Detailed information for compound 1176296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.406 | Formula: C27H26Cl2FN
  • H donors: 0 H acceptors: 0 LogP: 7.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCC1(CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ccccc1
  • InChi: 1S/C27H26Cl2FN/c28-24-12-6-4-10-22(24)26(23-11-5-7-13-25(23)29)31-20-14-15-21(31)17-27(16-20,18-30)19-8-2-1-3-9-19/h1-13,20-21,26H,14-18H2
  • InChiKey: AEHBDXWWYVXDOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opiate receptor-like 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis growth hormone secretagogue receptor type 1 opiate receptor-like 1 370 aa 349 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromobox protein, putative 0.0255 0.0763 0.1641
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0173 0.0424 0.0424
Trichomonas vaginalis penicillin-binding protein, putative 0.0263 0.0794 0.1706
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0798 0.1715
Schistosoma mansoni jumonji domain containing protein 0.0868 0.3276 0.3276
Plasmodium vivax SET domain protein, putative 0.0155 0.0352 0.3244
Echinococcus granulosus histone acetyltransferase MYST2 0.0173 0.0424 0.0424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0422 0.1447 0.1447
Echinococcus multilocularis polycomb protein SCMH1 0.0152 0.0338 0.0338
Entamoeba histolytica hypothetical protein 0.0114 0.0185 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0152 0.0338 0.0338
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.1111 0.4274 0.4274
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0108 0.0157 0.0311
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0263 0.0794 0.1567
Echinococcus granulosus Chromobox protein 3 0.0069 0.00000003296 0.00000003296
Trichomonas vaginalis chromobox protein, putative 0.0255 0.0763 0.1641
Schistosoma mansoni chromobox protein 0.0423 0.1453 0.1453
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.0798 0.1575
Trypanosoma cruzi ISWI complex protein 0.0282 0.0873 1
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0258 0.0509
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0109 0.0163 0.1267
Onchocerca volvulus 0.0176 0.0438 0.0941
Mycobacterium ulcerans esterase/lipase LipP 0.0263 0.0794 0.5
Onchocerca volvulus 0.0069 0.00000003296 0.000000070849
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0115 0.0186 0.0186
Echinococcus granulosus jumonji domain containing 1A 0.0108 0.0157 0.0157
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0426 0.0915
Echinococcus granulosus beta LACTamase domain containing family member 0.0263 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0333 0.1084 0.2139
Echinococcus granulosus geminin 0.051 0.1807 0.1807
Brugia malayi Pre-SET motif family protein 0.0155 0.0352 0.0647
Schistosoma mansoni cpg binding protein 0.0221 0.0624 0.0624
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0798 0.1715
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.0537 0.0988
Loa Loa (eye worm) hypothetical protein 0.1304 0.5066 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0109 0.0164 0.0352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0449 0.1557 0.1557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0091 0.0088 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0258 0.0258
Giardia lamblia PHD finger protein 15 0.0333 0.1084 0.5
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0258 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0263 0.0794 0.1706
Trichomonas vaginalis chromobox protein, putative 0.0423 0.1453 0.3122
Toxoplasma gondii PHD-finger domain-containing protein 0.0333 0.1084 0.843
Brugia malayi AF-10 protein 0.0109 0.0163 0.03
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1057 0.4055 0.8004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.1111 0.4274 0.4274
Leishmania major hypothetical protein, conserved 0.0282 0.0873 1
Schistosoma mansoni phosphatidylserine receptor 0.0108 0.0157 0.0157
Echinococcus multilocularis chromobox protein 1 0.0423 0.1453 0.1453
Loa Loa (eye worm) hypothetical protein 0.02 0.0537 0.1059
Loa Loa (eye worm) bromodomain containing protein 0.0326 0.1052 0.2077
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0798 0.1715
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1678 0.6603 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0333 0.1084 0.1084
