Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0623 | 0.0623 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3737 | 0.6314 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.3737 | 0.3737 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.4413 | 0.7685 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.5554 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.2731 | 0.4273 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0085 | 0.5554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4413 | 0.4413 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.3737 | 0.3737 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.2731 | 0.4273 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0182 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.7678 | 0.7678 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.3737 | 0.3737 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0085 | 0.5554 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.3737 | 0.6314 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3737 | 0.6314 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5554 | 0.5554 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.2731 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.3737 | 0.6314 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0029 | 0.0182 | 0.0328 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.3737 | 0.3737 |
Brugia malayi | RNA binding protein | 0.0066 | 0.3737 | 0.3737 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.7678 | 0.7678 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.4413 | 0.4413 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3737 | 0.6314 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0085 | 0.5554 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.7678 | 0.7678 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.7678 | 0.7678 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0623 | 0.0623 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.5554 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0056 | 0.2731 | 0.4744 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0182 | 0.0328 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0623 | 0.0623 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0623 | 0.0623 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.3737 | 0.3737 |
Brugia malayi | Probable ClpP-like protease | 0.0085 | 0.5554 | 0.5554 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3737 | 0.6314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3737 | 0.6314 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.5554 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.2731 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.000001 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | No reference |
T/C (functional) | = 145 % | In vivo cytotoxicity against mouse P388 cells at 0.4 to 12.5 mg/kg | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.