TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.358 | Formula: C16H14N2O4S
H donors: 3 H acceptors: 4 LogP: 2.5 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: [O-]S(=O)(=O)O.C[n+]1c2ccccc2cc2c1c1ccccc1[nH]2
InChi: 1S/C16H12N2.H2O4S/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;1-5(2,3)4/h2-10H,1H3;(H2,1,2,3,4)
InChiKey: HYHSZPYVASNZJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0188	0.0829	0.0829
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0035	0.0098	0.0098
Schistosoma mansoni	ran	0.0024	0.0047	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0138	0.1669
Plasmodium vivax	potassium channel, putative	0.0035	0.0098	0.0836
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0036	0.0439
Mycobacterium tuberculosis	Probable lipase LipD	0.0188	0.0829	0.141
Schistosoma mansoni	calcium-activated potassium channel	0.0836	0.393	0.393
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.012	0.1453
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0047	0.0567
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0035	0.0098	0.1187
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0035	0.0098	0.1187
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0035	0.0098	0.1187
Entamoeba histolytica	hypothetical protein	0.0027	0.0059	0.2406
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Schistosoma mansoni	ap endonuclease	0.0022	0.0034	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.1155
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0036	0.0439
Schistosoma mansoni	calcium-activated potassium channel	0.0035	0.0098	0.0098
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0035	0.0098	0.1187
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0089	0.1073
Onchocerca volvulus		0.0035	0.0098	0.0836
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0035	0.0098	0.1187
Brugia malayi	hypothetical protein	0.0021	0.0032	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0829	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0089	0.0226
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.1155
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.012	0.109
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0089	0.1073
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0053	0.0643
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.012	0.109
Leishmania major	hypothetical protein, conserved	0.0035	0.0098	0.1187
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0036	0.0036
Mycobacterium leprae	Probable lipase LipE	0.0188	0.0829	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.1155
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0035	0.0098	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.0418	0.0418
Echinococcus multilocularis	microtubule associated protein 2	0.2105	1	1
Plasmodium vivax	potassium channel, putative	0.0035	0.0098	0.0836
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0035	0.0098	0.0098
Onchocerca volvulus		0.0188	0.0829	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0036	0.0005
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0032	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0032	0.0081
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0032	0.0032
Onchocerca volvulus		0.0035	0.0098	0.0836
Trichomonas vaginalis	D-aminoacylase, putative	0.0188	0.0829	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0829	0.2109
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.012	0.1453
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0036	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0047	0.229
Onchocerca volvulus		0.0188	0.0829	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0035	0.0098	0.1187
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0047	0.0047
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0035	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trypanosoma brucei	unspecified product	0.0015	0.0003	0.0042
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.0418	0.0418
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0138	0.1669
Schistosoma mansoni	calcium-activated potassium channel	0.0686	0.3212	0.3212
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0188	0.0829	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0138	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0138	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0035	0.0098	0.1187
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0096	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	TWK-7 protein	0.0035	0.0098	0.025
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0188	0.0829	1
Brugia malayi	beta-lactamase	0.0188	0.0829	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0036	0.0439
Onchocerca volvulus		0.0035	0.0098	0.0836
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0138	0.1669
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0034	0.0296
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0035	0.0098	0.1187
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Echinococcus granulosus	calcium activated potassium channel variant	0.0035	0.0098	0.0098
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.0418	0.0418
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0035	0.0098	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0188	0.0829	0.0829
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0516	0.1312
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0035	0.0098	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	inositol-1	0.004	0.012	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0035	0.0098	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Leishmania major	hypothetical protein, conserved	0.0188	0.0829	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0047	0.012
