Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0132 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2615 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.0571 | 0.2184 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0557 | 0.088 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.2615 | 0.2615 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0132 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.005 | 0.0079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2615 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0132 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0132 | 0.0132 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.2615 | 0.413 |
Onchocerca volvulus | 0.0056 | 0.0571 | 1 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0132 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.2615 | 0.413 |
Echinococcus multilocularis | tumor protein p63 | 0.0381 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0557 | 0.088 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0557 | 0.088 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2615 | 1 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0132 | 0.0209 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.2615 | 0.413 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.005 | 0.0191 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0132 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.005 | 0.0079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.2615 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.0009 | 1 |
Brugia malayi | RNA binding protein | 0.0126 | 0.2615 | 0.413 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0132 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0132 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.5634 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0255 | 0.6333 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0132 | 0.0505 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.3491 | 0.5513 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.3491 | 0.3491 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.3491 | 0.3491 |
Brugia malayi | MH2 domain containing protein | 0.0255 | 0.6333 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.3491 | 0.5513 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.2615 | 0.413 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0571 | 0.0902 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.2615 | 0.413 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.2615 | 0.2615 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.3491 | 0.5513 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0132 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0132 | 0.0505 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0132 | 0.0209 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.0009 | 0.0015 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0132 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.3491 | 0.3491 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0557 | 0.088 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0255 | 0.6333 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.