Loa Loa (eye worm) MBCTL1 0.0173 0.0424 0.0836
Trichomonas vaginalis D-aminoacylase, putative 0.0263 0.0794 0.1706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.0537 0.1059
Loa Loa (eye worm) jmjC domain-containing protein 0.0688 0.2541 0.5015
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0109 0.0163 0.0078
Echinococcus multilocularis PHD finger protein rhinoceros 0.0333 0.1084 0.1084
Trypanosoma cruzi ISWI complex protein 0.0282 0.0873 1
Echinococcus multilocularis dnaJ subfamily B 0.2506 1 1
Echinococcus multilocularis snurportin 1 0.0317 0.1015 0.1015
Plasmodium vivax hypothetical protein, conserved 0.0263 0.0794 0.7324
Loa Loa (eye worm) hypothetical protein 0.0154 0.0349 0.0688
Brugia malayi beta-lactamase family protein 0.0263 0.0794 0.1462
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0153 0.0343 0.0343
Echinococcus granulosus polycomb protein SCMH1 0.0152 0.0338 0.0338
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0158 0.0365 0.0365
Loa Loa (eye worm) mbt repeat family protein 0.0152 0.0338 0.0666
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0155 0.0352 0.0352
Leishmania major hypothetical protein, conserved 0.0263 0.0794 0.8891
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0597 0.2166 0.2166
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.1092 0.4197 0.4197
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0405 0.0871
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0422 0.1447 0.1447
Echinococcus multilocularis Chromobox protein 3 0.0069 0.00000003296 0.00000003296
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.0794 0.8891
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Mycobacterium ulcerans hypothetical protein 0.0263 0.0794 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.1092 0.4197 0.4197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0469 0.1642 0.1642
Loa Loa (eye worm) beta-lactamase 0.0263 0.0794 0.1567
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0422 0.1447 0.2856
Schistosoma mansoni hypothetical protein 0.0109 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0689 0.1482
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Schistosoma mansoni jumonji/arid domain-containing protein 0.0449 0.1557 0.1557
Brugia malayi beta-lactamase family protein 0.0263 0.0794 0.1462
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0277 0.051
Schistosoma mansoni myelin transcription factor 1 myt1 0.0173 0.0424 0.0424
Schistosoma mansoni cpg binding protein 0.0176 0.0438 0.0438
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0255 0.0763 0.1641
Toxoplasma gondii histone lysine methyltransferase SET1 0.0383 0.1286 1
Brugia malayi Bromodomain containing protein 0.1393 0.5431 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0794 0.1567
Brugia malayi jmjC domain containing protein 0.0108 0.0157 0.029
Brugia malayi PHD-finger family protein 0.0469 0.1642 0.3023
Schistosoma mansoni bromodomain containing protein 0.0089 0.0081 0.0081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0263 0.0794 0.1462
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Echinococcus multilocularis JmjC domain containing protein 4 0.0108 0.0157 0.0157
Echinococcus granulosus lysine specific demethylase 6a 0.0108 0.0157 0.0157
Toxoplasma gondii PHD-finger domain-containing protein 0.0109 0.0163 0.1267
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0236 0.0465
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0263 0.0794 0.1567
Schistosoma mansoni methyl-cpg binding protein mbd 0.0314 0.1006 0.1006
Echinococcus multilocularis zinc finger protein 0.0371 0.1238 0.1238
Echinococcus granulosus lysine specific demethylase 5A 0.0449 0.1557 0.1557
Brugia malayi Muscleblind-like protein 0.046 0.1605 0.2955
Loa Loa (eye worm) hypothetical protein 0.0263 0.0794 0.1567
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0426 0.1462 0.1462
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0662 0.2434 0.2434
Schistosoma mansoni hypothetical protein 0.0282 0.0873 0.0873
Trichomonas vaginalis esterase, putative 0.0263 0.0794 0.1706
Schistosoma mansoni zinc finger protein 0.0282 0.0873 0.0873
Loa Loa (eye worm) hypothetical protein 0.0152 0.0338 0.0666
Echinococcus granulosus SAM and MBT domain containing protein 0.0152 0.0338 0.0338
