Detailed information for compound 1175793

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.329 | Formula: C13H15NO2S
  • H donors: 1 H acceptors: 2 LogP: 2.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS(=O)(=O)NCCc1cccc2c1cccc2
  • InChi: 1S/C13H15NO2S/c1-17(15,16)14-10-9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,14H,9-10H2,1H3
  • InChiKey: MQGUPLUYVSZGAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens NAD(P)H dehydrogenase, quinone 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Giardia lamblia NADPH oxidoreductase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Giardia lamblia NADPH oxidoreductase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Giardia lamblia NADPH oxidoreductase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis NAD(P)H dehydrogenase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis NAD(P)H dehydrogenase, putative Get druggable targets OG5_130380 All targets in OG5_130380
Trichomonas vaginalis NAD(P)H dehydrogenase, putative Get druggable targets OG5_130380 All targets in OG5_130380
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis NAD(P)H dehydrogenase, putative NAD(P)H dehydrogenase, quinone 2 231 aa 213 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 0.0025 0.0346 0.0327
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0538 0.0635
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0172 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0172 0.012
Echinococcus granulosus Smad4 0.0017 0.0075 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0172 0.012
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0346 0.1732
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0299 0.0185
Schistosoma mansoni ran 0.0021 0.0225 0.0151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0538 0.0538
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0604 0.0604
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0643 0.4481
Echinococcus multilocularis smad 0.0017 0.0075 0.0056
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0174 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0827 0.6186
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0174 0.01
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0576 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.4817 0.4807
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0346 0.0313
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 0.2762 0.3436
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Echinococcus multilocularis snurportin 1 0.031 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0174 0.0112
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 0.2762 0.3436
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0346 0.0313
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0225 0.0169
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0934 0.1461
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0061 0.1563 0.2641
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Schistosoma mansoni survival motor neuron protein 0.0057 0.1423 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0485 0.3016
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0172 0.012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0116 0.3423 0.5988
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0225 0.0225
Loa Loa (eye worm) cytochrome P450 family protein 0.0102 0.2951 0.2951
Echinococcus granulosus geminin 0.0166 0.5144 0.5135
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0299 0.1294
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.5477 0.5468
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0116 0.3423 0.5456
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.1239 0.1805
Brugia malayi Doublecortin family protein 0.0019 0.0155 0.0091
Brugia malayi intermediate filament protein 0.0032 0.0576 0.0566
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0346 0.0313
Echinococcus granulosus peregrin 0.0036 0.0735 0.0716
Schistosoma mansoni polycystin 1-related 0.0019 0.0155 0.0081
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0174 0.01
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0196 0.6143 0.6135
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0174 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0485 0.0485
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0346 0.0313
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0024 0.0316 0.0207
Schistosoma mansoni lipoxygenase 0.0054 0.1333 0.1267
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0172 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0159 0.0139
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0172 0.0152
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0346 0.0313
Echinococcus granulosus lamin 0.0032 0.0576 0.0557
Loa Loa (eye worm) inositol-1 0.0038 0.0785 0.0785
Echinococcus granulosus smad 0.0017 0.0075 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2645 0.2589
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.6143 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0346 0.0313
Loa Loa (eye worm) hypothetical protein 0.0032 0.0576 0.0576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0174 0.0174
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.065 0.0592
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.1239 1
Brugia malayi steroid hormone receptor 0.002 0.0174 0.0112
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.1239 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0346 0.0313
Entamoeba histolytica Ran family GTPase 0.0021 0.0225 0.0853
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.8923 0.8921
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0604 0.0745
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0172 0.0167
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0174 0.01
Onchocerca volvulus Huntingtin homolog 0.0245 0.7792 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0346 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Brugia malayi MAP kinase sur-1 0.0051 0.1239 0.1315
Echinococcus multilocularis lamin 0.0032 0.0576 0.0557
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0827 0.1117
Echinococcus granulosus intermediate filament protein 0.0032 0.0576 0.0557
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.3114 0.3101
Onchocerca volvulus 0.0032 0.0576 0.055
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0024 0.0316 0.0207
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0827 0.8619
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0785 0.8072
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0827 0.085
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0177 0.5485 1
Schistosoma mansoni lamin 0.0032 0.0576 0.0504
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.002
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0196 0.6143 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0604 0.0745
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0077 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1239 0.1426
Brugia malayi Pre-SET motif family protein 0.0213 0.6734 0.7525
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0346 0.0313
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0174 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0172 0.012
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0174 0.0155
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0225 0.0131
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0061 0.1563 0.2368
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0346 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0346 0.0313
Echinococcus multilocularis dna polymerase kappa 0.002 0.0172 0.0152
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.2645 0.2905
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0172 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0174 0.0112
Loa Loa (eye worm) hypothetical protein 0.0056 0.1392 0.1392
