Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.1352 | 0.1598 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0034 | 0 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.1352 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.1352 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.1352 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.1352 | 0.1598 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0204 | 0.8463 | 1 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.1352 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0204 | 0.8463 | 0.8463 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0204 | 0.8463 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0235 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.1352 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0204 | 0.8463 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0204 | 0.8463 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0204 | 0.8463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.8463 | 0.8463 |
Echinococcus multilocularis | acetylcholinesterase | 0.0204 | 0.8463 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0204 | 0.8463 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.1352 | 0.1598 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0034 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0204 | 0.8463 | 0.8463 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.1352 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.1352 | 0.1598 |
Brugia malayi | Carboxylesterase family protein | 0.0204 | 0.8463 | 0.8463 |
Onchocerca volvulus | 0.0034 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.8463 | 0.8463 |
Brugia malayi | Carboxylesterase family protein | 0.0204 | 0.8463 | 0.8463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of HIV1 integrase by qualitative integration assay system | ChEMBL. | 17403681 | |
Activity (binding) | Inhibition of HIV1 integrase by quantitative ELISA | ChEMBL. | 17403681 | |
Kd (binding) | Binding affinity to HIV1 integrase by fluorescence anisotrophy | ChEMBL. | 17403681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.