Toxoplasma gondii PHD-finger domain-containing protein 0.0333 0.1084 0.843
Echinococcus multilocularis muscleblind protein 0.046 0.1605 0.1605
Brugia malayi MH2 domain containing protein 0.0127 0.0236 0.0434
Onchocerca volvulus 0.0224 0.0636 0.1367
Loa Loa (eye worm) CXXC zinc finger family protein 0.0176 0.0438 0.0864
Brugia malayi mbt repeat family protein 0.0152 0.0338 0.0622
Echinococcus multilocularis SAM and MBT domain containing protein 0.0152 0.0338 0.0338
Onchocerca volvulus Alhambra homolog 0.0333 0.1084 0.233
Loa Loa (eye worm) hypothetical protein 0.0263 0.0794 0.1567
Echinococcus multilocularis muscleblind protein 1 0.046 0.1605 0.1605
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0426 0.1462 0.1462
Loa Loa (eye worm) hypothetical protein 0.0572 0.2061 0.4069
Echinococcus granulosus cpg binding protein 0.0221 0.0624 0.0624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0422 0.1447 0.1447
Loa Loa (eye worm) hypothetical protein 0.0263 0.0794 0.1567
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0115 0.0186 0.0186
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0597 0.2166 0.2166
Loa Loa (eye worm) CHromoDomain protein family member 0.0115 0.0186 0.0367
Echinococcus granulosus peregrin 0.0377 0.1263 0.1263
Mycobacterium leprae Probable lipase LipE 0.0263 0.0794 0.5
Loa Loa (eye worm) hypothetical protein 0.0751 0.2798 0.5522
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0314 0.1006 0.1006
Entamoeba histolytica hypothetical protein 0.0114 0.0185 1
Onchocerca volvulus 0.0263 0.0794 0.1706
Loa Loa (eye worm) hypothetical protein 0.0237 0.0689 0.1361
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0798 0.1715
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Loa Loa (eye worm) jmjC domain-containing protein 0.0449 0.1557 0.3074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1447 0.1447
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0422 0.1447 0.1447
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0333 0.1084 0.1084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0469 0.1642 0.1642
Plasmodium falciparum JmjC domain-containing protein, putative 0.0108 0.0157 0.1452
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0109 0.0163 0.0078
Brugia malayi CHD4 protein 0.0115 0.0186 0.0342
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0173 0.0424 0.078
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.0157 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0263 0.0794 0.0794
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0464 0.0997
Loa Loa (eye worm) hypothetical protein 0.0796 0.2983 0.5889
Loa Loa (eye worm) PHD-finger family protein 0.038 0.1277 0.252
Echinococcus multilocularis peregrin 0.0377 0.1263 0.1263
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0379 0.127 0.127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0109 0.0164 0.0352
Brugia malayi Bromodomain containing protein 0.0377 0.1263 0.2325
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0224 0.0636 0.0636
Toxoplasma gondii ABC1 family protein 0.0263 0.0794 0.6174
Echinococcus granulosus chromobox protein 1 0.0423 0.1453 0.1453
Echinococcus multilocularis phd:f box containing protein 0.0108 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0469 0.1642 0.3241
Brugia malayi jmjC domain containing protein 0.0108 0.0157 0.029
Brugia malayi TAR-binding protein 0.0132 0.0258 0.0475
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0108 0.0157 0.1224
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0464 0.0997
Entamoeba histolytica hypothetical protein 0.0114 0.0185 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0258 0.0258
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.0157 0.0311
Loa Loa (eye worm) RNA binding protein 0.0132 0.0258 0.0509
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.0798 0.1469
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0152 0.0338 0.0726
Trichomonas vaginalis D-aminoacylase, putative 0.0263 0.0794 0.1706
Echinococcus granulosus fetal alzheimer antigen falz 0.0426 0.1462 0.1462
Brugia malayi jmjC domain containing protein 0.1092 0.4197 0.7727
Echinococcus multilocularis histone acetyltransferase MYST2 0.0173 0.0424 0.0424
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0146 0.0313 0.0313
Loa Loa (eye worm) PHD-finger family protein 0.0333 0.1084 0.2139