Schistosoma mansoni lipoxygenase 0.0019 0.0155 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0827 0.6186
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0785 0.1046
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0061 0.1563 0.2636
Leishmania major DNA polymerase kappa, putative 0.002 0.0172 0.0022
Echinococcus granulosus jumonji domain containing protein 0.0045 0.1036 0.1019
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.1423 0.1523
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1239 0.1426
Plasmodium falciparum phd finger protein, putative 0.0033 0.0604 0.0842
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0346 0.0313
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0785 0.1175
Loa Loa (eye worm) hypothetical protein 0.0033 0.0604 0.0604
Echinococcus multilocularis dna polymerase eta 0.002 0.0172 0.0152
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0827 0.0882
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0172 0.012
Leishmania major DNA polymerase eta, putative 0.002 0.0172 0.0022
Schistosoma mansoni jumonji domain containing protein 0.0085 0.2372 0.2314
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0177 0.5485 0.8901
Brugia malayi Importin beta-1 subunit 0.0029 0.0485 0.0463
Plasmodium vivax importin-beta 2, putative 0.0029 0.0485 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0174 0.0174
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0485 0.0544
Schistosoma mansoni hypothetical protein 0.0025 0.0346 0.0273
Brugia malayi jmjC domain containing protein 0.0039 0.0836 0.086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.1064 0.1196
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0643 0.0643
Brugia malayi jmjC domain containing protein 0.0107 0.3114 0.3435
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0172 0.0022
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0177 0.5485 0.8901
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.1239 0.415
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0155 0.0136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0174 0.0112
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0827 0.0827
Trichomonas vaginalis ran, putative 0.0021 0.0225 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0934 0.2979
Echinococcus granulosus lamin dm0 0.0032 0.0576 0.0557
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0174 0.0155
Loa Loa (eye worm) hypothetical protein 0.0278 0.8923 0.8923
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0225 0.0131
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0061 0.1563 0.2641
Schistosoma mansoni hypothetical protein 0.0166 0.5144 0.5107
Schistosoma mansoni lamin 0.0032 0.0576 0.0504
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0827 0.8619
Schistosoma mansoni hypothetical protein 0.031 1 1
Onchocerca volvulus 0.0102 0.2957 0.3669
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0346 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0174 0.0174
Schistosoma mansoni cytochrome P450 0.0025 0.0346 0.0273
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0485 0.3016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2645 0.2631
Giardia lamblia NADPH oxidoreductase, putative 0.0096 0.2762 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0172 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0075 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0174 0.0155
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0075 0.0075
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0346 0.1732
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0174 0.0155
Brugia malayi nuclear receptor NHR-88 0.002 0.0174 0.0112
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0785 0.0826
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0159 0.0139
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0346 0.0313
Loa Loa (eye worm) hypothetical protein 0.0245 0.7792 0.7792
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1239 0.1805
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0836 0.0836
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1239 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0836 0.0767
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0836 0.0818
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0538 0.0467
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0346 0.0313
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0174 0.0112
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0172 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0346 0.0313
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0827 0.0882
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0346 0.0313
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0172 0.0017
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0075 0.0056
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.1239 0.1805
Plasmodium falciparum importin beta, putative 0.0029 0.0485 0.0618
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0346 0.0313
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.1947 0.2361
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0155 0.0136
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.4668 0.4657
Brugia malayi PHD-finger family protein 0.0033 0.0604 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.6734 0.6734
Echinococcus multilocularis peptidase Clp (S14 family) 0.0116 0.3423 0.3411
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0172 0.0022
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0785 0.0826
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Brugia malayi Probable ClpP-like protease 0.0177 0.5485 0.6114
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1239 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0346 0.0313
Brugia malayi hypothetical protein 0.0019 0.0155 0.0091
Leishmania major GTP-binding protein, putative 0.0021 0.0225 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0172 0.012
Loa Loa (eye worm) Smad1 0.0017 0.0075 0.0075
Brugia malayi hypothetical protein 0.0019 0.0155 0.0091
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0174 0.01
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0159 0.0159
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0346 0.0313
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Onchocerca volvulus 0.002 0.0174 0.0025
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0077 0.0002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0604 0.0586
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0346 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Leishmania major cytochrome p450-like protein 0.0034 0.0643 0.0809
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0827 0.0882
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.1239 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0174 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2645 0.2589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2645 0.2589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2645 0.2631
Plasmodium vivax SET domain protein, putative 0.0031 0.0538 0.0719
Leishmania major cytochrome p450-like protein 0.0025 0.0346 0.0313
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0538 0.052
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0174 0.0155
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.1064 0.1513
Echinococcus granulosus dna polymerase kappa 0.002 0.0172 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0174 0.0112
Trypanosoma brucei protein kinase, putative 0.0051 0.1239 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0155 0.0136
Brugia malayi Cytochrome P450 family protein 0.0025 0.0346 0.0306
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0346 0.0313
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.1064 0.1196
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1239 0.1426
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Brugia malayi cytochrome P450 0.0025 0.0346 0.0306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0174 0.0174
