Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0594 | 0.0594 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0594 | 0.0599 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0594 | 0.0599 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0868 | 0.0875 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0594 | 0.1205 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1332 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0594 | 0.0599 |
Brugia malayi | RNA binding protein | 0.0067 | 0.5144 | 0.5144 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.5144 | 0.5187 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0594 | 0.0594 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0868 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1332 | 0.1332 |
Onchocerca volvulus | 0.0025 | 0.1332 | 0.1258 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.4929 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.5144 | 0.5187 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0594 | 0.0594 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0594 | 0.0594 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.9918 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0059 | 0.4419 | 0.8965 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1332 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0755 | 0.5671 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0594 | 0.1205 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0594 | 0.0594 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0011 | 0.0084 | 0.0085 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0755 | 0.5885 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1332 | 0.2702 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0868 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0755 | 0.0755 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.4929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0755 | 0.0755 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.5144 | 0.5187 |
Onchocerca volvulus | 0.002 | 0.0868 | 0.0791 | |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0594 | 0.1205 |
Echinococcus multilocularis | RUN | 0.002 | 0.0868 | 0.0875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0594 | 0.4088 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0051 | 0.3671 | 0.7448 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0868 | 0.0875 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0868 | 0.0875 |
Brugia malayi | cathepsin L-like precursor | 0.0011 | 0.0084 | 0.0084 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0594 | 0.0599 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.9918 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1332 | 0.2702 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.5144 | 0.5187 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1332 | 0.2702 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.5144 | 0.5144 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0868 | 0.0875 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0868 | 0.0875 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0868 | 0.0875 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0594 | 0.0514 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0755 | 0.0755 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0755 | 0.5671 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0755 | 0.0755 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0594 | 0.0599 |
Toxoplasma gondii | cathepsin CPL | 0.0017 | 0.0594 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.1332 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0594 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7665 | 0.7729 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0594 | 0.0514 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0594 | 0.0594 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0084 | 0.0084 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0011 | 0.0084 | 0.0085 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.341 | 0.341 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.1332 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0594 | 0.0594 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0755 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0868 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0017 | 0.0594 | 0.1205 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0662 | 0.4972 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0594 | 0.4088 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.4929 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0868 | 1 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0594 | 0.0594 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.4929 | 1 |
Leishmania major | cathepsin L-like protease | 0.0065 | 0.4929 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.1332 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0594 | 0.0599 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0594 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1332 | 0.1332 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.341 | 0.341 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0084 | 0.0084 |
Echinococcus granulosus | RUN | 0.002 | 0.0868 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1332 | 0.1332 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1332 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0868 | 0.0868 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.5144 | 0.5144 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0594 | 0.0594 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.1332 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0594 | 0.0599 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.6648 | 0.6703 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0868 | 0.0868 |
Leishmania major | cysteine peptidase A (CPA) | 0.0017 | 0.0594 | 0.1205 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0594 | 0.0599 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0065 | 0.4929 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0868 | 0.0875 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.1332 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.1332 | 1 |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0594 | 0.1205 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.1332 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0065 | 0.4929 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.7665 | 0.7665 |
Brugia malayi | hypothetical protein | 0.002 | 0.0868 | 0.0868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.1332 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.7665 | 0.7729 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.9918 | 1 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0868 | 0.0868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7665 | 0.7729 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.5144 | 0.5187 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0594 | 0.0599 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0594 | 0.0594 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.1332 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.5144 | 0.5144 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0594 | 0.0594 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.5144 | 0.5187 |
Onchocerca volvulus | Cathepsin F homolog | 0.0017 | 0.0594 | 0.0514 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0594 | 0.0594 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1332 | 1 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.5144 | 0.5144 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0662 | 0.4972 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0868 | 0.0868 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0065 | 0.4929 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0594 | 0.0599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.5144 | 0.5187 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1332 | 0.1332 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.7665 | 0.7729 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.7665 | 0.7729 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.7665 | 0.7665 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7665 | 0.7729 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Onchocerca volvulus | 0.0017 | 0.0594 | 0.0514 | |
Leishmania major | cathepsin L-like protease | 0.0017 | 0.0594 | 0.1205 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.5144 | 0.5144 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0662 | 0.4972 |
Brugia malayi | hypothetical protein | 0.002 | 0.0868 | 0.0868 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0662 | 0.4972 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1332 | 0.1332 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.7665 | 0.7729 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.1332 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0011 | 0.0084 | 0.0084 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0755 | 0.5885 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.1332 | 0.1332 |
Onchocerca volvulus | 0.002 | 0.0868 | 0.0791 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0594 | 0.4088 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0594 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0868 | 0.0875 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0868 | 0.0875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.