Loa Loa (eye worm)	TWK-28 protein	0.0035	0.0098	0.025
Leishmania major	DNA polymerase eta, putative	0.0022	0.0036	0.0439
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0034	0.0407
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0034	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0098	0.1187
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.1155
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.012	1
Mycobacterium ulcerans	transmembrane cation transporter	0.0035	0.0098	0.0814
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0324	0.1483	0.3773
Mycobacterium tuberculosis	Probable esterase LipL	0.0188	0.0829	0.141
Schistosoma mansoni	importin beta-1	0.0033	0.0089	0.0089
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.012	0.012
Mycobacterium ulcerans	beta-lactamase	0.0188	0.0829	1
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.012	0.012
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.012	0.1453
Brugia malayi	beta-lactamase family protein	0.0188	0.0829	1
Onchocerca volvulus		0.0188	0.0829	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Schistosoma mansoni	hypothetical protein	0.0021	0.0032	0.0032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0047	0.0192
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0035	0.0098	0.1187
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0354	0.1625	0.4134
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Schistosoma mansoni	ap endonuclease	0.0022	0.0034	0.0034
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0035	0.0098	0.025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0047	0.0567
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0836	0.393	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0034	0.0034
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0035	0.0098	0.1187
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0035	0.0098	0.1187
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0102	0.0418	0.1063
Schistosoma mansoni	microtubule-associated protein tau	0.2105	1	1
Mycobacterium tuberculosis	Conserved protein	0.0188	0.0829	0.141
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0032	0.0032
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0047	0.127
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0089	0.0717
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0059	0.071
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0479	0.122
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0036	0.0034
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0127	0.0538	0.0538
Echinococcus granulosus	RUN	0.0021	0.0032	0.0032
Schistosoma mansoni	polycystin 1-related	0.0021	0.0032	0.0032
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0029	0.0345
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0138	0.1669
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0035	0.0098	0.1187
Schistosoma mansoni	lipoxygenase	0.0127	0.0538	0.0538
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0036	0.0439
Mycobacterium leprae	conserved hypothetical protein	0.0188	0.0829	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Echinococcus granulosus	snurportin 1	0.0354	0.1625	0.1625
Trichomonas vaginalis	penicillin-binding protein, putative	0.0188	0.0829	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.012	0.1453
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0138	0.1669
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0138	0.1669
Echinococcus multilocularis	twik family of potassium channels	0.0035	0.0098	0.0098
Giardia lamblia	Hypothetical protein	0.0035	0.0098	0.6183
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0096	0.1157
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.12	0.5672	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0036	0.0439
Trichomonas vaginalis	D-aminoacylase, putative	0.0188	0.0829	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0034	0.0025
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0059	0.071
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0032	0.0032
Trichomonas vaginalis	esterase, putative	0.0188	0.0829	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0055	0.0658
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0059	0.071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0053	0.0643
Schistosoma mansoni	loxhd1	0.0021	0.0032	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0188	0.0829	1
Trypanosoma brucei	hypothetical protein, conserved	0.0188	0.0829	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.007	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0043	0.0514
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0018	0.0017	0.0201
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0098	0.1187
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0034	0.0034
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0035	0.0098	0.1187
Toxoplasma gondii	ion channel protein	0.0035	0.0098	0.0814
Echinococcus granulosus	dna polymerase eta	0.0022	0.0036	0.0036
Trichomonas vaginalis	ran, putative	0.0024	0.0047	0.0567
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0138	0.1669
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0035	0.0098	0.1187
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0138	0.1669
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0034	0.0407
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0036	0.0439
Brugia malayi	beta-lactamase family protein	0.0188	0.0829	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0036	0.0036
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0036	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0032	0.0081
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0034	0.0407