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Loa Loa (eye worm) hypothetical protein 0.0019 0.0155 0.0155
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0155 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0174 0.0155
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 0.8901
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0346 0.0313
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0934 1
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0024 0.0316 0.2024
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 0.5
Brugia malayi hypothetical protein 0.0278 0.8923 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0174 0.0155
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0096 0.2762 0.3436
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0196 0.6143 1
Loa Loa (eye worm) hypothetical protein 0.0245 0.7792 0.7792
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0174 0.0112
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0024 0.0316 0.2024
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Schistosoma mansoni rab6-interacting 0.0019 0.0155 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Schistosoma mansoni hypothetical protein 0.0019 0.0155 0.0081
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0346 0.0313
Schistosoma mansoni alpha glucosidase 0.0039 0.0827 0.0758
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0346 0.0313
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0174 0.0155
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0785 0.5794
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1239 0.1222
Onchocerca volvulus Huntingtin homolog 0.0245 0.7792 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0172 0.005
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0827 0.0809
Toxoplasma gondii hypothetical protein 0.0061 0.1563 0.2346
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.7927 0.7927
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0174 0.0155
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0485 0.0466
Schistosoma mansoni thyroid hormone receptor 0.002 0.0174 0.01
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0346 0.0313
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.1064 0.1047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0174 0.0155
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0225 0.0206
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0075 0.0056
Brugia malayi Bromodomain containing protein 0.0036 0.0735 0.0745
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1333 0.1316
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0827 0.0882
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0643 0.4481
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0172 0.012
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.8923 0.8921
Echinococcus multilocularis peregrin 0.0036 0.0735 0.0716
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0643 0.0643
Schistosoma mansoni importin beta-1 0.0029 0.0485 0.0413
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0177 0.5485 0.5476
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.5477 0.5468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0538 0.0467
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0174 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0174 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.0084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0174 0.0174
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Echinococcus multilocularis geminin 0.0166 0.5144 0.5135
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0172 0.0152
Schistosoma mansoni alpha-glucosidase 0.0152 0.4644 0.4604
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0225 0.0206
Entamoeba histolytica hypothetical protein 0.0024 0.0299 0.1803
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0827 0.0882
Schistosoma mansoni rab6-interacting 0.0019 0.0155 0.0081
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0346 0.0313
Toxoplasma gondii aldehyde dehydrogenase 0.0196 0.6143 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0174 0.01
Brugia malayi MH2 domain containing protein 0.0249 0.7927 0.8874
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0159 0.0095
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.6143 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0174 0.0112
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0827 0.0882
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1779 0.1779
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0172 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0196 0.6143 0.6135
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0346 0.0313
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0785 0.0766
Brugia malayi nuclear hormone receptor 0.002 0.0174 0.0112
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 0.8901
Echinococcus granulosus peptidase Clp S14 family 0.0116 0.3423 0.3411
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1239 0.1173
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.4817 0.5359
Giardia lamblia NADPH oxidoreductase, putative 0.0096 0.2762 1
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.7927 0.7927
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0346 0.0327
Schistosoma mansoni inositol monophosphatase 0.0038 0.0785 0.0715
Schistosoma mansoni alpha-glucosidase 0.0152 0.4644 0.4604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0174 0.0174
Onchocerca volvulus 0.0032 0.0576 0.055
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0299 0.0185
Echinococcus multilocularis musashi 0.0032 0.0576 0.0557
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0576 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0174 0.0112
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0024 0.0316 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Brugia malayi Cytochrome P450 family protein 0.0034 0.0643 0.0642
Schistosoma mansoni DNA polymerase eta 0.002 0.0172 0.0097
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0346 0.0313
Giardia lamblia NADPH oxidoreductase, putative 0.0096 0.2762 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.1064 0.1706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0538 0.0467
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.05 0.0482
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0174 0.01
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0604 0.0586
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0116 0.3423 0.5456
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0174 0.01
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0174 0.0155
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0174 0.01
Trichomonas vaginalis set domain proteins, putative 0.0243 0.7733 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.065 0.0821
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0174 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0643 0.0643
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0346 0.0313
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.6143 0.6113
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Brugia malayi Cytochrome P450 family protein 0.0102 0.2951 0.325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.6143 1
Brugia malayi hypothetical protein 0.0245 0.7792 0.8721
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0643 0.4481
Onchocerca volvulus Alhambra homolog 0.0033 0.0604 0.0588
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0225 0.0612
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0174 0.0155
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0346 0.0313
Schistosoma mansoni coup transcription factor 0.002 0.0174 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2645 0.2631
Onchocerca volvulus 0.0057 0.1423 0.166
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0075 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0174 0.0174