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0237 0.0689 0.1482
Echinococcus multilocularis jumonji domain containing protein 0.0464 0.162 0.162
Brugia malayi jmjC domain containing protein 0.0108 0.0157 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.0157 0.0311
Loa Loa (eye worm) hypothetical protein 0.0707 0.2619 0.5169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0155 0.0352 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Trichomonas vaginalis D-aminoacylase, putative 0.0263 0.0794 0.1706
Echinococcus granulosus tar DNA binding protein 0.0132 0.0258 0.0258
Brugia malayi beta-lactamase 0.0263 0.0794 0.1462
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0108 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.2506 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0109 0.0164 0.0352
Brugia malayi hypothetical protein 0.0114 0.0185 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0088 0.0189
Brugia malayi RNA binding protein 0.0132 0.0258 0.0475
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0798 0.1715
Loa Loa (eye worm) heterochromatin protein 1 0.0423 0.1453 0.2867
Loa Loa (eye worm) hypothetical protein 0.0089 0.0081 0.0159
Loa Loa (eye worm) hypothetical protein 0.0137 0.0277 0.0547
Schistosoma mansoni jumonji domain containing protein 0.0108 0.0157 0.0157
Echinococcus multilocularis beta LACTamase domain containing family member 0.0263 0.0794 0.0794
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0109 0.0164 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0333 0.1084 1
Onchocerca volvulus 0.0263 0.0794 0.1706
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0173 0.0424 0.0424
Echinococcus granulosus chromobox protein 1 0.0423 0.1453 0.1453
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.012 0.0207 0.1909
Loa Loa (eye worm) hypothetical protein 0.0186 0.0479 0.0945
Brugia malayi chromobox protein homolog 3 0.0237 0.0689 0.1269
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0258 0.0258
Brugia malayi Bromodomain containing protein 0.0706 0.2613 0.4812
Schistosoma mansoni methyl-cpg binding protein mbd 0.0314 0.1006 0.1006
Schistosoma mansoni hypothetical protein 0.0137 0.0277 0.0277
Trichomonas vaginalis chromobox protein, putative 0.0423 0.1453 0.3122
Schistosoma mansoni sex comb on midleg homolog 0.0152 0.0338 0.0338
Echinococcus multilocularis cpg binding protein 0.0221 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.051 0.1807 0.1807
Loa Loa (eye worm) hypothetical protein 0.0108 0.0157 0.0311
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Echinococcus granulosus muscleblind protein 0.046 0.1605 0.1605
Mycobacterium ulcerans beta-lactamase 0.0263 0.0794 0.5
Brugia malayi SET domain containing protein 0.0079 0.0039 0.0071
Trypanosoma brucei ISWI complex protein 0.0282 0.0873 1
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0405 0.0871
Echinococcus multilocularis chromobox protein 1 0.0423 0.1453 0.1453
Brugia malayi mbt repeat family protein 0.0152 0.0338 0.0622
Echinococcus granulosus phd:f box containing protein 0.0108 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0689 0.1482
Echinococcus granulosus snurportin 1 0.0317 0.1015 0.1015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0258 0.0509
Echinococcus granulosus JmjC domain containing protein 4 0.0108 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.046 0.1605 0.3167
Echinococcus multilocularis lysine specific demethylase 6a 0.0108 0.0157 0.0157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0263 0.0794 0.0794
Schistosoma mansoni bromodomain containing protein 0.1177 0.4544 0.4544
Loa Loa (eye worm) hypothetical protein 0.0173 0.0424 0.0836
Schistosoma mansoni hypothetical protein 0.038 0.1277 0.1277
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0662 0.2434 0.2434
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0469 0.1642 0.1642
Brugia malayi F/Y-rich N-terminus family protein 0.0203 0.0551 0.1014
Echinococcus multilocularis lysine specific demethylase 5A 0.0404 0.1372 0.1372
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0426 0.0915
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0422 0.1447 0.2665
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0109 0.0164 0.0352
Schistosoma mansoni sex comb on midleg homolog 0.0152 0.0338 0.0338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0088 0.0076 0.0163