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0036	0.0036
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0089	0.0694
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0036	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Onchocerca volvulus		0.0035	0.0098	0.0836
Trypanosoma cruzi	hypothetical protein, conserved	0.0188	0.0829	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Toxoplasma gondii	ion channel protein	0.0035	0.0098	0.0814
Brugia malayi	hypothetical protein	0.0035	0.0098	0.1187
Trichomonas vaginalis	D-aminoacylase, putative	0.0188	0.0829	1
Schistosoma mansoni	inositol monophosphatase	0.004	0.012	0.012
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0047	0.0567
Schistosoma mansoni	inositol monophosphatase	0.004	0.012	0.012
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0516	0.1312
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.012	0.1453
Echinococcus granulosus	beta LACTamase domain containing family member	0.0188	0.0829	0.0829
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0047	0.0047
Toxoplasma gondii	ABC1 family protein	0.0188	0.0829	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Trypanosoma cruzi	ion transport protein, putative	0.0035	0.0098	0.1187
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0032	0.0032
Onchocerca volvulus		0.0035	0.0098	0.0836
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0055	0.0658
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0034	0.0407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0108	0.1302
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0036	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0829	0.2109
Trichomonas vaginalis	penicillin-binding protein, putative	0.0188	0.0829	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0096	0.1157
Echinococcus multilocularis	small conductance calcium activated potassium	0.0836	0.393	0.393
Schistosoma mansoni	hypothetical protein	0.0836	0.393	0.393
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0042	0.0512
Brugia malayi	hypothetical protein	0.0021	0.0032	0.0383
Trypanosoma cruzi	ion transport protein, putative	0.0035	0.0098	0.1187
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0036	0.0259
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0036	0.0036
Echinococcus granulosus	twik family of potassium channels	0.0035	0.0098	0.0098
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0034	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0362	0.166	0.4224
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0098	0.1187
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0032	0.0032
Echinococcus multilocularis	potassium channel subfamily K	0.0035	0.0098	0.0098
Schistosoma mansoni	twik family of potassium channels-related	0.0035	0.0098	0.0098
Giardia lamblia	GTOR	0.0044	0.0138	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0098	0.1187
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0034	0.0407
Brugia malayi	MH2 domain containing protein	0.0122	0.0516	0.6219
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0035	0.0098	0.1187
Leishmania major	calcium/potassium channel (CAKC), putative	0.0035	0.0098	0.1187
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0188	0.0829	0.141
Brugia malayi	Doublecortin family protein	0.0021	0.0032	0.0383
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0188	0.0829	0.141
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Onchocerca volvulus		0.0035	0.0098	0.0836
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0188	0.0829	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Plasmodium falciparum	importin beta, putative	0.0033	0.0089	0.8576
Mycobacterium tuberculosis	Conserved protein	0.0188	0.0829	0.141
Mycobacterium ulcerans	ion transport protein	0.0035	0.0098	0.0814
Onchocerca volvulus		0.0035	0.0098	0.0836
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0127	0.0538	0.0538
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0055	0.0658
Leishmania major	GTP-binding protein, putative	0.0024	0.0047	0.0567
Mycobacterium ulcerans	lipase LipD	0.0188	0.0829	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0188	0.0829	1
Plasmodium falciparum	potassium channel	0.0035	0.0098	1
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0059	0.071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.0418	0.0418
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0035	0.0098	0.0115
Loa Loa (eye worm)	beta-lactamase	0.0188	0.0829	0.2109
Echinococcus granulosus	potassium channel subfamily K 8	0.0035	0.0098	0.0098
Schistosoma mansoni	calcium-activated potassium channel	0.0035	0.0098	0.0098
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Schistosoma mansoni	lipoxygenase	0.0089	0.0355	0.0355
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0036	0.0439
Brugia malayi	hypothetical protein	0.0035	0.0098	0.1187
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0035	0.0098	0.025
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0035	0.0098	0.1187
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Echinococcus multilocularis	twik family of potassium channels	0.0035	0.0098	0.0098
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0032	0.0085	0.0645
Schistosoma mansoni	hypothetical protein	0.0035	0.0098	0.0098
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.012	0.1453
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0098	0.1187
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Brugia malayi	Inositol-1	0.004	0.012	0.1453
Brugia malayi	Importin beta-1 subunit	0.0033	0.0089	0.1073
Schistosoma mansoni	ran	0.0024	0.0047	0.0047
Echinococcus granulosus	twik family of potassium channels	0.0035	0.0098	0.0098