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.2645 0.2645
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0346 0.0313
Echinococcus multilocularis RUN 0.0019 0.0155 0.0136
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 0.0007
Loa Loa (eye worm) hypothetical protein 0.0177 0.5485 0.5485
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0155 0.0136
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0174 0.01
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0346 0.0313
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0174 0.0155
Schistosoma mansoni hypothetical protein 0.0033 0.0604 0.0533
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0827 0.0882
Schistosoma mansoni thyroid hormone receptor 0.002 0.0174 0.01
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0576 0.0576
Schistosoma mansoni peptidase Clp (S14 family) 0.0177 0.5485 0.5451
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0172 0.012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0785 0.0826
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0785 0.1046
Trypanosoma brucei glucosidase, putative 0.0039 0.0827 0.6186
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0346 0.1732
Brugia malayi RNA, U transporter 1 0.0083 0.2298 0.2512
Schistosoma mansoni inositol monophosphatase 0.0038 0.0785 0.0715
Trypanosoma brucei unspecified product 0.002 0.0172 0.012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0174 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0174 0.0174
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.3114 0.3101
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Echinococcus granulosus importin subunit beta 1 0.0029 0.0485 0.0466
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0174 0.0155
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Echinococcus multilocularis Smad4 0.0017 0.0075 0.0056
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0225 0.0254
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 1 1
Echinococcus granulosus dna polymerase eta 0.002 0.0172 0.0152
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0346 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0785 0.1046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0174 0.0112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0174 0.0155
Giardia lamblia PHD finger protein 15 0.0033 0.0604 0.1712
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.5477 0.5477
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0172 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0346 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0827 0.0882
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0538 0.052
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0075 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0346 0.0313
Schistosoma mansoni hypothetical protein 0.0057 0.1423 0.1358
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0346 0.0313
Leishmania major importin beta-1 subunit, putative 0.0024 0.0299 0.0234
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0346 0.0313
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1239 0.1239
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.0084
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0604 0.0533
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0174 0.0155
Echinococcus granulosus RUN 0.0019 0.0155 0.0136
Brugia malayi Pre-SET motif family protein 0.0031 0.0538 0.0524
Leishmania major cytochrome p450-like protein 0.0025 0.0346 0.0313
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0785 0.5794
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0538 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0836 0.0767
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0172 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0174 0.0112
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0299 0.0185
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.1036 0.1019
Brugia malayi Inositol-1 0.0038 0.0785 0.0802
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0604 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0174 0.0112
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0785 0.0766
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0155 0.0155
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0225 0.0612
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.4817 0.4778
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1333 0.1316
Onchocerca volvulus 0.0031 0.0538 0.0502
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0172 0.0109
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0836 0.0818
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0225 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.6143 0.6113
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0346 0.0313
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1239 0.1426
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1239 0.1222
Schistosoma mansoni ran 0.0021 0.0225 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0827 0.1117
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0827 0.0809
Loa Loa (eye worm) cytochrome P450 0.0025 0.0346 0.0346
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1239 0.1222
Entamoeba histolytica hypothetical protein 0.0024 0.0316 0.2024
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0174 0.0112
Schistosoma mansoni loxhd1 0.0019 0.0155 0.0081
Brugia malayi Cytochrome P450 family protein 0.0034 0.0643 0.0642
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0225 0.0612
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0346 0.0313
Loa Loa (eye worm) hypothetical protein 0.0019 0.0155 0.0155
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1239 0.1222
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.5477 0.6105
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0174 0.0112
Schistosoma mansoni hypothetical protein 0.0166 0.5144 0.5107
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0346 0.0313
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0177 0.5485 1
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Echinococcus multilocularis lamin dm0 0.0032 0.0576 0.0557
Trichomonas vaginalis modulator of drug activity B, putative 0.0024 0.0316 0.0207
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0538 0.052
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0177 0.5485 0.5
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0346 0.0313
Onchocerca volvulus 0.0243 0.7733 0.9923
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0346 0.1732
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.1064 0.1513
Brugia malayi ecdysteroid receptor 0.002 0.0174 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0316 0.0207
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0172 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0172 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0556 0.0556
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.5477 0.5468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2645 0.2631
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0785 0.5794
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0643 0.0809
Schistosoma mansoni nuclear hormone receptor 0.002 0.0174 0.01
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0827 0.0882
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.2762 0.3436
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0155 0.0136
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0177 0.5485 0.5476
Loa Loa (eye worm) acetyltransferase 0.0157 0.4817 0.4817
Schistosoma mansoni intermediate filament proteins 0.0032 0.0576 0.0504

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.55 Displacement of [125I]iodomelatonin from MT3/QR2 melatonin binding site expressed in CHO cells ChEMBL. 18400335

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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