054 0.0042
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0054 0.0042
Schistosoma mansoni cpg binding protein 0.0125 0.1301 0.1291
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0525 0.1963
Brugia malayi chromobox protein homolog 3 0.0039 0.0277 0.0405
Echinococcus multilocularis presenilin enhancer 2 0.0233 0.2574 0.2565
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.013 0.0269
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0258 0.2871 0.3877
Schistosoma mansoni hypothetical protein 0.0368 0.4173 0.4166
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0477 0.0465
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.01 0.0088
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0639 0.0863
Echinococcus granulosus geminin 0.0368 0.4173 0.4166
Echinococcus granulosus gamma secretase subunit aph 1 0.0592 0.6827 0.6823
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0189 0.0178
Trichomonas vaginalis helicase, putative 0.0027 0.0132 0.026
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0189 0.0178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0262 0.025
Entamoeba histolytica hypothetical protein 0.0036 0.024 0.0576
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0189 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0189 0.0278
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0262 0.025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1757 0.1747
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.013 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0283 0.0882
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Brugia malayi RNA binding protein 0.0258 0.2871 0.4206
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0452 0.8485
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0945 0.0934
Schistosoma mansoni ap endonuclease 0.0019 0.0044 0.0032
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0245 0.082
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0044 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2311 0.3121
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Echinococcus multilocularis Nicastrin 0.0121 0.1247 0.1237
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0245 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0137 0.0345
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1757 0.1747
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0945 0.0934
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0283 0.0834
Schistosoma mansoni cpg binding protein 0.0125 0.1301 0.1291
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0283 0.0271
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.013 0.0252
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0189 0.0256
Trypanosoma brucei glucosidase, putative 0.0036 0.0245 0.0741
Echinococcus multilocularis nicalin 0.0044 0.034 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0079 0.0104
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.013 0.0252
Brugia malayi gamma-secretase subunit aph-1 0.0592 0.6827 1
Onchocerca volvulus 0.024 0.2655 0.7351
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0198 0.063
Loa Loa (eye worm) hypothetical protein 0.0029 0.0155 0.021
Echinococcus granulosus presenilin enhancer 2 0.0233 0.2574 0.2565
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.0175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0256
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.3449 1
Echinococcus granulosus GPCR family 2 0.0095 0.0945 0.0934
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0029 0.0017
Echinococcus granulosus dna polymerase kappa 0.004 0.0283 0.0271
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.013 0.0317
Schistosoma mansoni DNA polymerase eta 0.004 0.0283 0.0271
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0016
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.013 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0189 0.0278
Schistosoma mansoni coup transcription factor 0.0032 0.0189 0.0178
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0162 0.0237
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0028 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0189 0.0178
Echinococcus multilocularis geminin 0.0368 0.4173 0.4166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0198 0.0186
Loa Loa (eye worm) hypothetical protein 0.0206 0.2258 0.3049
Schistosoma mansoni tar DNA-binding protein 0.0258 0.2871 0.2862
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.2755 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0031 0.0176 0.0164
Echinococcus multilocularis dnaJ subfamily B 0.0859 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1589 0.4849
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0283 0.0882
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0054 0.008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0189 0.0178
Leishmania major GTP-binding protein, putative 0.0022 0.0079 0.0131
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0012 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0012 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0141 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0132 0.026
Brugia malayi AMP-binding enzyme family protein 0.0027 0.013 0.019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 220 nM Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells ChEMBL. 20724152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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