Echinococcus granulosus	potassium channel subfamily K	0.0035	0.0098	0.0098
Schistosoma mansoni	rab6-interacting	0.0021	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0043	0.0514
Echinococcus multilocularis	potassium channel subfamily K 8	0.0035	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Mycobacterium tuberculosis	Conserved protein	0.0188	0.0829	0.141
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0043	0.0514
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0036	0.0036
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0138	0.1669
Echinococcus multilocularis	potassium channel subfamily K 8	0.0035	0.0098	0.0098
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0035	0.0098	0.1187
Echinococcus granulosus	potassium channel subfamily K 8	0.0035	0.0098	0.0098
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0047	0.0567
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0047	0.0167
Mycobacterium tuberculosis	Probable hydrolase	0.0188	0.0829	0.141
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0138	0.0352
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0138	0.1669
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0042	0.0512
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0036	0.0036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0003	0.0042
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0035	0.0098	0.1187
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0036	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0035	0.0098	0.0098
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.01	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0043	0.0514
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.012	0.1453
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0829	0.2109
Mycobacterium ulcerans	hypothetical protein	0.0188	0.0829	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0096	0.1155
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0138	0.0138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0065	0.0788
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0035	0.0098	0.6183
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0188	0.0829	0.141
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0829	0.2109
Schistosoma mansoni	hypothetical protein	0.0354	0.1625	0.1625
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0059	0.071
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.0418	0.0418
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0102	0.0418	0.5037
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0036	0.0036
Plasmodium vivax	hypothetical protein, conserved	0.0188	0.0829	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0034	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Echinococcus multilocularis	RUN	0.0021	0.0032	0.0032
Entamoeba histolytica	Ran family GTPase	0.0024	0.0047	0.127
Onchocerca volvulus		0.0035	0.0098	0.0836
Echinococcus multilocularis	calcium activated potassium channel variant	0.0035	0.0098	0.0098
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0034	0.0407
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0098	0.1187
Leishmania major	potassium channel subunit-like protein	0.0035	0.0098	0.1187
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0138	0.0138
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0036	0.0439
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.012	0.8286
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0829	0.2109
Mycobacterium tuberculosis	Probable lipase LipE	0.0188	0.0829	0.141
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0093
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0003	0.0042
Trypanosoma brucei	unspecified product	0.0015	0.0003	0.0042
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0003	0.0042
Echinococcus multilocularis	snurportin 1	0.0354	0.1625	0.1625
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0042	0.0512
Loa Loa (eye worm)	uncoordinated protein 58	0.0035	0.0098	0.025
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0035	0.0098	0.1187
Leishmania major	ion transport protein-like protein	0.0035	0.0098	0.1187
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0036	0.0439
Trypanosoma brucei	unspecified product	0.0022	0.0036	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0098	0.1187
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0089	0.0089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0085	0.1026
Echinococcus granulosus	small conductance calcium activated potassium	0.0836	0.393	0.393
Brugia malayi	RNA, U transporter 1	0.0094	0.0382	0.4603
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0036	0.0259
Leishmania major	hypothetical protein, conserved	0.0035	0.0098	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0098	0.025
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0035	0.0098	0.025
Plasmodium falciparum	potassium channel	0.0035	0.0098	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0188	0.0829	0.0829
Schistosoma mansoni	rab6-interacting	0.0021	0.0032	0.0032

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.44 uM	In vitro antiplasmodial activity of the compound against Plasmodium falciparum	ChEMBL.	15801861
IC50 (functional)	= 0.44 uM	Normalized IC50 value is obtained by multiplying antiplasmodial IC50 value with IC50 value of compound accumulated in the vacuole	ChEMBL.	15801861
Vascular accumulation ratio (functional)	= 79.43	Vascular accumulation ratio is calculated by accumulation of compound into acidic parasitic food vacuole (pH=5.5)	ChEMBL.	15801861

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum		15801861

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL553878

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1176440