Onchocerca volvulus 0.0263 0.0794 0.1706
Brugia malayi jmjC domain containing protein 0.0449 0.1557 0.2868
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0185 0.0185
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.0798 0.1715
Brugia malayi Pre-SET motif family protein 0.1057 0.4055 0.7466
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0109 0.0164 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1447 0.1447
Mycobacterium ulcerans lipase LipD 0.0263 0.0794 0.5
Schistosoma mansoni zinc finger protein 0.0371 0.1238 0.1238
Schistosoma mansoni hypothetical protein 0.051 0.1807 0.1807
Schistosoma mansoni phd/f-box containing protein 0.0108 0.0157 0.0157
Plasmodium falciparum phd finger protein, putative 0.0333 0.1084 1
Trypanosoma brucei hypothetical protein, conserved 0.0263 0.0794 0.8891
Onchocerca volvulus 0.0152 0.0338 0.0726
Brugia malayi Heterochromatin protein 1 0.0423 0.1453 0.2674
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.1015 0.2004
Onchocerca volvulus 0.0186 0.0479 0.103
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0108 0.0157 0.1224
Brugia malayi CXXC zinc finger family protein 0.0176 0.0438 0.0806
Schistosoma mansoni hypothetical protein 0.0114 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0317 0.1015 0.1015
Brugia malayi jmjC domain containing protein 0.0108 0.0157 0.029
Loa Loa (eye worm) hypothetical protein 0.046 0.1605 0.3167
Schistosoma mansoni hypothetical protein 0.0333 0.1084 0.1084
Mycobacterium leprae conserved hypothetical protein 0.0263 0.0794 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0155 0.0352 0.2735
Brugia malayi RNA, U transporter 1 0.0084 0.0062 0.0114
Loa Loa (eye worm) hypothetical protein 0.0263 0.0794 0.1567
Echinococcus granulosus jumonji domain containing protein 0.0464 0.162 0.162
Entamoeba histolytica hypothetical protein 0.0114 0.0185 1
Trypanosoma cruzi hypothetical protein, conserved 0.0263 0.0794 0.8891
Brugia malayi PHD-finger family protein 0.0154 0.0349 0.0642
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0185 0.0185
Onchocerca volvulus 0.1203 0.4652 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0263 0.0794 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0236 0.0465
Plasmodium vivax JmjC domain containing protein 0.0108 0.0157 0.1452
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0109 0.0164 0.0352
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0115 0.0186 0.0186
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0258 0.0475
Trichomonas vaginalis set domain proteins, putative 0.1203 0.4652 1
Brugia malayi PHD-finger family protein 0.0333 0.1084 0.1996
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0153 0.0343 0.0343
Echinococcus multilocularis geminin 0.051 0.1807 0.1807
Echinococcus granulosus methyl CpG binding domain protein 2 0.0314 0.1006 0.1006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0422 0.1447 0.1447
Echinococcus multilocularis jumonji domain containing 1A 0.0108 0.0157 0.0157
Plasmodium vivax hypothetical protein, conserved 0.012 0.0207 0.1909
Schistosoma mansoni chromobox protein 0.0423 0.1453 0.1453
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.0537 0.0988
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0109 0.0164 0.0352
Echinococcus granulosus zinc finger protein 0.0371 0.1238 0.1238
Schistosoma mansoni cpg binding protein 0.0221 0.0624 0.0624
Schistosoma mansoni protein phosphatase 2C 0.0108 0.0157 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0258 0.0258
Echinococcus granulosus histone lysine methyltransferase setb 0.0469 0.1642 0.1642
Schistosoma mansoni hypothetical protein 0.0921 0.3496 0.3496

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) Agonist activity at human NOP assessed as stimulation of GDP-induced [35S]GTPgammaS binding ChEMBL. 19339177
EC50 (functional) Agonist activity at human mu opioid assessed as stimulation of GDP-induced [35S]GTPgammaS binding ChEMBL. 19339177
Ki (binding) Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cells ChEMBL. 19339177
Ki (binding) = 3151 nM Displacement of [125I][Tyr14]nociceptin from human cloned NOP receptor expressed in CHO cells ChEMBL. 19339177

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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