Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.3113 | 0.2798 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.061 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.177 | 0.3349 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0023 | 0.061 | 0.0181 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.061 | 0.0181 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0023 | 0.061 | 0.1603 |
Entamoeba histolytica | recQ family helicase, putative | 0.0023 | 0.061 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.061 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0326 | 0.5348 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0023 | 0.061 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0595 | 0.0166 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.4073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1923 | 0.5054 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.3337 | 0.3337 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0436 | 0.1147 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0326 | 0.5348 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0436 | 0.0436 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.061 | 1 |
Echinococcus multilocularis | geminin | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.00000000051285 | 0.0000000013481 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1621 | 0.1239 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0929 | 0.0923 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0436 | 0.0436 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.3113 | 0.2798 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0436 | 0.0436 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.061 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.061 | 0.1603 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0781 | 0.036 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0595 | 0.0166 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0661 | 0.0661 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0023 | 0.061 | 0.0181 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 0.061 | 0.061 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0023 | 0.061 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1774 | 0.4663 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0781 | 0.036 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3804 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.061 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.061 | 0.1603 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 0.061 | 0.061 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0023 | 0.061 | 0.0181 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0436 | 0.0436 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0000000010793 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.1621 | 0.1239 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0781 | 0.0781 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.061 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.061 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0475 | 0.1248 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0023 | 0.061 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0661 | 0.1737 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2042 | 0.5369 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.061 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.00000000051285 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.061 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0326 | 0.0326 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.